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| 1 | The Structure of Ore-controlling Strain and Stress Fields in the Shangzhuang Gold Deposit in Shandong Province,China显示文摘Shangzhuang 改变岩石的类型金牌矿石存款位于中间的片断并且在 Jiaodong 金省的西北的部分由 Wang'ershan 差错地区控制了,中国。在 Shangzhuang 存款的变丑进化,紧张的结构和压力地和它的控制矿石的效果在这份报纸被讨论。变丑进化主要经历了四个阶段,这被揭示:早可锻的变丑,第二 NE 惹人注目水平简单砍,第三 NE 惹人注目的压缩砍和最后的 NW 惹人注目的压缩。矿化作用发生在在的第三个阶段期间最大的主要压力逐渐地从 NE 的 transited 到 NW。 3-D 压力地的数字模拟证明在最大的主要压力是NE惹人注目的条件上,在差错地区的破裂发展被赞成,当时当最大的主要压力是NW惹人注目的时,差错地区是相对 extensional 和它对形成矿石的液体的流入和炮兵阵地合适。压缩砍紧张地被类型结构在矿化作用期间描绘,积极的花结构,等等。Orebodies 等距离地主要位于 dilatational 空格,它在不可分的有压缩性的情形是分布式的。并且在差错态度变化的地方, dilatational 空格被开发或砍联合系统发展。在全面压缩砍应力地里,紧张地在多重规模忍受自我类似,包括 orebody,矿石存款和 orefield。结构的自我类似在各种各样的规模在一样的规模和破裂的类似的形状包括破裂的 subequidistant 分发。由于特殊地质的结构,然而, orebodies 主要在 Shangzhuang 存款位于挂的墙它与在 Jiaodong 金省的大多数存款不同。在存款的控制矿石的压力和紧张地的分析为寻求的沉积物提供一个重要基础。 | DENG Jun WANG Qingfei YANG Liqiang ZHOU Lei GONG Qingjie YUAN Wanming XU Hao GUO Chunying LIU Xiangwei | 2008 | Acta Geologica Sinica(English Edition)2008，82，4： | 41 |
| 2 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 3 | Mutual effects of nitric oxide and iron on the growth of marine algae显示文摘Experiments on the effects of nitric oxide (NO) and iron on the growth of marine microalgae Skeletonema costatum were conducted. The results are as follows: exogenous NO could increase the growth rate of marine algae and raise the biomass remarkably under iron-deficient conditions. But it was a complicated process that the phytoplankton growth was influenced by NO and iron, which was controlled by the NO concentration, the nutrition level of the culture medium and the iron concentration, etc. Meanwhile, the iron concentration in the medium also has a direct influence on the growth and NO release capacity of the algae. Therefore, the effects of NO and iron on the growth of marine phytoplankton were mutual. | LIU Chunying ZHANG Zhengbin CHEN Xiaorui | 2005 | Acta Oceanologica Sinica2005，24，5： | 11 |
| 4 | Identification of genomic regions determining flower and pod numbers development in soybean (Glycine max L.)显示文摘Flower and pod numbers per plant are important agronomic traits underlying soybean yield. So far quantitative trait loci (QTL) detected for flower and pod-related traits have mainly focused on the final stage, and might therefore have ignored genetic effects expressed during a specific developmental stage. Here, dynamic expressions of QTL for flower and pod numbers were identified using 152 recom-binant inbred lines (RILs) and a linkage map of 306 markers. Wide genetic variation was found among RILs; 17 unconditional and 18 conditional QTL were detected for the two traits at different developmental stages over two years. Some QTL were detected only at one stage and others across two or more stages, indicating that soybean flower and pod numbers development may be governed by time-dependent gene expression. Three main QTL (qfn-Chr18-2, qfn-Chr20-1, and qfn-Chr19) were detected for flower number, and two main QTL (qpn-Chr11 and qpn-Chr20) were detected for pod number. The phenotypic variation explained by them ranged from 6.1% to 34.7%. The markers linked to these QTL could be used in marker-assisted selection for increasing soybean flower and pod numbers, with the ultimate aim of increasing soybean yield. Comparison of the QTL regions for flower and pod numbers traits with the related genes reported previously showed that seven and four related genes were located in the QTL regions of qfn-Chr11 and qfn-Chr19, respectively. These results provide a basis for fine mapping and cloning of flower and pod development-related genes. | Dan Zhang, Hao Cheng, Hui Wang, Hengyou Zhang, Chunying Liu, Deyue Yu National Center for Soybean Improvement, National Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing 210095, China | 2010 | Journal of Genetics and Genomics2010，37，8： | 11 |
| 5 | Land Use Changes in Northeast China Driven by Human Activities and Climatic Variation显示文摘Human-induced land use/cover change (LUCC) forms an important component of global environmental change. Therefore, it is important to study land use/cover and its change at local, regional and global scales. In this paper we conducted the study of land use change in Northeast China, one of the most important agricultural zones of the nation. From 1986 to 2000, according to the study results obtained from Landsat images, widespread changes in land use/cover took place in the study area. Grassland, marsh, water body and woodland decreased by 9864, 3973, 1367 and 10,052km2, respectively. By comparison, paddy field, dry farmland, and built-up land expanded by 7339, 17193 and 700km2, respectively. Those changes bore an interactive relationship with the environment, especially climate change. On the one hand, climate warming created a potential environment for grassland and marsh to be changed to farmland as more crops could thrive in the warmer climate, and for dry farmland to paddy field. On the other hand, the changed surface cover modified the local climate. Those changes, in turn, have adversely influenced the local environment by accelerating land degradation. In terms of socio-economic driving forces, population augment, regional economic development, and national and provincial policies were confirmed as main driving factors for land use change. | WANG Zongming LIU Zhiming SONG Kaishan ZHANG Bai ZHANG Sumei LIU Dianwei REN Chunying YANG Fei | 2009 | Chinese Geographical Science2009，19，3： | 10 |
| 6 | Modification on the tribological properties of ceramics lubricated by water using fullerenol as a lubricating additive显示文摘It is necessary to modify the running-in process for the application of ceramics using water as a lubricant in real conditions because ceramics sliding in water are characterized by a running-in period with severe friction and wear.Fullerenol,a kind of highly water-soluble nanoparticle,was synthesized and then used to ameliorate the tribological properties of Si 3 N 4 sliding against Al 2 O 3 in pure water.With the addition of fullerenol,the running-in period was shortened from 30 min to 100 s at a speed of 250 mm/s.The speed threshold above which ultralow friction can be obtained in a short time was expanded from 450 mm/s to 80 mm/s.Meanwhile,the load-carrying ability of water film was increased.The role of fullerenol was discussed based on observation of the wear scar by an optical interferometer and XPS characterization of the tribo-film on the wear track. | LIU YuHong WANG XiaoKang LIU PengXiao ZHENG JunPeng SHU ChunYing PAN GuoShun LUO JianBin | 2012 | Science China(Technological Sciences)2012，55，9： | 9 |
| 7 | Study on patterns and chemical features of NO effect on marine phytoplankton growth显示文摘This article discusses the patterns of NO effect on marine phytoplankton growth from chemical perspective.The experimental results of four algae,which are Platymonas hal-golandica var.tsingtaoensis,Platymonas subcordiformis,Skeletonema costatum and Nitzschia closterium farma minutissima,are as follows:(i) In f/2 medium or f/50 medium,the growth of these four algae was obviously promoted or inhibited when nitric oxide of different concentrations was added once or twice each day during the cultivation;(ii) The NO effects on the growth of marine phytoplankton are in normal distribution.Different phytoplankton has different optimum NO concentration,which is consistent with the influence of NO on the growth of high plants;(iii) The effect of NO on Platymonas halgolandica var.tsingtaoensi,which is a food alga,is different from that on the red tide algae Skeletonema costatum and Nitzschia closterium farma minutis-sima.The authors put forward a new opinion that every alga has its own NO threshold concen-tration.All the above results may provide new clues to understand the formation of red tide. | ZHANG Zhengbin LIN Cai LIU Chunying XING Lei WU Zhenzhen SUN Feng | 2005 | Science China Chemistry2005，48，4： | 9 |
| 8 | Filtration of fine particles in atmospheric aerosol with electrospinning nanofibers and its size distribution显示文摘In this study,the size distribution of atmospheric aerosol in Beijing was monitored by the scanning mobility particle sizer spectrometer and the optical particle sizer.The size of particles in atmospheric aerosol was primarily distributed in the range of less than 1 m.It showed different changes with the mass concentrations of particulate matters with an aerodynamic diameter of 2.5 m(PM2.5)for different sizes of fine particles.The amount of ultrafine particles(less than about 60 nm)decreased while the larger ones(>60 nm)increased along with the mass concentration of PM2.5 in atmospheric aerosol.This was because of the formation of the secondary atmospheric aerosol.The polylactic acid(PLA)nanofibers were prepared for filtering the aerosol by electrospinning.PLA nanofiber mats were used as the middle layer to design the composite filter membranes.Atmospheric aerosol was used as dust source in the filtration test.The results showed that the filtration efficiency of the composite filter media increased along with the thickness of nanofiber mats,which was controlled by the collection time during electrospinning.Filtration efficiency can be improved obviously by compositing with a thin layer of nanofibers. | LI Juan SHI XiaoFei GAO Feng LIU LuQi CHEN Rui CHEN ChunYing ZHANG Zhong | 2014 | Science China(Technological Sciences)2014，57，2： | 7 |
| 9 | Coordination-responsive drug release inside gold nanorod @ metal-organic framework core-shell nanostructures for near-infrared-induced synergistic chemo-photothermal therapy显示文摘 | Yantao Li Jun Jin Dawei Wang Jiawei Lv Ke Hou Yaling Liu Chunying Chen Zhiyong Tang | 2018 | Nano Research2018，11，6： | 7 |
| 10 | Smart CU1.75S nanocapsules with high and stable photothermal efficiency for NIR photo-triggered drug release显示文摘Thermosensitive 药交货系统(DDS ) 面对主要挑战,例如遥远、可重复的控制在 vivo 温度,尽管这些能增加药的治疗学的功效。处理这个问题,我们涂在红外线附近(NIR ) photothermal Cu 1.75 有 pH/thermos-sensitive 聚合物由的 S nanocrystals 在 situ 聚合。装载内容的 doxorubicine (纪录影片) 直到 40 wt.% ,与纪录影片在正常生理的条件下面正在被漏的不到 8.2 wt.%(pH = 7.4, 37 吗? | Sheng Huang Jing Liu Qian He Hongli Chen Jiabin Cui Suying Xu Yuliang Zhao Chunying Chen Leyu Wang | 2015 | Nano Research2015，8，12： | 7 |
| 11 | Discovery of nitric oxide in marine ecological system and the chemical characteristics of nitric oxide显示文摘Nitric oxide was discovered in both the lab and the alga culture pond of Daya Bay (1―300 m3) before the growth of alga reached the maximum. The results included: (1) NO was detected before the growth of alga reached the maximum in the case of red tide alga and food alga, and the concentration of NO decreased rapidly after the growth maximum; (2) the curve between NO con-centration and time indicated that the concentration of NO in the daytime was more than that at night, and the maximal concentration of NO appeared in the midday (1―3 pm); (3) the growth of alga reached the maximum in the alga culture pond of Daya Bay in about 8―10 d, and NO was discovered in 5―7 d; (4) the measured NO concentration was 10-9 mol/L, 10-9―10-8 mol/L, and 10-8 mol/L for Haeterosigma akashiwo, mixed alga in Daya Bay and Chaetoceros Curvisetus individually; (5) the relation of illumination with NO production was discussed. | ZHANG Zhengbin XING Lei WU Zhenzhen LIU Chunying LIN Cai LIU Liansheng | 2006 | Science China Chemistry2006，49，5： | 7 |
| 12 | Seasonal variations of dimethylsulfide (DMS) and dim-ethylsulfoniopropionate (DMSP) in the sea-surface microlayer and subsurface water of Jiaozhou Bay and its adjacent area显示文摘The distributions of DMS and its precursor dimethylsulfoniopropionate, in both dissolved (DMSPd) and particulate fractions (DMSPp) were determined in the sea-surface microlayer and correspond-ing subsurface water of the Jiaozhou Bay, China and its adjacent area in May and August 2006. The concentrations of all these components showed a clear seasonal variation, with higher concen-trations occurring in summer. This can be mainly attributed to the higher phytoplankton biomass observed in summer. Simultaneously, the enrichment extents of DMSPd and DMSPp in the mi-crolayer also exhibited seasonal changes, with higher values in spring and lower ones in summer. Higher water temperature and stronger radiant intensity in summer can enhance their solubility and photochemical reaction in the microlayer water, reducing their enrichment factors (the ratio of concentration in the microlayer to that in the corresponding subsurface water). A statistically significant relationship was found between the microlayer and subsurface water concentrations of DMS, DMSP and chlorophyll a, demonstrating that the biogenic materials in the microlayer come primarily from the underlying water. Moreover, our data show that the concentrations of DMSPp and DMS were significantly correlated with the levels of chlorophyll a, indicating that phytoplank-ton biomass might play an important role in controlling the distributions of biogenic sulfurs in the study area. The ratios of DMS/chlorophyll a and DMSPp/chlorophyll a varied little from spring to summer, suggesting that there was no obvious change in the proportion of DMSP producers in the phytoplankton community. The mean sea-to-air flux of DMS from the study area was estimated to be 5.70 μmol/(m2·d), which highlights the effects of human impacts on DMS emission. | ZHANG Honghai YANG Guipeng LIU Chunying LI Chenxuan | 2009 | Acta Oceanologica Sinica2009，28，2： | 6 |
| 13 | TWO PRIVACY-PRESERVING PROTOCOLS FOR POINT-CURVE RELATION显示文摘Numerous privacy-preserving issues have emerged along with the fast development of Internet, both in theory and in real-life applications. To settle the privacy-preserving problems, secure multi-party computation is essential and critical. In this paper, we have solved two problems regarding to how to determine the position relation between points and curves without revealing any private information. Two protocols have been proposed in order to solve the problems in different conditions. In addition, some building blocks have been developed, such as scalar product protocol, so that we can take advantage of them to settle the privacy-preserving computational geometry problems which are a kind of special secure multi-party computation problems. Moreover, oblivious transfer and power series expansion serve as significant parts in our protocols. Analyses and proofs have also been given to argue our conclusion. | Liu Liang Wu Chunying Li Shundong | 2012 | Journal of Electronics(China)2012，29，5： | 6 |
| 14 | Fractionation characteristics of rare earth elements(REEs) linked with secondary Fe, Mn, and Al minerals in soils显示文摘Soil secondary minerals are important scavengers of rare earth elements(REEs) in soils and thus affect geochemical behavior and occurrence of REEs. The fractionation of REEs is a common geochemical phenomenon in soils but has received little attention, especially fractionation induced by secondary minerals. In this study, REEs(La to Lu and Y) associated with soil-abundant secondary minerals Fe-, Al-, and Mn-oxides in 196 soil samples were investigated to explore the fractionation and anomalies of REEs related to the minerals. The results show right-inclined chondrite-normalized REE patterns for La–Lu in soils subjected to total soil digestion and partial soil extraction. Light REEs(LREEs) enrichment features were negatively correlated with a Eu anomaly and positively correlated with a Ce anomaly. The fractionation between LREEs and heavy REEs(HREEs) was attributed to the high adsorption affinity of LREEs to secondary minerals and the preferred activation/leaching of HREEs.The substantial fractions of REEs in soils extracted byoxalate and Dithionite-Citrate-Bicarbonate buffer solutions were labile(10 %–30 %), which were similar to the mass fraction of Fe(10 %–20 %). Furthermore, Eu was found to be more mobile than the other REEs in the soils, whereas Ce was less mobile. These results add to our understanding of the distribution and geochemical behavior of REEs in soils, and also help to deduce the conditions of soil formation from REE fractionation. | Chunying Chang Fangbai Li Chengshuai Liu Jianfeng Gao Hui Tong Manjia Chen | 2016 | Acta Geochimica2016，35，4： | 5 |
| 15 | Uniqueness of the Gossypium mustelinum Genome Revealed by GISH and 45S rDNA FISH显示文摘Gossypium mustelinum ((广告) 4 ) 是在 Gossypium 的五 disomic 种之一。三 45S ribosomal DNA (rDNA ) loci 被检测在(广告) 4 作为探针与 Gossypium D 染色体种类的 genomic DNA (gDNA ) 作为探查,和三个更明亮的信号与 45S rDNA 被检测。尺寸和这些更明亮的信号的地点与作为探查与 45S rDNA 检测的那些一样,并且被称为 GISH -- 也不。他们之一是超级专业的,它说明了因为在染色体 3,和另外的二点关于它在中期的染色体的一个一半被定位的事实在染色体次要、定位 5 和 9 分别地。所有 GISH 也不位于一个亚染色体染色体,从另外的四 allopolyploid 棉花种分开。GISH -- 也没作为探查,然而并非 A 与 D 染色体种类被检测。极大地反常尺寸和地点(广告) 4 NORs 或 GISH 也不为列在后面的 45S rDNA 多样化(广告) 显示可能的机制 4 种形成。GISH 紧张和 GISH 的比较 -- 有 gDNA 的生产也不在 A 和 D 染色体表演之间探查更好的关系(广告) 4 与一个染色体。最短 G 的一个亚染色体的二个染色体。mustelinum 比 D 亚染色体染色体的最长的染色体短。因此,最长, tetraploid 棉花的 13 个染色体作为一个亚染色体正在被分类,当时更突然, 13 个染色体作为 D 亚染色体正在被分类在传统细胞发生并且 karyotype 分析不能是完全正确的。 | Qiong Wu Fang Liu Shaohui Li Guoli Song Chunying Wang Xiangdi Zhang Yuhong Wang David Stelly Kunbo Wang | 2013 | Journal of Integrative Plant Biology2013，55，7： | 4 |
| 16 | Direct site-specific treatment of skin cancer using doxorubicin-loaded nanofibrous membranes显示文摘Doxorubicin(DOX) is widely used in cancer therapy. However, its application is sometimes limited by its adverse cardiotoxicity and delivery pathways. In our study, we prepared a topical implantable delivery device for controlled drug release and site-specific treatment. The core region consisted of poly(lactic co-glycolic acid) and poly-caprolactone, whereas the shell region was composed of cross-linked gelatin.DOX was enclosed in the core region of a core-shell nanofiber obtained by electrospinning. This implantable delivery device was implanted on the top of the melanoma in a mouse model, which had shown a DOX-controlled release profile with sustained and sufficient local concentration against melanoma growth in mice with negligible side effects. Compared with the traditional intravenous administration,the implantable device allows precisely localized treatment and therefore can reduce the dose, decrease the injection frequency, and ensure antitumor efficacy associated with lower side effects to normal tissues. Using a coaxial electrospinning process, it is promising to deliver different hydrophobic or hydrophilic drugs for direct tumor site-specific therapy without large systemic doses and minimized systemic toxicity. | Mengyu Guo Guoqiang Zhou Zhu Liu Jing Liu Jinglong Tang Yating Xiao Wenshi Xu Ying Liu Chunying Chen | 2018 | Science Bulletin2018，63，2： | 4 |
| 17 | C:N:P stoichiometry of Ericaceae species in shrubland biomes across Southern China:influences of climate,soil and species identity显示文摘Aims Carbon(C),nitrogen(N)and phosphorus(P)stoichiometry strongly affect functions and nutrient cycling within ecosystems.However,the related researches in shrubs were very limited.In this study,we aimed to inves-tigate leaf stoichiometry and its driving factors in shrubs,and whether stoichiometry significantly differs among closely related species.Methods We analyzed leaf C,N and P concentrations and their ratios in 32 species of Ericaceae from 161 sites across southern China.We examined the relationships of leaf stoichiometry with environmen-tal variables using linear regressions,and quantified the interactive and independent effects of climate,soil and species on foliar stoi-chiometry using general linear models(GLM).Important Findings The foliar C,N and P contents of Ericaceae were 484.66,14.44 and 1.06 mg g−1,respectively.Leaf C,N and P concentrations and their ratios in Ericaceae were significantly related with latitude and altitude,except the N:P insignificantly correlated with latitude.Climate(mean annual temperature and precipitation)and soil properties(soil C,N and P and bulk density)were significantly influenced element stoichiom-etry.The GLM analysis showed that soil exerted a greater direct effect on leaf stoichiometry than climate did,and climate affected leaf traits mainly via indirect ways.Further,soil properties had stronger influ-ences on leaf P than on leaf C and N.Among all independent factors examined,we found species accounted for the largest proportion of the variation in foliar stoichiometry.These results suggest that species can largely influence foliar stoichiometry,even at a lower taxonomic level. | Qiang Zhang Qing Liu Huajun Yin Chunzhang Zhao Lin Zhang Guoying Zhou Chunying Yin Zhijun Lu Gaoming Xiong Yuelin Li Jiaxiang Li Wenting Xu Zhiyao Tang Zongqiang Xie | 2019 | Journal of Plant Ecology2019，12，2： | 4 |
| 18 | A Multilayer Study of pCO2 in the Surface Waters of the Yellow and South China Seas in Spring and the Sea-Air Carbon Dioxide Flux显示文摘A multilayer study of pCO2 for the Yellow and South China Seas in the surface waters was conducted based on data from four cruises sponsored by the China SOLAS Project in 2005 and 2006,including data for the surface microlayer(SML) ,subsurface layer(SSL) and surface layer(SL) . The carbon fluxes across the air-sea interface were calculated. The results showed that the pCO2 values in the surface waters of the study area decreased in the following order:pCO2 SML> pCO2 SSL> pCO2 SL. The highest values were found in March for all SML,SSL and SL,followed by those in April,and the lowest were in May. The pCO2 values had a significant positive correlation with temperature or salinity. While there was no relationship between pCO2 and longitude,there was a significant negative correlation between it and latitude,i.e.,'high latitude low pCO2'. By using four calculation models,the carbon dioxide fluxes(FC O2) in spring in the Yellow and South China Seas,which were found to act as a 'sink' of atmospheric CO2,were preliminarily estimated on the basis of the pCO2 data in the SML to be -7.00×106 t C and -22.35×106 t C,respectively. It is suggested that the FC O2calculated on the basis of pCO2 data in the SML is more reliable than that calculated on the basis of those in the SL. | LIU Chunying ZHANG Chuang YANG Xiaoman GONG Haidong ZHANG Zhengbin | 2008 | Journal of Ocean University of China2008，7，3： | 3 |
| 19 | Toxicity of manufactured nanomaterials显示文摘Manufactured nanomaterials with unique properties have been extensively applied in various indus-trial,agricultural or medical fields.However,some of the properties have been identified to be closely related to nanomaterial toxicity.The'nano-paradox'has aroused concerns over the use and develop-ment of nanotechnology,which makes it difficult for regulatory agencies to regulate nanomaterials.The key to fulfilling proper nanomaterial regulation lies in the adequate understanding of the impact of nanomaterial properties on nano-bio interactions.To this end,we start the present work with a brief intro-duction to nano-bio interactions at different levels.Based on that,how key toxicity-associated properties of manufactured nanomaterials(i.e.,size,shape,chemical composition,surface properties,biocorona formation,agglomeration and/or aggregation state,and biodegradability)impact their toxicokinetics,cel-lular uptake,trafficking and responses,and toxicity mechanisms is deeply explored.Moreover,advanced analytical methods for studying nano-bio interactions are introduced.Furthermore,the current reg-ulatory and legislative frameworks for nanomaterial-containing products in different regions and/or countries are presented.Finally,we propose several challenges facing the nanotoxicology field and their possible solutions to shed light on the safety evaluation of nanomaterials. | Yaping Liu Shuang Zhu Zhanjun Gu Chunying Chen Yuliang Zhao | 2022 | Particuology2022，20，10： | 3 |
| 20 | Wnt3a expression during the differentiation of adipose-derived stem cells into cholinergic neurons显示文摘The present study analyzed changes in Wnt3a expression during differentiation of adipose-derived stem cells into cholinergic neurons.Immunocytochemistry and immunofluorescence revealed significantly increased nestin,neuron-specific enolase,microtubule-associated protein 2,and choline acetyltransferase expression in adipose-derived stem cells isolated from Sprague-Dawley rats and cultured in vitro in neural-induced medium.These expressions increased with prolonged induction time.Real-time reverse transcription-PCR and western blot assay results demonstrated significantly increased choline acetyltransferase and Wnt3a protein and mRNA expressions,respectively,in adipose-derived stem cells following induction.Choline acetyltransferase expression positively correlated with Wnt3a protein and mRNA expressions.These results demonstrated that neural-induced medium induced differentiation of adipose-derived stem cells into cholinergic neuronal-like cells,with subsequent increased Wnt3a expression. | Bin Liu Chunying Deng Yuqin Zhang Jinxia Zhang | 2012 | Neural Regeneration Research2012，7，19： | 3 |
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