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| 1 | Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules显示文摘由病毒的 transduction 的四抄写因素 Oct4, Klf4, Sox2 和 c-Myc 的介绍能导致体的房间的 reprogramming 进导致的 pluripotent 干细胞(iPSCs ) ,但是 iPSCs 的使用被病毒的交货系统的使用妨碍。导致化学药品的 reprogramming 把一条新奇途径提供给没有任何病毒的基于向量的基因修正,产生 iPSCs。尽管,以前的报告证明几个小分子能代替一些 reprogramming 因素至少二个抄写因素, Oct4 和 Klf4,仍然被要求从老鼠产生 iPSCs 胚胎的成纤维细胞。这里,我们识别特定的化学联合,它是足够的面对一个单个抄写因素从胚胎的老鼠和成年成纤维细胞允许 reprogramming, Oct4 在 20 天以内,代替 Sox2, Klf4 和 c-Myc。用这个处理产生的 iPSCs 类似于胚胎的干细胞以全球基因表示介绍的老鼠,在 vitro 并且在 vivo 的 epigenetic 地位和 pluripotency。我们也发现那 8 天 Oct4 正式就职是足够的面对小分子启用导致 Oct4 的 reprogramming,它建议 reprogramming 在开始的 8 天以内被开始并且独立于连续外长的 Oct4 表示。没有基因修正,这些发现将帮助 iPSCs 的未来产生,以及阐明位于 reprogramming 过程下面的分子的机制。 | Yanqin Li Qiang Zhang Xiaolei Yin Weifeng Yang Yuanyuan Du Pingping Hou Jian Ge Chun Liu Weiqi Zhang Xu Zhang Yetao Wu Honggang Li Kang Liu Chen Wu Zhihua Song Yang Zhao Yan Shi Hongkui Deng | 2011 | Cell Research2011，21，1： | 51 |
| 2 | A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts显示文摘Terminally differentiated cells can be generated by lineage reprogramming,which is,however,hindered by incomplete conversion with residual initial cell identity and partial functionality. Here, we demonstrate a new reprogramming strategy by mimicking the natural regeneration route, which permits generating expandable hepatic progenitor cells and functionally competent human hepatocytes. Fibroblasts were first induced into human hepatic progenitor-like cells (hHPLCs), which could robustly expand in vitro and efficiently engraft in vivo. Moreover, hHPLCs could be efficiently induced into mature human hepatocytes (hiHeps) in vitro, whose molecular identity highly resembles primary human hepatocytes (PHHs). Most importantly, hiHeps could be generated in large quantity and were functionally competent to replace PHHs for drug-metabolism estimation, toxicity prediction and hepatitis B virus infection modeling. Our results highlight the advantages of the progenitor stage for successful lineage reprogramming. This strategy is promising for generating other mature human cell types by lineage reprogramming. | Bingqing Xie Da Sun Yuanyuan Du Jun Jia Shicheng Sun Jun Xu Yifang Liu Chengang Xiang Sitong Chen Huangfan Xie Qiming Wang Guangya Li Xuehui LYU Hui Shen Shiyu Li Min Wu Xiaonan Zhang Yue Pu Kuanhui Xiang Weifeng Lai Peng Du Zhenghong Yuan Cheng Li Yan Shi Shichun Lu Hongkui Deng | 2019 | Cell Research2019，29，9： | 9 |
| 3 | GATA family members as inducers for cellular reprogramming to pluripotency显示文摘GATA 蛋白质家庭的成员在系说明和 transdifferentiation 起重要作用。以前的报告证明 GATA 蛋白质家庭罐头的一些成员也由代替 Oct4 在体的房间导致 pluripotency,一个关键联系 pluripotency 的因素。然而,连接指定系的暗示的机制和 pluripotency 的激活留下逃犯。这里,我们报导所有 GATA 家庭成员能代替让 Oct4 导致 pluripotency。我们发现 GATA 家庭的所有成员能禁止 overrepresented ectodermal 系基因,它与以前的报告显示不同指定系的力量的平衡为 pluripotency 的恢复是重要的一致。一根保存锌手指在 C 终点的 DNA 有约束力的领域是批评的让 GATA 家庭导致 pluripotency。用 RNA-seq 和 ChIP-seq,我们决定 pluripotency 相关的基因 Sall4 在 reprogramming 期间是 GATA 家庭成员的一个直接目标并且用作连接指定系的 GATA 家庭到 pluripotency 电路的一座桥。因此, GATA 家庭是所有成员能作为 reprogramming 进程的 inducers 工作并且能代替 Oct4 的第一个蛋白质家庭。我们的结果建议在 reprogramming 的 GATA 家庭的角色被低估了并且 GATA 家庭可以担任房间命运变换的一个重要调停人。 | Jian Shu Ke Zhang Minjie Zhang Yao Sida Shao Fengxia Du Caiyun Yang Wenhan Chen Chen Wu Weifeng Yang Yingli Sun Hongkui Deng | 2015 | Cell Research2015，25，2： | 5 |
| 4 | Genomic characterizations of H4 subtype avian influenza viruses from live poultry markets in Sichuan province of China, 2014–2015显示文摘Dear Editor,Avian influenza viruses (AIVs) have posed a serious threat to poultry production and public health. To date, more than fourteen AIV subtypes that are able to infect human beings have been documented. Also, it is suggested that new subtypes may be reported in the future, owing to the migration of wild birds and live poultry transportation (Gao, 2018).Poultry may act as a potential incubator for novel subtypes of avian influenza virus (Bi et al., 2016a; Bi et al., 2016b; Liu et al., 2014a; Su et al., 2017). Up to date, the H7N9 AIV emerged in February 2013 has caused 1,567 human cases,with a fatality rate of 39.2%(http://gffzz36b398b81f8a4a4chcn9ppukfvqvq655p.ffgz.tsg.suse.edu.cn/influenza/ | Chuansong Quan Ting Huang Xiuwei Chen Jie Zhang Qianli Wang Cheng Zhang Tiyan Zhang Lijun Zhou Liumei Shu Chunrong Long Lei Yang Xunbo Du Yingze Zhao Peipei Liu Hao Song Weifeng Shi Yuhai Bi Qiang Lv William J.Liu George F.Gao | 2018 | Science China(Life Sciences)2018，61，9： | 4 |
| 5 | Association of ABCB1 Gene Polymorphisms with Efficacy and Adverse Reaction to Risperidone or Paliperidone in Han Chinese Schizophrenic Patients显示文摘Dear editor,P-glycoprotein(P-gp,also known as ATP-binding cassette transport sub-family B member 1,ABCB1)is a potent ATP-dependent efflux pump for a wide variety of drugs.Although studies of its substrates are abundant[1,2],and ABCB1 is a well-conserved gene,there is increasing evidence that its polymorphisms affect substrate specificity[3].A previous study reported that the synonymous | Weifeng Mi Feihu Liu Yongqiao Liu Bo Du Weidong Xiao Lingzhi Li Lan Huang Tianlan Lu Jia He Le Shi Weihua Yue Hongyan Zhang | 2016 | Neuroscience Bulletin2016，32，6： | 3 |
| 6 | Microstructure and ablation properties of zirconium carbide doped carbon/carbon composites显示文摘 | Shen Xuetao Li Kezhi Li Hejun Du Hongying Cao Weifeng Lan Fengtao | 2009 | Carbon2009，，2： | 2 |
| 7 | Use of Support Vector Regression Based on Mean Impact Value Model to Identify Active Compounds in a Combination of Curcuma longa L.and Glycyrrhiza extracts显示文摘A support vector regression based on the mean impact value (MIV) model was constructed to identify the bioactive compounds inhibiting proliferation of He La cells in a combination of turmeric (Curcuma longa L.)and liquorice (Glycyrrhiza) extracts.The quantitative chemical fingerprint from 50 batches of turmeric and liquorice extracts was established using high performance liquid chromatography hyphenated to an ultraviolet visible detector.Qualitative results were obtained using ultra performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry.A total of 46 peaks (peaks 1–15 from turmeric and 16–46 from liquorice) were selected as 'common peaks' for analysis.The inhibitory effect of the combined extracts on He La cells was measured by MTT (3- (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay.It was found that 15 compounds (peaks:8,12,30,24,46,11,14,9,3,1,44,18,7,45 and 43)possessing high absolute MIV exhibited a significant correlation with the cytotoxicity against He La cells; most of these have already been confirmed with potential cytotoxicity in previous research.The important potential application of the present model can be extended to help discover active compounds from complex herbal medicine prior to traditional bioassay-guided separation.It is considered that this could be a useful tool for redeveloping herbal medicine based on the use of these active compounds. | Jianlan Jiang Qingjie Tan Weifeng Li Xinyun Du Ningzhi Liu | 2017 | Transactions of Tianjin University2017，23，3： | 2 |
| 8 | Al-doped ZnO thin films deposited by reactive frequency magnetron sputtering:H2-induced property changes显示文摘 | Du Guotong Sun Yanfeng | 2007 | Materials Chemistry and Physics2007，101，： | 1 |
| 9 | Realizing a“solid to solid”process via in situ cathode electrolyte interface(CEI)by solvent-in-salt electrolyte for Li-S batteries显示文摘Lithium-sulfur batteries(LSBs)are regarded as the most promising next-generation energy system due to their high theoretical energy density.However,LSBs suffer the“shuttle effect”if undergoing the solid-liquid-solid sulfur conversion process during cycling.Herein,we design a solvent-in-salt(SIS)electrolyte with co-solvent vinylene carbonate(VC)to synthesize an in situ dense cathode electrolyte interface(CEI)and successfully change sulfur conversion into a solid-solid way to avoid shuttle effect by separating the contact of sulfur and ether solvent.Dense CEI is formed at the beginning of first discharge by the combined action of SIS electrolyte and filmogen VC.Experiments and simulations show that SIS electrolyte controls the initial formed lithium polysulfides(LiPSs)to stay very closely on the cathode surface,and then converts them into a dense CEI film.As a result,Coulombic efficiency(above 99%)and cycling performance of LSBs are improved.Furthermore,the in situ dense CEI can nearly stop the self-discharge of LSBs,and enable the LSBs to work under a pretty lean electrolyte condition. | Jiajun Huang Mengli Tao Weifeng Zhang Guangli Zheng Li Du Zhiming Cui Xiujun Wang Zhenxing Liang Shijun Liao Huiyu Song | 2023 | Nano Research2023，16，4： | 1 |
| 10 | Correction to:Efficient derivation of extended pluripotent stem cells from NOD-scid II2rg^-/-mice显示文摘Figure 1.Generation of NOD-scid II2rg^-1-extended pluripotent stem cells.(A)Schematic of two approaches used for generating NOD-scid II2rg^-1-extended pluripotent stem cells:de novo derivation from blastocysts(upper panels)and chemical reprogramming from embryonic fibroblasts(lower panels).(B)Phase-contrast images of de novo derived outgrowth and EPS colonies for 17 passages in LCDM medium.Scale bars,100 pm.(C)qRT-PCR analysis of XEN marker genes expression during the chemical induction process(day 16).Error bars indicate SEM(n=2).(D)Co-immunostaining of XEN marker genes during the chemical induction process(day 16).Upper panels:GATA6 and SALL4;lower panels:SOX17 and SALL4.Scale bars,100 pm. | Yaqin Du Ting Wang Jun Xu Chaoran Zhao Haibo Li Yao Fu Yaxing Xu Liangfu Xie Jingru Zhao Weifeng Yang Ming Yin Jinhua Wen Hongkui Deng | 2019 | Protein & Cell2019，10，2： | 1 |
| 11 | Simultaneous de- termination of six active components in curde and processed Fruc- tus Comi by high performance liquid chromatography 显示文摘 | Weifeng Du Hao Cai Mingyan Wang | 2008 | Jour- nal of Pharmaceutical and Biomedical Analysis2008，48，1： | 1 |
| 12 | Linear Conjugate Boundary Value Problems显示文摘We discuss the linear conjugate boundary value prob-lems on the unit circle and the real axis. We obtain some Fredholm integral equations. Using thess equations we discuss the solvable conditions on these problems and we also give a direct method for the extension problems on the real axis. | LI Weifeng DU Jinyuan | 2007 | Wuhan University Journal of Natural Sciences2007，12，6： | 1 |
| 13 | Simultaneous determination of six active components in crude and pro- cessed fructus corni by high performance liquid chroma- tography显示文摘 | Du Weifeng Hao Cai Wang Mingyan | 2008 | Journal of Pharmaceutical and Biomedical Analysis2008，48，： | 1 |
| 14 | Performance research of modulation for optical wireless communication system显示文摘 | Gao Yan Wu Min Du Weifeng | 2011 | Journal of Networks2011，6，8： | 1 |
| 15 | Simultaneous determi- nation of six active components in crude and processed Fructus Corni by high performance liquid chromatography显示文摘 | DU Weifeng CAI Hao WANG Mingyan | 2008 | Journal of Pharmaceutical and Biomedical Analysis2008，48，1： | 1 |
| 16 | Characteristics and Mechanism of Upper Permian Reef Reservoirs in the Eastern Longgang Area, Northeastern Sichuan Basin, China显示文摘As a typical kind of lithologic reservoirs,reef reservoirs are generally featured by their large single-well reservoir thickness,good reservoir physical properties,and high gas well productivity.The Upper Permian Changxing Formation is an important natural gas exploration target in the Sichuan Basin,which hosts a large reef gas reservoir and is mainly distributed along the Kaijiang-Liangping Trough.Comprehensive analyses are implemented to investigate reservoir characteristics and identify controlling factors of reef reservoirs in Changxing Formation in the Eastern Longgang Area,Northeastern Sichuan Basin,including core,logging,and seismic data analyses.Changxing Formation reservoirs in the study area mainly occur in the reef-shoal complex,which are featured by wide distribution,large thickness and generally good physical properties.Reservoir rocks are dominantly composed of bioclastic dolomite and silty-fine dolomite(with grain phantom structure),while the main reservoir space consists of residual intergranular pores,intergranular dissolution pores,and karst vugs.In the seismic profiles,typical mound-shaped chaotic reflections can be clearly seen.It is suggested by the main reservoir development controlling factor analysis that the distributions of reef reservoirs are typically controlled by sedimentary facies belts,while the scale of the reef-shoal complex is determined by the pene-sedimentary micro-paleo-geomorphology.Dolomitization can not only significantly preserve the primary pores but also enhance the permeability of rocks.Moreover,karstification is the key to high-quality reef-shoal reservoirs. | Lei Tan Hong Liu Yuzhe Tang Bing Luo Ya Zhang Yuran Yang Yisha Liao Weifeng Du Xiran Yang | 2020 | Petroleum2020，6，2： | 1 |
| 17 | Al-doped ZnO thin films deposited by reactive frequency magnetron sputtering:H2-induced property changes显示文摘 | Weifeng Liu Guotong Du | 2007 | Thin Solid Films2007，515，5： | 1 |
| 18 | Decoy Nanozymes Enable Multitarget Blockade of Proinflammatory Cascades for the Treatment of Multi-Drug- Resistant Bacterial Sepsis显示文摘Sepsis is a life-threatening organ dysfunction characterized by severe systemic inflammatory response to infection.Effective treatment of bacterial sepsis remains a paramount clinical challenge,due to its astonishingly rapid progression and the prevalence of bacterial drug resistance. | Xuancheng Du Mingzhen Zhang Huiting Zhou Weijie Wang Chengmei Zhang Lei Zhang Yuanyuan Qu Weifeng Li Xiangdong Liu Mingwen Zhao Kangsheng Tu Yong-Qiang Li | 2023 | Research2023，，2： | 0 |
| 19 | A review of high‐velocity impact on fiber‐reinforced textile composites: Potential for aero engine applications显示文摘Considerable research has indicated that fiber‐reinforced textile composites are significantly beneficial to the aerospace industry,especially aero engines,due to their high specific strength,specific stiffness,corrosion resistance,and fatigue re-sistance.However,damage caused by high‐velocity impacts is a critical limitation factor in a wide range of applications.This paper presents an overview of the development,material characterizations,and applications of fiber‐reinforced textile composites for aero engines.These textile composites are classified into four ca-tegories including two‐dimensional(2D)woven composites,2D braided composites,3D woven composites,and 3D braided composites.The complex damage me-chanisms of these composite materials due to high‐velocity impacts are discussed in detail as well. | Yinghong Li Xuefeng Chen Jin Zhou Xiaochuan Liu Di Zhang Feiping Du Weifeng He Pu Jia Haibao Liu | 2022 | International Journal of Mechanical System Dynamics2022，2，1： | 0 |
| 20 | Incorporation of intra-city human mobility into urban growth simulation:A case study in Beijing显示文摘The effective modeling of urban growth is crucial for urban planning and analyzing the causes of land-use dynamics.As urbanization has slowed down in most megacities,improved urban growth modeling with minor changes has become a crucial open issue for these cities.Most existing models are based on stationary factors and spatial proximity,which are unlikely to depict spatial connectivity between regions.This research attempts to leverage the power of real-world human mobility and consider intra-city spatial interaction as an imperative driver in the context of urban growth simulation.Specifically,the gravity model,which considers both the scale and distance effects of geographical locations within cities,is employed to characterize the connection between land areas using individual trajectory data from a macro perspective.It then becomes possible to integrate human mobility factors into a neural-network-based cellular automata(ANN-CA)for urban growth modeling in Beijing from 2013 to 2016.The results indicate that the proposed model outperforms traditional models in terms of the overall accuracy with a 0.60%improvement in Cohen’s Kappa coefficient and a 0.41%improvement in the figure of merit.In addition,the improvements are even more significant in districts with strong relationships with the central area of Beijing.For example,we find that the Kappa coefficients in three districts(Chaoyang,Daxing,and Shunyi)are considerably higher by more than 2.00%,suggesting the possible existence of a positive link between intense human interaction and urban growth.This paper provides valuable insights into how fine-grained human mobility data can be integrated into urban growth simulation,helping us to better understand the human-land relationship. | WANG Siying FEI Teng LI Weifeng ZHANG Anqi GUO Huagui DU Yunyan | 2022 | Journal of Geographical Sciences2022，32，5： | 0 |
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