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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Levels of synthetic musk fragrances in human milk from three cities in the Yangtze River Delta in Eastern China显示文摘Synthetic musks are used as additives in many household products.After absorption into the human body,they accumulate and their concentrations in human milk reflect both the mother and her infant's exposure level.Concentrations of four synthetic musks,musk xylene(1-tert-butyl-2,6-dimethyl-2,4,6-trinitrobenzene,MX),musk ketone(4-tert-butyl-2,6-dimethyl-3,5-dinitroacetophenone,MK),1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[γ]-2-benzopyran(HHCB) and 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4tetrahydronaphthalene(AHTN),were determined in human milk samples collected from Shanghai,Wuxi,and Shaoxing in Eastern China.The four synthetic musks were found in most samples analyzed,with HHCB the dominant component followed by MX.The median(mean) values for HHCB,AHTN,MX and MK concentrations were 63(82),5(12),17(24) and 4(9) ng/g lipid weight,respectively.These data suggested the total synthetic musk contamination was low,and the distribution percentage was HHCB > MX > AHTN ≈ MK.The relative high ratio of nitro to polycylic musk indicated that nitro musks were still widely used.The musk concentrations in these cities were not significantly different from each other(p > 0.05).Principal components score plots were obtained,which showed similar exposure sources.The amount of total synthetic musks in human milk were not associated with mother's age,although HHCB was significantly correlated with AHTN(p < 0.05).Daily ingestion of HHCB,AHTN,MX and MK for infants from human milk were estimated as(2526 ± 2926),(370 ± 524),(7391 ± 832),and(277 ± 462) ng/day,respectively.Those doses were 1-2 orders of magnitude below the provisional tolerable daily intakes. | Xiaolan Zhang Gaofeng Liang Xiangying Zeng Jing Zhou Guoying Sheng Jiamo Fu | 2011 | Journal of Environmental Sciences2011，23，6： | 8 |
| 3 | A novel procedure for pollen-based quantitative paleoclimate reconstructions and its application in China显示文摘Traditionally, the evaluation of pollen-based quantitative paleoclimate reconstructions focuses on the ability of calibration sets to infer present climatic conditions and/or the similarity between fossil and modern assemblages. Objective criteria for choosing the most appropriate climate parameter(s) to be reconstructed at a specific site are thus lacking. Using a novel approach for testing the statistical significance of a quantitative reconstruction using random environmental data, in combination with the advantageous large environmental gradients, abundant vegetation types and comprehensive modern pollen databases in China, we describe a new procedure for pollen-based quantitative paleoclimatic reconstructions. First, the most significant environmental variable controlling the fossil pollen assemblage changes is identified. Second, a calibration set to infer changes in this targeted variable is built up, by limiting the modern ranges of other environmental variables. Finally, the pollen-based quantitative reconstruction is obtained and its statistical significance assessed. This novel procedure was used to reconstruct the mean annual precipitation(Pann) from Gonghai Lake in the Lvliang Mountains, and Tianchi Lake in the Liupan Mountains, on the eastern and western fringe of the Chinese Loess Plateau, respectively. Both Pann reconstructions are statistically significant(p<0.001), and a sound and stable correlation relationship exists in their common period, showing a rapid precipitation decrease since 3300 cal yr BP. Thus, we propose that this procedure has great potential for reducing the uncertainties associated with pollen-based quantitative paleoclimatic reconstructions in China. | CHEN JianHui LV FeiYa HUANG XiaoZhong H.John B.BIRKS Richard J.TELFORD ZHANG ShengRui XU QingHai ZHAO Yan WANG HaiPeng ZHOU AiFeng HUANG Wei LIU JianBao WEI GuoYing | 2017 | Science China Earth Sciences2017，60，11： | 6 |
| 4 | C:N:P stoichiometry of Ericaceae species in shrubland biomes across Southern China:influences of climate,soil and species identity显示文摘Aims Carbon(C),nitrogen(N)and phosphorus(P)stoichiometry strongly affect functions and nutrient cycling within ecosystems.However,the related researches in shrubs were very limited.In this study,we aimed to inves-tigate leaf stoichiometry and its driving factors in shrubs,and whether stoichiometry significantly differs among closely related species.Methods We analyzed leaf C,N and P concentrations and their ratios in 32 species of Ericaceae from 161 sites across southern China.We examined the relationships of leaf stoichiometry with environmen-tal variables using linear regressions,and quantified the interactive and independent effects of climate,soil and species on foliar stoi-chiometry using general linear models(GLM).Important Findings The foliar C,N and P contents of Ericaceae were 484.66,14.44 and 1.06 mg g−1,respectively.Leaf C,N and P concentrations and their ratios in Ericaceae were significantly related with latitude and altitude,except the N:P insignificantly correlated with latitude.Climate(mean annual temperature and precipitation)and soil properties(soil C,N and P and bulk density)were significantly influenced element stoichiom-etry.The GLM analysis showed that soil exerted a greater direct effect on leaf stoichiometry than climate did,and climate affected leaf traits mainly via indirect ways.Further,soil properties had stronger influ-ences on leaf P than on leaf C and N.Among all independent factors examined,we found species accounted for the largest proportion of the variation in foliar stoichiometry.These results suggest that species can largely influence foliar stoichiometry,even at a lower taxonomic level. | Qiang Zhang Qing Liu Huajun Yin Chunzhang Zhao Lin Zhang Guoying Zhou Chunying Yin Zhijun Lu Gaoming Xiong Yuelin Li Jiaxiang Li Wenting Xu Zhiyao Tang Zongqiang Xie | 2019 | Journal of Plant Ecology2019，12，2： | 4 |
| 5 | Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos显示文摘 | Yuyu Niu Bin Shen Yiqiang Cui Yongchang Chen Jianying Wang Lei Wang Yu Kang Xiaoyang Zhao Wei Si Wei Li Andy Peng Xiang Jiankui Zhou Xuejiang Guo Ye Bi Chenyang Si Bian Hu Guoying Dong Hong Wang Zuomin Zhou Tianqing Li Tao Tan Xiuqiong Pu Fang Wang Shaohu | 2014 | Cell2014，，： | 3 |
| 6 | Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation显示文摘Dear Editor,Herpesviridae is a large family of double-stranded DNA(dsDNA)viruses that cause a variety of human diseases ranging from cold sores and chicken pox to congenital defects,blindness and cancer(Chayavichitsilp et al.,2009;Wang et al.,2018).In the past 70 years,substantial advances in our knowledge of the molecular biology of herpesviruses have led to insights into disease pathogenesis and management.However,the mechanism for capsid assembly that requires the ordered packing of about 4,000 protein subunits into the hexons,pentons and triplexes remains elusive.It is still a puzzle how initially identical subunits adopt both hexameric and pentameric conformations in the capsid and select the correct locations needed to form closed shells of the proper size.Biochemical and genetic studies have shown that the portal is involved in initiation of capsid assembly(Newcomb et al.,2005)and functions akin to a DNA-sensor coupling genome-packaging achieved by a genome-packaging machinery-“terminase complex”(Chen et al.,2020;Yunxiang Yang,2020)with icosahedral capsid maturation(Lokareddy et al.,2017).Structural investigations of the herpesvirus portal have proven challenging due to the small size of this dodecamer,which accounts for less than 1%of the total mass of the capsid protein layer and the technical difficulties involved in resolving non-icosahedral components of such large icosahedral viruses(diameter is∼1,250Å).Efforts of many investigators over two decades have made to reconstruct the cryo-electron microscopy(cryo-EM)structure of herpesvirus portal vertex and more recently near-atomic structures of two herpesvirus(herpes simplex virus type 1(HSV-1)and Kaposi’s sarcoma-associated herpesvirus(KSHV))portal vertices were reported(McElwee et al.,2018;Gong et al.,2019;Liu et al.,2019). | Nan Wang Wenyuan Chen Ling Zhu Dongjie Zhu Rui Feng Jialing Wang Bin Zhu Xinzheng Zhang Xiaoqing Chen Xianjie Liu Runbin Yan Dongyao Ni Grace Guoying Zhou Hongrong Liu Zihe Rao Xiangxi Wang | 2020 | Protein & Cell2020，11，5： | 2 |
| 7 | Enhanced trimethylamine-containing particles during fog events detected by single particle aerosol mass spectrometry in urban Guangzhou, China显示文摘 | Guohua Zhang Xinhui Bi Lo Yin Chan Lei Li Xinming Wang Jialiang Feng Guoying Sheng Jiamo Fu Mei Li Zhen Zhou | 2012 | Atmospheric Environment2012，，： | 2 |
| 8 | Discovery of carbon-based strongest and hardest amorphous material显示文摘Carbon is one of the most fascinating elements due to its structurally diverse allo tropic forms stemming from its bonding varieties(sp,sp^(2)and sp^(3)).Exploring new forms of carbon has been the eternal theme of scientific research.Herein,we report on amorphous(AM) carbon materials with a high fraction of sp^(3)bonding recovered from compression of fullerene C_(60) under high pressure and high temperature,previously unexplored.Analysis of photoluminescence and absorption spectra demonstrates that they are semiconducting with a bandgap range of 1.5-2.2 eV,comparable to that of widely used AM silicon.Comprehensive mechanical tests demonstrate that synthesized AM-Ⅲ carbon is the hardest and strongest AM material known to date,and can scratch diamond crystal and approach its strength.The produced AM carbon materials combine outstanding mechanical and electronic properties,and may potentially be used in photovoltaic applications that require ultrahigh strength and wear resistance. | Shuangshuang Zhang Zihe Li Kun Luo Julong He Yufei Gao Alexander V.Soldatov Vicente Benavides Kaiyuan Shi Anmin Nie Bin Zhang Wentao Hu Mengdong Ma Yong Liu Bin Wen Guoying Gao Bing Liu Yang Zhang Yu Shu Dongli Yu Xiang-Feng Zhou Zhisheng Zhao Bo Xu Lei Su Guoqiang Yang Olga P.Chernogorova Yongjun Tian | 2022 | National Science Review2022，9，1： | 2 |
| 9 | Termination of Transcription of LAT Increases the Amounts of ICP0 mRNA but Does Not Alter the Course of HSV-1 Infection in Latently Infected Murine Ganglia显示文摘On entering sensory ganglia,herpes simplex viruses 1(HSV-1)establishes a latent infection with the synthesis of a latency associated transcript(LAT)or initiates productive infection with expression of a set of immediate early viral proteins.The precise mechanisms how expression of a genes is suppressed during the latency are unknown.One mechanism that has been proposed is illustrated in the case of ICP0,a key immediate early viral regulatory protein.Specifically,the 2 kb LAT intron is complementary to the 30 terminal portion of ICP0 m RNA.To test the hypothesis that accumulation of LAT negatively affects the accumulation of ICP0 m RNA,we inserted a DNA fragment encoding two poly(A)sequences into LAT to early terminate LAT transcript without interrupting the complementary sequence of ICP0 transcript(named as SR1603).Comparisons of the parent(SR1601)and mutant(SR1603)HSV-1 viruses showed the following:Neurons harboring latent SR1603 virus accumulated equivalent amounts of viral DNA but higher amounts of ICP0 m RNA and lower amounts of LAT,when compared to neurons harboring the SR1601 virus.One notable difference between the two viruses is that viral RNA accumulation in explanted ganglia harboring SR1603 virus initiated significantly sooner than that in neurons harboring SR1601 virus,suggesting that ICP0 may act as an activator of viral gene expression in permissive cells.Collectively,these data suggest that increased ICP0 m RNA by suppressed LAT did not affect the establishment of latency in latently infected murine ganglia. | Haifang Jiang Jiaming Wu Xianjie Liu Ruitao Lu Manling Zhou Meiling Chen Yonghong Liu Grace Guoying Zhou Wenmin Fu | 2021 | Virologica Sinica2021，36，2： | 2 |
| 10 | N-doped honeycomb-like porous carbon towards high-performance supercapacitor显示文摘Biomass-derived porous carbon with developed pore structure is critical to achieving high performance electrode materials.In this work,we report a grape-based honeycomb-like porous carbon(GHPC)prepared by KOH activation and carbonization,followed by N-doping(NGHPC).The obtained NGHPC exhibits a unique honeycomb-like structure with hierarchically interconnected micro/mesopores,and high specific surface area of 1268 m^2/g.As a supercapacitor electrode,the NGPHC electrode exhibits a remarkable specific capacitance of 275 F/g at 0.5 A/g in a three-electrode cell.Moreover,the NGHPC//NGHPC symmetric supercapacitor displays a high energy density of 12.6 Wh/kg,and excellent cycling stability of approximately 95.2% capacitance retention after 5000 cycles at 5 A/g.The excellent electrochemical performance of NGHPC is ascribed to its high specific surface area,honeycomb-like structure and high-content of pyrodinic-N(36.29%).It is believed that grape-based carbon materials show great potential as advanced electrode materials for supercapacitors. | Feng Wang Lian Chen Huiling Li Gaigai Duan Shuijian He Lin Zhang Guoying Zhang Zhengping Zhou Shaohua Jiang | 2020 | Chinese Chemical Letters2020，31，7： | 2 |
| 11 | Identification of long chain isoprenoid hydrocarbons from pyrolytic product of Dunaliella显示文摘In the pyrolytic research on Dunaliella salina cultured under natural conditions, abundant long chain regular isoprenoid hydrocarbons have been first detected and identified from algal pyrolytic product. Specially, the discovery of high abundant 2,6,10,14,18-pentamethyle-icosane indicated that regular iC25 probably originated from specific holophilic algae in hyper- | Ruiyong Wang Wen Zhou Junbiao Dai Qingyu Wu Guoying Sheng Jiamo Fu | 1999 | Chinese Science Bulletin1999，44，18： | 1 |
| 12 | Comparisonoftheimmu-nologicalactivitiesofarabinoxylansfromwheatbranwithal-kaliandxylanase-aidedextraction显示文摘 | ZhouS LiuXZ GuoY etal | 2010 | CarbohydratePoly-mers2010，81，4： | 1 |
| 13 | Deletion of the waaf gene affects O antigen synthesis and pathogenicity in Vibrio parahaemolyticus from shellfish显示文摘Vibrio parahaemolyticus is the main cause of foodborne gastroenteritis,which is widely distributed in shellfish and other seafood.Most V.parahaemolyticus are nonpathogenic,and only a few types,such as serotype O3:K6,are pathogenic,which is also the most prevalent strain in Asia.However,the relationship between this serotype and pathogenicity has yet to be established.The waaf gene is located in the O antigen synthesis gene cluster.Thus,we constructed a waaf gene deletion mutant(i.e.,Δwaaf)of wild-type(WT)which isolated from shellfish serotype O3:K6 via chitin-mediated transformation technology.We then constructed theΔwaaf complementary strain(i.e.,C-△waaf)via the Escherichia coli S17λpir strain by conjugation.The basic physiological characteristics,adhesion to Caco2 cells,and pathogenicity of the WT,△waaf,and C-△waaf strains were compared.Growth curves showed no remarkable differences between the WT andΔwaaf strains.However,theΔwaaf strain non-reactive to O3 antisera and other 12 O-group antisera of V.parahaemolyticus.Moreover,the number of flgella and extracellular polysaccharides decreased,the adhesion decreased,and the pathogenicity weakened.These characteristics of the C-△waaf strain were similar to those of the WT strain These results indicated that the waaf gene is vital to the serotype in V.parahaemolyticus,and changes in O antigen could affect the pathogenicity of this bacterium.This study will be helpful to understand the pathogenic mechanism of V.parahaemolyticus. | Feng Zhao Guoying Ding Qilong Wang Huihui Du Guosheng Xiao Deqing Zhou | 2022 | Food Science and Human Wellness2022，11，2： | 1 |
| 14 | Thesequence and de novo assembly of the giant panda genome显示文摘 | LI R FAN W TIAN G ZHU H HE L CAI J HUANG Q CAIQ LI B BAI Y ZHANG Z ZHANG Y WANG W LI J WEI F LI H JIAN M LI J ZHANG Z NIELSEN R LI D GU W YANG Z XUAN Z RYDER OA LEUNG FC ZHOU Y CAO J SUN X FU Y FANG X GUO X WANG B HOU R SHEN F MU B NI P LIN R QIAN W WANG G YU C NIE W WANGJ WU Z LIANG H MIN J WU Q CHENG S RUAN J WANGM SHI Z WEN M LIU B REN X ZHENG H DONG D COOKK SHAN G ZHANG H KOSIOL C XIE X LU Z ZHENG H LI Y STEINER CC LAM TT LIN S ZHANG Q LI G TIAN J GONG T LIU H ZHANG D FANG L YE C ZHANG J HU W XU A REN Y ZHANG G BRUFORD MW LI Q MA L GUOY AN N HU Y ZHENG Y SHI Y LI Z LIU Q CHEN Y ZHAO J QU N ZHAO S TIAN F WANG X WANG H XU L LIU X VINAR T WANG Y LAM TW YIU SM LIU S ZHANGH LI D HUANG Y WANG X YANG G JIANG Z WANG J QIN N LI L LI J BOLUND L KRISTIANSEN K WONG GK OLSON M ZHANG X LI S YANG H WANG J WANG J | 2010 | Na-ture2010，463，： | 1 |
| 15 | Investigation of tunable stretcher for ultrashort pulses based on silica wires with sub- wavelength-diameters显示文摘 | Zhou Guorui Feng Guoying Zhou Shouhuan | 2012 | Optics and Laser Technology2012，44，4： | 1 |
| 16 | Epoxidation of propylene by using3 as catalyst and with hydrogen peroxide by 2-ethylanthrahydroquinone and molecular oxygen显示文摘 | Zhou Ning Xi Zuwei Cao Guoying | 2003 | Applied catalysis A2003，250，： | 1 |
| 17 | A glutamic acid-rich protein identified in Verticillium dahliae from an insertional mutagenesis affects microsclerotial formation and pathogenicity显示文摘 | Gao Feng Zhou Bangjun Li Guoying | 2010 | PLoS One2010，5，15： | 1 |
| 18 | Source and mixing state of iron-containing particles in Shanghai by individual particle analysis显示文摘 | Guohua Zhang Xinhui Bi Shengrong Lou Lei Li Hongli Wang Xinming Wang Zhen Zhou Guoying Sheng Jiamo Fu Changhong Chen | 2014 | Chemosphere2014，，： | 1 |
| 19 | Enhanced trimethylamine-containing particles during fog events detected by single particle aerosol mass spectrometry in urban Guangzhou, China显示文摘 | Guohua Zhang Xinhui Bi Lo Yin Chan Lei Li Xinming Wang Jialiang Feng Guoying Sheng Jiamo Fu Mei Li Zhen Zhou | 2012 | Atmospheric Environment2012，，： | 1 |
| 20 | Mixing state of biomass burning particles by single particle aerosol mass spectrometer in the urban area of PRD, China显示文摘 | Xinhui Bi Guohua Zhang Lei Li Xinming Wang Mei Li Guoying Sheng Jiamo Fu Zhen Zhou | 2011 | Atmospheric Environment2011，，20： | 1 |
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