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| 1 | Lichong decoction reduces Matrix Metalloproteinases-2 expression but increases Tissue Inhibitors of Matrix Metalloproteinases-2 ex-pression in a rat model of uterine leiomyoma显示文摘OBJECTIVE:To study the effect of Lichong decoction(LD) on expression of matrix metalloproteinase-2(MMP-2) and metalloproteinase-2(TIMP-2) in a rat model of uterine leiomyoma(UL).METHODS:UL was induced in rats using exogenous estrogen and progesterone.LD was administered(p.o.) for 4 weeks,and mifepristone(RU-486)used as a control.To observe the effect of LD on the uterine coefficient and uterine transverse diameter,a radioimmunoassay method was used to detect serum levels of sex hormones.Light microscopic analyses of pathologic changes in the tissues of UL rats were evaluated.Expression of the proteins of matrix metalloproteinases(MMPs) and tissue inhibitors of metalloproteinases(TIMPs) in uterine tissues was assessed by immunohistochemical staining and western blotting.RESULTS:A UL model in rats was established successfully.LD reduced uterine weight,uterine coefficient,and uterine transverse diameter compared with untreated controls.LD reduced levels of estradiol,progesterone,follicle-stimulating hormone,and luteinizing hormone in our UL models.LD improved the pathologic condition of uterine muscle.Expression of MMP-2 protein decreased to varying extents in LD-treated groups,but TIMP-2 levels were enhanced.LD appears to reduce MMP-2 expression and increase TIMP-2 expression in UL tissue.CONCLUSION:These data suggest that the mechanism of action of LD on ULs may involve reduction of MMP-2 expression and increase in TIMP-2 expression in rats. | Wang Yasong Li Donghua Xu Xin Qian Ruiya Zhang Yalan Huang Yuhua Geng Jianguo Zou Xiaoli Han Hon-gjuan Zhang Wufang | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 12 |
| 2 | Development and validation of an endoscopic images-based deep learning model for detection with nasopharyngeal malignancies显示文摘Background:Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperpla-sia,the positive rate for malignancy identification during biopsy is low,thus leading to delayed or missed diagnosis for nasopharyngeal malignancies upon initial attempt.Here,we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies under endoscopic examination based on deep learning.Methods:An endoscopic images-based nasopharyngeal malignancy detection model(eNPM-DM)consisting of a fully convolutional network based on the inception architecture was developed and fine-tuned using separate training and validation sets for both classification and segmentation.Briefly,a total of 28,966 qualified images were collected.Among these images,27,536 biopsy-proven images from 7951 individuals obtained from January 1st,2008,to December 31st,2016,were split into the training,validation and test sets at a ratio of 7:1:2 using simple randomiza-tion.Additionally,1430 images obtained from January 1st,2017,to March 31st,2017,were used as a prospective test set to compare the performance of the established model against oncologist evaluation.The dice similarity coef-ficient(DSC)was used to evaluate the efficiency of eNPM-DM in automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images,by comparing automatic segmentation with manual segmenta-tion performed by the experts.Results:All images were histopathologically confirmed,and included 5713(19.7%)normal control,19,107(66.0%)nasopharyngeal carcinoma(NPC),335(1.2%)NPC and 3811(13.2%)benign diseases.The eNPM-DM attained an overall accuracy of 88.7%(95%confidence interval(CI)87.8%-89.5%)in detecting malignancies in the test set.In the prospective comparison phase,eNPM-DM outperformed the experts:the overall accuracy was 88.0%(95%CI 86.1%-89.6%)vs.80.5%(95%CI 77.0%-84.0%).The eNPM-DM required less time(40 s vs.110.0±5.8 min)and exhibited encouraging performance in automatic segmentation of nasopharyngeal malignant area from the background,with an average DSC of 0.78±0.24 and 0.75±0.26 in the test and prospective test sets,respectively.Conclusions:The eNPM-DM outperformed oncologist evaluation in diagnostic classification of nasopharyngeal mass into benign versus malignant,and realized automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images. | Chaofeng Li Bingzhong Jing Liangru Ke Bin Li Weixiong Xia Caisheng He Chaonan Qian Chong Zhao Haiqiang Mai Mingyuan Chen Kajia Cao Haoyuan Mo Ling Guo Qiuyan Chen Linquan Tang Wenze Qiu Yahui Yu Hu Liang Xinjun Huang Guoying Liu Wangzhong Li Lin Wang Rui Sun Xiong Zou Shanshan Guo Peiyu Huang Donghua Luo Fang Qiu Yishan Wu Yijun Hua Kuiyuan Liu Shuhui Lv Jingjing Miao Yanqun Xiang Ying Sun Xiang Guo Xing Lv | 2018 | Cancer Communications2018，38，1： | 9 |
| 3 | The epigallocatechin gallate derivative Y_6 reverses drug resistance mediated by the ABCB1 transporter both in vitro and in vivo显示文摘Previously, we reported that Y_6, a new epigallocatechin gallate derivative, is efficacious in reversing doxorubicin(DOX)–mediated resistance in hepatocellular carcinoma BEL-7404/DOX cells. In this study, we evaluated the efficacy of Y_6 in reversing drug resistance both in vitro and in vivo by determining its effect on the adenosine triphosphate-binding cassette protein B1 transporter(ABCB1 or P-glycoprotein, P-gp). Our results showed that Y_6 significantly sensitized cells overexpressing the ABCB1 transporter to anticancer drugs that are ABCB1 substrates. Y_6 significantly stimulated the adenosine triphosphatase activity of ABCB1. Furthermore, Y_6 exhibited a higher docking score as compared with epigallocatechin gallate inside the transmembrane domain of ABCB1. In addition, in the nude mousetumor xenograft model, Y_6(110 mg/kg, intragastric administration), in combination with doxorubicin(2 mg/kg, intraperitoneal injection), significantly inhibited the growth of BEL-7404/DOX cell xenograft tumors, compared to equivalent epigallocatechin gallate. In conclusion, Y_6 significantly reversed ABCB1-mediated multidrug resistance and its mechanisms of action may result from its competitive inhibition of the ABCB1 drug efflux function. | Yan Wen Ruiqiang Zhao Pranav Gupta Yingfang Fan Yunkai Zhang Zhenguang Huang Xiaohui Li Yuangang Su Lijuan Liao Yu-An Xie Donghua Yang Zhe-Sheng Chen Gang Liang | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 3 |
| 4 | Pirh2 mediates the sensitivity of myeloma cells to bortezomib via canonical NF-κB signaling pathway显示文摘 | Li Yang Jing Chen Xiaoyan Han Enfan Zhang Xi Huang Xing Guo Qingxiao Chen Wenjun Wu Gaofeng Zheng Donghua He Yi Zhao Yang Yang Jingsong He Zhen Cai | 2018 | Protein & Cell2018，9，9： | 3 |
| 5 | Overview of SMP-CAIL2020-Argmine:The Interactive Argument-Pair Extraction in Judgement Document Challenge显示文摘In this paper we present the results of the Interactive Argument-Pair Extraction in Judgement Document Challenge held by both the Chinese AI and Law Challenge(CAIL)and the Chinese National Social Media Processing Conference(SMP),and introduce the related data set-SMP-CAIL2020-Argmine.The task challenged participants to choose the correct argument among five candidates proposed by the defense to refute or acknowledge the given argument made by the plaintiff,providing the full context recorded in the judgement documents of both parties.We received entries from 63 competing teams,38 of which scored higher than the provided baseline model(BERT)in the first phase and entered the second phase.The best performing system in the two phases achieved accuracy of 0.856 and 0.905,respectively.In this paper,we will present the results of the competition and a summary of the systems,highlighting commonalities and innovations among participating systems.The SMP-CAIL2020-Argmine data set and baseline modelshave been already released. | Jian Yuan Zhongyu Wei Yixu Gao Wei Chen Yun Song Donghua Zhao Jinglei Ma Zhen Hu Shaokun Zou Donghai Li Xuanjing Huang | 2021 | Data Intelligence2021，3，2： | 3 |
| 6 | Ultralong cycle life enabled by in situ growth of CoMo_(1-x)P/Mo heterostructure for lithium-sulfur batteries显示文摘Lithium-sulfur batteries(Li-S batteries) are considered as promising new-generation electrochemical energy storage devices due to their extremely high theoretical energy density(2600 Wh kg-1) and theoretical specific capacity(1675 m Ah g^(-1)). However, numerous problems such as poor conductivity and the shuttle effect during discharge-charge process limit the practical application of lithium-sulfur batteries. In this work, porous tubular Co Mo_(1-x)P/Mo constructed by in situ growth of metal Mo was designed as the sulfur host for lithium-sulfur batteries. The introduction of Mo modulated the electronic structure of Co Mo P to improve the conductivity of cathode and facilitate the redox kinetics, as well as the Co Mo_(1-x)P/Mo heterostructure was beneficial to inhibit the shuttle effect through the interaction with lithium polysulfides, which improved cycling stability. As a result, Co Mo_(1-x)P/Mo/S cathode had a low-capacity decay rate of only 0.029% per cycle after 2000 cycles at 0.5 C. This work provided a new perspective for the further design of high-performance lithium-sulfur battery cathode materials. | Donghua Guo Mengwei Yuan Xingzi Zheng Miaomiao Li Caiyun Nan Genban Sun Xianqiang Huang Huifeng Li | 2022 | Journal of Energy Chemistry2022，31，10： | 2 |
| 7 | Effects of simvastatin on early oxidative stress and endothelial function in apolipoprotein E-deficient mice显示文摘Objective:To investigate the mechanisms that Simvastatin,a 3-hydroxy-3-methylglutaryl coenzyme A(HMG-CoA) reductase inhibitor,plays an important role in primary prevention of atherosclerosis independently of its lipid-lowering effect in Apolipoprotein E-deficient mice in the early stage of atherosclerosis.Methods:Twenty-four 6-week old male apoE-deficient mice were randomly divided into two groups:control group(normal saline) and treatment group[simvastatin(5 mg/(kg·d))].Simvastatin was administered to treatment group mice by gavage and the same volume of normal saline was administered to control group mice by the same method for 2 or 4 weeks.Total cholesterol(TC),super-oxide dismutase(SOD),malondialdehyde(MDA) and serum nitric oxide(NO) were measured by bio-chemical analysis.Results:There was no significant difference in serum TC between control and treatment groups.Compared with the control's,the effects of simvastatin were more significant in decreasing serum MDA level(P < 0.01 vs control's at 2-week;P < 0.006 vs control's at 4-week),increasing serum SOD level(P < 0.03 vs control's at 2-week;P < 0.003 vs control's at 4-week) and NO level(P < 0.01 control's at 2-week;P < 0.001 vs control's at 4-week) either at 2 or 4 weeks.Conclusion:Simvastatin attenuates oxidative stress and protects endothelial function by the mechanisms of decreasing serum MDA level,increasing serum SOD level and NO level ,which were inconsistent with its cholesterol-lowering effect.It may play an important role in primary(if not all) prevention of atherosclerosis and might be independent of lipid-regulation mechanism. | Donghua Yin Meng Liu Guoping Yang Jun Huang Ming Gui | 2007 | Journal of Nanjing Medical University2007，21，6： | 2 |
| 8 | Thermal behaviors and growth of reduced ferronickel particles in carbon-laterite composites显示文摘The thermal behaviors of single laterite ore and graphite-laterite mixtures were investigated by thermogravimetry (TG), derivative thermo-gravimetry (DTG), and differential thermal analysis (DTA). Four mass loss steps maximized at about 78, 272, 583, and 826°C are observed for the laterite ore, representing the vaporization of free water, the dehydroxylation of goethite, the decomposition of serpentines, and the second dehydroxylation of serpentines, respectively. The reduction reactions of the graphite-laterite mixtures start at around 700°C and can be divided into three major temperature regions. Coal-laterite composites with an addition of 10 wt.% CaO were roasted at 1100-1350°C for 30 min, and the reduced samples were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The results indi-cate that the reduction reactions proceed more completely at higher temperatures. The growth of the reduced ferronickel particles is greatly influenced by the roasting temperature. Obvious growth of the reduced ferronickel particles appears with the formation of worm-like crystals for the sample reduced at 1250°C, and spheric particles are observed for the sample reduced at 1300°C. When the reduction temperature in-creases to 1350°C, the reduced ferronickel particles agglomerate to ferronickel granules of 3-8 mm in diameter. The main elements in the granules include iron, nickel, chromium, carbon, and sulfur, with the content of nickel and that of iron of 9.08 wt.% and 85.21 wt.%, respec-tively. | HUANG Donghua ZHANG Jianliang MAO Rui CAO Mingming | 2011 | Rare Metals2011，30，6： | 2 |
| 9 | Diagnosis of coronary artery disease using targeted post-mortem computed tomography coronary angiography:a case report显示文摘Targeted post-mortem computed tomography(PMCT)combined with coronary angiography has the potential to play a significant role in the investigation of sudden cardiac death.The authors utilized a targeted PMCT coronary angiography in a case involving a 53-year-old man who died from acute myocardial ischemia and cardiac decompensation which may result from coronary artery disease(CAD).The victim collapsed suddenly at work and died soon after arrival to hospital.The body was examined using PMCT and targeted PMCT coronary angiography.The left anterior descending coronary artery exhibited 75%-100%stenosis in the middle segment;however,the distal segment could not be clearly visualized.In addition,the left circumflex and right coronary artery exhibited calcification,atherosclerosis and an area of 50% stenosis.Signs of cardiogenic pulmonary oedema were also identified.The imaging results suggested that this individual had coronary atherosclerosis and probably died from CAD.The autopsy and histological examination revealed acute myocardial ischemia and myocardial scarring,confirming the cause of death while excluding other probabilities.In summary,targeted post-mortem computed tomography angiography(PMCTA)can visualize the arteries and estimate the degree of principal pathological changes.This method is a simple,reliable and sensitive technique for identifying the presence of coronary atherosclerosis.It is a valuable post-mortem forensic imaging method and should be recommended in the investigation of suspicious cardiac deaths. | Lei Wan Yu Shao Donghua Zou Ping Huang Zhengdong Li Maowen Wang Yijiu Chen | 2017 | Forensic Sciences Research2017，2，2： | 2 |
| 10 | Proper animal experimental designs for preclinical research of biomaterials for intervertebral disc regeneration显示文摘Low back pain is a vital musculoskeletal disease that impairs life quality,leads to disability and imposes heavy economic burden on the society,while it is greatly attributed to intervertebral disc degeneration(IDD).However,the existing treatments,such as medicines,chiropractic adjustments and surgery,cannot achieve ideal disc regeneration.Therefore,advanced bioactive therapies are implemented,including stem cells delivery,bioreagents administration,and implantation of biomaterials etc.Among these researches,few reported unsatisfying regenerative outcomes.However,these advanced therapies have barely achieved successful clinical translation.The main reason for the inconsistency between satisfying preclinical results and poor clinical translation may largely rely on the animal models that cannot actually simulate the human disc degeneration.The inappropriate animal model also leads to difficulties in comparing the efficacies among biomaterials in different reaches.Therefore,animal models that better simulate the clinical charateristics of human IDD should be acknowledged.In addition,in vivo regenerative outcomes should be carefully evaluated to obtain robust results.Nevertheless,many researches neglect certain critical characteristics,such as adhesive properties for biomaterials blocking annulus fibrosus defects and hyperalgesia that is closely related to the clinical manifestations,e.g,low back pain.Herein,in this review,we summarized the animal models established for IDD,and highlighted the proper models and parameters that may result in acknowledged IDD models.Then,we discussed the existing biomaterials for disc regeneration and the characteristics that should be considered for regenerating different parts of discs.Finally,well-established assays and parameters for in vivo disc regeneration are explored. | Yizhong Peng Xiangcheng Qing Hongyang Shu Shuo Tian Wenbo Yang Songfeng Chen Hui Lin Xiao Lv Lei Zhao Xi Chen Feifei Pu Donghua Huang Xu Cao Zengwu Shao | 2021 | Biomaterials Translational2021，2，2： | 2 |
| 11 | Equity of Accessibility to Health Care Services and Identification of Underserved Areas显示文摘Characterizing the availability of opportunities to residents has been a long-term aim in health care geographic investigation.It is important to measure the degree of inequity in health care accessibility and to identify underserved areas, due to the uneven distribution of health care services. In this study, JavaScript was used to calculate travel time based on Amap, as this can provide a more reliable data support to measure the health care accessibility in Xi’an communities, China. Based on the overall equity, herein, an attempt was made to quantify the equity of health care accessibility, and to identify health care underserved areas inside the different communities. Results show that the accessibility to low-level health care services is high in the northern areas and low in the southern areas, while the accessibility to high-level and comprehensive health care services shows a clear core-periphery spatial structure. Moreover, the overall equity of the health care accessibility is relatively low, and the inequity of high-level health care accessibility is further aggravated.Furthermore, the quantified equity of accessibility to high-level and comprehensive health care services in the central urban areas is better;however low-level health care services are relatively inadequate. There are significant differences among health care underserved areas, in particular, for the worst equity and the lowest accessibility areas(A1) and the worse equity and the lowest accessibility areas(B1) in high-level underserved areas. Notably, the sharing of health care services and the reasonable flow of health technical personnel among different levels of health institutions can make the high-level health care services in the central urban areas have a greater trickle effect on the surrounding areas. | WANG Donghua CAO Xiaoshu HUANG Xiaoyan | 2021 | Chinese Geographical Science2021，31，1： | 2 |
| 12 | Comparative Study of Outcome in Treating Upper Ureteral Impacted Stones Using Minimally Invasive Percutaneous Nephrolithotomy With Aid of Patented System or Transurethral Ureteroscopy显示文摘 | Zhongsheng Yang Leming Song Donghua Xie Min Hu Zuofeng Peng Tairong Liu Chuance Du Jiuqing Zhong Wen Qing Shulin Guo Lunfeng Zhu Lei Yao Jianrong Huang Difu Fan Zhangqun Ye | 2012 | Urology2012，，6： | 1 |
| 13 | Magnetic field of a tu-bular linear motor with special permanent magnet 显示文摘 | LI Liyi HUANG Xuzhen PAN Donghua | 2011 | IEEE Transactions on Plasma Science2011，39，1： | 1 |
| 14 | Identification and characterization of pltZ , a gene involved in the repression of pyoluteorin biosynthesis in Pseudomonas sp. M18显示文摘 | Xianqing Huang Donghua Zhu Yihe Ge Hongbo Hu Xuehong Zhang Yuquan Xu | 2004 | FEMS Microbiology Letters2004，，2： | 1 |
| 15 | Attachment, proliferation and differentiation of BMSCs on gas-jet/electrospun nHAP/PHB fibrous scaffolds显示文摘 | Donghua Guan Zhiqing Chen Chunpeng Huang Yinghe Lin | 2008 | Applied Surface Science2008，，2： | 1 |
| 16 | Decellularized Disc Hydrogels for hBMSCs tissue-specific differentiation and tissue regeneration显示文摘Tissue specificity,a key factor in the decellularized tissue matrix(DTM),has shown bioactive functionalities in tuning cell fate-e.g.,the differentiation of mesenchymal stem cells.Notably,cell fate is also determined by the living microenvironment,including material composition and spatial characteristics.Herein,two neighboring tissues within intervertebral discs,the nucleus pulposus(NP)and annulus fibrosus(AF),were carefully processed into DTM hydrogels(abbreviated DNP-G and DAF-G,respectively)to determine the tissue-specific effects on stem cell fate,such as specific components and different culturing methods,as well as in vivo regeneration.Distinct differences in their protein compositions were identified by proteomic analysis.Interestingly,the fate of human bone marrow mesenchymal stem cells(hBMSCs)also responds to both culturing methods and composition.Generally,hBMSCs cultured with DNP-G(3D)differentiated into NP-like cells,while hBMSCs cultured with DAF-G(2D)underwent AF-like differentiation,indicating a close correlation with the native microenvironments of NP and AF cells,respectively.Furthermore,we found that the integrin-mediated RhoA/LATS/YAP1 signaling pathway was activated in DAF-G(2D)-induced AF-specific differentiation.Additionally,the activation of YAP1 determined the tendency of NP-or AF-specific differentiation and played opposite regulatory effects.Finally,DNP-G and DAF-G specifically promoted tissue regeneration in NP degeneration and AF defect rat models,respectively.In conclusion,DNP-G and DAF-G can specifically determine the fate of stem cells through the integrin-mediated RhoA/LATS/YAP1 signaling pathway,and this tissue specificity is both compositional and spatial,supporting the utilization of tissue-specific DTM in advanced treatments of intervertebral disc degeneration. | Yizhong Peng Xiangcheng Qing Hui Lin Donghua Huang Jinye Li Shuo Tian Sheng Liu Xiao Lv Kaige Ma Rui Li Zilong Rao Ying Bai Songfeng Chen Ming Lei Daping Quan Zengwu Shao | 2021 | Bioactive Materials2021，6，10： | 1 |
| 17 | Reversal of cardiomyopathy in patients with congestive heart failure secondary to tachycardia显示文摘 | Zhao Donghua Peng Jian Xiao Zhongbo Zhang Feifei Peng Xinhui Yang Hao Liu Fuqiang Li Yan Xie Yong Huang Xinfu Meng Surong Wu Muli Xu Dingli | 2013 | Journal of Interventional Cardiac Electrophysiology2013，，： | 1 |
| 18 | A two-year follow-up for Chinese patients with abdominal aortic aneurysm undergoing open/endovascular repair显示文摘 | Sun Tao Zhang Hongju Cheng Yutong Wang Su Tao Ying Zhang Donghua Huang Ji Zhang Jingmei Li Zhizhong | 2014 | Chinese Medical Journal2014，，3： | 1 |
| 19 | Design, Selection and Application of High Efficient Complex Alloys显示文摘The design, selection and application principles of complex alloys according to the requirements of making low-alloy steels are discussed. The designed complex alloys containing calcium, barium, magnesium, strontium, rare earth elements, etc. should not only be able to deoxidize, desulphurize and refine liquid steel, but also alloy it. The application principles of alloys are as follows: using Si- Mn or Si-Mn-Al alloys for pre-deoxidizing, Si-Al-Ba or Si-Al-Ca-Ba alloys for final deoxidizing and Si-CaBa-Mg(Sr) alloys for refi- ning. | Jianliang Zhang, Donghua Huang, Zongwang Zhang, Zhanhui Yan, Xuefei Li, Qingsong Huang Metallurgy School, University of Science and Technology Beijing, Beijing 100083, China No. 2 Steelmaking Plant, Shougang Group, Beijing 100041, China | 2001 | Journal of University of Science and Technology Beijing2001，8，3： | 1 |
| 20 | Comparative Study of Outcome in Treating Upper Ureteral Impacted Stones Using Minimally Invasive Percutaneous Nephrolithotomy With Aid of Patented System or Transurethral Ureteroscopy显示文摘 | Zhongsheng Yang Leming Song Donghua Xie Min Hu Zuofeng Peng Tairong Liu Chuance Du Jiuqing Zhong Wen Qing Shulin Guo Lunfeng Zhu Lei Yao Jianrong Huang Difu Fan Zhangqun Ye | 2012 | Urology2012，，6： | 1 |
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