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| 1 | Polysaccharide extracts of Astragalus membranaceus and Atractylodes macrocephala promote intestinal epithelial cell migration by activating the polyamine-mediated K^+ channel显示文摘Astragalus membranaceus(Radix Astragali, RA) and Atractylodes macrocephala(Rhizoma Atractylodis Macrocephalae, RAM) are often used to treat gastrointestinal diseases. In the present study, we determined the effects of polysaccharides extracts from these two herbs on IEC-6 cell migration and explored the potential underlying mechanisms. A migration model with IEC-6 cells was induced using a single-edged razor blade along the diameter of cell layers in six-well polystyrene plates. The cells were grown in control--media or media containing spermidine(5 μmol·L^(-1), SPD), alpha-difluoromethylornithine(2.5 mmol·L^(-1), DFMO), 4-Aminopyridine-(40 μ-mol·L^(-1), 4-AP), the polysaccharide extracts of RA or RAM(50, 100, or 200 mg·L^(-1)), DFMO plus SPD, or DFMO plus polysaccharide extracts of RA or RAM for 12 or 24 h. Next, cytosolic free Ca^(2+)([Ca^(2+)]cyt) was measured using laser confocal microscopy, and cellular polyamine content was quantified with HPLC. Kv1.1 mRNA expression was assessed using RT-qPCR and Kv1.1 and RhoA protein expressions were measured with Western blotting analysis. A cell migration assay was carried out using Image-Pro Plus software. In addition, GC-MS was introduced to analyze the monosaccharide composition of both polysaccharide extracts. The resutls showed that treatment with polysaccharide extracts of RA or RAM significantly increased cellular polyamine content, elevated [Ca^(2+)]cyt and accelerated migration of IEC-6 cells, compared with the controls(P < 0.01). Polysaccharide extracts not only reversed the inhibitory effects of DFMO on cellular polyamine content and [Ca^(2+)]cyt, but also restored IEC-6 cell migration to control level(P < 0.01 or < 0.05). Kv1.1 mRNA and protein expressions were increased(P < 0.05) after polysaccharide extract treatment in polyamine-deficient IEC-6 cells and RhoA protein expression was increased. Molar ratios of D-ribose, D-arabinose, L-rhamnose, D-mannose, D-glucose, and D-galactose was 1.0:14.1:0.3:19.9:181.3:6.3 in RA and 1.0:4.3:0.1:5.7:2.8:2.2 in RAM. In conclusion, treatment with RA and RAM polysaccharide extracts stimulated migration of intestinal epithelial cells via a polyamine-Kv1.1 channel activated signaling pathway, which facilitated intestinal injury healing. | ZENG Dan HU Can LI Ru-Liu LIN Chuan-Quan CAI Jia-Zhong WU Ting-Ting SUI Jing-Jing LU Wen-Biao CHEN Wei-Wen | 2018 | Chinese Journal of Natural Medicines2018，16，9： | 14 |
| 2 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 3 | A BLIND SNR ESTIMATOR FOR DIGITAL BANDPASS SIGNALS显示文摘A subspace-based blind Signal-to-Noise Ratio (SNR) estimation algorithm for digital bandpass signals in Additive White Gaussian Noise (AWGN) channel is discussed. The lower bounds of the mean and variance of the estimation are derived, and simulations are performed for the commonly used digital bandpass signals, such as MPSK (M=2, 4, 8), MFSK (M=2, 4) and MQAM (M=16, 64, 128, 256) signals. Theoretical analyses and simulation results indicate that the proposed algorithm is ef- fective even when the SNR is below 0dB. Furthermore, the algorithm can provide a blind estimator in that it needs neither the parameters of the received signals, such as the carrier frequency, symbol rate and modulation scheme, nor the synchronization of the system. | Sui Dan Ge Lindong | 2008 | Journal of Electronics(China)2008，25，1： | 4 |
| 4 | Simultaneous polyandry and heteropaternity in tiger(Panthera tigris altaica):Implications for conservation of genetic diversity in captive populations of felids显示文摘Male tigers(Panthera tigris altaica) in captivity copulate alternatively with an estrous female,suggesting a potential for heteropaternity as an effective reproductive strategy to maximize genetic diversity of offspring.We analyzed microsatellites to test and compare the genetic output of multiple male mating(simultaneous polyandry) and single male mating(monogamy) with a female in a captive population.Simultaneous polyandry resulted in heteropaternity in 66.7% observed litters.No significant differences between parental populations and between offspring populations were detected in the number of alleles(A),expected heterozygosity(H e),number of effective alleles(N e) per locus and standard individual heterozygosity(SH)(P>0.05 for all 4 indexes).Comparisons showed no significant reduction of A,H o,H e and SH from parental population to offspring population for the two mating modes(P>0.05) except for SH in polyandrous families(P=0.029).However,such reduction was equivalent to single mating families when the influence of relatedness was eliminated using effective SH(E SH)(P>0.05).These results highlight an alternative strategy for managing captive populations of tiger and other wild felids in which animals are combined at one location allowing for copulation by multiple males to encourage heteropaternity in favor of maintained genetic diversity among offspring. | LIU Dan MA Yue LI HuiYi XU YanChun ZHANG Yan DAHMER Thomas BAI SuYing WANG Jian | 2013 | Chinese Science Bulletin2013，58，17： | 3 |
| 5 | Activation of Uterine Smad3 Pathway Is Crucial for Embryo Implantation显示文摘Embryo implantation is a complicated physiological process tightly regulated by multiple biological molecules including growth factors.Transforming growth factor-betas(TGF-βs)and their most specific signal transduction factors,Smads,are expressed in the endometrium during the window of implantation.Recent researches indicated that Smad dependent TGF-β signaling may play an important role in the process of embryo implantation.In this study,we measured the expression of TGF-β1,TGF-β receptor type I(TpRI),Smad3 and p-Smad3 in the endometrium of mice and observed their elevation on day 4,5 and 6 of pseudopregnancy.Then we administrated a specific Smad3 inhibitor(Sis3)into the uterine cavity of mice on day 3 of pregnancy.The results showed a reduction in insulin-like growth factor-1(IGFBP-1)expression and the decreased number of implanted embryo after the administration.In addition,Sis3 was found to reduce the IGFBP-1 secretion in decidualized endometrial stromal cells.Taken all together,our findings demonstrated that TGF-β/Smad3 signaling is involved in the process of embryo implantation. | Juan LI Xi-yuan DONG Pei-wen YANG Shu-lin YANG Dan HU Han-wang ZHANG Cong SUI | 2019 | Current Medical Science2019，39，6： | 3 |
| 6 | An Aerothermal Study of Influence of Blockage Ratio on a Supersonic Tube Train System显示文摘Evacuated tube transportation is an important development direction for the high-speed transportation technology of the future.However,a train running at supersonic speed in a closed tube can create an unstable aerothermal phenomenon,causing the temperature to rise sharply inside the tube and endangering the safe operation of trains and equipment.The blockage ratio is one of the key factors affecting the aerodynamic characteristics in the tube.In this paper,a 2 D axisymmetric model and Delayed Detached Eddy Simulation(DDES)based on the Shear Stress Transport(SST)k-ωturbulence model are used to study the aerothermal environment in the tube.The calculation method used in this paper was verified by a wind tunnel experiment.The aerothermal phenomenon and distribution of the flow field in the tube with different blockage ratios were compared and analysed.The results show that the aerothermal environment is significantly affected by the blockage ratio.A choking limit formed in the flow field will aggravate the aerodynamic phenomenon as the blockage ratio increases,which further deteriorates the aerothermal environment of the tube.Moreover,the existence of the choking limit,shock wave,and Mach disk make the flow field in the tube more complicated. | SUI Yang NIU Jiqiang YUAN Yanping YU Qiujun CAO Xiaoling WU Dan YANG Xiaofeng | 2022 | Journal of Thermal Science2022，31，2： | 2 |
| 7 | Improvement of Wired Drill Pipe Data Quality via Data Validation and Reconciliation显示文摘Wired drill pipe(WDP)technology is one of the most promising data acquisition technologies in today s oil and gas industry.For the first time it allows sensors to be positioned along the drill string which enables collecting and transmitting valuable data not only from the bottom hole assembly(BHA),but also along the entire length of the wellbore to the drill floor.The technology has received industry acceptance as a viable alternative to the typical logging while drilling(LWD)method.Recently more and more WDP applications can be found in the challenging drilling environments around the world,leading to many innovations to the industry.Nevertheless most of the data acquired from WDP can be noisy and in some circumstances of very poor quality.Diverse factors contribute to the poor data quality.Most common sources include mis-calibrated sensors,sensor drifting,errors during data transmission,or some abnormal conditions in the well,etc.The challenge of improving the data quality has attracted more and more focus from many researchers during the past decade.This paper has proposed a promising solution to address such challenge by making corrections of the raw WDP data and estimating unmeasurable parameters to reveal downhole behaviors.An advanced data processing method,data validation and reconciliation(DVR)has been employed,which makes use of the redundant data from multiple WDP sensors to filter/remove the noise from the measurements and ensures the coherence of all sensors and models.Moreover it has the ability to distinguish the accurate measurements from the inaccurate ones.In addition,the data with improved quality can be used for estimating some crucial parameters in the drilling process which are unmeasurable in the first place,hence provide better model calibrations for integrated well planning and realtime operations. | Dan Sui Olha Sukhoboka Bernt Sigve Aadn?y | 2018 | International Journal of Automation and computing2018，15，5： | 2 |
| 8 | Four Method for Roundness Evaluation显示文摘 | Wen tao Sui Dan Zhang | 2012 | Physics Procedia2012，24，： | 1 |
| 9 | A blind SNR estimation for digital bandpass signals显示文摘 | Sui Dan Ge Lindong | | 0，，01： | 1 |
| 10 | 显示文摘 | Zhu Jiahua Wei Suying Dan Rutman Guo Zhanhu | 2011 | Poly- mer2011，52，： | 1 |
| 11 | Power Allocation for Energy Harvesting in Wireless Body Area Networks显示文摘Wireless Body Area Networks(WBANs) are expected to achieve high reliable communications among a large number of sensors.The outage probability can be used to measure the reliability of the WBAN.In this paper,we optimize the outage probability with the harvested energy as constraints.Firstly,the optimal transmit power of the sensor is obtained while considering a single link between an access point(AP) located on the waist and a sensor attached on the wrist over the Rayleigh fading channel.Secondly,an optimization problem is formed to minimize the outage probability.Finally,we convert the non-convex optimization problem into convex solved by the Lagrange multiplier method.Simulations show that the optimization problem is solvable.The outage probability is optimized by performing power allocation at the sensor.And our proposed algorithm achieves minimizing the outage probability when the sensor uses energy harvesting.We also demonstrate that the average outage probability is reduced with the increase of the harvested energy. | Xiaolan Liu Fengye Hu Meiqi Shao Dan Sui Gengxin He | 2017 | China Communications2017，14，6： | 1 |
| 12 | Solvent-free selective hydrogenation of o-chloronitrobenzene to o-chloroaniline over alumina supported Pt nanoparticles显示文摘A supported Pt/Al2O3 catalyst was prepared by immobilizing preformed colloidal Pt nanoparticles on Al2O3. The particle size and size distribution of Pt particles on Al2O3 remained the same as the colloidal nanoparticles. Selective hydrogenation of o-chloronitrobenzene to ochloroaniline was performed on the as-prepared Pt/Al2O3 nanocatalyst without using any solvent and 88.5% selectivity to o-chloroaniline at98.2% conversion of o-chloronitrobenzene was achieved. Further catalytic experiments with metal cation modification showed that some metal cations could improve the activity in various degrees while maintaining the high selectivity. Especially, 99.8% selectivity to o-chloroaniline at 100% conversion was attained with Sn4+. | Qiang Bai Dan Li Lu He Hailian Xiao Ning Sui Manhong Liu | 2015 | Progress in Natural Science:Materials International2015，25，3： | 1 |
| 13 | In Vitro Micropropagation of Freesia hybrida and the Assessment of Genetic and Epigenetic Stability in Regenerated Plantlets显示文摘 | Xiang Gao Dan Yang Donghui Cao Man Ao Xin Sui Qinmei Wang J. N. Kimatu Li Wang | 2010 | Journal of Plant Growth Regulation2010，，3： | 1 |
| 14 | Effect of Secondary Structure determined by FTIR Spectra on Surface Hydrophobicity of Soybean Protein Isolate显示文摘 | Chen Wang Lianzhou Jiang Dongxu Wei Yang Li Xiaonan Sui Zhongjiang Wang Dan Li | 2011 | Procedia Engineering2011，，： | 1 |
| 15 | Genomes of 12 fig wasps provide insights into the adaptation of pollinators to fig syconia显示文摘Figs and fig pollinators are one of the few classic textbook examples of obligate pollination mutualism.The specific dependence of fig pollinators on the relatively safe living environment with sufficient food sources in the enclosed fig syconia implies that they are vulnerable to habitat changes.However,there is still no extensive genomic evidence to reveal the evolutionary footprint of this long-term mutually beneficial symbiosis in fig pollinators.In fig syconia,there are also non-pollinator species.The non-pollinator species differ in their evolutionary and life histories from pollinators.We conducted comparative analyses on 11 newly sequenced fig wasp genomes and one previously published genome.The pollinators colonized the figs approximately 66.9 million years ago,consistent with the origin of host figs.Compared with nonpollinators,many more genes in pollinators were subject to relaxed selection.Seven genes were absent in pollinators in response to environmental stress and immune activation.Pollinators had more streamlined gene repertoires in the innate immune system,chemosensory toolbox,and detoxification system.Our results provide genomic evidence for the differentiation between pollinators and nonpollinators.The data suggest that owing to the long-term adaptation to the fig,some genes related to functions no longer required are absent in pollinators. | Jinhua Xiao Xianqin Wei Yi Zhou Zhaozhe Xin Yunheng Miao Hongxia Hou Jiaxing Li Dan Zhao Jing Liu Rui Chen Liming Niu Guangchang Ma Wenquan Zhen Shunmin He Jianxia Wang Xunfan Wei Weihao Dou Zhuoxiao Sui Haikuan Zhang Shilai Xing Miao Shi Dawei Huang | 2021 | Journal of Genetics and Genomics2021，48，3： | 1 |
| 16 | Rab22a-NeoF1 fusion protein promotes osteosarcoma lung metastasis through its secretion into exosomes显示文摘It remains unknown for decades how some of the therapeutic fusion proteins positive in a small percentage of cancer cells account for patient outcome.Here,we report that osteosarcoma Rab22a-NeoF1 fusion protein,together with its binding partner PYK2,is sorted into exosomes by HSP90 via its KFERQ-like motif(RVLFLN^(142)).The exosomal Rab22a-NeoF1 fusion protein facilitates the pulmonary pre-metastatic niche formation by recruiting bone marrow-derived macrophages.The exosomal PYK2 activates RhoA in its negative recipient osteosarcoma cells and induces signal transducer and activator of transcription 3 activation in its recipient macrophages to increase M2 phenotype.Consequently,lung metastases of its recipient osteosarcoma cells are promoted by this exosomal Rab22a-NeoF1 fusion protein,and this event can be targeted by disrupting its interaction with PYK2 using a designed internalizing RGD peptide. | Li Zhong Dan Liao Jingjing Li Wenqiang Liu Jingxuan Wang Cuiling Zeng Xin Wang Zhiliang Cao Ruhua Zhang Miao Li Kuntai Jiang Yi-Xin Zeng Jianhua Sui Tiebang Kang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 1 |
| 17 | Parallel profiling of antigenicity alteration and immune escape of SARS-CoV-2 Omicron and other variants显示文摘SARS-CoV-2 variants have evolved a variety of critical mutations,leading to antigenicity changes and immune escape.The recent emerging SARS-CoV-2 Omicron variant attracted global attention due to its significant resistance to current antibody therapies and vaccines. | Cong Sun Yin-Feng Kang Yuan-Tao Liu Xiang-Wei Kong Hui-Qin Xu Dan Xiong Chu Xie Yi-Hao Liu Sui Peng Guo-Kai Feng Zheng Liu Mu-Sheng Zeng | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 1 |
| 18 | Uniform hierarchical silica film with perpendicular macroporous channels and accessible ordered mesopores for biomolecule separation显示文摘Herein, we demonstrate that silica films with perpendicular macroporous channels and accessible ordered mesopores can be conveniently prepared. The hierarchical macroporous–mesoporous silica films are synthesized by using zinc oxide nanorod array as macroporous template and CTAB surfactant as mesoporous template. In basic surfactant-containing solution, ordered mesoporous silica shells homogeneously grow on the zinc oxide nanorod array. The growth of the mesostructures do not require any chemical modification for the zinc oxide nanorod, which opens a new way for preparing hierarchical silica films with perpendicular mesochannels. The prepared hierarchical macroporous–mesoporous silica films possess a uniform thickness of 2μm, large perpendicular macropores with a length of 1.8μm and a width of 80 nm, and accessible ordered mesopores. Separation experiment demonstrates that this macroporous–mesoporous film can effectively separate biomolecules with different sizes. | Xiaodan Su Jun Tao Sui Chen Peng Xu Dan Wang Zhaogang Teng | 2019 | Chinese Chemical Letters2019，30，5： | 0 |
| 19 | Error term concerning number of subgroups of group Z_(m)×Z_(n) with m^(2)+n^(2)≤x显示文摘Let Zm be the additive group of residue classes modulo m.Let s(m,n)denote the number of subgroups of the group Z_(m)×Z_(n),where m and n are arbitrary positive integers.For any x≥1,we consider the asymptotic behavior of D_(s)(x):=∑m^(2)+n^(2)≤xS(M,n)and obtain an asymptotic formula by using the elementary method. | Yankun SUI Dan LIU | 2022 | Frontiers of Mathematics in China2022，17，5： | 0 |
| 20 | Microstructure and properties of LZQT600-3 HCCDIBs for plunger pump cylinder显示文摘It is important to improve the comprehensive performance of the ductile iron bars(DIBs)for the cylinder block of the extra high pressure hydraulic plunger pump and accelerate the industrial application.In this work,the LZQT600-3 DIBs with the diameter of 145 mm were prepared by the horizontal continuous casting(HCC)process,that is,LZQT600-3 HCCDIBs.The microstructure and room temperature tensile properties of different sections[left-edge(surface layer),left-1/2R(left half of the radius),and the center of the HCCDIBs]were studied.The results show that the spheroidization of LZQT600-3 HCCDIBs matrix from the left-edge,left-1/2R to the center is at nodulizing grade II and above.As the cooling rate gradually decreases from surface to the center of the HCCIBs,the number of spheroidized graphite is gradually reduced,the size is gradually increased,the shape factor is decreased,and the pearlite content and lamellate spacing are increased.Along the horizontal direction of the section,the hardness of the material is distributed symmetrically around the center of the HCCDIBs.In the vertical direction,the hardness distribution in the center of the HCCDIBs is asymmetrical due to the gravity during the solidification process.Therefore,the microstructure in the lower part of the section solidifies relatively quickly.The left-edge has the best tensile mechanical properties,and the ultimate tensile strength,yield tensile strength and elongation are 597.3 MPa,418.5 MPa and 9.6%,respectively.The tensile fracture belongs to the ductile-brittle hybrid fracture.The comprehensive performances of LZQT600-3 HCCDIBs meet the actual application requirements of ultra-high pressure hydraulic plunger pump cylinder. | Chun-jie Xu Yuan-ying Jin Dong Ma Zhen Zhao Jia-wei Qi Shang Sui Xiang-quan Wu Can Guo Zhong-ming Zhang Yong-hui Liu Dan Shechtman | 2024 | China Foundry2024，21，2： | 0 |
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