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| 1 | Methodology of drug screening and target identification for new necroptosis inhibitors显示文摘Apoptosis has been considered as the only form of regulated cell death for a long time. However, a novel form of programmed cell death called necroptosis was recently reported. The process of necroptosis is regulated and plays a critical role in the occurrence and development of multiple human diseases. Thus,the study on the molecular mechanism of necroptosis and its effective inhibitors has been an attractive field for researchers. Herein, we introduce the molecular mechanism of necroptosis and focus on the literature about necroptosis drug screening in recent years. In addition, the identification of the critical drug targets of the necroptosis is also discussed. | Pengchao Pan Zhenyu Cai Chunlin Zhuang Xiaofei Chen Yifeng Chai | 2019 | Journal of Pharmaceutical Analysis2019，9，2： | 3 |
| 2 | Effect of annealing on leakage current characteristics of Pt/Ba0.6Sr0.4TiO3/Pt thin-film capacitors显示文摘 | Chunlin Fu Fusheng Pan Hongwei Chen Wei Cai Chuanren Yang | 2007 | Journal of Materials Science: Materials in Electronics2007，，4： | 1 |
| 3 | Synthesis of self-assembly BaTiO3 nanowire by sol-gel and microwave method 显示文摘 | FU Chunlin CAI Wei ZHOU Longlong | 2009 | Applied Surface Science2009，255，23： | 1 |
| 4 | 趋化因子IL-8、MCP-1和MIP-1α在胆囊癌中表达的临床病理学意义(英文)显示文摘Objective: Gallbladder carcinoma was one of the malignant tumors in the digestive system, characterized by high recurrence and invasion. Recent research indicates that chemotactic factors such as IL-8, MCP-1 and MIP-1α have played an important role in such aspects as formulation, growth, shifting of the tumor. The aim of this study was to investigate expressions of IL-8, MCP-1 and MIP-1α in gallbladder adenocarcinoma tissues. Methods: Gallbladder adenocarcinoma and noncancerous tissues were routinely formalin-fixed and paraffin-embedded, and in situ hybridization assay for IL-8, MCP-1and MIP-1α mRNA. Results:(1) The positive rates or the scorings of IL-8, MCP-1 and MIP-1α mRNA were significantly higher in human gallbladder adenocarcinoma than those in human chronic cholecystitis(P < 0.01). The positive rates or the scorings of three factors were lower in well-differentiatiated gallbladder adenocarcinoma than in poorly-differenfiatted ones, whereas there was only one significant difference between MCP-1 mRNA(P < 0.05). The closely positive correlation were found among IL-8, MCP-1 and MIP-1α mRNA.(2) Both the positive rates of IL-8 mRNA and MCP-1 mRNA as well as their scorings were tightly related to their invasion of the common bile duct and the occurrence of lymph node transfer, moreover, the positive rates of MIP-1α mRNA and its scorings were tightly related to its invasion of liver.(3) Close positive correlation exists not only in IL-8 mRNA and MCP-1 mRNA(r = 0.528), but also in MIP-1α mRNA and IL-8 mRNA(r = 0.422), so does in MCP-1mRNA and MIP-1α mRNA(r = 0.638). Conclusion: The positive rates or the scorings of IL-8, MCP-1 and MIP-1α mRNA are significantly higher in human gallbladder adenocarcinoma than those in human chronic cholecystitis, and the closely positive correlation are found among them, which suggests that IL-8, MCP-1 and MIP-1α regulate and influence the development and transformation of the gallbladder adencarcinoma together. | Liang Zeng Xiaoyan Wang Lixue Zhou Chao Guo Chunlin Cai Jinshu Wu | 2013 | The Chinese-German Journal of Clinical Oncology2013，12，10： | 1 |
| 5 | Effect of Hf doping on the dielectric properties of barium zirconate ti- tanate ceramics 显示文摘 | Cai Wei Fu Chunlin Gao Jiacheng | 2011 | Materials Science Forum2011，687，： | 1 |
| 6 | Comparison of BBFs Observed by Single and Multi Satellites显示文摘This paper,using the data of three Cluster satellites,compares the observations of Bursty Bulk Flow (BBF) by single satellite with those by multi satellites.The results indicate that there exists remarkable difference between observations of BBF by single satellite and multi satellites.The observations of BBF by a single satellite depend on its position relative to the flow channel.The difference is caused by the localization characteristics of fast flows in the plasma sheet,and can lead to diverging views about substorm and causal relations among substorm phenomena. | Cao Jinbin Cheng Chao Ma Yuduan Cai Chunlin | 2010 | 空间科学学报2010，30，4： | 1 |
| 7 | Effect of Mn doping on the dielectric properties of BaZr0.2Ti0.8O3 ceramics显示文摘 | Wei Cai Chunlin Fu Jiacheng Gao Xiaoling Deng | 2010 | Journal of Materials Science: Materials in Electronics2010，，4： | 1 |
| 8 | Lacquer-based agroforestry system in western Yunnan, China显示文摘 | Chunlin Long Kui Cai Ken Marr Xiaorong Guo Zhiqin Ouyang | 2003 | Agroforestry Systems2003，，2： | 1 |
| 9 | Solitary Langerhans cell histiocytosis of frontal lobe: a case report and literature review显示文摘The brain parenchymal Langerhans cell histiocytosis(LCH) without systemic disease or lytic skull lesions is extremely rare. We report a 23-year-old male presenting with new onset 1 hour seizure with loss of consciousness 20 days prior to admission, and recurrent seizure 2 weeks later. Brain magnetic resonance imaging(MRI) showed an irregularly mass with enhancement involving the right frontal lobe. Microscopically, the lesion was characterized by sheets of Langerhans cells in addition to reactive inflammatory elements. Immunohistochemically, Langerhans cells were positive for Langerin, CD1a and S-100 protein. The patient received no chemotherapy or radiotherapy after surgery. After 24 months of follow-up, no recurrence or other systemic lesions were observed. Although there is no standard treatment for solitary cerebral LCH, the prognosis generally appears to be good. | Shanshan Cai Sheng Zhang Xueyong Liu Yuanxiang Lin Chunlin Wu Yupeng Chen Jianping Hu Xingfu Wang | 2014 | Chinese Journal of Cancer Research2014，26，2： | 1 |
| 10 | Guidelines for the diagnosis and treatment of acute pancreatitis in China (2021)显示文摘Acute pancreatitis(AP)is a common acute abdominal condition of the digestive system.In recent years,treatment concepts,methods,and strategies for the diagnosis of AP have advanced,and this has played an important role in promoting the standardization of AP diagnosis and treatment and improving the treatment quality of AP patients.On the basis of previous guidelines and expert consensus,this guideline adopts an evidence-based,problem-based expression;synthesizes important clinical research data at home and abroad in the most recent 5 years;and forms 29 recommendations through multidisciplinary expert discussion,including diagnosis,treatment,and follow-up.It is expected to provide evidence support for the treatment of AP in the clinical setting in China. | Fei Li Shouwang Cai Feng Cao Rufu Chen Deliang Fu Chunlin Ge Chunyi Hao Jihui Hao Heguang Huang Zhixiang Jian Gang Jin Ang Li Haimin Li Shengping Li Weiqin Li Yixiong Li Tingbo Liang Xubao Liu Wenhui Lou Yi Miao Yiping Mou Chenghong Peng Renyi Qin Chenghao Shao Bei Sun Guang Tan Xiaodong Tian Huaizhi Wang Lei Wang Wei Wang Weilin Wang Junmin Wei Heshui Wu Wenming Wu Zheng Wu Changqing Yan Yinmo Yang Xiaoyu Yin Xianjun Yu Chunhui Yuan Taiping Zhang Yupei Zhao on behalf of the Chinese Pancreatic Surgery Association | 2021 | Journal of Pancreatology2021，4，2： | 1 |
| 11 | Novel hepacivirus in Asian house shrew, China显示文摘Dear Editor,Hepatitis C virus (HCV) is a leading global cause of various liver diseases, including chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. The genome of HCV is monopartite, single-stranded, positive RNA, about 10 kb in size.HCV is the prototype species of the Hepacivirus genus,which contains 14 species according to the update from the International Committee on Taxonomy of Viruses (Smith et al., 2016). | Hua Guo Chunlin Cai Bo Wang Fei Zhuo Rendi Jiang Ning Wang Bei Li Wei Zhang Yan Zhu Yi Fan Wushen Chen Weihong Chen Xinglou Yang Zhengli Shi | 2019 | Science China(Life Sciences)2019，62，5： | 1 |
| 12 | Uniform Pricing Strategy vs. Price Differentiation Strategy in the Presence of Cost Saving and Demand Increasing显示文摘Price differentiation or discrimination strategy has been regarded as the best choice for firms with online and offline channels, however, recent years often witnessed the practices of the uniform pricing strategy. This paper aims to address the question whether the uniform pricing strategy may be better for the manufacturer, when the uniform pricing strategy has a positive impact on increasing the ciistomer demand and reducing the operations cost. The research shows that the uniform pricing strategy can be bet ter than the price differentiation strategy when the cost saving and demand increasing are large enough or the consumers' acceptance of online channel lies in a certain interval. Moreover, the manufac tu rers or brand owners need a tradeoff bet ween the benefit from online channel and the negative impact from the offline channel when they implement the price differentiation strategy. Finally, the authors obtain some managerial insights and implications based on the numerical analyses, which are in line with the phenomena in practice. | CAI Qiang LUO Chunlin TIAN Xin WANG Shouyang | 2019 | Journal of Systems Science & Complexity2019，32，3： | 0 |
| 13 | Multi-case Study of Current Sheet Flapping Motions Induced by Non-adiabatic Ions显示文摘In this paper,the y-component of magnetic field line curvature in the plasma sheet was analyzed,and two kinds of shear structures of the flapping current sheet were found,i.e.symmetric and antisymmetric.The alternating bending orientations of the guiding field are exactly corresponding to alternating north-south asymmetries of the bouncing ion population in the sheet center.Those alternating asymmetric plasma sources consequently induce the current sheet flapping motion as a driver.In addition,a substantial particle population with downward motion was observed in the center of a bifurcated current sheet.This population is identified as the quasi-adiabatic particles,and provides a net current opposite to the conventional cross-tail current. | WEI Xinhua CAI Chunlin | 2021 | 空间科学学报2021，41，6： | 0 |
| 14 | Consensus of clinical diagnosis and treatment for non-functional pancreatic neuroendocrine neoplasms with diameter<2 cm显示文摘In clinical practice,pancreatic neuroendocrine neoplasms(pNENs)with a diameter smaller than 2 cm are commonly referred to as small pNENs.Due to their generally favorable biological characteristics,the diagnosis and treatment of small pNENs differ from other pNENs and are somewhat controversial.In response to this,the Chinese Pancreatic Surgery Association,Chinese Society of Surgery,Chinese Medical Association have developed a consensus on the diagnosis and treatment of small pNENs,which is based on evidence-based medicine and expert opinions.This consensus covers various topics,including concepts,disease assessment,treatment selection,follow-up,and other relevant aspects. | Wu Wenming Cai Shouwang Chen Rufu Fu Deliang Ge Chunlin Hao Chunyi Hao Jihui Huang Heguang Jian Zhixiang Jin Gang Li Fei Li Haimin Li Shengping Li Weiqin LiYixiong Liang Tingbo Liu Xubao Lou Wenhui Miao Yi Mou Yiping Peng Chenghong Qin Renyi Shao Chenghao Sun Bei Tan Guang Wang Huaizhi Wang Lei Wang Wei Wang Weilin Wei Junmin Wu Heshui Wu Zheng Yan Changqing Yang Yinmo Yin Xiaoyu Yu Xianjun Yuan Chunhui Zhao Yupei | 2023 | Journal of Pancreatology2023，6，3： | 0 |
| 15 | The electronic structure and optical properties of Ca_(3)(Mn_(1-x)Ti_(x))_(2)O_(7) from first-principle calculations显示文摘The electronic structure and optical properties of Ca_(3)(Mn_(1-x)Ti_(x))_(2)O_(7)(x¼0,1/8,2/8,3/8,4/8)were studied by first-principle calculations within the generalized gradient approximation approaches(GGA).The lattice constants of Ca_(3)(Mn_(1-x)Ti_(x))_(2)O_(7) increase with the increase of Ti^(4+)content caused by the substitution of Ti^(4+)with larger ionic radius for Mn^(4+).Ca_(3)(Mn_(1-x)Ti_(x))_(2)O_(7) is a direct band gap semiconductor,and the band gap(Eg)increases with the increase of Ti^(4+)content.From the density of states,the introduction of Ti-3d states can weaken the effects of Mn-3d states on the bottom of conduction band and has little influence on O-2p states on the top of valence band.The introduction of nonmagnetic Ti^(4+)ions can weaken the magnetism of Ca_(3)(Mn_(1-x)Ti_(x))_(2)O_(7).According to the Mulliken population analysis,it is found that the introduction of Ti^(4+)enhances the electronic accepting capacity of oxygen ions and enhances the electronic losing capacity of manganese ions.The bond strength of Ti–O covalent bond is stronger than that of Mn–O covalent bond.Furthermore,the optical properties of Ca_(3)(Mn_(1-x)Ti_(x))_(2)O_(7) was calculated.As Ti^(4+)content increases,the absorption edge of Ca_(3)(Mn_(1-x)Ti_(x))_(2)O_(7) has a blue shift,the static refractive index n0 decreases,the static dielectric constant'1(0)decreases,the position of loss peak moves to higher energy. | Fengqi Wang Wei Cai Chunlin Fu Rongli Gao Gang Chen Xiaoling Deng Zhenhua Wang Chaoyang Zhang | 2019 | Journal of Advanced Dielectrics2019，9，1： | 0 |
| 16 | Extraction Process of Green Pigment from Leaves of Arctium lappa L. by Ultrasound Assisted Method and Its Stability Study显示文摘[Objectives] The research aimed to extract green pigment from leaves of Arctium lappa L. and inspect its stability. [Methods] Ultrasound assisted method was used. [Results] Water bath temperature had little impact on green pigment, and Al^(3+), Cu^(2+), Mg^(2+) and Zn^(2+) in metal ions greatly affected green pigment, while Fe^(3+) had very little impact on the stability of green pigment. pH did not basically affect green pigment of A. lappa L. [Conclusions] The extraction rate and stability of green pigment from leaves of A. lappa L. were higher, and it was one of materials suitable for extracting green pigment. | Yongxia KE Chunlin LIU Xuexue LI Xiaoxia CAI Jingxia WANG Yuan LIU | 2019 | Medicinal Plant2019，10，1： | 0 |
| 17 | Guidelines for the diagnosis and treatment of pancreatic cancer in China (2021)显示文摘The incidence of pancreatic cancer has been rising worldwide,and its clinical diagnosis and treatment remain a great challenge.To present the update and improvements in the clinical diagnosis and treatment of pancreatic cancer in recent years,Chinese Pancreatic Association,the Chinese Society of Surgery,Chinese Medical Association revised the Guidelines for the Diagnosis and Treatment of Pancreatic Cancer in China(2014)after reviewing evidence-based and problem-oriented literature published during 2015-2021,mainly focusing on highlight issues regarding diagnosis and surgical treatment of pancreatic cancer,conversion strategies for locally advanced pancreatic cancer,treatment of pancreatic cancer with oligo metastasis,adjuvant and neoadjuvant therapy,standardized processing of surgical specimens and evaluation of surgical margin status,systemic treatment for unresectable pancreatic cancer,genetic testing,as well as postoperative follow up of patients with pancreatic cancer.Forty recommendation items were finally proposed based on the above issues,and the quality of evidence and strength of recommendations were graded using the Grades of Recommendation,Assessment,Development,and Evaluation system.This guideline aims to standardize the clinical diagnosis and therapy,especially surgical treatment of pancreatic cancer in China,and further improve the prognosis of patients with pancreatic cancer. | Yinmo Yang Xueli Bai Dapeng Bian Shouwang Cai Rufu Chen Feng Cao Menghua Dai Chihua Fang Deliang Fu Chunlin Ge Xiaochao Guo Chunyi Hao Jihui Hao Heguang Huang Zhixiang Jian Gang Jin Fei Li Haimin Li Shengping Li Weiqin Li Yixiong Li Hongzhen Li Tingbo Liang Xubao Liu Wenhui Lou Yi Miao Yiping Mou Chenghong Peng Renyi Qin Chenghao Shao Bei Sun Guang Tan Xiaodong Tian Huaizhi Wang Lei Wang Wei Wang Weilin Wang Junmin Wei Heshui Wu Wenming Wu Zheng Wu Jingyong Xu Changqing Yan Xiaoyu Yin Xianjun Yu Chunhui Yuan Taiping Zhang Jixin Zhang Jun Zhou Yupei Zhao on behalf of the Chinese Pancreatic Surgery Association | 2021 | Journal of Pancreatology2021，4，2： | 0 |
| 18 | The investigation of electrical properties and microstructure of ZnO-doped Ba_(0.9)Sr_(0.1)TiO_(3)ceramics显示文摘Ba_(0.9)Sr_(0.1)TiO_(3) ceramics with or without ZnO have been prepared by traditional solid state reaction method.The XRD analysis showed that the doped Zn^(2+) ions diffused into the BST crystal lattice,resulting in the variation of dielectric properties.Especially the dielectric constant at Curie point decreased with doping ZnO content when it is lower than 0.5 mol%.Due to the promotion of sintering,doping ZnO can enhance the density of ceramics but increase grain size.However,ZnO is a kind of semiconductor and can lead to the decrease in electrical breakdown strength value. | Gang Liu Wentao Jiang Jingyong Jiao Li Liu Ziyang Wang Jing Cai Wenting Luo Chunlin Song | 2017 | Journal of Advanced Dielectrics2017，7，1： | 0 |
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