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| 1 | aunalysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza显示文摘 | Haibin Xu Jingyuan Song Hongmei Luo Yujun Zhang Qiushi Li Yingjie Zhu Jiang Xu Ying Li Chi Song Bo Wang Wei Sun Guoan Shen Xin Zhang Jun Qian Aijia Ji Zhichao Xu Xiang Luo Liu He Chuyuan Li Chao Sun Haixia Yah Guanghong Cui Xiwen Li Xian 'en Li Jianhe Wei Juyan Liu Yitao Wang Alice Hayward David Nelson Zemin Ning Reuben J. Peters Xiaoquan Qi Shilin Chen | 2016 | Molecular Plant2016，9，6： | 70 |
| 2 | Petawatt and exawatt class lasers worldwide显示文摘In the 2015 review paper‘Petawatt Class Lasers Worldwide’a comprehensive overview of the current status of highpower facilities of>200 TW was presented.This was largely based on facility specifications,with some description of their uses,for instance in fundamental ultra-high-intensity interactions,secondary source generation,and inertial confinement fusion(ICF).With the 2018 Nobel Prize in Physics being awarded to Professors Donna Strickland and Gerard Mourou for the development of the technique of chirped pulse amplification(CPA),which made these lasers possible,we celebrate by providing a comprehensive update of the current status of ultra-high-power lasers and demonstrate how the technology has developed.We are now in the era of multi-petawatt facilities coming online,with 100 PW lasers being proposed and even under construction.In addition to this there is a pull towards development of industrial and multi-disciplinary applications,which demands much higher repetition rates,delivering high-average powers with higher efficiencies and the use of alternative wavelengths:mid-IR facilities.So apart from a comprehensive update of the current global status,we want to look at what technologies are to be deployed to get to these new regimes,and some of the critical issues facing their development. | Colin N.Danson Constantin Haefner Jake Bromage Thomas Butcher Jean-Christophe FChanteloup Enam A.Chowdhury Almantas Galvanauskas Leonida A.Gizzi Joachim Hein David I.Hillier Nicholas W.Hopps Yoshiaki Kato Efim A.Khazanov Ryosuke Kodama Georg Korn Ruxin Li Yutong Li Jens Limpert Jingui Ma Chang Hee Nam David Neely Dimitrios Papadopoulos Rory R.Penman Liejia Qian Jorge J.Rocca andrey A.Shaykin Craig W.Siders Christopher Spindloe Sándor Szatmári Raoul M.G.M.Trines Jianqiang Zhu Ping Zhu Jonathan D.Zuegel | 2019 | High Power Laser Science and Engineering2019，7，3： | 33 |
| 3 | HYDRAULIC RESISTANCE OF SUBMERGED VEGETATION RELATED TO EFFECTIVE HEIGHT显示文摘Submerged vegetation has a significant impact on water flow velocity.Current investigations include the impact through adding drag resistance and increasing bottom roughness coefficient,which cannot elucidate the characters of real submerged vegetation.To evaluate the effects of submerged vegetation on water currents at different velocities,a laboratory experiment was conducted using three kinds of vegetations.The effective heights of these vegetations on varying flow velocities were evaluated.An equation describing the relationship between the normalized resistance of the submerged plants and the Reynolds number based on the plant effective height was then established and used to calculate the hydraulic resistance parameters of submerged plants in different stages of growth. | WANG Pei-fang WANG Chao ZHU David Z. | 2010 | Journal of Hydrodynamics2010，22，2： | 24 |
| 4 | Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer显示文摘尽管有最近的进展, oncogenic K 地岬驾驶的胰腺的 ductal 腺癌(PDAC ) 在最致命的人的癌症之中留在现代医学。PDAC 的致病对内在的染色体不稳定性和外来的发炎激活部分可归因。然而,在在胰腺的 tumorigenesis 的这二个事件之间的分子的连接充分还没被建立了。这里,我们证明(HMGB1 ) 细胞内部的高活动性组盒子 1 显著地压制 oncogenic 由禁止染色体的 K-Ras-driven 胰腺的 tumorigenesis 调停不稳定性的支持 inflammatory nucleosome 版本。任何一个单身者的有条件的基因脱离或在胰的 HMGB1 的两等位基因在出生使老鼠变为极其敏感到先锋损害的 oncogenic K-Ras-driven 开始,包括胰腺的 intraepithelial 瘤, intraductal 乳突的 mucinous 瘤,和 mucinous 膀胱的瘤。在胰的 HMGB1 的损失与染色体重新整理和 telomere 畸形描绘的氧化 DNA 损坏和 chromosomal 不稳定性被联系。这些导致煽动性的 nucleosome 版本并且宣传 K-Ras-driven 胰腺的 tumorigenesis。细胞外的 nucleosomes 支持 interleukin 6 (IL-6 ) 由渗入 macrophages/neutrophils 的分泌物并且提高在胰腺的损害表明激活的 oncogenic K 地岬。到 IL-6 或 histone H3 或为先进 glycation 的受体的大美人的抵销的抗体结束产品都限制表明激活的 K 地岬,阻止癌症开发和转移 / 侵略,并且延长在 Pdx1-Cre 的动物幸存; K 地岬 G12D/+;Hmgb1/ 鼠标。由 glycyrrhizin 的 HMGB1 损失的药理学抑制在煽动性的条件下面在老鼠限制 oncogenic K-Ras-driven tumorigenesis。减少在 PDAC 病人的 HMGB1 的原子、全部的细胞的表示与差的全面幸存相关,在 PDAC 与预示、治疗学的关联作为新奇肿瘤 suppressor 支持细胞内部的 HMGB1。 | Rui Kang Yangchun Xie Qiuhong Zhang Wen Hou Qingping Jiang Shan Zhu Jinbao Liu Dexing Zeng Haichao Wang David L Bartlet Timothy R Billiar Herbert J Zeh III Michael T Lotze Daolin Tang | 2017 | Cell Research2017，27，7： | 22 |
| 5 | Out of southern East Asia: the natural history of domestic dogs across the world显示文摘 | Guo-Dong Wang Weiwei Zhai He-Chuan Yang Lu Wang LioZhong Yan-Hu Liu Ruo-Xi Fan Ting-Ting Yin Chun-Ling Zhu Andrei D Poyarkov David M Irwin Marjo K Hytonen Hannes Lohi Chung-I Wu Peter Savolainen Ya-Ping Zhang | 2016 | Cell Research2016，26，1： | 16 |
| 6 | Clinical significance of connective tissue growth factor in hepatitis B virus-induced hepatic fibrosis显示文摘AIM:To determine the utility of connective tissue growth factor(CCN2/CTGF) for assessing hepatic fibrosis in hepatitis B virus(HBV)-induced chronic liver diseases(CLD-B).METHODS:Enzyme-linked immunosorbent assay was used to measure CCN2 in sera from 107 patients with chronic hepatitis B(CHB) and 39 patients with HBVinduced active liver cirrhosis and 30 healthy individuals.Liver samples from 31 patients with CHB,8 patients with HBV-induced liver cirrhosis and 8 HBV carriers with normal liver histology were examined for transforming growth factor β-1(TGF-β1) or CCN2 mRNA levels by in situ hybridization,and computer image analysis was performed to measure integrated optimal density(IOD) of CCN2 mRNA-positive cells in liver tissues.Histological inflammation grading and fibrosis staging were evaluated by H and E staining and Van Gieson's method.RESULTS:Serum CCN2 concentrations were,respectively,4.0-or 4.9-fold higher in patients with CHB or active liver cirrhosis as compared to healthy individuals(P < 0.01).There was good consistency between the levels of CCN2 in sera and CCN2 mRNA expression in liver tissues(r = 0.87,P < 0.01).The levels of CCN2 in sera were increased with the enhancement of histological fibrosis staging in patients with CLD-B(r = 0.85,P < 0.01).Serum CCN2 was a reliable marker for the assessment of liver fibrosis,with areas under the receiver operating characteristic(ROC) curves(AUC) of 0.94 or 0.85 for,respectively,distinguishing normal liver controls from patients with F1 stage liver fibrosis or discriminating between mild and significant fibrosis.CONCLUSION:Detection of serum CCN2 in patients with CLD-B may have clinical significance for assessment of severity of hepatic fibrosis. | Rong-Li Piao David R Brigstock Jie Zhu Man-Li Zhang Run-Ping Gao | 2012 | World Journal of Gastroenterology2012，18，18： | 12 |
| 7 | Sedimentary cycles of trace elements in Salawusu River Valley since 150 ka BP显示文摘The paper makes some analyses on 11 trace elements in the Milanggouwan stratigraphical section in the Salawusu River valley, which is regarded as a prototype geology-palaeoclimate record since 150 ka BP. The results show that the content and variation of trace elements has experienced remarkably regular changes in the pace with coarse and fine sedimentary cycles of palaeo-aeolian sands to its overlying fluvio-lacustrine facies or/and palaeosols. The trace elements with chemical properties of relatively active (V, Sr, Cu, Ni, As) and relatively stable (P, Pb, Rb, Mn, Nb, Zr) are a manifestation of the corresponding 27 changeable cycles between peak and valley values, appearing a multi-fluctuational process line of relative gathering and migration since then. The low numerical value distribution of these two types of trace elements in the aeolian sand facies represents erosion and accumulation under wind force during the cold-dry climate. Whereas their enrichments in both fluvio-lacustrine facies and palaeosols are related to the valley抯 special low-lying physiognomic position between the Ordos Plateau and the Loess Plateau under the warm and humid climate conditions. The above relatively migrated and gathered change of the trace elements is the result of 27 climatic cycles of cold-dry and warm-humid, which is probably caused by repeated alternations of winter monsoon and summer monsoon in the Mu Us Sandy Land influenced by the climate vicissitudes in northern hemisphere during glacial and interglacial periods since 150 ka BP. | YAO Chun-xia1,2, LI Bao-sheng1,2, JIN He-ling3, David Dian Zhang4, YAN Man-cun5, ZHU Yi-zhi2, LI Hou-xin1, ZHANG Yu-hong1, Luo Kai-li1 (1. Dept. of Geography, South China Normal University, Guangzhou 510631, China 2. State Key Laboratory of Loess | 2002 | Journal of Geographical Sciences2002，12，1： | 10 |
| 8 | Clinical practice of transarterial chemoembolization for hepatocellular carcinoma:consensus statement from an international expert panel of International Society of Multidisciplinary Interventional Oncology(ISMIO)显示文摘Importance:Transarterial chemoembolization(TACE)has been associated with a wide range of practice variations for hepatocellular carcinoma(HCC)between the East and the West.This considerable ambiguity may lead to the heterogeneous quality in treatment and have a negative impact on the role of TACE in the overall multidisciplinary HCC treatment system.Objective:It may be a good start to establish a guideline worldwide to have this consensus from experts who represent east and west,although it does not cover all aspects of TACE.Evidence Review:An international expert panel on TACE is convened to cluster the expert’s opinions and summary a standard consensus.This panel committee consist of leading physicians in TACE on HCC from USA,France,Japan,Singapore,Korea,China,and so on.The first-round face-to-face consensus meeting was held during in Nanjing,China in October 2019.The second-round conference for revision of the consensus was held during the Annual Meeting of Chinese College of Interventionalists in August 2020 by a hybrid format of a Webinar and roundtable meeting.After several on-line revisions,the final manuscript was approved by all members of the panel in June 2021.Findings:The consensus statements were organized into the following categories:patients’selection,performing the procedure,TACE outcomes,repeat TACE,TACE failure/refractory,and TACE-based combination treatments.Conclusions and Relevance for Reviews:More and more evidences have showed the better outcomes with strategy of combined TACE with other local therapies such as ablations.The most-recently developing strategy of combined TACE with PD-1/PD-L1 plus tyrosine kinase inhibitor(TKI)agents has shined a light to the HCC patients,especially to those with high risk of tumor recurrence after treatment or TACE failure/refractory. | Jian Lu Ming Zhao Yasuaki Arai Bin-Yan Zhong Hai-Dong Zhu Xiao-Long Qi Thierry de Baere Uei Pua Hyun Ki Yoon David C.Madoff Gao-Jun Teng International Society of Multidisciplinary Interventional Oncology(ISMIO) | 2021 | Hepatobiliary Surgery and Nutrition2021，10，5： | 9 |
| 9 | Electro-Pulse-Boring(EPB): Novel Super-Deep Drilling Technology for Low Cost Electricity显示文摘The inexhaustible heat deposit in great depths(5–10km) is a scientific fact. Such deposit occurs around the globe. Thereby,everybody is enabled to generate autonomously clean and renewable energy,ample electricity and heat. The economical exploration and exploitation of this superdeep geothermal heat deposit requires a novel drilling technique,because the currently only deep drilling method(Rotary) is limited to about 5km,due to the rising costs,depending exponentially on depth. Electro-pulse-boring(EPB) is a valuable option to Rotary drilling. EPB,originally investigated in Russia,is ready to be developed for industrialization. The feasibility of EPB is proven by many boreholes drilled up to 200 m in granite(crystalline). Estimates show outstanding low costs for drilling by EPB: 100 €/m for a borehole with a large diameter such as 20'(50 cm),independent on depth and applicable likewise for sediments and crystalline rocks,such as granite. The current rate of penetration(ROP) of 3 m per hour is planned to be augmented up to 35m per hour,and again,irrespective whether in sedimentary or crystalline formations. Consequently,a 10km deep borehole with 50 cm will ultimately be drilled within 12 days. EPB will create new markets,such as:(i) EPB shallow drilling for geotechnics,energy piles,measures in order to mitigate natural hazards,etc.,(ii) EPB deep drilling(3–5km) for hydro-geothermics,exploration campaigns etc. and(iii) EPB super-deep drilling(5–10km) for petro-geothermics,enabling the economic generation of electricity. The autonomous and unlimited supply with cost efficient electricity,besides ample heat,ensures reliably clean and renewable energy,thus,high supply security. Such development will provide a substantial relief to cope with the global challenge to limit the climate change below 2 oC. The diminution of fossil fuels,due to the energy transition in order to mitigate the climate change,implies likewise the decrease of air pollution. | Hans O.Schiegg Arild Rdland Guizhi Zhu David A.Yuen | 2015 | Journal of Earth Science2015，26，1： | 8 |
| 10 | Inactivation of SACE_3446, a TetR family transcriptional regulator, stimulates erythromycin production in Saccharopolyspora erythraea显示文摘Erythromycin A is a widely used antibiotic produced by Saccharopolyspora erythraea;however,its biosynthetic cluster lacks a regulatory gene,limiting the yield enhancement via regulation engineering of S.erythraea.Herein,six TetR family transcriptional regulators(TFRs)belonging to three genomic context types were individually inactivated in S.erythraea A226,and one of them,SACE_3446,was proved to play a negative role in regulating erythromycin biosynthesis.EMSA and qRT-PCR analysis revealed that SACE_3446 covering intact N-terminal DNA binding domain specifically bound to the promoter regions of erythromycin biosynthetic gene eryAI,the resistant gene ermE and the adjacent gene SACE_3447(encoding a longchain fatty-acid CoA ligase),and repressed their transcription.Furthermore,we explored the interaction relationships of SACE_3446 and previously identified TFRs(SACE_3986 and SACE_7301)associated with erythromycin production.Given demonstrated relatively independent regulation mode of SACE_3446 and SACE_3986 in erythromycin biosynthesis,we individually and concomitantly inactivated them in an industrial S.erythraea WB.Compared with WB,the WBΔ3446 and WBΔ3446Δ3986 mutants respectively displayed 36%and 65%yield enhancement of erythromycin A,following significantly elevated transcription of eryAI and ermE.When cultured in a 5 L fermentor,erythromycin A ofWBΔ3446 and WBΔ3446Δ3986 successively reached 4095 mg/L and 4670 mg/L with 23%and 41%production improvement relative to WB.The strategy reported here will be useful to improve antibiotics production in other industrial actinomycete. | Hang Wu Yansheng Wang Li Yuan Yongrong Mao Weiwei Wang Lin Zhu Panpan Wu Chengzhang Fu Rolf Muller David T.Weaver Lixin Zhang Buchang Zhang | 2016 | Synthetic and Systems Biotechnology2016，1，1： | 7 |
| 11 | Neuronal failure in Alzheimer's disease: a view through the oxidative stress looking-glass显示文摘Considerable debate and controversy surround the cause(s) of Alzheimer's disease(AD). To date, several theories have gained notoriety, however none is universally accepted. In this review, we provide evidence for the oxidative stress-induced AD cascade that posits aged mitochondria as the critical origin of neurodegeneration in AD. | David J. Bonda Xinglong Wang Hyoung-Gon Lee Mark A. Smith George Perry Xiongwei Zhu | 2014 | Neuroscience Bulletin2014，30，2： | 7 |
| 12 | Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells显示文摘有各种各样的长度的 telomeres 的返老还童在导致的 pluripotent 干细胞(iPSCs ) 被发现了。telomere 长度规定的机制在 iPSCs 的正式就职和增长期间留下逃犯。我们证明 telomere 动力学在 reprogramming 和经过期间在鼠标 iPSCs 是可变的,并且建议这些差别多半源于多重潜在的因素,包括包括外长的 reprogramming 因素的表示的 telomerase 机械, telomerase 独立的机制和同种细胞的影响。用一个基因模型 telomerase 缺乏(为 iPSCs 的推导和段落的 Terc −/− 和 Terc +/−) 房间,我们发现 telomerase 在 iPSCs 的 reprogramming 和自强起一个关键作用。进一步,当由再结合的延伸和维护的其他的小径也被要求时, telomeres 的 telomerase 维护为真 pluripotency 的正式就职是必要的,然而并非足够。一起, telomere 生物学的几个方面可以在 iPSCs 说明可变 telomere 动力学。尤其是,采用在 iPSC reprogramming 期间维持 telomeres 的机制很类似于胚胎的干细胞的那些。这些调查结果可以也联系到这些机制能为在由体的房间的原子 reprogramming 以后的 telomere 异质负责的克隆的地原子转移。 | Fang Wang Yu Yin Xiaoying Ye Kai Liu Haiying Zhu Lingling Wang Maria Chiourea Maja Okuka Guangzhen Ji Jiameng Dan Bingfeng Zuo Minshu Li Qian Zhang Na Liu Lingyi Chen Xinghua Pan Sarantis Gagos David L Keefe Lin Liu | 2012 | Cell Research2012，22，4： | 7 |
| 13 | Hierarchical highly ordered SnO_(2) nanobowl branched ZnO nanowires for ultrasensitive and selective hydrogen sulfide gas sensing显示文摘Highly sensitive and selective hydrogen sulfide(H_(2)S)sensors based on hierarchical highly ordered SnO_(2) nanobowl branched ZnO nanowires(NWs)were synthesized via a sequential process combining hard template processing,atomic-layer deposition,and hydrothermal processing.The hierarchical sensing materials were prepared in situ on microelectromechanical systems,which are expected to achieve high-performance gas sensors with superior sensitivity,long-term stability and repeatability,as well as low power consumption.Specifically,the hierarchical nanobowl SnO_(2)@ZnO NW sensor displayed a high sensitivity of 6.24,a fast response and recovery speed(i.e.,14 s and 39 s,respectively),and an excellent selectivity when detecting 1 ppm H_(2)S at 250°C,whose rate of resistance change(i.e.,5.24)is 2.6 times higher than that of the pristine SnO_(2) nanobowl sensor.The improved sensing performance could be attributed to the increased specific surface area,the formation of heterojunctions and homojunctions,as well as the additional reaction between ZnO and H_(2)S,which were confirmed by electrochemical characterization and band alignment analysis.Moreover,the well-structured hierarchical sensors maintained stable performance after a month,suggesting excellent stability and repeatability.In summary,such well-designed hierarchical highly ordered nanobowl SnO_(2)@ZnO NW gas sensors demonstrate favorable potential for enhanced sensitive and selective H_(2)S detection with long-term stability and repeatability. | Li-Yuan Zhu Kai-Ping Yuan Jia-He Yang Cheng-Zhou Hang Hong-Ping Ma Xin-Ming Ji Anjana Devi Hong-Liang Lu David Wei Zhang | 2020 | Microsystems & Nanoengineering2020，6，1： | 7 |
| 14 | Pickering emulsions stabilized by colloidal surfactants:Role of solid particles显示文摘Pickering emulsions are emulsions stabilized by colloidal surfactants,i.e.solid particles.Compared with traditional molecular suffactant-stabilized emulsions,Pickering emulsions show many advantages,such as high resistance to coalescence,long-term stability,good biocompatibility and tunable properties.In recent years,Pickering emulsions are widely applied in scientific researches and industrial applications.In this review,we focus on the influences of particle properties on Pickering emulsions,including particle amphiphilicity,concentration,size and shape,and summarize the strategies developed for the preparation of amphiphilic Janus particles.The applications of Pickering emulsions in food industry,cosmetic industry,material science,drug delivery,biomedical research and vaccine adjuvant will also be covered.Pickering emulsions are a unique system for multi-disciplinary studies and will become more and more important in the future. | Zhu Sun Xiaoxiao Yan Yao Xiao Lingjie Hu Max Eggersdorfer Dong Chen Zhenzhong Yang David AWeitz | 2022 | Particuology2022，20，5： | 6 |
| 15 | Neuroprotectants attenuate hypobaric hypoxia-induced brain injuries in cynomolgus monkeys显示文摘Hypobaric hypoxia (HH) exposure can cause serious brain injury as well as life-threatening cerebral edema in severe cases. Previous studies on the mechanisms of HH-induced brain injury have been conducted primarily using non-primate animal models that are genetically distant to humans, thus hindering the development of disease treatment. Here, we report that cynomolgus monkeys (Macaca fascicularis) exposed to acute HH developed human-like HH syndrome involving severe brain injury and abnormal behavior. Transcriptome profiling of white blood cells and brain tissue from monkeys exposed to increasing altitude revealed the central role of the HIF-1 and other novel signaling pathways, such as the vitamin D receptor (VDR) signaling pathway, in co-regulating HH-induced inflammation processes. We also observed profound transcriptomic alterations in brains after exposure to acute HH, including the activation of angiogenesis and impairment of aerobic respiration and protein folding processes, which likely underlie the pathological effects of HH-induced brain injury. Administration of progesterone (PROG) and steroid neuroprotectant 5α-androst-3β,5,6β-triol (TRIOL) significantly attenuated brain injuries and rescued the transcriptomic changes induced by acute HH. Functional investigation of the affected genes suggested that these two neuroprotectants protect the brain by targeting different pathways, with PROG enhancing erythropoiesis and TRIOL suppressing glutamate-induced excitotoxicity. Thus, this study advances our understanding of the pathology induced by acute HH and provides potential compounds for the development of neuroprotectant drugs for therapeutic treatment. | Pei Zhang Jie-Si Chen Qi-Ye Li Long-Xiang Sheng Yi-Xing Gao Bing-Zheng Lu Wen-Bo Zhu Xiao-Yu Zhan Yuan Li Zhi-Bing Yuan Gang Xu Bi-Tao Qiu Min Yan Chun-Xue Guo You-Qiong Wang Yi-Jun Huang Jing-Xia Zhang Fu-Yu Liu Zhong-Wei Tang Sui-Zhen Lin David NCooper Huan-Ming Yang Jian Wang Yu-Qi Gao Wei Yin Guo-Jie Zhang Guang-Mei Yan | 2020 | Zoological Research2020，41，1： | 6 |
| 16 | Analysis on the influence factors of Bitcoin’s price based on VEC model显示文摘Background:Bitcoin,the most innovate digital currency as of now,created since 2008,even through experienced its ups and downs,still keeps drawing attentions to all parts of society.It relies on peer-to-peer network,achieved decentralization,anonymous and transparent.As the most representative digital currency,people curious to study how Bitcoin’price changes in the past.Methods:In this paper,we use monthly data from 2011 to 2016 to build a VEC model to exam how economic factors such as Custom price index,US dollar index,Dow jones industry average,Federal Funds Rate and gold price influence Bitcoin price.Result:From empirical analysis we find that all these variables do have a long-term influence.US dollar index is the biggest influence on Bitcoin price while gold price influence the least.Conclusion:From our result,we conclude that for now Bitcoin can be treated as a speculative asset,however,it is far from being a proper credit currency. | Yechen Zhu David Dickinson Jianjun Li | 2017 | Financial Innovation2017，3，1： | 5 |
| 17 | Artemisinin Biosynthesis in Non-glandular Trichome Cells of Artemisia annua显示文摘Artemisinin-based combination therapy(ACT)forms the first line of malaria treatment.However,the yield fluctuation of artemisinin has remained an unsolved problem in meeting the global demand for ACT.This problem is mainly caused by the glandular trichome(GT)-specific biosynthesis of artemisinin in all currently used Artemisia annua cultivars.Here,we report that non-GT cells of self-pollinated inbred A.annua plants can express the artemisinin biosynthetic pathway.Gene expression analysis demonstrated the transcription of six known pathway genes in GT-free leaves and calli of inbred A.annua plants.LC-qTOF-MS/MS analysis showed that these two types of GT-free materials produce artemisinin,artemisinic acid,and arteannuin B.Detailed IR-MALDESI image profiling revealed that these three metabolites and dihydroartemisinin are localized in non-GT cells of leaves of inbred A.annua plants.Moreover,we employed all the above approaches to examine artemisinin biosynthesis in the reported XL annua glandless(gl)mutant.The resulting data demonstrated that leaves of regenerated gl plantlets biosynthesize artemisinin.Codectively,these findings not only add new knowledge leading to a revision of the current dogma of artemisinin biosynthesis inannua but also may expedite innovation of novel metabolic engineering approaches for high and stable production of artemisinin in the future. | Rika Judd M.Caleb Bagley Mingzhuo Li Yue Zhu Caiyan Lei Seyit Yuzuak Mans Ekelof Gaobin Pu Xiting Zhao David C.Muddiman De-Yu Xie | 2019 | Molecular Plant2019，12，5： | 5 |
| 18 | CSCO_3 CYCLES IN SALAWUSU RIVER BASINSINCE 150KA B.P.显示文摘ABSTRACT: This paper, with Milanggouwan stratigraphic section as a typical section of the Salawusu River Basin, explores the relation between CaCO3 content distribution and climate change since 150 ka B. P. and concludes that: 1) The low-high changes of CaCO3 content in the section has a remarkable corresponding relation with the sedimentary cycles of ancient aeolian sand and overlying fluviolacustrine facies or palaeosols. 2) CaCO3 distribution in aeolian sand is relatively meagre, ranging from 0. 8% - 7. 18%, or on an average 2. 50% but relatively enriches in the fluviolacustrine faceis and palaeosols, ranging from 2. 20% - 14. 9% , or on an average 5. 74%. This implies that they have different climatic backgrounds. The former was the product of erosion, transport and deposition by wind under arid and cold climatic conditions, whereas the latter was related to its special low-lying geomorphic position between the Ordos Plateau and Loess Plateau and warm-humid climatic environment. When the climatic became warm and humid, fluviolacustrine and swamp facies developed, soil-forming action strengthened, and low-lying catchment condition was favorable to CaCO3 accumulation. 3) The basic cause responsible for the multicycle of CaCO3 migration and accumulation in the Milanggouwan section may be the multiple alterations of winter and summer monsoons over the Mu Us Desert under the influences of climatic fluctuation of glacial and interglacial periods in the Northern Hemisphere since 150ka B. P. . | LUO Kai-li1,2, LI Bao-sheng1,2, ZHU Yi-zhi2, JIN He-ling3, ZHANG David Dian4, YAN Man-cun5, LI Hou-xin1, YAO Chun-xia1, ZHANG Yu-hong1f 1. Department of Geography, South China Normal University, Guangzhou 510631, P. R. China 2. State Key Labor | 2001 | Chinese Geographical Science2001，11，4： | 4 |
| 19 | Road traffic injury mortality and morbidity by country development status, 2011- 2017显示文摘Purpose:This research examined road traffic injury mortality and morbidity disparities across of country development status,and discussed the possibility of reducing country disparities by various actions to accelerate the pace of achieving Sustainable Development Goals target 3.6 e to halve the number of global deaths and injuries from road traffic accidents by 2020.Methods:Data for road traffic mortality,morbidity,and socio-demographic index(SDI)were extracted by country from the estimates of the Global Burden of Disease study,and the implementation of the three types of national actions(legislation,prioritized vehicle safety standards,and trauma-related post-crash care service)were extracted from the Global Status Report on Road Safety byWorld Health Organization.We fitted joinpoint regression analysis to identify and quantify the significant rate changes from 2011 to 2017.Results:Age-adjusted road traffic mortality decreased substantially for all the five SDI categories from 2011 to 2017(by 7.52%e16.08%).Age-adjusted road traffic mortality decreased significantly as SDI increased in the study time period,while age-adjusted morbidity generally increased as SDI increased.Subgroup analysis by road user yielded similar results,but with two major differences during the study period of 2011 to 2017:(1)pedestrians in the high SDI countries experienced the lowest mortality(1.68e1.90 per 100,000 population)and morbidity(110.45e112.72 per 100,000 population for incidence and 487.48e491.24 per 100,000 population for prevalence),and(2)motor vehicle occupants in the high SDI countries had the lowest mortality(4.07e4.50 per 100,000 population)but the highest morbidity(428.74e467.78 per 100,000 population for incidence and 1025.70e1116.60 per 100,000 population for prevalence).Implementation of the three types of national actions remained nearly unchanged in all five SDI categories from 2011 to 2017 and was consistently stronger in the higher SDI countries than in the lower SDI countries.Lower income nations comprise the heaviest burden of global road traffic injuries and deaths.Conclusion:Global road traffic deaths would decrease substantially if the large mortality disparities across country development status were reduced through full implementation of proven national actions including legislation and law enforcement,prioritized vehicle safety standards and trauma-related postcrash care services. | Jie-Yi He Wang-Xin Xiao David CSchwebel Mo-Tao Zhu Pei-Shan Ning Li Li Xun-Jie Cheng Jun-Jie Hua Guo-Qing Hu | 2021 | Chinese Journal of Traumatology2021，24，2： | 4 |
| 20 | Polluted lake restoration to promote sustainability in the Yangtze River Basin,China显示文摘China has sought to address water pollution in the last decade by introducing a wide range of laws and regulations(Table S1), which led to nationwide water quality improvement ^([1]). However, recent quantitative assessment of progress toward Sustainable Development Goals (SDGs) in China suggests that some SDGs underpinning goals for water pollution and biodiversity have not been met ^([2]). | Boqiang Qin Yunlin Zhang Jianming Deng Guangwei Zhu Jianguo Liu David P.Hamilton Hans W.Paerl Justin D.Brookes Tingfeng Wu Kai Peng Yizhou Yao Kan Ding Xiaoyan Ji | 2022 | National Science Review2022，9，1： | 4 |
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