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| 1 | Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer显示文摘尽管有最近的进展, oncogenic K 地岬驾驶的胰腺的 ductal 腺癌(PDAC ) 在最致命的人的癌症之中留在现代医学。PDAC 的致病对内在的染色体不稳定性和外来的发炎激活部分可归因。然而,在在胰腺的 tumorigenesis 的这二个事件之间的分子的连接充分还没被建立了。这里,我们证明(HMGB1 ) 细胞内部的高活动性组盒子 1 显著地压制 oncogenic 由禁止染色体的 K-Ras-driven 胰腺的 tumorigenesis 调停不稳定性的支持 inflammatory nucleosome 版本。任何一个单身者的有条件的基因脱离或在胰的 HMGB1 的两等位基因在出生使老鼠变为极其敏感到先锋损害的 oncogenic K-Ras-driven 开始,包括胰腺的 intraepithelial 瘤, intraductal 乳突的 mucinous 瘤,和 mucinous 膀胱的瘤。在胰的 HMGB1 的损失与染色体重新整理和 telomere 畸形描绘的氧化 DNA 损坏和 chromosomal 不稳定性被联系。这些导致煽动性的 nucleosome 版本并且宣传 K-Ras-driven 胰腺的 tumorigenesis。细胞外的 nucleosomes 支持 interleukin 6 (IL-6 ) 由渗入 macrophages/neutrophils 的分泌物并且提高在胰腺的损害表明激活的 oncogenic K 地岬。到 IL-6 或 histone H3 或为先进 glycation 的受体的大美人的抵销的抗体结束产品都限制表明激活的 K 地岬,阻止癌症开发和转移 / 侵略,并且延长在 Pdx1-Cre 的动物幸存; K 地岬 G12D/+;Hmgb1/ 鼠标。由 glycyrrhizin 的 HMGB1 损失的药理学抑制在煽动性的条件下面在老鼠限制 oncogenic K-Ras-driven tumorigenesis。减少在 PDAC 病人的 HMGB1 的原子、全部的细胞的表示与差的全面幸存相关,在 PDAC 与预示、治疗学的关联作为新奇肿瘤 suppressor 支持细胞内部的 HMGB1。 | Rui Kang Yangchun Xie Qiuhong Zhang Wen Hou Qingping Jiang Shan Zhu Jinbao Liu Dexing Zeng Haichao Wang David L Bartlet Timothy R Billiar Herbert J Zeh III Michael T Lotze Daolin Tang | 2017 | Cell Research2017，27，7： | 22 |
| 2 | Distribution,Frequency and Variation of Stripe Rust Resistance Loci Yr10,Lr34/Yr18 and Yr36 in Chinese Wheat Cultivars显示文摘Wheat stripe rust is a devastating disease in many regions of the world.In wheat,49 resistance genes for stripe rust have been officially documented,but only three genes are cloned,including the race-specific resistance Yr10 candidate gene(Yr10_(CG)) and slow-rusting genes Lr34/Yr18(hereafter designated as Yr18) and Yr36.In this study,we developed gene-specific markers for these genes and used them to screen a collection of 659 wheat accessions,including 485 Chinese cultivars.Thirteen percent and eleven percent of the tested Chinese cultivars were positive for the markers for Yr10_(CG) and Yr18_(RH)(the resistant haplotype of Yr18),respectively,but none were positive for the Yr36 marker.Since there is a limited use of the Yr10 gene in Chinese wheat,the relatively high frequency of wheat varieties with the Yr10_(CG) marker suggests that the identity of the Yr10 gene is unknown.With regards to the Yr18 gene,29%of the tested cultivars that are used in the Middle and Lower Yangtze Valleys' winter wheat zone were positive for Yr18_(RH) markers.A non-functional allele of Yr18_(RH) was identified in 'Mingxian 169',a commonly used susceptible check for studying stripe rust.The data presented here will provide useful information for marker-assisted selection for wheat stripe rust resistance. | Cuiling Yuan Hui Jiang Honggang Wang Kun Li Heng Tang Xianbin Li Daolin Fu | 2012 | Journal of Genetics and Genomics2012，39，11： | 12 |
| 3 | Extraction of Lithium from Salt Lake Brine with Triisobutyl Phosphate in Ionic Liquid and Kerosene显示文摘 | GAO Daolin YU Xiaoping GUO Yafei WANG Shiqiang LIU Mingming DENG Tianlong CHEN Yuwei BELZILE Nelson | 2015 | Chemical Research in Chinese Universities2015，31，4： | 10 |
| 4 | WheatOmics:A platform combining multiple omics data to accelerate functional genomics studies in wheat显示文摘Dear Editor,Mold-breaking progress in whole-genome sequencing and rapid accumulation of multi-omics data have revolutionized the research strategies of functional genomics in wheat(Wang et al.,2018).However,how to access these vast multi-omics data and to extract key information on genes of in-terest,is still challenging for most wet-lab or field wheat re-searchers who have little bioinformatic experiences and cannot access the expensive computational resources.Here,we pre-sent WheatOmics(http://gffzz513af15b15bc4712hpfxbocpbn0vc60px.ffgz.tsg.suse.edu.cn/,previously designated as Triticeae Multi-omics Center,http://gffzz601e21d286504235hpfxbocpbn0vc60px.ffgz.tsg.suse.edu.cn/),a free,web-accessible,and user-friendly platform.WheatOmics not only empowers the effective access to the visualized multi-omics data of user-interested genes but also offers several distinctive and practical toolkits that can ease almost every aspect of wheat functional genomics studies(Figure 1A). | Shengwei Ma Meng Wang Jianhui Wu Weilong Guo Yongming Chen Guangwei Li Yanpeng Wang Weiming Shi Guangmin Xia Daolin FU Zhensheng Kang Fei Ni | 2021 | Molecular Plant2021，14，12： | 9 |
| 5 | Insights into the differences in leaf functional traits of heterophyllous Syringa oblata under different light intensities显示文摘Many plants exhibit heterophylly; the spatially and temporally remarkable ontogenetic differences in leaf morphology may play an adaptative role in their success under diverse habitats. Thus, this study aimed to gain insights into differences in leaf functional traits of heterophyllous Syringa oblata Lindl., which has been widely used as an ornamental tree around the world under different light intensities in East China. No significant differences existed in specific leaf area(SLA) between lanceolate- and heart-shaped leaves. Differences in the investment per unit of light capture surface area deployed between lanceolate- and heart-shaped leaves may be not obvious. This may be attributing to the fact that single leaf wet and dry weight of heart-shaped leaves were significantly higher than those of lanceolate leaves but leaf length and leaf thickness of heart-shaped leaves were significantly lower than those of lanceolate leaves. The SLA of shade trees was significantly higher than that of sun trees. The investment per unit of light capture surface of shade trees was lower than that of sun trees, making it possible to increase light capture and use efficiency in low-light environments. The phenotypic plasticity of most leaf functional traits of lanceolate leaves was higher than those of heart-shaped leaves because the former is the juvenile and the latter is the adult leaf shape during the process of phylogenetic development of S. oblate. The higher range of phenotypic plasticity of leaf thickness and leaf moisture for sun trees may be beneficial to obtain a more efficient control of water loss and nutrient deprivation in highlight environments, and the lower range of phenotypic plasticity of single leaf wet and dry weight, and SLA for shade trees may gain an advantage to increase resource(especially light) capture and use efficiency in low-light environments. In brief, the successfully ecological strategy of plants is to find an optimal mode for the trade-off between various functional traits to obtain more living resources and achieve more fitness advantage as much as possible in the multivariate environment. | Hongguang Xiao Congyan Wang Jun Liu Lei Wang Daolin Du | 2015 | Journal of Forestry Research2015，26，3： | 8 |
| 6 | Leukocyte Membrane-Coated Liquid Metal Nanoswimmers for Actively Targeted Delivery and Synergistic Chemophotothermal Therapy显示文摘We report a leukocyte membrane-coated gallium nanoswimmer(LMGNS)capable of ultrasound-propelled motion,antibiofouling,and cancer cell recognition and targeting.The LMGNS consists of a needle-shaped gallium core encapsulating an anticancer drug and a natural leukocyte membrane shell.Under the propulsion of an ultrasound field,LMGNSs could autonomously move in biological media with a speed up to 108.7μms^(-1).The velocity and motion direction of the LMGNSs can be modulated by regulating the frequency and voltage of the applied ultrasound field.Owing to the leukocyte membrane coating,LMGNSs can not only avoid biofouling during the motion in blood but also possess cancer cell recognition capability.These LMGNSs could actively seek,penetrate,and internalize into the cancer cells and achieve enhanced anticancer efficiency by combined photothermal and chemical therapy.Such biofunctionalized liquid metal nanoswimmer presents a new type of multifunctional platform for biomedical applications. | Daolin Wang Changyong Gao Chang Zhou Zhihua Lin Qiang He | 2020 | Research2020，，1： | 8 |
| 7 | The BET family in immunity and disease显示文摘Innate immunity serves as the rapid and frst-line defense against invading pathogens,and this process can be regulated at various levels,including epigenetic mechanisms.The bromodomain and extraterminal domain(BET)family of proteins consists of four conserved mammalian members(BRD2,BRD3,BRD4,and BRDT)that regulate the expression of many immunity-associated genes and pathways.In particular,in response to infection and sterile inflammation,abnormally expressed or dysfunctional BETs are involved in the activation of pattern recognition receptor(e.g,TLR,NLR,and CGAS)pathways,thereby linking chromatin machinery to innate immunity under disease or pathological conditions.Mechanistically,the BET family controls the transcription of a wide range of proinflammatory and immunoregulatory genes by recognizing acetylated histones(mainly H3 and H4)and recruiting transcription factors(e.g.,RELA)and transcription elongation complex(e.g.P-TEFb)to the chromatin,thereby promoting the phosphorylation of RNA polymerase II and subsequent transcription initiation and elongation.This review covers the accumulating data about the roles of the BET family in innate immunity,and discusses the attractive prospect of manipulating the BET family as a new treatment for disease. | Nian Wang Runliu Wu Daolin Tang Rui Kang | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 4 |
| 8 | HMGB1 in health and disease显示文摘 | Rui Kang Ruochan Chen Qiuhong Zhang Wen Hou Sha Wu Lizhi Cao Jin Huang Yan Yu Xue-gong Fan Zhengwen Yan Xiaofang Sun Haichao Wang Qingde Wang Allan Tsung Timothy R. Billiar Herbert J. Zeh Michael T. Lotze Daolin Tang | 2014 | Molecular Aspects of Medicine2014，，： | 2 |
| 9 | Acoustophoretic Motion of Erythrocyte-mimicking Hemoglobin Micromotors显示文摘of main observation and conclusion Biocompatible micromotors have received increasing attention,due to their powerful motion,diverse functionalities and autonomous navigation in the field of biomedical applications.Herein,we report an acoustically-propelled,magnetic-guided,erythrocyte-mimicking hemoglobin micromotor with oxygen-carrying capability.These hemoglobin micromotors were fabricated by encapsulating magnetic nanoparticles in hybrid hemoglobin/calcium carbonate microparticles,followed by covalently layer-by-layer assembly of hemoglobin multilayers.The asymmetric distribution of magnetic nanoparticles enables these micromotors to move rapidly under the propulsion of an acoustic field.The velocity of acoustophoretic motion of hemoglobin micromotors increases with the increase of input voltage of acoustic field,up to 58.2 pirn s^-1 at 10 V.The hemoglobin micromotors are directionally navigated by applying an external magnetic field,and also could pass through microchannels toward the targeted region.Moreover,such hemoglobin micromotors show effective oxygen loading and releasing capability,holding considerable promise as a new platform for oxygen delivery applications. | Changyong Gao Zhihua Lin Chang Zhou Daolin Wang Qiang He | 2020 | Chinese Journal of Chemistry2020，38，12： | 1 |
| 10 | Lithium Ion Extraction from the High Ration Mg/Li Salt Lake Brine with Ionic Liquid in Triisobutyl Phosphate and Kerosene显示文摘1 Introduction As the lightest metal with the unique properties of energy production and storage,lithium is regarded as the new century energy metal.Lithium and its compounds were widely used in various industrial fields,especially | GAO Daolin LIU Mingming GUO Yafei YU Xiaoping WANG Shiqiang DENG Tianlong | 2014 | Acta Geologica Sinica(English Edition)2014，88，S1： | 1 |
| 11 | Catalytic kinetics of oxidative desulfurization with surfactant-type polyoxometalate-based ionic liquids显示文摘 | Wenshuai Zhu Guopeng Zhu Huaming Li Yanhong Chao Ming Zhang Daolin Du Qian Wang Zhen Zhao | 2013 | Fuel Processing Technology2013，，： | 1 |
| 12 | Involvement of miR-21 in resistance to daunorubicin by regulating PTEN expression in the leukaemia K562 cell line显示文摘 | Haitao Bai Rang Xu Zhongwei Cao Daolin Wei Chun Wang | 2010 | FEBS Letters2010，，2： | 1 |
| 13 | Design and experimental study of a compact quasi-zero-stiffness isolator using wave springs显示文摘The quasi-zero-stiffness(QZS)vibration isolation has been proven to be an effective way to isolate low-frequency vibration.However,most of the existing QZS isolators are space-consuming,which could not be employed in the space-limited circumstances.In this paper,a quite compact QZS isolator is engineered by connecting a pair of mutually repulsive magnet rings and a space-saving wave spring in parallel,called WQZS isolator.The restoring force of the magnet ring is derived by the equivalent magnetic charge method,and an empirical formula for the restoring force of the wave spring is derived by the least squares method based on experimental data.The dynamic model of the WQZS vibration isolation system is built,and the vibration isolation performance is evaluated through transmissibility.Finally,an experimental prototype is fabricated,and the experimental tests on frequency sweep are carried out.The results show that compared with the linear counterpart,the vibration isolation frequency of the WQZS isolator is reduced by 48.89%,and the peak transmissibility is decreased by 59.33%.Most importantly,the space occupancy of the WQZS isolator designed in this paper is much lower than that of the traditional QZS isolators,and thus it should be a potential solution for low-frequency vibration isolation in the space-limited environment. | WANG Qiang ZHOU JiaXi WANG Kai XU DaoLin WEN GuiLin | 2021 | Science China(Technological Sciences)2021，64，10： | 1 |
| 14 | THE INHIBITION OF LPS-INDUCED PRODUCTION OF INFLAMMATORY CYTOKINES BY HSP70 INVOLVES INACTIVATION OF THE NF-κB PATHWAY BUT NOT THE MAPK PATHWAYS显示文摘 | Yongzhong Shi Zizhi Tu Daolin Tang Huali Zhang Meidong Liu Kangkai Wang Stuart K. Calderwood Xianzhong Xiao | 2006 | Shock2006，，3： | 1 |
| 15 | 干旱利于刺苋的竞争优势显示文摘干旱可以影响入侵植物的生长和土壤酶活性。因此,非常有必要评估干旱背景下入侵植物的竞争优势以及入侵植物和干旱对土壤酶活性的影响。本研究旨在分析干旱背景下起源于热带美洲的入侵植物刺苋(Amaranthus spinosus)与本地植物苋菜(Amaranthus tricolor)共存时的竞争优势和土壤酶活性。通过栽植实验进行刺苋与苋菜的竞争共栽培,并进行不同水平的干旱处理,即:(i)对照;(ii)轻度干旱;(iii)重度干旱。实验结束后测定两种苋属植物的功能性状、渗透调节、抗氧化酶活性以及土壤pH、电导率、土壤微生物生物量碳含量和土壤酶活性。干旱背景下,刺苋的相对竞争强度和相对优势度均高于苋菜。因此,干旱利于刺苋的竞争优势。干旱背景下,刺苋的土壤水溶性盐含量和蔗糖水解能力均大于苋菜。而较高的土壤水溶性盐含量和蔗糖水解能力利于刺苋对养分的获取和利用。 | Youli Yu Huiyuan Cheng Shu Wang Mei Wei Congyan Wang Daolin Du | 2022 | Journal of Plant Ecology2022，15，3： | 1 |
| 16 | ACOD1 in immunometabolism and disease显示文摘Immunometabolism plays a fundamental role in health and diseases and involves multiple genes and signals.Aconitate decarboxylase 1(ACOD1;also known as IRG1)is emerging as a regulator of immunometabolism in inflammation and infection.Upregulation of ACOD1 expression occurs in activated immune cells(e.g.,macrophages and monocytes)in response to pathogen infection(e.g.,bacteria and viruses),pathogen-associated molecular pattern molecules(e.g.,LPS),cytokines(e.g.,TNF and IFNs),and damage-associated molecular patterns(e.g.,monosodium urate).Mechanistically,several immune receptors(e.g.,TLRs and IFNAR),adapter proteins(e.g.,MYD88),ubiquitin ligases(e.g.,A20),and transcription factors(e.g.,NF-κB,IRFs,and STATs)form complex signal transduction networks to control ACOD1 expression in a context-dependent manner.Functionally,ACOD1 mediates itaconate production,oxidative stress,and antigen processing and plays dual roles in immunity and diseases.On the one hand,activation of the ACOD1 pathway may limit pathogen infection and promote embryo implantation.On the other hand,abnormal ACOD1 expression can lead to tumor progression,neurodegenerative disease,and immune paralysis.Further understanding of the function and regulation of ACOD1 is important for the application of ACOD1-based therapeutic strategies in disease. | Runliu Wu Feng Chen Nian Wang Daolin Tang Rui Kang | 2020 | Cellular & Molecular Immunology2020，17，8： | 1 |
| 17 | 重度干旱降低两种菊科入侵植物凋落物共同降解的速率显示文摘当前,中国已分布的入侵植物隶属于菊科的种类数量最多。更关键的是,两种入侵植物可以在同一生境中形成共同入侵。此外,干旱可以影响入侵植物的凋落物降解和土壤酶活性。基于此,本研究旨在解析干旱背景下两种菊科入侵植物鬼针草(Bidens pilosa)和加拿大一枝黄花(Solidago canadensis)对凋落物降解和土壤酶活性的单一影响和复合影响。本研究主要通过聚乙烯凋落袋实验完成,其中每一个凋落袋装入5 g入侵植物鬼针草的凋落物,或装入5 g入侵植物加拿大一枝黄花的凋落物,或装入5 g两种菊科入侵植物鬼针草和加拿大一枝黄花等比例混匀的凋落物。干旱处理水平设置为:对照、轻度干旱和重度干旱。实验结束后测定两种菊科入侵植物凋落物单一降解速率和共同降解速率以及土壤酶活性。两种菊科入侵植物凋落物共同降解对土壤脲酶活性的影响为叠加效应。两种菊科入侵植物凋落物共同降解速率以及入侵植物鬼针草凋落物单一降解速率显著高于入侵植物加拿大一枝黄花凋落物单一降解速率。轻度干旱显著增加土壤脲酶活性,但重度干旱显著降低土壤脲酶活性。重度干旱显著降低两种菊科入侵植物凋落物共同降解速率以及入侵植物鬼针草凋落物单一降解速率,但干旱处理未显著影响入侵植物加拿大一枝黄花凋落物单一降解速率。因此,重度干旱可能通过减缓营养循环速率显著影响两种菊科入侵植物共同入侵进程以及入侵植物鬼针草单一入侵进程,但并未显著影响入侵植物加拿大一枝黄花单一入侵进程。 | Youli Yu Huiyuan Cheng Congyan Wang Daolin Du | 2023 | Journal of Plant Ecology2023，16，1： | 0 |
| 18 | Sulfur mediated heavy metal biogeochemical cycles in coastal wetlands:From sediments,rhizosphere to vegetation显示文摘The interactions and mechanisms between sulfur and heavy metals are a growing focus of biogeochemical studies in coastal wetlands.These issues underline the fate of heavy metals bound in sediments or released into the system through sediments.Despite the fact that numerous published studies have suggested sulfur has a significant impact on the bioavailability of heavy metals accumulated in coastal wetlands,to date,no review article has systematically summarized those studies,particularly from the perspective of the three major components of wetland ecosystems(sediments,rhizosphere,and vegetation).The present review summarizes the studies published in the past four decades and highlights the major achievements in this field.Research and studies available thus far indicate that under anaerobic conditions,most of the potentially bioavailable heavy metals in coastal wetland sediments are fixed as precipitates,such as metal sulfides.However,fluctuations in physicochemical conditions may affect sulfur cycling,and hence,directly or indirectly lead to the conversion and migration of heavy metals.In the rhizosphere,root activities and microbes together affect the speciation and transformation of sulfur which in turn mediate the migration of heavy metals.As for plant tissues,tolerance to heavy metals is enhanced by sulfur-containing compounds via promoting a series of chelation and detoxification processes.Finally,to further understand the interactions between sulfur and heavy metals in coastal wetlands,some major future research directions are proposed. | Yueming Wu Zhanrui Leng Jian Li Chongling Yan Xinhong Wang Hui Jia Lingyun Chen Sai Zhang Xiaojun Zheng Daolin Du | 2022 | Frontiers of Environmental Science & Engineering2022，16，8： | 0 |
| 19 | Rheological and physicomechanical properties of rod milling sand-based cemented paste backfill modified by sulfonated naphthalene formaldehyde condensate显示文摘Rod milling sand(RMS)—a coarse sand aggregate—was recycled for cemented paste backfill(CPB)for the underground mined area at the Jinchuan nickel deposit,named rod milling sand-based cemented paste backfill(RCPB).The adverse effects of coarse particles on the transportation of CPB slurry through pipelines to underground stopes resulting in weakening of the stability of the backfill system are well known.Therefore,sulfonated naphthalene formaldehyde(SNF)condensate was used for the performance improvement of RCPB.The synergistic effect of solid content(SC),lime-to-sand ratio,and SNF dosage on the rheological and physicomechanical properties,including slump,yield stress,bleeding rate,uniaxial compressive strength(UCS),as well as mechanism analysis of RCPB,have been explored.The results indicate that the effect of SNF on RCPB performance is related to the SNF dosage,lime-to-sand ratio,and SC.The slump of fresh RCPB with 0.1wt%-0.5wt%SNF increased by 2.6%-26.2%,whereas the yield stress reduced by 4.1%-50.3%,indicating better workability and improved cohesiveness of the mix.The bleeding rate of fresh RCPB decreased first and then rose with the increase of SNF dosage,and the peak decrease was 67.67%.UCS of RCPB first increased and then decreased with the increase of SNF dosage.At the optimal SNF addition ratio of 0.3wt%,the UCS of RCPB curing for 7,14 and,28 d ages increased by 31.5%,28.4%,and 29.5%,respectively.The beneficial effects of SNF in enhancing the early UCS of RCPB have been corroborated.However,the later UCS increases at a slower rate.The research findings may guide the design and preparation of RCPB with adequate performance for practical applications. | Qinli Zhang Hao Wu Yan Feng Daolin Wang Huaibin Su Xiaoshuang Li | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，2： | 0 |
| 20 | Fractional nonlinear energy sinks显示文摘The cubic or third-power(TP)nonlinear energy sink(NES)has been proven to be an effective method for vibration suppression,owing to the occurrence of targeted energy transfer(TET).However,TET is unable to be triggered by the low initial energy input,and thus the TP NES would get failed under low-amplitude vibration.To resolve this issue,a new type of NES with fractional nonlinearity,e.g.,one-third-power(OTP)nonlinearity,is proposed.The dynamic behaviors of a linear oscillator(LO)with an OTP NES are investigated numerically,and then both the TET feature and the vibration attenuation performance are evaluated.Moreover,an analogy circuit is established,and the circuit simulations are carried out to verify the design concept of the OTP NES.It is found that the threshold for TET of the OTP NES is two orders of magnitude smaller than that of the TP NES.The parametric analysis shows that a heavier mass or a lower stiffness coefficient of the NES is beneficial to the occurrence of TET in the OTP NES system.Additionally,significant energy transfer is usually accompanied with efficient energy dissipation.Consequently,the OTP NES can realize TET under low initial input energy,which should be a promising approach for micro-vibration suppression. | Shengtao ZHANG Jiaxi ZHOU Hu DING Kai WANG Daolin XU | 2023 | Applied Mathematics and Mechanics(English Edition)2023，44，5： | 0 |
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