|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer显示文摘Metastasis,the development of secondary malignant growths at a distance from a primary tumor,is the cause of death for 90%of cancer patients,but little is known about how metastatic cancer cells adapt to and colonize new tissue environments.Here,using clinical samples,patient-derived xenograft(PDX)samples,PDX cells,and primary/metastatic cell lines,we discovered that liver metastatic colorectal cancer(CRC)cells lose their colon-specific gene transcription program yet gain a liver-specific gene transcription program.We showed that this transcription reprogramming is driven by a reshaped epigenetic landscape of both typical enhancers and super-enhancers.Further,we identified that the liver-specific transcription factors FOXA2 and HNF1A can bind to the gained enhancers and activate the liver-specific gene transcription,thereby driving CRC liver metastasis.Importantly,similar transcription reprogramming can be observed in multiple cancer types.Our data suggest that reprogrammed tissue-specific transcription promotes metastasis and should be targeted therapeutically. | Shuaishuai Teng Yang Eric Li Ming Yang Rui Qi Yiming Huang Qianyu Wang Yanmei Zhang Shanwen Chen Shasha Li Kequan Lin Yang Cao Qunsheng Ji Qingyang Gu Yujing Cheng Zai Chang Wei Guo Pengyuan Wang Ivan Garcia-Bassets Zhi John Lu Dong Wang | 2020 | Cell Research2020，30，1： | 11 |
| 2 | Synthesis of 6-sulfamoyl-4-oxoquinoline-3-carboxylic acid derivatives as integrase antagonists with anti-HIV activity显示文摘一系列新奇 6-sulfamoyl-4-oxoquinoline-3-carboxylic 酸衍生物为 HIV integrase 抑制活动被综合了并且屏蔽。他们的结构被 ESIMS 证实, 1 H NMR 和 13 C NMR。 | Zai Gang Luo Cheng Chu Zeng Lei Fu Yang Hong Qiu He Cun Xin Wang Li Ming Hu | 2009 | Chinese Chemical Letters2009，20，7： | 3 |
| 3 | Changing Grains for the Prevention and Treatment of Kashin-Beck Disease in Children: a Meta-analysis显示文摘To evaluate the efficacy of changing grains on the prevention and treatment of Kashin-Beck Disease(KBD)in children,community-based trials were acquired from seven electronic databases(up to July 2014).As a result,the methodological quality of the six trials that have been included into our analysis was low.The pooled ORs favoring the prevention and treatment effects of changing grains were 0.15(95%CI:0.03-0.70)and 2.13(95% | HAN Jing YU Fang Fang CHANG Zai Ping YANG Bo QU Cheng Juan ZHOU Tian Tian LIU Rui Yu GUO Xiong | 2015 | Biomedical and Environmental Sciences2015，28，4： | 2 |
| 4 | Preparation and Properties of Water-based Conducting Polyaniline显示文摘IntroductionInthepastdecade,conjugatedconductingpolymerslikepolyaniline,polythiopheneandpolypyrolehavereceivedconsiderableate... | WANG Xian hong, GENG Yan hou, YU Lei, SUN Zai cheng Li Ji, JING Xia bin ** and WANG Fo song (Polymer Chemistry Lab, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022) LEE Chang jin and RHEE Suh bo | 1998 | Chemical Research in Chinese Universities1998，14，3： | 1 |
| 5 | Application of virtual instrument in time delay signal analysis显示文摘 | Li Mingjiang Wang Chunlan Cheng Zai | 2011 | Applied Mechanics and Materials2011，4041，： | 1 |
| 6 | Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production, and neuronal apoptosis显示文摘 | Zai Fang Yu Mariana Nikolova-Karakashian Daohong Zhou Guanjun Cheng Edward H. Schuchman Mark P. Mattson | 2000 | Journal of Molecular Neuroscience2000，，2： | 1 |
| 7 | Resourcemanagement of bridge deck rehabilitation : Jacques cartier bridge case study显示文摘 | Zhang Cheng Zayed Tarek Hammad Amin | 2008 | Journal of Construction Engineering and Management2008，134，5： | 1 |
| 8 | Effects of expandable graphite and dimethyl methylphosphonate on mechanical, thermal, and flame‐retardant properties of flexible polyurethane foams显示文摘 | Cheng‐Qun Wang Feng‐Yan Ge Jie Sun Zai‐Sheng Cai | 2013 | J. Appl. Polym. Sci2013，，2： | 1 |
| 9 | Synthesis of biodisiel from used cooking oils catalyzed by solid acid 显示文摘 | ZHENG ZAI CHENG SU SU LIN RUI LEI | 2011 | Advaneed Materials Research2011，，： | 1 |
| 10 | Granularmechanical analysis of the strength and dilatancy ofsands显示文摘 | CHANG Zai YANG Jun CHENG Xiao-hui | 2003 | Engineering Mechanics2003，43，3： | 1 |
| 11 | Genetic diversity among and within populations of Oryza granulate from Yunnan of China revealed by RAPD and ISSR markers : implications for conservation of the endangered species 显示文摘 | Wu Chengjun Cheng Zai quan | 2004 | Plant Science2004，167，： | 1 |
| 12 | Genetic diversity among and within populations of Oryza granulate from Yunnan of China revealed by RAPD and ISSR markers: implications for conservation of the endangered species显示文摘 | WU CHENGJUN CHENG ZAI QUAN | 2004 | Plant Science2004，167，： | 1 |
| 13 | Assessing Heat-related Mortality Risks in Beijing,China显示文摘Objective To obtain the exposure-response relationship for temperature and mortality,and assess the risk of heat-related premature death.Methods A statistical model was developed using a Poisson generalized linear regression model with Beijing mortality and temperature data from October 1st,2006 to September 30th,2008.We calculated the exposure-response relationship for temperature and mortality in the central city,and inner suburban and outer suburban regions.Based on this relationship,a health risk model was used to assess the risk of heat-related premature death in the summer(June to August) of 2009.Results The population in the outer suburbs had the highest temperature-related mortality risk.People in the central city had a mid-range risk,while people in the inner suburbs had the lowest risk.Risk assessment predicted that the number of heat-related premature deaths in the summer of 2009 was 1581.The city areas of Chaoyang and Haidian districts had the highest number of premature deaths.The number of premature deaths in the southern areas of Beijing(Fangshan,Fengtai,Daxing,and Tongzhou districts) was in the mid-range.Conclusion Ambient temperature significantly affects human mortality in Beijing.People in the city and outer suburban area have a higher temperature-related mortality risk than people in the inner suburban area.This may be explained by a temperature-related vulnerability. | LI Tian Tian GAO Yan Lin WEI Zai Hua WANG Jing GUO Ya Fei LIU Fan LIU Zhao Rong CHENG Yah Li | 2012 | Biomedical and Environmental Sciences2012，25，4： | 1 |
| 14 | Impeded degradation of perovskite solar cells via the dual interfacial modification of siloxane显示文摘It is challenging to improve the long-term stability of perovskite solar cells(PSCs) without sacrificing efficiency. The perovskite absorbers degrade from the film surface/interfaces, which follows entangled mechanisms that have not been fully revealed yet.Herein, we decouple and elaborate two distinctive pathways regarding film degradation based on FACsPbI3perovskites.Moreover, a dual interfacial modification strategy has been developed for improving the material’s intrinsic stability, thus leading to the film degrading in a more retardant pathway. The corresponding PSCs achieve a stable power output efficiency of 23.75%.More importantly, the unencapsulated PSCs devices retain over 93% of their initial PCE after the maximum power point(MPP)tracking under the continuous 1-sun illumination and show significantly improved stability after aged under the thermal treatment or stored in ambient atmosphere for over 1500 hours without obvious PCE decay. This work shows the importance of modulating the degradation pathway on stability improvement, and at the same time, proposes a strategy for designing perovskite-based optoelectronics with excellent performance and stability. | Xiao Zhang Changsu Cao Yang Bai Cheng Zhu Huachao Zai Sai Ma Yihua Chen Zhenhua Cui Congbo Shi Chenyue Wang Chenxiao Zhou Guizhou Yuan Ziyan Gao Jiawang Hong Jie Dou Hao Wang Huanping Zhou Hai Xiao Jun Li Qi Chen | 2022 | Science China Chemistry2022，65，11： | 0 |
| 15 | SYNTHESIS OF N-GLUCURONIDES OF 5-FLUOROURACIL AND THEIR ANTITUMOR ACTIVITIES显示文摘SYNTHESISOFN-GLUCURONIDESOF5-FLUOROURACILANDTHEIRANTITUMORACTIVITIES￥ChangJunSUN;YiGuiWANG;ZaiChengCHEN;PengXUE;WeiFengHU(Dep... | Chang Jun SUN Yi Gui WANG Zai Cheng CHEN Peng XUE Wei Feng HU (Department of chemistry, Shandong University,Jinan 250100)Bet Li XU Yao Ran ZHAO Mei Ling WANG (Shandong Academy of Medical Sciences,Jinan 250014) | 1994 | Chinese Chemical Letters1994，5，5： | 0 |
| 16 | Stress compensation based on interfacial nanostructures for stable perovskite solar cells显示文摘The long-term stability issue of halide perovskite solar cells hinders their commercialization.The residual stress-strain affects device stability,which is derived from the mismatched thermophysical and mechanical properties between adjacent layers.In this work,we introduced the Rb_(2)CO_(3)layer at the interface of SnO_(2)/perovskite with the hierarchy morphology of snowflake-like microislands and dendritic nanostructures.With a suitable thermal expansion coefficient,the Rb_(2)CO_(3)layer benefits the interfacial stress relaxation and results in a compressive stress-strain in the perovskite layer.Moreover,reduced nonradiative recombination losses and optimized band alignment were achieved.An enhancement of open-circuit voltage from 1.087 to 1.153 V in the resultant device was witnessed,which led to power conversion efficiency(PCE)of 22.7%(active area of 0.08313 cm^(2))and 20.6%(1 cm2).Moreover,these devices retained 95%of its initial PCE under the maximum power point tracking(MPPT)after 2700 h.It suggests inorganic materials with high thermal expansion coefficients and specific nanostructures are promising candidates to optimize interfacial mechanics,which improves the operational stability of perovskite cells. | Cheng Zhu Xi Wang Hangxuan Li Chenyue Wang Ziyan Gao Pengxiang Zhang Xiuxiu Niu Nengxu Li Zipeng Xu Zhenhuang Su Yihua Chen Huachao Zai Haipeng Xie Yizhou Zhao Ning Yang Guilin Liu Xueyun Wang Huanping Zhou Jiawang Hong Xingyu Gao Yang Bai Qi Chen | 2023 | Interdisciplinary Materials2023，2，2： | 0 |
| 17 | STUDIES ON THE SYNTHESIS OF D-GLUCURONIC ACID DERIVATIVES OF 2-BUTOXY-5-FLUORO-3H-4-PYRIMIDONE AND THEIR ANTICANCER ACTIVITIES显示文摘2-Butoxy-5-fluoro-3H-4-pyrimidone derivatives of D-glucuronic acid having0-glycosidic linkage or N-glycosidic linkage were synthesized and their anticanceractivity tested.Their structures were confirmed by elementary analysis,IR spectraand ~1HNMR. | Chang Jun SUN Zai Cheng CHEN Yi Gui WANG Peng XUE Department of Chemistry,Shandong University,Jinan,250100Feng Yao LIU Department of Chemistry,Zaozhuang Teachers College,Zaozhuang,Shandong,277000 | 1993 | Chinese Chemical Letters1993，4，3： | 0 |
| 18 | AN IMPROVED METHOD FOR PREPARING 2—ALKOXY—5—FLUORO—3H—4—PYRIMIDONE~△显示文摘In this paper, we report an improved method for preparing 2--alkoxy 5 fluoro--3H--4--pyrimidone from 2--chloro--5--fluoro--3H--4--pyrimidone and sodium alkoxide under normalpressure at reflux temperature. Some new compounds were synthesized in higher yield by this method. | Chang Jun SUN Zai Cheng CHEN Yi MENG Yi Gui WANG Peng XUE Jian Guo ZHANG Gui Xiang CUI Department of Chemistry, Shandong University, Jinan 250100 | 1993 | Chinese Chemical Letters1993，4，7： | 0 |
| 19 | Efficient Isomerization for Preparing thans-2,2-Dimethyl-3-(2,2-dichloroethenyl) cyclopropanecarbonyl Chloride显示文摘Trans-2,2-dimethyl-3-(2,2-dichloroethenyl)cyclopropanecarbonyl chloride, which is animportant intermediate for insecticides, is obtained by isomerization of the cis/trans-mixture with4- (N,N-dimethylamino) pyridine (DMAP) in the presence or absence of halogen compounds ingood yield. | Jun An MA Run Qiu HUANG Jun Ran CHENG Rui Lian SHAO Zai Guo LI(Institute and State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin300071) | 1999 | Chinese Chemical Letters1999，10，2： | 0 |
| 20 | Bioinspired Activation of N_(2) on Asymmetrical Coordinated Fe Grafted 1T MoS_(2) at Room Temperature显示文摘Main observation and conclusion Inspired by the nitrogen fixation process on MoFe nitrogenase,asymmetrical coordinated Fe grafted onto 1T MoS_(2) were successfully synthesized.The unique electron-rich structure with asymmetrical coordination made the 1T Fe_(0.1)Mo_(0.9)S_(2) layered material actively react with water and dinitrogen at room temperature and atmosphere pressure. | Jiaojiao Guo Maoyu Wang Liang Xu Xiaomin Li Asma Iqbal George ESterbinsky Hao Yang Miao Xie Jiantao Zai Zhenxing Feng Tao Cheng Xuefeng Qian | 2021 | Chinese Journal of Chemistry2021，39，7： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员