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| 1 | On the Key Dynamical Processes Supporting the 21.7 Zhengzhou Record-breaking Hourly Rainfall in China显示文摘An extremely heavy rainfall event occurred in Zhengzhou,China,on 20 July 2021 and produced an hourly rainfall rate of 201.9 mm,which broke the station record for China's Mainland.Based on radar observations and a convection-permitting simulation using the WRF-ARW model,this paper investigates the multiscale processes,especially those at the mesoscale,that support the extreme observed hourly rainfall.Results show that the extreme rainfall occurred in an environment characteristic of warm-sector heavy rainfall,with abundant warm moist air transported from the ocean by an abnormally northward-displaced western Pacific subtropical high and Typhoon In-Fa(2021).However,rather than through back building and echo training of convective cells often found in warm-sector heavy rainfall events,this extreme hourly rainfall event was caused by a single,quasi-stationary storm in Zhengzhou.Scale separation analysis reveals that the extreme-rainproducing storm was supported and maintained by the dynamic lifting of low-level converging flows from the north,south,and east of the storm.The low-level northerly flow originated from a mesoscale barrier jet on the eastern slope of the Taihang Mountain due to terrain blocking of large-scale easterly flows,which reached an overall balance with the southerly winds in association with a low-level meso-β-scale vortex located to the west of Zhengzhou.The large-scale easterly inflows that fed the deep convection via transport of thermodynamically unstable air into the storm prevented the eastward propagation of the weak,shallow cold pool.As a result,the convective storm was nearly stationary over Zhengzhou,resulting in record-breaking hourly precipitation. | Peng WEI Xin XU Ming XUE Chenyue ZHANG Yuan WANG Kun ZHAO Ang ZHOU Shushi ZHANG Kefeng ZHU | 2023 | Advances in Atmospheric Sciences2023，40，3： | 9 |
| 2 | Small molecules in targeted cancer therapy:advances,challenges,and future perspectives显示文摘Due to the advantages in efficacy and safety compared with traditional chemotherapy drugs,targeted therapeutic drugs have become mainstream cancer treatments.Since the first tyrosine kinase inhibitor imatinib was approved to enter the market by the US Food and Drug Administration(FDA)in 2001,an increasing number of small-molecule targeted drugs have been developed for the treatment of malignancies.By December 2020,89 small-molecule targeted antitumor drugs have been approved by the US FDA and the National Medical Products Administration(NMPA)of China.Despite great progress,small-molecule targeted anti-cancer drugs still face many challenges,such as a low response rate and drug resistance.To better promote the development of targeted anti-cancer drugs,we conducted a comprehensive review of small-molecule targeted anti-cancer drugs according to the target classification.We present all the approved drugs as well as important drug candidates in clinical trials for each target,discuss the current challenges,and provide insights and perspectives for the research and development of anti-cancer drugs. | Lei Zhong Yueshan Li Liang Xiong Wenjing Wang Ming Wu Ting Yuan Wei Yang Chenyu Tian Zhuang Miao Tianqi Wang Shengyong Yang | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 5 |
| 3 | Bistratal Au@Bi2S3 nanobones for excellent NIR-triggered/multimodal imaging-guided synergistic therapy for liver cancer显示文摘To fabricate a highly biocompatible nanoplatform enabling synergistic therapy and real-time imaging,novel Au@Bi2S3 core shell nanobones(NBs)(Au@Bi2S3 NBs)with Au nanorods as cores were synthesized.The combination of Au nanorods with Bi2S3 film made the Au@Bi2S3 NBs exhibit ultrahigh photothermal(PT)conversion efficiency,remarkable photoacoustic(PA)imaging and high computed tomography(CT)performance;these Au@Bi2S3 NBs thus are a promising nanotheranostic agent for PT/PA/CT imaging.Subsequently,poly(N-vinylpyrrolidone)-modified Au@Bi2S3 NBs(Au@Bi2S3-PVP NBs)were successfully loaded with the anticancer drug doxorubicin(DOX),and a satisfactory pH sensitive release profile was achieved,thus revealing the great potential of Au@Bi2S3-PVP NBs in chemotherapy as a drug carrier to deliver DOX into cancer cells.Both in vitro and in vivo investigations demonstrated that the Au@Bi2S3-PVP NBs possessed multiple desired features for cancer therapy,including extremely low toxicity,good biocompatibility,high drug loading ability,precise tumor targeting and effective accumulation.Highly efficient ablation of the human liver cancer cell HepG2 was achieved through Au@Bi2S3-PVP NB-mediated photothermal therapy(PTT).As both a contrast enhancement probe and therapeutic agent,Au@Bi2S3-PVP NBs provided outstanding NIR-triggered multi-modal PT/PA/CT imaging-guided PTT and effectively inhibited the growth of HepG2 liver cancer cells via synergistic chemo/PT therapy. | Ruizhuo Ouyang Penghui Cao Pengpeng Jia Hui Wang Tianyu Zong Chenyu Dai Jie Yuan Yuhao Li Dong Sun Ning Guo Yuqing Miao Shuang Zhou | 2021 | Bioactive Materials2021，6，2： | 5 |
| 4 | Responses of Mean and Extreme Precipitation to Different Climate Forcing Under Radiative-Convective Equilibrium显示文摘Understanding the responses of mean and extreme precipitation to climate change is of great importance.Previous studies have mainly focused on the responses to prescribed sea surface warming or warming due to increases of CO2.This study uses a cloud-resolving model under the idealization of radiative-convective equilibrium to examine the responses of mean and extreme precipitation to a variety of climate forcings,including changes in prescribed sea surface temperature,CO2,solar insolation,surface albedo,stratospheric volcanic aerosols,and several tropospheric aerosols.The different responses of mean precipitation are understood by examining the changes in the surface energy budget.It is found that the cancellation between shortwave scattering and longwave radiation leads to a small dependence of the mean precipitation response on forcings.The responses of extreme precipitation are decomposed into three components(thermodynamic,dynamic,and precipitation efficiency).The thermodynamic components for all climate forcings are similar.The dynamic components and the precipitation-efficiency components,which have large spreads among the cases,are negatively correlated,leading to a small dependence of the extreme precipitation response on the forcings. | Chenyu MA Wei YUAN Ji NIE | 2020 | Advances in Atmospheric Sciences2020，37，4： | 2 |
| 5 | Spreading kinetics of a Sn-30Bi-0.5Cu alloy on a Cu substrate显示文摘The reactive wetting kinetics of a Sn-30Bi-0.5Cu Pb-free solder alloy on a Cu substrate was investigated by the sessile drop method from 493 to 623 K.The triple line frontier,characterized by the drop base radius R was recorded dynamically with a high resolution CCD using different spreading processes in an Ar-H 2 flow.We found a good agreement with the De Gennes model for the relationship between ln(dR/dt) and lnR for the spreading processes at 493 and 523 K.However,a significant deviation from the De Gennes model was found for the spreading processes at 548 and 623 K.Our experimental results show a complicated temperature effect on the spreading kinetics.Intermetallics at the Sn-30Bi-0.5Cu/Cu interface were identified as Cu 6 Sn 5 adjacent to the solder and Cu 3 Sn adjacent to the Cu substrate.The intermetallic compounds effectively enhanced the triple line mobility because of reaction product formation at the diffusion frontier. | ZANG LiKun YUAN ZhangFu ZHAN YaPeng WANG ChenYu XU BingSheng | 2012 | Chinese Science Bulletin2012，57，6： | 1 |
| 6 | Deconvolutional artificial-neural-network framework for subfilter-scale models of compressible turbulence显示文摘We establish a deconvolutional artificial-neural-network(D-ANN)approach in large-eddy simulation(LES)of compressible turbulent flow.Filtered variables in the neighboring locations are taken as the inputs of D-ANN to recover original(unfiltered)variables,including density,momentum and pressure.The scale-similarity form is adopted to reconstruct subfilter-scale(SFS)terms.The proposed D-ANN models can give better a priori predictions of the sub-filter stress and heat flux than the classical approximate-deconvolution method(ADM)and the velocity-gradient model(VGM).The predicted SFS terms with the D-ANN models have correlation coefficients larger than 98.4%and relative errors smaller than 18%.In the a posteriori analysis,the D-ANN model compares against the implicit LES(ILES),the dynamic-Smagorinsky model(DSM),and the dynamic-mixed model(DMM).The D-ANN model predicts better than these classical models for velocity spectra,statistical properties of SFS kinetic energy flux and velocity increments.The turbulence statistics and transient velocity divergence are also accurately reconstructed.The type of explicit filter and the impact of compressibility do not significantly affect a posteriori accuracy of the D-ANN model.Results showthat the proposed D-ANN approach has a great potential in developing highly accurate SFS models for large-eddy simulation of complex compressible turbulent flow. | Zelong Yuan Yunpeng Wang Chenyue Xie Jianchun Wang | 2021 | Acta Mechanica Sinica2021，37，12： | 1 |
| 7 | Rhesus monkeys exhibiting spontaneous ritualistic behaviors resembling obsessive-compulsive disorder显示文摘Obsessive-compulsive disorder(OCD)is a chronic and debilitating psychiatric disorder that affects∼2%–3%of the population globally.Studying spontaneous OCD-like behaviors in non-human primates may improve our understanding of the disorder.In large rhesus monkey colonies,we found 10 monkeys spontaneously exhibiting persistent sequential motor behaviors(SMBs)in individual-specific sequences that were repetitive,time-consuming and stable over prolonged periods.Genetic analysis revealed severely damaging mutations in genes associated with OCD risk in humans.Brain imaging showed that monkeys with SMBs had larger gray matter(GM)volumes in the left caudate nucleus and lower fractional anisotropy of the corpus callosum.The GM volume of the left caudate nucleus correlated positively with the daily duration of SMBs.Notably,exposure to a stressor(human presence)significantly increased SMBs.In addition,fluoxetine,a serotonergic medication commonly used for OCD,decreased SMBs in these monkeys.These findings provide a novel foundation for developing better understanding and treatment of OCD. | Rongwei Zhai Geya Tong Zheqin Li Weichen Song Yang Hu Sha Xu Qiqi Wei Xiaocheng Zhang Yi Li Bingbing Liao Chenyu Yuan Yinqing Fan Ge Song Yinyin Ouyang Wenxuan Zhang Yaqiu Tang Minghui Jin Yuxian Zhang He Li Zhi Yang Guan Ning Lin Dan JStein Zhi-Qi Xiong Zhen Wang | 2023 | National Science Review2023，10，11： | 1 |
| 8 | Impeded degradation of perovskite solar cells via the dual interfacial modification of siloxane显示文摘It is challenging to improve the long-term stability of perovskite solar cells(PSCs) without sacrificing efficiency. The perovskite absorbers degrade from the film surface/interfaces, which follows entangled mechanisms that have not been fully revealed yet.Herein, we decouple and elaborate two distinctive pathways regarding film degradation based on FACsPbI3perovskites.Moreover, a dual interfacial modification strategy has been developed for improving the material’s intrinsic stability, thus leading to the film degrading in a more retardant pathway. The corresponding PSCs achieve a stable power output efficiency of 23.75%.More importantly, the unencapsulated PSCs devices retain over 93% of their initial PCE after the maximum power point(MPP)tracking under the continuous 1-sun illumination and show significantly improved stability after aged under the thermal treatment or stored in ambient atmosphere for over 1500 hours without obvious PCE decay. This work shows the importance of modulating the degradation pathway on stability improvement, and at the same time, proposes a strategy for designing perovskite-based optoelectronics with excellent performance and stability. | Xiao Zhang Changsu Cao Yang Bai Cheng Zhu Huachao Zai Sai Ma Yihua Chen Zhenhua Cui Congbo Shi Chenyue Wang Chenxiao Zhou Guizhou Yuan Ziyan Gao Jiawang Hong Jie Dou Hao Wang Huanping Zhou Hai Xiao Jun Li Qi Chen | 2022 | Science China Chemistry2022，65，11： | 0 |
| 9 | Modification strategies for metal-organic frameworks targeting at mem brane-based gas separations显示文摘Metal-organic frameworks(MOFs)hold great promises as membrane candidates for highly efficient separation applications,benefiting from the diversified structures,high surface areas and adjustable chemical functionalities.However,non-selective defects and framework flexibility are two main concerns which would attenuate the ultimate separation performance and stability.Modification helps to orientationally optimize the gas adsorption and diffusion behaviors via manipulation towards framework chemical components,aperture sizes,nanocages,and intercrystalline/intracrystalline defects,consequently promoting membrane separation performance and membrane stability.In view of recent progresses of modification on MOF-based membranes,two categories of modification strategies were summarized,namely post-synthetic modification and in situ modification.And the merits and demerits are elucidated.Furthermore,challenges and opportunities for the current modification strategies were discussed from our perspectives,with an expectation to provide guidelines to the future development of MOF-based membranes which were aspired to reach the commercially attractive performance region. | Chenyu Zhu Yuan Peng Weishen Yang | 2021 | Green Chemical Engineering2021，2，1： | 0 |
| 10 | A case of pulmonary mucormycosis presented with cardiac arrest显示文摘Mucormycosis is an uncommon and opportunistic fungal infection with high mortality. Infections may result from ingestion of contaminated food, inhalation of spores into the respiratory tract or inoculation into disruptedskin.^([1])Pulmonarymucormycosis(PM)is the most common clinical type. | Haijiang Zhou Xuan Qi Jifei Cai Wenxin Liu Chenyu Kang Guyu Zhang Miaomiao Wang Xuefei Xie Chao Liang Lihua Liu Jie Gao Wei Yuan Xue Mei Shubin Guo | 2023 | World Journal of Emergency Medicine2023，14，6： | 0 |
| 11 | Evaluating Tislelizumab, Lenvatinib, and FOLFOX4-HAIC as a Conversion Therapy for Unresectable Hepatocellular Carcinoma显示文摘Background and aims:Conversion therapy downstages tumors and renders patients with unresectable hepatocel-lular carcinoma(HCC)eligible for radical resection.This study aimed to evaluate the efficacy and safety of tislelizumab plus lenvatinib and hepatic artery infusion chemotherapy with oxaliplatin,fluorouracil,and leuco-vorin(FOLFOX4-HAIC)as a first-line conversion therapy.Methods:Clinical data from HCC patients who were treated with the triple therapy between April 2021 and April 2022 were retrospectively analyzed.The primary outcome included objective response rate(ORR),disease control rate(DCR),conversion resection rate(CRR),and treatment-related adverse events(TRAEs).Results:A total of 18 patients completed conversion therapy assessment,which ended on March 27,2023.The patients had a median age of 55.5(37–72)years,and 94.4%were male.According to mRECIST,tumor shrinkage was observed in all patients,with an ORR of 94.4%(17/18),a DCR of 94.4%(17/18),and a median time to response of 1.4(0.7–3.0)months.Successful conversion was observed in 61.1%(11/18)of patients(mRECIST).The CRR and pathological complete response were 38.9%(7/18)and 57.1%(4/7),respectively.The median progression-free survival(PFS)was 17.8 months,while median overall survival was not reached.The 6-and 9-month PFS rates were 83.3%and 66.7%,respectively.The most common TRAE(16/18 patients,88.9%)was an increase in aspartate aminotransferase levels.Conclusion:Tislelizumab combined with lenvatinib and FOLFOX4-HAIC achieved a high conversion rate and acceptable toxicity in patients with unresectable HCC,suggesting that this combination may represent a new conversion strategy for this population. | Kai Tan Xiaojun He Haoran Yuan Shoujie Zhao Chenyu Gong Yaoyao Zhao Haiyan Nan Li Zang Zhonghua Luo Xilin Du | 2023 | iLIVER2023，2，3： | 0 |
| 12 | In Situ Iodide Passivation Toward Efficient CsPbI_(3) Perovskite Quantum Dot Solar Cells显示文摘All-inorganic CsPbI_3 quantum dots(QDs) have demonstrated promising potential in photovoltaic(PV) applications. However, these colloidal perovskites are vulnerable to the deterioration of surface trap states, leading to a degradation in efficiency and stability. To address these issues, a facile yet effective strategy of introducing hydroiodic acid(HI) into the synthesis procedure is established to achieve high-quality QDs and devices. Through an in-depth experimental analysis, the introduction of HI was found to convert PbI_2 into highly coordinated [PbI_m]~(2-m), enabling control of the nucleation numbers and growth kinetics. Combined optical and structural investigations illustrate that such a synthesis technique is beneficial for achieving enhanced crystallinity and a reduced density of crystallographic defects. Finally, the effect of HI is further reflected on the PV performance. The optimal device demonstrated a significantly improved power conversion efficiency of 15.72% along with enhanced storage stability. This technique illuminates a novel and simple methodology to regulate the formed species during synthesis, shedding light on ofurther understanding solar cell performance, and aiding the design of future novel synthesis protocols for high-performance optoelectronic devices. | Junwei Shi Ben Cohen‑Kleinstein Xuliang Zhang Chenyu Zhao Yong Zhang Xufeng Ling Junjun Guo Doo‑Hyun Ko Baomin Xu Jianyu Yuan Wanli Ma | 2023 | Nano-Micro Letters2023，15，10： | 0 |
| 13 | Different response of bacterial community to the changes of nutrients and pollutants in sediments from an urban river network显示文摘Microbial communities in sediment are an important indicator linking to environmental pollution in urban river systems.However,how the diversity and structure of bacterial communities in sediments from an urban river network respond to different environmental factors has not been well studied.The goal of this study was to understand the patterns of bacterial communities in sediments from a highly dense urbanized river network in the lower Yangtze River Delta by Illumina MiSeq sequencing.The correlations between bacterial communities,the environmental gradient and geographical distance were analyzed by redundancy analysis(RDA)and network methods.The diversity and richness of bacterial community in sediments increased from upstream to downstream consistently with the accumulation of nutrient in the urban river network.Bacterial community composition and structure showed obvious spatial changes,leading to two distinct groups,which were significantly related to the characteristics of nutrient and heavy metal in sediments.Humic substance,available nitrogen,available phosphorus,Zn,Cu,Hg and As were selected as the key environmental factors shaping the bacterial community in sediments based on RDA.The co-occurrence patterns of bacterial networks showed that positive interaction between bacterial communities increased but the connectivity among bacterial genera and stability of sediment ecosystem reduced under a higher content of nutrient and heavy metal in average.The sensitive and ubiquitous taxa with an overproportional response to key environmental factors were detected as indicator species,which provided a novel method for the prediction of the pollution risk of sediment in an urban river network. | Fang Zhang Hao Zhang Ying Yuan Dun Liu Chenyu Zhu Di Zheng Guanghe Li Yuquan Wei Dan Sun | 2020 | Frontiers of Environmental Science & Engineering2020，14，2： | 0 |
| 14 | A 24−30 GHz 8-element dual-polarized 5G FR2 phased-array transceiver IC with 20.8-dBm TX OP1dB and 4.1-dB RX NF in 65-nm CMOS显示文摘This article presents an 8-element dual-polarized phased-array transceiver(TRX)front-end IC for millimeter-wave(mm-Wave)5G new radio(NR).Power enhancement technologies for power amplifiers(PA)in mm-Wave 5G phased-array TRX are discussed.A four-stage wideband high-power class-AB PA with distributed-active-transformer(DAT)power combining and multi-stage second-harmonic traps is proposed,ensuring the mitigated amplitude-to-phase(AM-PM)distortions across wide carrier frequencies without degrading transmitting(TX)power,gain and efficiency.TX and receiving(RX)switching is achieved by a matching network co-designed on-chip T/R switch.In each TRX element,6-bit 360°phase shifting and 6-bit 31.5-dB gain tuning are respectively achieved by the digital-controlled vector-modulated phase shifter(VMPS)and differential attenuator(ATT).Fabricated in 65-nm bulk complementary metal oxide semiconductor(CMOS),the proposed TRX demonstrates the measured peak TX/RX gains of 25.5/21.3 dB,covering the 24−29.5 GHz band.The measured peak TX OP1dB and power-added efficiency(PAE)are 20.8 dBm and 21.1%,respectively.The measured minimum RX NF is 4.1 dB.The TRX achieves an output power of 11.0−12.4 dBm and error vector magnitude(EVM)of 5%with 400-MHz 5G NR FR2 OFDM 64-QAM signals across 24−29.5 GHz,covering 3GPP 5G NR FR2 operating bands of n257,n258,and n261. | Yongran Yi Dixian Zhao Jiajun Zhang Peng Gu Chenyu Xu Yuan Chai Huiqi Liu Xiaohu You | 2024 | Journal of Semiconductors2024，45，1： | 0 |
| 15 | Allosteric probe-modified liposome loading bufalin-fluorouracil complex for targeted colorectal cancer therapy显示文摘Objective Bufalin,the main active anti-tumor monomer of toad venom,is crucial in cancer treatment.However,intrinsic issues,such as poor solubility and systematic toxicity,have considerably mitigated its anticancer functions and caused unwanted side effects.It is essential to develop innovative targeting systems to precisely and efficiently deliver anticancer drugs to achieve satisfying therapeutic efficiency.Methods This work established a novel and more efficient system for simultaneously detecting and killing colorectal cancer cells.The proposed method designed two allosteric probes,a report probe and a recognize probe.The method exhibited high sensitivity towards cell detection via the recognizing probe identifying target cancer cells and the report probe’s signal report.Combining bufalin and fluorouracil endowed better tumor cell inhibition.Results We observed significantly enhanced fluorescence dots surrounding the HCT-116 cell membranes.No fluorescence increments in the other three cells were identified,indicating that the established liposome complex could specifically bind with target cells.In addition,the best ratio of bufalin to fluorouracil was 0.15 and 0.5,respectively.This improved the anti-tumor effects and achieved more than 60%tumor cell inhibition.Conclusion This method will provide new opportunities for intracellular biomolecule detection and targeted cancer cell therapy. | Fajiang Mao Xingli Wu Chenyue Yuan Haiyan Huang Yanyan Qiu Jianlin Ren Peihao Yin | 2022 | Oncology and Translational Medicine2022，8，5： | 0 |
| 16 | Dynamic nonlinear algebraic models with scale-similarity dynamic procedure for large-eddy simulation of turbulence显示文摘A dynamic nonlinear algebraic model with scale-similarity dynamic procedure(DNAM-SSD)is proposed for subgrid-scale(SGS)stress in large-eddy simulation of turbulence.The model coefficients of the DNAM-SSD model are adaptively calculated through the scale-similarity relation,which greatly simplifies the conventional Germano-identity based dynamic procedure(GID).The a priori study shows that the DNAM-SSD model predicts the SGS stress considerably better than the conventional velocity gradient model(VGM),dynamic Smagorinsky model(DSM),dynamic mixed model(DMM)and DNAM-GID model at a variety of filter widths ranging from inertial to viscous ranges.The correlation coefficients of the SGS stress predicted by the DNAM-SSD model can be larger than 95%with the relative errors lower than 30%.In the a posteriori testings of LES,the DNAM-SSD model outperforms the implicit LES(ILES),DSM,DMM and DNAM-GID models without increasing computational costs,which only takes up half the time of the DNAM-GID model.The DNAM-SSD model accurately predicts plenty of turbulent statistics and instantaneous spatial structures in reasonable agreement with the filtered DNS data.These results indicate that the current DNAM-SSD model is attractive for the development of highly accurate SGS models for LES of turbulence. | Zelong Yuan Yunpeng Wang Chenyue Xie Jianchun Wang | 2022 | Advances in Aerodynamics2022，4，1： | 0 |
| 17 | Development and Validation of a Prognostic Risk Score System for COVID-19 Inpatients:A Multi-Center Retrospective Study in China显示文摘Coronavirus disease 2019(COVID-19)has become a worldwide pandemic.Hospitalized patients of COVID-19 suffer from a high mortality rate,motivating the development of convenient and practical methods that allow clinicians to promptly identify high-risk patients.Here,we have developed a risk score using clinical data from 1479 inpatients admitted to Tongji Hospital,Wuhan,China(development cohort)and externally validated with data from two other centers:141 inpatients from Jinyintan Hospital,Wuhan,China(validation cohort 1)and 432 inpatients from The Third People’s Hospital of Shenzhen,Shenzhen,China(validation cohort 2).The risk score is based on three biomarkers that are readily available in routine blood samples and can easily be translated into a probability of death.The risk score can predict the mortality of individual patients more than 12 d in advance with more than 90%accuracy across all cohorts.Moreover,the Kaplan-Meier score shows that patients can be clearly differentiated upon admission as low,intermediate,or high risk,with an area under the curve(AUC)score of 0.9551.In summary,a simple risk score has been validated to predict death in patients infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2);it has also been validated in independent cohorts. | Ye Yuan Chuan Sun Xiuchuan Tang Cheng Cheng Laurent Mombaerts Maolin Wang Tao Hu Chenyu Sun Yuqi Guo Xiuting Li Hui Xu Tongxin Ren Yang Xiao Yaru Xiao Hongling Zhu Honghan Wu Kezhi Li Chuming Chen Yingxia Liu Zhichao Liang Zhiguo Cao Hai-Tao Zhang Ioannis Ch.Paschaldis Quanying Liu Jorge Goncalves Qiang Zhong Li Yan | 2022 | Engineering2022，8，1： | 0 |
| 18 | 利用微孔板测序技术绘制小鼠细胞图谱显示文摘文章简介长久以来,生命科学的研究主要基于群体细胞水平的分析,近几年所涌现的单细胞组学技术,使我们能够从单个细胞的水平上更为精确的解析细胞的分化、再生、衰老以及病变。在本研究中,科研团队自主开发了一套完全国产化的Microwell-seq高通量单细胞测序平台. | Xiaoping Han Renying Wang Yincong Zhou Lijiang Fei Huiyu Sun Shujing Lai Assieh Saadatpour Ziming Zhou Haide Chen Fang Ye Daosheng Huang Yang Xu Wentao Huang Mengmeng Jiang Xinyi Jiang Jie Mao Yao Chen Chenyu Lu Jin Xie Qun Fang Yibin Wang Rui Yue Tiefeng Li He Huang Stuart H.Orkin Guo-Cheng Yuan Ming Chen 郭国骥 | 2019 | 科学新闻2019，0，2： | 0 |
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