|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 2 | Single-shot compressed ultrafast photography: a review显示文摘Compressed ultrafast photography(CUP)is a burgeoning single-shot computational imaging technique that provides an imaging speed as high as 10 trillion frames per second and a sequence depth of up to a few hundred frames.This technique synergizes compressed sensing and the streak camera technique to capture nonrepeatable ultrafast transient events with a single shot.With recent unprecedented technical developments and extensions of this methodology,it has been widely used in ultrafast optical imaging and metrology,ultrafast electron diffraction and microscopy,and information security protection.We review the basic principles of CUP,its recent advances in data acquisition and image reconstruction,its fusions with other modalities,and its unique applications in multiple research fields. | Dalong Qi Shian Zhang Chengshuai Yang Yilin He Fengyan Cao Jiali Yao Pengpeng Ding Liang Gao Tianqing Jia Jinyang Liang Zhenrong Sun Lihong V.Wange | 2020 | Advanced Photonics2020，2，1： | 5 |
| 3 | Single-shot spectral-volumetric compressed ultrafast photography显示文摘In ultrafast optical imaging,it is critical to obtain the spatial structure,temporal evolution,and spectral composition of the object with snapshots in order to better observe and understand unrepeatable or irreversible dynamic scenes.However,so far,there are no ultrafast optical imaging techniques that can simultaneously capture the spatial–temporal–spectral five-dimensional(5D)information of dynamic scenes.To break the limitation of the existing techniques in imaging dimensions,we develop a spectral-volumetric compressed ultrafast photography(SV-CUP)technique.In our SV-CUP,the spatial resolutions in the x,y and z directions are,respectively,0.39,0.35,and 3 mm with an 8.8 mm×6.3 mm field of view,the temporal frame interval is 2 ps,and the spectral frame interval is 1.72 nm.To demonstrate the excellent performance of our SV-CUP in spatial–temporal–spectral 5D imaging,we successfully measure the spectrally resolved photoluminescent dynamics of a 3D mannequin coated with CdSe quantum dots.Our SV-CUP brings unprecedented detection capabilities to dynamic scenes,which has important application prospects in fundamental research and applied science. | Pengpeng Ding Yunhua Yao Dalong Qi Chengshuai Yang Fengyan Cao Yilin He Jiali Yao Chengzhi Jin Zhengqi Huang Li Deng Lianzhong Deng Tianqing Jia Jinyang Liang Zhenrong Sun Shian Zhang | 2021 | Advanced Photonics2021，3，4： | 3 |
| 4 | Gankyrin promotes tumor growth and metastasis through activation of IL‐6/STAT3 signaling in human cholangiocarcinoma显示文摘 | Tongsen Zheng Xuehui Hong Jiabei Wang Tiemin Pei Yingjian Liang Dalong Yin Ruipeng Song Xuan Song Zhaoyang Lu Shuyi Qi Jiaren Liu Boshi Sun Changming Xie Shangha Pan Yuejin Li Xiaohe Luo Shuai Li Xiang Fang Nishant Bhatta Hongchi Jiang Lianxin Liu | 2014 | Hepatology2014，，： | 2 |
| 5 | High-fidelity image reconstruction for compressed ultrafast photography via an augmented-Lagrangian and deep-learning hybrid algorithm显示文摘Compressed ultrafast photography(CUP) is the fastest single-shot passive ultrafast optical imaging technique,which has shown to be a powerful tool in recording self-luminous or non-repeatable ultrafast phenomena.However, the low fidelity of image reconstruction based on the conventional augmented-Lagrangian(AL)and two-step iterative shrinkage/thresholding(Tw IST) algorithms greatly prevents practical applications of CUP, especially for those ultrafast phenomena that need high spatial resolution. Here, we develop a novel AL and deep-learning(DL) hybrid(i.e., AL+DL) algorithm to realize high-fidelity image reconstruction for CUP. The AL+DL algorithm not only optimizes the sparse domain and relevant iteration parameters via learning the dataset but also simplifies the mathematical architecture, so it greatly improves the image reconstruction accuracy. Our theoretical simulation and experimental results validate the superior performance of the AL+DL algorithm in image fidelity over conventional AL and Tw IST algorithms, where the peak signalto-noise ratio and structural similarity index can be increased at least by 4 d B(9 d B) and 0.1(0.05) for a complex(simple) dynamic scene, respectively. This study can promote the applications of CUP in related fields, and it will also enable a new strategy for recovering high-dimensional signals from low-dimensional detection. | CHENGSHUAI YANG YUNHUA YAO CHENGZHI JIN DALONG QI FENGYAN CAO YILIN HE JIALI YAO PENGPENG DING LIANG GAO TIANQING JIA JINYANG LIANG ZHENRONG SUN SHIAN ZHANG | 2021 | Photonics Research2021，9，2： | 2 |
| 6 | Exploring Femtosecond Laser Ablation by Snapshot Ultrafast Imaging and Molecular Dynamics Simulation显示文摘Femtosecond laser ablation(FLA)has been playing a prominent role in precision fabrication of material because of its circumvention of thermal effect and extremely high spatial resolution.Molecular dynamics modeling,as a powerful tool to study the mechanism of femtosecond laser ablation,still lacks the connection between its simulation results and experimental observations at present.Here we combine a single-shot chirped spectral mapping ultrafast photography(CSMUP)technique in experiment and a three-dimensional two-temperature model-based molecular dynamics(3D TTM-MD)method in theory to jointly investigate the FLA process of bulky gold.Our experimental and simulated results show quite high consistency in time-resolved morphologic dynamics.According to the highly accurate simulations,the FLA process of gold at the high laser fluence is dominated by the phase explosion,which shows drastic vaporized cluster eruption and pressure dynamics,while the FLA process at the low laser fluence mainly results from the photomechanical spallation,which shows moderate temperature and pressure dynamics.This study reveals the ultrafast dynamics of gold with different ablation schemes,which has a guiding significance for the applications of FLA on various kinds of materials. | Jiali Yao Dalong Qi Hongtao Liang Yilin He Yunhua Yao Tianqing Jia Yang Yang Zhenrong Sun Shian Zhang | 2022 | Ultrafast Science2022，，5： | 1 |
| 7 | Seasonal diet and microbiome shifts in wild rhesus macaques are better correlated at the level of nutrient components than food items显示文摘Food supply is one of the major drivers of animal behavior,and the gut microbiome is an important mediator be-tween food supply and its effects on physiology.However,predicting the outcome of diet change on microbiome and consequences for the animal has proven extremely challenging.We propose this reflects processes occurring at different scales.Inadequate accounting for the multi-level complexity of nutrition(nutrients,foods,diets)obscures the diet influence on microbiome and subsequently animal.Here,we present a detailed year-round,multi-level analysis of diet and microbiome changes in a wild population of a temperate primate,the rhesus macaque(Macaca mulatta).Total daily food and nutrient intake of 6 male and 6 female macaques was monitored in each of the 4 sea-sons(total 120 days observations).For each individual,we found significant variation in the microbiome between all 4 seasons.This response was more strongly correlated with changes in macronutrient intake than with food items and much of the response could be explained at the level of 6 ecological guilds—sets of taxa sharing similar responses to nutrient intake.We conclude that study of diet,microbiome,and animal performance in ecology will more effectively identify patterns if diet is recorded at the level of nutrient intake.Although microbiome response to diet does show variation in species-level taxa in response to food items,there is greater commonality in response at the level of guilds.A goal for microbiome researchers should be to identify genes encoding microbial attributes that can define such guilds. | Zhenwei CUI Andrew JHOLMES Wenjuan ZHANG Dalong HU Qi SHAO Zhenlong WANG Jiqi LU David RAUBENHEIMER | 2022 | Integrative Zoology2022，17，6： | 0 |
| 8 | Functional prediction of tomato PLATZ family members and functional verification of Sl PLATZ17显示文摘PLATZ is a novel zinc finger DNA-binding protein that plays an important role in regulating plant growth and development and resisting abiotic stress.However,there has been very little research on the function of this family gene in tomatoes,which limits its application in germplasm resource improvement.Therefore,the PLATZ gene family was identified and analyzed in tomato,and its roles were predicted and verified to provide a basis for in-depth research on SlPLATZ gene function.In this study,the PLATZ family members of tomato were identified in the whole genome,and 19 SlPLATZ genes were obtained.Functional prediction was conducted based on gene and promoter structure analysis and RNA-seq-based expression pattern analysis.SlPLATZ genes that responded significantly under different abiotic stresses or were significantly differentially expressed among multiple tissues were screened as functional gene resources.SlPLATZ17 was selected for functional verification by experiment-based analysis.The results showed that the downregulation of SlPLATZ17 gene expression reduced the drought and salt tolerance of tomato plants.Tomato plants overexpressing SlPLATZ17 had larger flower sizes and long,thin petals,adjacent petals were not connected at the base,and the stamen circumference was smaller.This study contributes to understanding the functions of the SlPLATZ family in tomato and provides a reference for functional gene screening. | Min Xu Zhao Gao Dalong Li Chen Zhang Yuqi Zhang Qian He Yingbin Qi He Zhang Jingbin Jiang Xiangyang Xu Tingting Zhao | 2024 | Journal of Integrative Agriculture2024，23，1： | 0 |
| 9 | Temporal compressive super-resolution microscopy at frame rate of 1200 frames per second and spatial resolution of 100 nm显示文摘Various super-resolution microscopy techniques have been presented to explore fine structures of biological specimens.However,the super-resolution capability is often achieved at the expense of reducing imaging speed by either point scanning or multiframe computation.The contradiction between spatial resolution and imaging speed seriously hampers the observation of high-speed dynamics of fine structures.To overcome this contradiction,here we propose and demonstrate a temporal compressive super-resolution microscopy(TCSRM)technique.This technique is to merge an enhanced temporal compressive microscopy and a deep-learning-based super-resolution image reconstruction,where the enhanced temporal compressive microscopy is utilized to improve the imaging speed,and the deep-learning-based super-resolution image reconstruction is used to realize the resolution enhancement.The high-speed super-resolution imaging ability of TCSRM with a frame rate of 1200 frames per second(fps)and spatial resolution of 100 nm is experimentally demonstrated by capturing the flowing fluorescent beads in microfluidic chip.Given the outstanding imaging performance with high-speed super-resolution,TCSRM provides a desired tool for the studies of high-speed dynamical behaviors in fine structures,especially in the biomedical field. | Yilin He Yunhua Yao Dalong Qi Yu He Zhengqi Huang Pengpeng Ding Chengzhi Jin Chonglei Zhang Lianzhong Deng Kebin Shi Zhenrong Sun Xiaocong Yuan Shian Zhang | 2023 | Advanced Photonics2023，5，2： | 0 |
| 10 | Single-shot real-time imaging of ultrafast light springs显示文摘Light springs(LSs) have played essential roles in particle rotation and manipulation, optical super-resolution imaging, and optical information coding. In related research areas, it is important to accurately measure spatiotemporal information on LSs to understand and analyze their applications. However, there is no experimental method that can accurately detect the drastic spatial evolution of ultrafast LSs to date. Therefore, in this study, we propose a compressed ultrafast photography(CUP) technique to observe LSs in spatial and temporal dimensions with a snapshot. Using our home-built CUP system, we successfully capture spatiotemporal information on picosecond LSs with two and four petals, involving spatial structure and rotation velocity;furthermore, the experimental measurements are in good agreement with theoretical simulations. This study provides a novel visualization method for specifically measuring the spatial structure and temporal evolution of LSs, thus establishing a new idea for accurately characterizing spatiotemporal information on complex ultrafast laser fields. | Chengzhi Jin Dalong Qi Yunhua Yao Fengyan Cao Li Deng Shixiang Xu Zhenrong Sun Shian Zhang | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，12： | 0 |
| 11 | A process study of high-quality Zn(O,S)thin-film fabrication for thin-film solar cells显示文摘The Zn(O,S)thin film is considered a most promising candidate for a cadmium-free buffer layer of the Cu(In,Ga)Se_(2)(CIGS)thin-film solar cell due to its advantages of optical responses in the short-wavelength region and adjustable bandgap.In this paper,the thin-film growth mechanism and process optimization of Zn(O,S)films fabricated using the chemical bath deposition method are sys-tematically investigated.The thickness and quality of Zn(O,S)films were found to be strongly affected by the concentration variation of the precursor chemicals.It was also revealed that different surface morphologies of Zn(O,S)films would appear if the reaction time were changed and,subsequently,the optimum reaction time was defined.The film-growth curve suggested that the growth rate varied linearly with the deposition temperature and some defects appeared when the temperature was too high.In addition,to further improve the film quality,an effective post-treatment approach was proposed and the experimental results showed that the microstructure of the Zn(O,S)thin film was improved by an ammonia etching process followed by an annealing process.For com-parison purposes,both Zn(O,S)-based and CdS-based devices were fabricated and characterized.The device with a Zn(O,S)-CIGS solar cell after post-treatment showed near conversion efficiency comparable to that of the device with the CdS-CIGS cell. | Qi Sun Boyan Li Xingye Huang Zhihua Han Dalong Zhong Ying Zhao | 2023 | Clean Energy2023，7，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员