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| 1 | Distinctive melt activity and chromite mineralization in Luobusa and Purang ophiolites, southern Tibet: constraints from trace element compositions of chromite and olivine显示文摘To investigate the factors controlling the mineralization in ophiolites we systematically compared the petrology and mineral compositions of the harzburgites/lherzolites, dunites and chromitites in the Luobusa and Purang ophiolites. Generally, the petrological features and trace element compositions of chromite and olivine in peridotite and chromitite are distinctly different between the two ophiolites.In Luobusa, boninitic melts are inferred to have interacted with the harzburgites and modified the distributions of some trace elements(e.g., Ni, Mn and V) in chromite and olivine. The subsequently formed dunites and chromitites experienced significant elemental exchange. In contrast, the Purang ophiolite contains a wider range of chromitite compositions and records diverse melt activities, such as the growth of relatively abundant secondary clinopyroxene. The metasomatic melts were enriched in Al and depleted in Si, Na and highly incompatible trace elements(e.g., Nb, Zr). Such melts resemble MORBlike melts proposed in the literature but are assumed to be more hydrous than typical MORB because of presence of hydrous minerals. The parental magmas of the Purang dunites and intermediate chromitites are inferred to be compositionally intermediate between boninitic and MORB-like melts. In addition,the more refractory nature of the Luobusa harzburgites facilitated a high Cr concentration gradient with the interacting melts, making it easier to increase Cr in the melts. Crystallization of clinopyroxene and amphibole in the Purang ophiolite accommodated significant amounts of Cr and water, respectively,and negatively affected Cr concentration and chromite crystallization. The concentration of chromite to form chromitites requires the presence of focused melt channels. | Benxun Su Meifu Zhou Jiejun Jing Paul T. Robinson Chen Chen Yan Xiao Xia Liu Rendeng Shi Davide Lenaz Yan Hu | 2019 | Science Bulletin2019，64，2： | 15 |
| 2 | Vacuolar Sorting Receptor (VSR) Proteins Reach the Plasma Membrane in Germinating Pollen Tubes显示文摘排序受体(VSR ) 的 Vacuolar 是类型我调停的不可分的膜蛋白质经由在植物的 prevacuolar 分隔空间(PVC ) 的可溶的货物蛋白质的 vacuolar 运输。共焦的 immunofluorescent 和 immunogold 电子显微镜(他们) 研究在各种各样的植物房间类型有局部性的 VSR 到 PVC 或 multivesicular 身体(MVB ) 和 trans-Golgi 网络(TGN ) ,包括暂停文化房间,根房间,发展中并且发芽的种子。这里,我们提供 VSR 在种花粉试管到达血浆膜(下午) 的证据。有特定的 VSR 抗体的 immunofluorescent 和 immunogold 他们研究证明除了以前表明的 PVC/MVB 本地化, VSR 也在百合和从化学固定或高压的结冰 / 结冰替换准备的烟草花粉试管本地化到下午。如此的下午本地化在调停建议 VSR 蛋白质的一个另外的角色蛋白质运输到在种花粉试管的下午和 endocytosis。用一台高速度的旋转圆盘共焦的显微镜,在 VSR 积极的 PVC 细胞器和 PM 之间的可能的熔化也在短暂地表示 PVC 记者 GFPVSR 的生活烟草花粉试管被观察。相反,在生活花粉试管的 GFPVSR 的突出的下午本地化的缺乏可能由于在这种快成长的房间类型的小囊的运输的高度有活力的状况。 | Hao Wang Xiao-Hong Zhuang Stefan Hillmer David G. Robinson Li-Wen Jiang | 2011 | Molecular Plant2011，4，5： | 5 |
| 3 | Chip-based digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction patients显示文摘miRNAs 为尖锐心肌的梗塞(AMI ) 作为潜在的 biomarkers 显示出诺言。然而,当前的使用的量的即时 PCR (qRT-PCR ) 完全为 nucleic 酸的相对表示允许,它产生日常可变性,它限制了把 miRNAs 用作 biomarkers 的有效性。在这研究,我们探索了技术质量和一种新技术的诊断潜力,基于薄片的数字 PCR,在确定在有 AMI 和 ischaemia-reperfusion 损害(I/R ) 的病人的 miRNAs。在合成 C.elegans-miR-39 的一个冲淡系列,基于薄片的数字 PCR 与 qRT-PCR 相比显示了变化(8.9% 对 46.3%) 和察觉(0.2 copies/L 对 1.1 copies/L ) 的更低的限制的一个更低的系数。在从有圣举起心肌的梗塞( STEMI )的 24 个病人和有稳定的冠的动脉疾病( CAD )的 20 个病人镇定的浆液在经皮的冠的干预(一种总线标准)以后的病人,我们使用了 qRT-PCR 和多路的基于薄片的数字 PCR 确定他们在优先的研究在 AMI 被验证了的 miRNA-21 和 miRNA-499 的浆液层次。在 STEMI, I/R 损害经由圣片断分辨率(ST-R ) 的测量被估计。基于薄片的数字 PCR 处于在稳定的 CAD 和 STEMI 组之间的 miR-21 层次的差别揭示了统计意义(118.8 copies/L 对 59 copies/L;P=0.0300 ) ,而 qRT-PCR 是不能的到达意义(136.4 copies/L 对 122.8 copies/L;P=0.2273 ) 。为 miR-499 层次,基于薄片的数字 PCR 和 qRT-PCR 揭示了稳定的 CAD 和 STEMI 组之间的统计上重要的差别(2 copies/L 对 8.5 copies/L, P=0.0011;0 copies/L 对 19.4 copies/L;P < 0.0001 ) 。在 miR-21/499 层次和 ST-R 之间没有协会一种总线标准以后。我们的结果证明基于薄片的数字 PCR 展出优异技术质量和诺言是一个优异方法因为确定的 miRNA 在发行量铺平,它可以为直接确定成为一个更精确、可再现的方法 miRNAs,特别地为在大多中心的使用临床的试用。 | Samuel ROBINSON Marie FOLLO David HAENE Maximilian MAULER Daniela STALLMANN Lukas Andreas HEGER Thomas HELBING Daniel DUERSCHMIED Karlheinz PETER Christoph BODE Ingo AHRENS Marcus HORTMANN | 2018 | Acta Pharmacologica Sinica2018，39，7： | 5 |
| 4 | Atrazine biodegradation efficiency, metabolite detection, and trzD gene expression by enrichment bacterial cultures from agricultural soil显示文摘Atrazine is a selective herbicide used in agricultural fields to control the emergence of broadleaf and grassy weeds. The persistence of this herbicide is influenced by the metabolic action of habituated native microorganisms. This study provides information on the occurrence of atrazine mineralizing bacterial strains with faster metabolizing ability. The enrichment cultures were tested for the biodegradation of atrazine by high-performance liquid chromatography(HPLC) and mass spectrometry. Nine cultures JS01.Deg01 to JS09.Deg01 were identified as the degrader of atrazine in the enrichment culture. The three isolates JS04.Deg01, JS07.Deg01, and JS08.Deg01 were identified as efficient atrazine metabolizers. Isolates JS04.Deg01 and JS07.Deg01 produced hydroxyatrazine(HA) N-isopropylammelide and cyanuric acid by dealkylation reaction. The isolate JS08.Deg01 generated deethylatrazine(DEA), deisopropylatrazine(DIA), and cyanuric acid by N-dealkylation in the upper degradation pathway and later it incorporated cyanuric acid in their biomass by the lower degradation pathway. The optimum pH for degrading atrazine by JS08.Deg01 was 7.0 and 16S rDNA phylogenetic typing identified it as Enterobacter cloacae strain JS08.Deg01. The highest atrazine mineralization was observed in case of isolate JS08.Deg01, where an ample amount of trzD mRNA was quantified at 72 h of incubation with atrazine. Atrazine bioremediating isolate E. cloacae strain JS08.Deg01 could be the better environmental remediator of agricultural soils and the crop fields contaminated with atrazine could be the source of the efficient biodegrading microbial strains for the environmental cleanup process. | Robinson David Jebakumar SOLOMON Amit KUMAR Velayudhan SATHEEJA SANTHI | 2013 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2013，14，12： | 5 |
| 5 | Tyrosine aminotransferase: biochemical and structural properties and molecular dynamics simulations显示文摘Tyrosine aminotransferase(TAT)catalyzes the transamination of tyrosine and other aromatic amino acids.The enzyme is thought to play a role in tyrosinemia type II,hepatitis and hepatic carcinoma recovery.The objective of this study is to investigate its biochemical and structural characteristics and substrate specificity in order to provide insight regarding its involvement in these diseases.Mouse TAT(mTAT)was cloned from a mouse cDNA library,and its recombinant protein was produced using Escherichia coli cells and purified using various chromatographic techniques.The recombinant mTAT is able to catalyze the transamination of tyrosine usingα-ketoglutaric acid as an amino group acceptor at neutral pH.The enzyme also can use glutamate and phenylalanine as amino group donors and p-hydroxyphenylpyruvate,phenylpyruvate and alpha-ketocaproic acid as amino group acceptors.Through macromolecular crystallography we have determined the mTAT crystal structure at 2.9Åresolution.The crystal structure revealed the interaction between the pyridoxal-5′-phosphate cofactor and the enzyme,as well as the formation of a disulphide bond.The detection of disulphide bond provides some rational explanation regarding previously observed TAT inactivation under oxidative conditions and reactivation of the inactive TAT in the presence of a reducing agent.Molecular dynamics simulations using the crystal structures of Trypanosoma cruzi TAT and human TAT provided further insight regarding the substrate-enzyme interactions and substrate specificity.The biochemical and structural properties of TAT and the binding of its cofactor and the substrate may help in elucidation of the mechanism of TAT inhibition and activation. | Prajwalini Mehere Qian Han Justin A.Lemkul Christopher J.Vavricka Howard Robinson David R.Bevan Jianyong Li | 2010 | Protein & Cell2010，1，11： | 4 |
| 6 | 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines显示文摘 | Neil J. Stone Jennifer G. Robinson Alice H. Lichtenstein C. Noel Bairey Merz Conrad B. Blum Robert H. Eckel Anne C. Goldberg David Gordon Daniel Levy Donald M. Lloyd-Jones Patrick McBride J. Sanford Schwartz Susan T. Shero Sidney C. Smith Karol Watson Pet | 2014 | Circulation (_suppl_ Suppl)2014，，25： | 2 |
| 7 | Minimally Invasive Surgery Improves Short-term Outcomes in Elderly Colorectal Cancer Patients显示文摘 | Celia N. Robinson Courtney J. Balentine Christy L. Marshall Jonathan A. Wilks Daniel Anaya Avo Artinyan David H. Berger Daniel Albo | 2011 | Journal of Surgical Research2011，，2： | 2 |
| 8 | Omega‐3 fatty acids and/or fluvastatin in hepatitis C prior non‐responders to combination antiviral therapy – a pilot randomised clinical trial显示文摘 | David A. Sheridan Simon H. Bridge Mary M. E. Crossey Daniel J. Felmlee Fiona I. Fenwick Howard C. Thomas R. Dermot G. Neely Simon D. Taylor‐Robinson Margaret F. Bassendine | 2014 | Liver Int2014，，5： | 2 |
| 9 | Prognostic significance of endoluminal ultrasound-defined disease length and tumor volume (EDTV) for patients with the diagnosis of esophageal cancer显示文摘 | Christopher P. Twine S. Ashley Roberts Wyn G. Lewis B. Vicki Dave Claire E. Rawlinson David Chan Mark Robinson Tom D. Crosby | 2010 | Surgical Endoscopy2010，，4： | 2 |
| 10 | New frontiers in food enzymology: recombinant lipoxygenases显示文摘 | Casey R West S I Hardy D David S Robinson Zecai W u Richard K Hughes | 1999 | Trends in Food Science & Technology1999，10，： | 1 |
| 11 | δ15N as an Integrator of the Nitrogen Cycle Trends显示文摘 | David Robinson | 2001 | Ecology & Evolution2001，16，3： | 1 |
| 12 | Effect of Angiotensin-Converting Enzyme Inhibition on Myocardial Fibrosis and Function in Hypertrophied and Failing Myocardium From the Spontaneously Hypertensive Rat显示文摘 | Wesley W. Brooks Oscar H.L. Bing Kathleen G. Robinson Mara T. Slawsky David M. Chaletsky Chester H. Conrad | 1997 | Circulation1997，，11： | 1 |
| 13 | Significance of peroxisome proliferator-activated receptors in the cardiovascular system in health and disease显示文摘 | Emma Robinson David J. Grieve | 2009 | Pharmacology and Therapeutics2009，，3： | 1 |
| 14 | Aggressive Behavior in Patients With Stroke: Association With Psychopathology and Results of Antidepressant Treatment on Aggression显示文摘 | Keen-Loong Chan Antonio Campayo David J. Moser Stephan Arndt Robert G. Robinson | 2006 | Archives of Physical Medicine and Rehabilitation2006，，6： | 1 |
| 15 | Clathrin-Mediated Constitutive Endocytosis of PIN Auxin Efflux Carriers in Arabidopsis显示文摘 | Pankaj Dhonukshe Fernando Aniento Inhwan Hwang David G. Robinson Jozef Mravec York-Dieter Stierhof Ji?í Friml | 2007 | Current Biology2007，，6： | 1 |
| 16 | Strategic alliances, venture capital, and exit decisions in early stage high-tech firms显示文摘 | Umit Ozmel David T. Robinson Toby E. Stuart | 2012 | Journal of Financial Economics2012，，： | 1 |
| 17 | Transcatheter Aortic-Valve Replacement with a Self-Expanding Prosthesis显示文摘 | David H. Adams Jeffrey J. Popma Michael J. Reardon Steven J. Yakubov Joseph S. Coselli G. Michael Deeb Thomas G. Gleason Maurice Buchbinder James Hermiller Neal S. Kleiman Stan Chetcuti John Heiser William Merhi George Zorn Peter Tadros Newell Robinson Ge | 2014 | The New England Journal of Medicine2014，，19： | 1 |
| 18 | Algal growth control by a barley straw extract显示文摘 | Andrew S Ball Matthew Williams David Vincent James Robinson | 2001 | Bioresource Technology2001，，2： | 1 |
| 19 | Analysis of Compressive Membrane Actionin Concrete Slabs显示文摘 | Yu Zheng Des Robinson Su Taylor David Clelund | 2008 | ICE Preceeding-Bridge Engineering2008，，： | 1 |
| 20 | The new ambiguity of open gov- ernment 显示文摘 | Harlan Yu David Robinson | 2012 | UCLA Law Review Discourse2012，59，： | 1 |
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