|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases显示文摘在各种各样的纸巾的 microRNAs (miRNAs ) 的 Dysregulated 表示与许多疾病被联系了,包括癌症。这里,我们证明 miRNAs 在象老鼠,老鼠,牛的胎儿,小牛,和马那样的人和另外的动物的浆液和血浆是在场的。在浆液的 miRNAs 的层次在一样的种类的个人之中稳定、可再现、一致。采用 Solexa,我们定序健康中国题目的所有浆液 miRNAs 并且分别地在男、女的题目发现超过 100 和 91 浆液 miRNAs。我们也为肺癌症, colorectal 癌症,和糖尿病识别了浆液 miRNAs 的特定的表示模式,提供证据那浆液 miRNAs 为各种各样的疾病包含指纹。癌症特定的浆液 miRNAs 由 Solexa 获得了的二个非小的房间肺进一步在 75 个健康施主和 152 个癌症病人的独立审判被验证,用量的反向的抄写聚合酶链反应试金。通过这些分析,我们断定浆液 miRNAs 能为各种各样的癌症和另外的疾病的察觉用作潜在的 biomarkers。 | Xi Chen Yi Ba Lijia Ma Xing Cai Yuan Yin Kehui Wang Jig ang Guo Yujing Zhang Jiangning Chen Xing Guo Qibin Li Xiaoying Li Wenjing Wang Yan Zhang Jin Wang Xueyuan Jiang Yang Xiang Chen Xu Pingping Zheng Juanbin Zhang Ruiqiang Li Hongjie Zhang Xiaobin Shang Ting Gong Guang Ning Jun Wang Ke Zen Junfeng Zhang Chen-Yu Zhang | 2008 | Cell Research2008，18，10： | 975 |
| 2 | Gastric cancer: Epidemiology, risk factors and prevention strategies显示文摘Gastric cancer(GC) is a global health problem, with more than 1 million people newly diagnosed with GC worldwide each year. GC is more prevalent in less developed countries than in more developed countries. About half of all GC cases worldwide occur in East Asia, notably China. Globally, overall incidence rates of GC are declining, which is potentially attributed to a decrease in Helicobacter pylori(H. pylori) infection and the use of refrigeration to preserve foods rather than salt. GC is a multifactorial disease, and its occurrence and development were impacted by environmental and genetic factors. H. pylori infection is the primary risk factor for GC, especially for non-cardia. The prognosis of GC is poor due to stages at the first diagnosis. The 5-year survival rate is less than 10% when patients are diagnosed at an advanced stage, but the rate is as high as 85% if patients are detected at an earlier stage. Endoscopic screening can potentially prevent GC by early diagnosis and early treatment and has been widely adopted in screening programs in East Asian countries, such as Japan and Korea. This review summarizes updated epidemiological aspects, risk factors, and prevention strategies of GC in recent years to help researchers determine the most effective intervention strategies for reducing risk of GC. | Lei Yang Xiangji Ying Shuo Liu Guoqing Lyu Zekuan Xu Xi Zhang Huichao Li Qingyu Li Ning Wang Jiafu Ji | 2020 | Chinese Journal of Cancer Research2020，32，6： | 52 |
| 3 | Programmable time-domain digital-coding metasurface for non-linear harmonic manipulation and new wireless communication systems显示文摘Optical non-linear phenomena are typically observed in natural materials interacting with light at high intensities, and they benefit a diverse range of applications from communication to sensing. However,controlling harmonic conversion with high efficiency and flexibility remains a major issue in modern optical and radio-frequency systems. Here, we introduce a dynamic time-domain digital-coding metasurface that enables efficient manipulation of spectral harmonic distribution. By dynamically modulating the local phase of the surface reflectivity, we achieve accurate control of different harmonics in a highly programmable and dynamic fashion, enabling unusual responses, such as velocity illusion. As a relevant application, we propose and realize a novel architecture for wireless communication systems based on the time-domain digital-coding metasurface, which largely simplifies the architecture of modern communication systems, at the same time yielding excellent performance for real-time signal transmission. The presented work, from new concept to new system, opens new pathways in the application of metamaterials to practical technology. | Jie Zhao Xi Yang Jun Yan Dai Qiang Cheng Xiang Li Ning Hua Qi Jun Chen Ke Guo Dong Bai Shuo Liu Shi Jin Andrea Alù Tie Jun Cui | 2019 | National Science Review2019，6，2： | 46 |
| 4 | SlMYB75,an MYB-type transcription factor,promotes anthocyanin accumulation and enhances volatile aroma production in tomato fruits显示文摘Genetic manipulation of genes to upregulate specific branches of metabolic pathways is a method that is commonly used to improve fruit quality.However,the use of a single gene to impact several metabolic pathways is difficult.Here,we show that overexpression of the single gene SlMYB75(SlMYB75-OE)is effective at improving multiple fruit quality traits.In these engineered fruits,the anthocyanin content reached 1.86mg g−1 fresh weight at the red-ripe stage,and these SlMYB75-OE tomatoes displayed a series of physiological changes,including delayed ripening and increased ethylene production.In addition to anthocyanin,the total contents of phenolics,flavonoids and soluble solids in SlMYB75-OE fruits were enhanced by 2.6,4,and 1.2 times,respectively,compared to those of wild-type(WT)fruits.Interestingly,a number of aroma volatiles,such as aldehyde,phenylpropanoid-derived and terpene volatiles,were significantly increased in SlMYB75-OE fruits,with some terpene volatiles showing more than 10 times higher levels than those in WT fruits.Consistent with the metabolic assessment,transcriptomic profiling indicated that the genes involved in the ethylene signaling,phenylpropanoid and isoprenoid pathways were greatly upregulated in SlMYB75-OE fruits.Yeast one-hybrid and transactivation assays revealed that SlMYB75 is able to directly bind to the MYBPLANT and MYBPZM cis-regulatory elements and to activate the promoters of the LOXC,AADC2 and TPS genes.The identification of SlMYB75 as a key regulator of fruit quality attributes through the transcriptional regulation of downstream genes involved in several metabolic pathways opens new avenues towards engineering fruits with a higher sensory and nutritional quality. | Wei Jian Haohao Cao Shu Yuan Yudong Liu Juanfang Lu Wang Lu Ning Li Jianhui Wang Jian Zou Ning Tang Chan Xu Yulin Cheng Yanqiang Gao Wanpeng Xi Mondher Bouzayen Zhengguo Li | 2019 | Horticulture Research2019，6，1： | 39 |
| 5 | Contemporary crustal movement of continental China obtained by global positioning system(GPS) measurements显示文摘We obtain a unified horizontal velocity field of continental China and vicinity through measurements at 81 GPS stations provided by the National Key Infrastructure Project, Crustal Movement Observation Network of China. The velocity field delineates patterns of movements and deformation of active crustal blocks in continental China under the Eurasia-fixed reference frame. The space-based geodesy also clearly shows for the first time the horizontal movementand deformation of continental China induced by indentation of the Indian plate. The data provide kinematic constraints for simulating dynamic process of continental litho-spheric deformation. | MA Zongjin, CHEN Xinlian, YE Shuhua, LAI Xian, WEI Ziqing, CHEN Junrong, NING Jinsheng, XU Huoze & DING Guoyu1. Insitute of Geology, China Seismological Bureau, Beijing 100029, China (e-mail: disgroup@publi.bta.net.cn)2. Center for Analysis and Prediction, China Seismological Bureau, Beijing 100036, China 3. Shanghai Astronomic Observatory, Chinese Academy of Sciences, Shanghai 200030, China 4. Institute of Seismology, China Seismological Bureau, Wuhan 430077, China 5. Institute of Survey and Mapping, Xi’an 710054, China 6. National Bureau of Survey and Mapping, Beijing 100830, China 7. Wuhan University, Wuhan 430077, China 8. Institute of Geodesy and Geophysics, Wuhan 430077, China 9. China Seismological Bureau, Beijing 100036, China | 2001 | Chinese Science Bulletin2001，46，18： | 34 |
| 6 | Fibrinogen-like protein 2 fibroleukin expression and its correlation with disease progression in murine hepatitis virus type 3-induced fulminant hepatitis and in patients with severe viral hepatitis B显示文摘AIM: To evaluate the expression of fibrinogenlike protein 2 (fgl2) and its correlation with disease progression in both mice and patients with severe viral hepatitis.METHODS: Balb/cJ or A/J mice were infected intraperitoneally (ip) with 100 PFU of murine hepatitis virus type 3 (MHV-3), liver and serum were harvested at 24, 48, and 72 h post infection for further use. Liver tissues were obtained from 23 patients with severe acute chronic (AOC) hepatitis B and 13 patients with mild chronic hepatitis B. Fourteen patients with mild chronic hepatitis B with cirrhosis and 4 liver donors served as normal controls. In addition, peripheral blood mononuclear cells (PBMC) were isolated from 30 patients (unpaired) with severe AOC hepatitis B and 10 healthy volunteers as controls. Procoagulant activity representing functional prothrombinaseactivity in PBMC and white blood cells was also assayed. A polyclonal antibody against fgl2 was used to detect the expression of both mouse and human fgl2 protein in liver samples as well as in PBMC by immunohistochemistry staining in a separate set of studies. Alanine aminotransferase (ALT) and total bilirubin (TBil) in serum were measured to assess the severity of liver injury.RESULTS: Histological changes were found in liver sections 12-24 h post MHV-3 infection in Balb/cJ mice.In association with changes in liver histology, marked elevations in serum ALT and TBil were observed. Mouse fgl2 (mfgl2) protein was detected in the endothelium of intrahepatic veins and hepatic sinusoids within the liver 24 h after MHV-3 infection. Liver tissues from the patients with severe AOC hepatitis B had classical pathological features of acute necroinflammation. Human fgl2 (hfgl2)was detected in 21 of 23 patients (91.30%)with severe AOC hepatitis B, while only 1 of 13 patients(7.69%) with mild chronic hepatitis B and cirrhosis had hfgl2 mRNA or protein expression. Twenty-eight of thirty patients (93.33%) with severe AOC hepatitis B and 1of 10 with mild chronic hepatitis B had detectable hfgl2expression in PBMC. No hfgl2 expression was found either in the liver tissue or in the PBMC from normal donors. There was a positive correlation between hfgl2expression and the severity of the liver disease as indicated by the levels of TBil. PCA significantly increased in PBMC in patients with severe AOC hepatitis B.CONCLUSION: The molecular and cellular results reported here in both mice and patients with severe viral hepatitis suggest that virus-induced hfgl2prothrombinase/fibroleukin expression and the coagulation activity associated with the encoded fgl2protein play a pivotal role in initiating severe hepatitis.The measurement of hfgl2/fibroleukin expression in PBMC may serve as a useful marker to monitor the severity of AOC hepatitis B and a target for therapeutic intervention. | Chuan-Long Zhu Wei-Ming Yan Fan Zhu Yong-Fen Zhu Dong Xi De-Ying Tian Gary Levy Xiao-Ping Luo Qin Ning | 2005 | World Journal of Gastroenterology2005，11，44： | 26 |
| 7 | Identification of a Stable Quantitative Trait Locus for Percentage Grains with White Chalkiness in Rice (Oryza sativa)显示文摘High chalkiness is a major problem in many rice-producing areas of the world, especially in hybrid rice (Oryza sativa L.) in China. We previously showed a major quantitative trait locus for the percentage of grains with white chalkiness (QTLqPGWC-8) in the interval G1149-R727 on chromosome 8 using a chromosome segment substitution line (CSSL). Here, we selected the line-CSSL50 harboring the QTLqPGWC-8 allele from the CSSLs derived from a cross between Asominori (as a recurrent parent) and IR24 (as a donor parent), which had higher percentage chalkiness, markedly different from that of Asominori. There were also significant differences in starch granules, appearance of amylose content (AAC) and milling qualities between Asominori and CSSL50, but not in grain size or thousand grain weight (TGW). The BC4F2 and BC4F3 populations from a cross between CSSL50 and Asominori were used for fine mapping of qPGWC-8. We narrowed down the location of this QTL to a 142 kb region between Indel markers 8G-7 and 8G-9. QTLqPGWC-8 accounted for 50.9% of the difference in PGWC between the parents. The markers tightly linked to qPGWC-8 should facilitate cloning of the gene underlying this QTL and will be of value for marker-assisted selection in breeding rice varieties with better grain quality. | Tao Guo Xiaolu Liu Xiangyuan Wan Jianfeng Weng Shijia Liu Xi Liu Mingjiang Chen Jingjing Li Ning Su Fuqing Wu Zhijun Cheng Xiuping Guo Cailin Lei Jiulin Wang Ling jiang Jianmin Wan | 2011 | Journal of Integrative Plant Biology2011，53，8： | 25 |
| 8 | Therapeutic effect of acupuncture and massage for shoulder-hand syndrome in hemiplegia patients:a clinical two-center randomized controlled trial显示文摘OBJECTIVE:To evaluate the therapeutic effects of acupuncture and massage for shoulder-hand syndrome in hemiplegia patients.METHODS:One hundred and twenty hemiplegia patients with stage I shoulder-hand syndrome were randomly divided into a group treated with standardized electric acupuncture and massage,and a group treated with rehabilitation therapy for 6 weeks.The primary indices evaluated were pain on passive movement of the shoulder using the numeric pain rating scale(NPRS),and the number of patients with shoulder-hand syndrome at Steinbrocker stage II or III after treatment.The secondary indices were Fugl-Meyer evaluation of functional movement of the upper limb and hand using the modified rankin scale(MRS).RESULTS:At post-treatment evaluation and a 12-week follow-up visit,NPRS score,number of patients with stage II or III shoulder-hand syndrome,and MRS score were all improved in the acupuncture-massage group compared with the rehabilitation group(P<0.05).On Fugl-Meyer evaluation,functional movement of the upper limb was also improved in the acupuncture-massage group compared with the rehabilitation group(P<0.05).CONCLUSION:Standardized acupuncture-massage therapy may have curative effects on shoulder-hand syndrome in hemiplegia patients. | Ning Li Fengwei Tian Chengwei Wang Pengming Yu Xi Zhou Qian Wen Xiulan Qiao Lu Huang | 2012 | Journal of Traditional Chinese Medicine2012，32，3： | 25 |
| 9 | Evaluation of Seven Function-Known Candidate Genes for their Effects on Improving Drought Resistance of Transgenic Rice under Field Conditions显示文摘许多强调应答的基因在在温室条件下面在模型植物改进压力抵抗上与效果被报导了。向为干旱抵抗繁殖的基因的鉴定,七很好记录了基因( CBF3 , SOS2 , NCED2 , NPK1 , LOS5 , ZAT10 ,并且 NHX1 )在应力,抵抗在这研究被选择并且在组成的倡导者 Actin1 和一个米饭 HVA22 相当或相同的事物,和转基因的米饭的压力可诱导的倡导者的控制下面转变了成米饭栽培变种 Zhonghua 11 在领域条件下面为干旱抵抗被测试。1598 独立转基因的 T0 植物的一个总数被产生。transgenes 的单个拷贝和表示的百分比分别地是 36.7% 和 57.6% 。为每基因构造,有 transgene 的表示的 30 个 T1 家庭为在领域里在繁殖阶段测试的干旱抵抗被选择,并且他们中的 10 个在一样的阶段与一个定义压力协议在 PVC 管子中被测试。相对产量和相对小穗状花小穗富饶被用作二个主要标准因为显著地减少的产量在 T1 产生被观察,评估干旱抵抗性能。八构造的转基因的家庭( HVA22P : CBF3 , HVA22P : NPK1 , Actin1 : LOS5 , HVA22P : LOS5 , Actin1 : ZAT10 , HVA22P : ZAT10 , Actin1 : NHX1 ,并且 HVA22P : NHX1 )比的显示出显著地更高的 RY 野类型( WT )在两个干旱压力下面,地和 PVC 试管调节。9 构造的转基因的家庭(HVA22P : 由两个倡导者的 SOS2 和 CBF3, LOS5, ZAT10,和 NHX1 ) 在这块地或 PVC 管子里比 WT 显示出显著地更高的相对小穗状花小穗富饶。在 T2 测试的地干旱抵抗,家庭们与相对更低的收益减少源于 T1 家庭,七构造的转基因的家庭( HVA22P : CBF3 , Actin1 : NPK1 , HVA22P : NPK1 , Actin1 : LOS5 , HVA22P : LOS5 , Actin1 : ZAT10 ,并且 HVA22P : ZAT10 )比九构造的 WT ,和家庭每工厂显示出显著地更高的产量( Actin1 : CBF3 , HVA22P : CBF3 , HVA22P : SOS2 , HVA22P : NPK1 , Actin1 : LOS5 , HVA22P : LOS5 , Actin1 : ZAT10 , HVA22P : ZAT10 ,并且 Actin1 : NHX1 )比 WT 有更高的小穗状花小穗富饶。一般来说, LOS5 和 ZAT10 在在地条件下面改进转基因的大米的干旱抵抗比另外的五基因显示出相对更好的效果。从这研究获得的结果和经验能是为在米饭设计的干旱抵抗的一本有用参考书。 | Ben-Ze Xiao Xi Chen Cheng-Bin Xiang Ning Tang Qi-Fa Zhang Li-Zhong Xiong | 2009 | Molecular Plant2009，2，1： | 24 |
| 10 | Clinical curative effect of electric acupuncture on acute cerebral infarction:a randomized controlled multicenter trial显示文摘OBJECTIVE: To examine whether electric acupuncture can improve the daily life of patients with ischemic cerebral apoplexy at acute stage.METHODS: A stratified-block randomized controlled multicenter trial was designed for this study.Totally 340 patients with acute ischemic cerebral apoplexy were randomly divided into an electric acupuncture group and a control group. In the electric acupuncture group, 170 patients were treated with electric acupuncture and routine therapy, and170 patients in the control group with routine therapy alone. Major indexes for judging curative effect were Barthel index at 3- and 6- months follow-up visits and number of re-hospitalized patients. Mi-nor indexes for judging curative effect were change in the score for nervous dysfunction at 4and 12 weeks follow-up visits and number of patients persisting in rehabilitation treatment with acupuncture during follow-up visit.RESULTS: Baseline data at the time of case selection between the two groups were similar. The odds ratio(OR) was 0.92, and the 95% confidence interval(CI) was 0.49-1.73 in disabled rate and 0.73 and 0.51-1.05 in the number of re-hospitalized patients in the electric acupuncture group at 6-month follow up visit compared with the control group.There was no difference in the score for nervous dysfunction at the end of 12-week follow-up visit between the two groups. The score for nervous dysfunction at the end of 4-week treatment in the electric acupuncture group was significantly higher than that in the control group(P<0.05). The number of patients discharged from hospital who persisted in rehabilitation treatment with acupuncture in the acupuncture group was significantly higher than that in the control group.CONCLUSION: Using electric acupuncture to treat patients with acute ischemic cerebral apoplexy can effectively improve the nervous dysfunction scores after 4-week treatment and their ability to deal with daily life after 6-month follow-up visit. Systematic treatment with acupuncture may also reduce the number of patients with secondary apoplexy. | Chengwei Wang Zhongchao Wu Ning Li Yu Zhao Fengwei Tian Xi Zhou Zhuxing Wang | 2014 | Journal of Traditional Chinese Medicine2014，34，6： | 22 |
| 11 | Relationship between tumor necrosis factor-α and liver fibrosis显示文摘RelationshipbetweentumornecrosisfactorαandliverfibrosisWANGXin,CHENYueXiang,XUCaiFu,ZHAOGuoNing,HUANGYuXinandWANGQinLiD... | WANG Xin, CHEN Yue Xiang, XU Cai Fu, ZHAO Guo Ning, HUANG Yu Xin and WANG Qin Li Department of Gastroenterology, Tangdu Hospital, The Fourth Military Medical University, Xi′an 710038, Shaanxi Province, China | 1998 | World Journal of Gastroenterology1998，4，1： | 21 |
| 12 | Fibrinogen-like protein 2/fibroleukin prothrombinase contributes to tumor hypercoagulability via IL-2 and IFN-γ显示文摘AIM: To examine the role of Fibrinogen-like protein 2 (fgl2)/fibroleukin in tumor development. Fgl2 has been reported to play a vital role in the pathogenesis in MHV-3 (mouse hepatitis virus) induced fulminant and severe hepatitis,spontaneous abortion,allo-and xeno-graft rejection by mediating 'immune coagulation'. METHODS: Tumor tissues from 133 patients with six types of distinct cancers and the animal tumor tissues from human hepatocellular carcinoma (HCC) model on nude mice (established from high metastasis HCC cell line MHCC97LM6) were obtained. RESULTS: Hfgl2 was detected in tumor tissues from 127 out of 133 patients as well as tumor tissues collected from human HCC nude mice. Hfgl2 was highly expressed both in cancer cells and interstitial inflammatory cells including macrophages,NK cells,and CD8+ T lymphocytes and vascular endothelial cells. Hfgl2 mRNA was localized in cells that expressed hfgl2 protein. Fibrin (nogen) co-localization with hfgl2 expression was determined by dual immunohistochemical staining. In vitro,IL-2 and IFN-γ increased hfgl2 mRNA by 10-100 folds and protein expression in both THP-1 and HUVEC cell lines. One-stage clotting assays demonstrated that THP-1 and HUVEC cells expressing hfgl2 had increased procoagulant activity following cytokines stimulation. CONCLUSION: The hfg12 contributes to the hypercoagulability in cancer and may induce tumor angiogenesis and metastasis via cytokine induction. | Kai Su Fang Chen Wei-Ming Yan Qi-Li Zeng Li Xu Dong Xi Bin Pi Xiao-Ping Luo Qin Ning | 2008 | World Journal of Gastroenterology2008，14，39： | 20 |
| 13 | TRANSITION OF CONVECTIVE PATTERNS IN A RECTANGULAR CELL显示文摘In this paper our interest is focussed on the behavior in the transition of the Traveling Wave (TW) convective patterns along the nonlinear branch in a rectangular cell of Γ=12 for ψ=-0.11. Our numerical simulations were performed by solving the two-dimensional hydrodynamic equations using the SIMPLE method. Three types of convection patterns appearing in the nonlinear branch of the bifurcation diagram were observed. In particular, the undulation TW state in the rectangular cell was obtained, and the hysteresis in the transition from the TW State to the Stationary Overturning Convection (SOC) was verified. | Ning Li-zhong Institute of Hydraulic Engineering, Xi’an University of Technology, Xi’an 710048, China Department of Engineering, Nitto Co. Ltd., Ikebukuro 2-77-5, Toushima-ku, Tokyo 171-0014, Japan Yoshifumi Harada Department of Applied Physics, Fac | 2001 | Journal of Hydrodynamics2001，13，4： | 20 |
| 14 | Minimally invasive percutaneous compression plating versus dynamic hip screw for intertrochanteric fractures: a randomized control trial显示文摘ObjectiveIntertrochanteric 腿节骨折是在老病人的普通损害。动态新潮的螺丝钉(DHS ) 为固定用作标准选择;然而,它有几个缺点。经皮的压缩板(PCCP ) 的研究关于它的功效和安全仍然是不确定的。由比较二个方法,我们与 intertrochanteric 腿节破裂估计了他们 121 个老病人的临床的治疗学的 outcome.MethodsA 总数(类型 AO/OTA 31 .A1-A2 , Evans 类型 1 )随机被划分成经历一个最低限度地侵略的 PCCP 过程或操作持续时间是的一个常规 DHS fixation.ResultsThe 平均数的二个组在 PCCP 组显著地更短( 55.2 ; min 对 88.5 ; min , P ;< ; 0.01 )。血损失是 156.5 ml ± 18.3 在 PCCP 组和 513.2 的 ml; ml ± 66.2 在 DHS 组的 ml (P < 0.01 ) 。在与 PCCP 对待的病人之中, 3.1% 需要输血,与 44.6% 那些那有的 DHS 外科相比(P < 0.01 ) 。PCCP 组显示了不太手术后的复杂并发症(P < 0.05 ) 。在 PCCP 组的麻醉学者分数和哈里斯臀部分数的吝啬的美国社会比在 DHS 组的那些好。在到几个优点的吝啬的医院停留,死亡率,或骨折 healing.ConclusionDue 没有重要差别, PCCP 有潜力为对待 intertrochanteric 破裂成为理想的选择(类型 AO/OTA 31 .A1-A2, Evans 类型 1 ) ,在特别地老。 | Cheng Qiang Huang Wei Gong Xuan Wang Changdong Liang Xi Hu Ning | 2014 | Chinese Journal of Traumatology2014，17，5： | 20 |
| 15 | Atomic force microscopy imaging and mechanical properties measurement of red blood cells and aggressive cancer cells显示文摘Mechanical properties play an important role in regulating cellular activities and are critical for unlocking the mysteries of life. Atomic force microscopy (AFM) enables researchers to measure mechanical properties of single living cells under physiological conditions. Here, AFM was used to investigate the topography and mechanical properties of red blood cells (RBCs) and three types of aggressive cancer cells (Burkitt's lymphoma Raji, cutaneous lymphoma Hut, and chronic myeloid leukemia K562). The surface topography of the RBCs and the three cancer cells was mapped with a conventional AFM probe, while mechanical properties were investigated with a microsphere glued onto a tip-less cantilever. The diameters of RBCs are significantly smaller than those of the cancer cells, and mechanical measurements indicated that Young's modulus of RBCs is smaller than those of the cancer cells. Aggressive cancer cells have a lower Young's modulus than that of indolent cancer cells, which may improve our understanding of metastasis. | LI Mi LIU LianQing XI Ning WANG YueChao DONG ZaiLi XIAO XiuBin ZHANG WeiJing | 2012 | Science China(Life Sciences)2012，55，11： | 16 |
| 16 | Impact of farmland changes on production potential in China during 1990-2010显示文摘The quantity and spatial pattern of farmland has changed in China, which has led to a major change in the production potential under the influence of the national project of ecological environmental protection and rapid economic growth during 1990–2010. In this study, the production potential in China was calculated based on meteorological, terrain elevation, soil and land-use data from 1990, 2000 and 2010 using the Global Agro-ecological Zones model. Then, changes in the production potential in response to farmland changes from 1990 to 2010 were subsequently analyzed. The main conclusions were the following. First, the total production potential was 1.055 billion tons in China in 2010. Moreover, the average production potential was 7614 kg/ha and showed tremendous heterogeneity in spatial pattern. Total production in eastern China was high, whereas that in northwestern China was low. The regions with high per unit production potential were mainly distributed over southern China and the middle and lower reaches of the Yangtze River. Second, the obvious spatiotemporal heterogeneity in farmland changes from 1990 to 2010 had a significant influence on the production potential in China. The total production potential decreased in southern China and increased in northern China. Furthermore, the center of growth of the production potential moved gradually from northeastern China to northwestern China. The net decrease in the production potential was 2.97 million tons, which occupied 0.29% of the national total actual production in 2010. Third, obvious differences in the production potential in response to farmland changes from 1990 to 2000 and from 2000 to 2010 were detected. The net increase in the production potential during the first decade was 10.11 million tons and mainly distributed in the Northeast China Plain and the arid and semi-arid regions of northern China. The net decrease in the production potential during the next decade was 13.08 million tons and primarily distributed in the middle and lower reaches of the Yangtze River region and the Huang-Huai-Hai Plain. In general, the reason for the increase in the production potential during the past two decades might be due to the reclamation of grasslands, woodlands and unused land, and the reason for the decrease in the production potential might be urbanization that occupied the farmland and Green for Grain Project, which returned farmland to forests and grasslands. | LIU Luo XU Xinliang LIU Jiyuan CHEN Xi NING Jia | 2015 | Journal of Geographical Sciences2015，25，1： | 16 |
| 17 | Serum hepatitis B virus RNA is a predictor of HBeAg seroconversion and virological response with entecavir treatment in chronic hepatitis B patients显示文摘BACKGROUND Characteristics of alterations of serum hepatitis B virus(HBV) RNA in different chronic hepatitis B(CHB) patients still cannot be fully explained. Whether HBV RNA can predict HBeAg seroconversion is still controversial.AIM To investigate whether HBV RNA can predict virological response or HBeAg seroconversion during entecavir(ETV) treatment when HBV DNA is undetectable.METHODS The present study evaluated 61 individuals who were diagnosed and treated with long-term ETV monotherapy at the Department of Infectious Diseases of Peking University First Hospital(China) from September 2006 to December 2007.Finally, 30 treatment-naive individuals were included. Serum HBV RNA were extracted from 140 μL serum samples at two time points. Then they were reverse transcribed to cDNA with the HBV-specific primer. The product was quantified by real-time quantitative PCR(RT-PCR) using TAMARA probes. Statistical analyses were performed with IBM SPSS 20.0.RESULTS Level of serum HBV RNA at baseline was 4.15 ± 0.90 log10 copies/mL. HBV RNA levels showed no significant difference between the virological response(VR)and partial VR(PVR) groups at baseline(P = 0.940). Serum HBV RNA significantly decreased among patients who achieved a VR during ETV therapy(P < 0.001). The levels of HBV RNA in both HBeAg-positive patients with seroconversion group and those with no seroconversion increased after 24 wk of treatment. Overall, HBV RNA significantly but mildly correlated to HBsAg(r =0.265, P = 0.041), and HBV RNA was not correlated to HBV DNA(r = 0.242, P =0.062). Furthermore, serum HBV RNA was an independent indicator for predicting HBeAg seroconversion and virological response. HBeAg seroconversion was more likely in CHB patients with HBV RNA levels below4.12 log10 copies/mL before treatment.CONLUSION The level of serum HBV RNA could predict HBeAg seroconversion and PVR during treatment. In the PVR group, the level of serum HBV RNA tends to be increasing. | Hao Luo Xia-Xia Zhang Li-Hua Cao Ning Tan Qian Kang Hong-Li Xi Min Yu Xiao-Yuan Xu | 2019 | World Journal of Gastroenterology2019，25，6： | 15 |
| 18 | Acupuncture-movement therapy for acute lumbar sprain: a randomized controlled clinical trial显示文摘OBJECTIVE: Several studies have reported that acupuncture is effective for treatment of acute lumbar sprain, but they neglected to consider that acupuncture cannot remarkably improve lumbar activity. We performed a randomized controlled trial to evaluate the effect of acupuncture-movement therapy versus conventional acupuncture in the treatment of acute lumbar sprain.METHODS: Sixty patients were randomized into four groups: the acupuncture-movement(AM)group, sham acupuncture-movement(SAM) group,conventional acupuncture(CA) group, and physical therapy(PT) group. Patients in the AM group were treated with acupuncture at Yintang(EX-HN 3) and exercise of the lumbar region during acupuncture.Patients in the SAM group were treated with sham acupuncture at Yintang(EX-HN 3) and exercise of the lumbar region during sham acupuncture. Conventional acupuncture was performed in the CA group, and physical therapy was applied in the PT group. Each treatment lasted for 20 min. Patients were assessed before and after treatment using a visual analogue scale(VAS) and the Roland Morris Questionnaire(RMQ).RESULTS: The VAS and RMQ scores in the AM group were significantly lower after than before treatment(P < 0.01). The AM group reported lower RMQ scores in after-treatment and 24 h after treatment and lower VAS score in 24 h after treatment in comparison with those of the CA, SAM, and PT groups(P < 0.05).CONCULSION: Acupuncture-movement therapy is effective for treating acute lumbar sprain with a persistent pain-relief and remarkable improvement of lumbar activity. Movement, that is, lumbar exercise during acupuncture, enhances the effect of acupuncture. | Lin Ruizhu Zhu Ning Liu Jian Li Xinjian Wang Yue Zhang Jie Xi Chaolei | 2016 | Journal of Traditional Chinese Medicine2016，36，1： | 14 |
| 19 | Ag nanoparticles sensitize IR-induced killing of cancer cells显示文摘 | Ruizhi Xu Jun Ma Xinchen Sun ZhongpingChen Xiaoli Jiang Zhirui auo Lan Huang YangLi Meng Wang Changling Wang Jiwei Liu XuFan Jiayu Gu Xi Chen Yu Zhang Ning Gu | 2009 | Cell Research2009，19，8： | 11 |
| 20 | Development and Future Challenges of Bio-Syncretic Robots显示文摘 | Chuang Zhang Wenxue Wang Ning Xi Yuechao Wang Lianqing Liu | 2018 | Engineering2018，4，4： | 10 |
您所在的机构暂未开通此部分的功能，请联系管理员