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| 1 | Reservoir reconstruction technologies for coalbed methane recovery in deep and multiple seams显示文摘Multiple coal seams widely develop in the deep Chinese coal-bearing strata. Ground in situ stress and coal seam gas pressure increase continuously with the increase of the mining depth, and coal and gas outburst disasters become increasingly severe. When the coal is very deep, the gas content and pressure will elevate and thus coal seams tends to outburst-prone seams. The safety and economics of exploited firstmined coal seams are tremendously restricted. Meanwhile, the multiple seams occurrence conditions resulted in different methane pressure systems in the coal-bearing strata, which made the reservoir reconstruction of coal difficult. Given the characteristics of low saturation, low permeability, strong anisotropy and soft coal of Chinese coal seams, a single hydraulic fracturing surface well for reservoir reconstruction to pre-drain the coalbed methane(CBM) of multiple seams concurrently under the different gas pressure systems has not yet gained any breakthroughs. Based on analyses of the main features of deep CBM reservoirs in China, current gas control methods and the existing challenges in deep and multiple seams, we proposed a new technology for deep CBM reservoir reconstruction to realize simultaneous high-efficiency coal mining and gas extraction. In particular, we determined the first-mined seam according to the principles of effectiveness and economics, and used hydraulic fracturing surface well to reconstruct the first-mined seam which enlarges the selection range of the first-mined seam. During the process of mining first-mined seam, adjacent coal seams could be reconstructed under the mining effect which promoted high-efficiency pressure relief gas extraction by using spatial and comprehensive gas drainage methods(combination of underground and ground CBM extraction methods). A typical integrated reservoir reconstruction technology, ‘‘One well for triple use', was detailed introduced and successfully applied in the Luling coal mine. The application showed that the proposed technology could effectively promote coal mining safety and simultaneously high-efficiency gas extraction. | Wang Liang Liu Shimin Cheng Yuanping Yin Guangzhi Zhang Dongming Guo Pinkun | 2017 | International Journal of Mining Science and Technology2017，27，2： | 10 |
| 2 | Uniformly grown PtCo-modified C03O4 nanosheets as a highly efficient catalyst for sodium borohydride electrooxidation显示文摘 | Congying Song Dongming Zhang Bin Wang Zhuang Cai Peng Yan Yang Sun Ke Ye Dianxue Cao Kui Cheng Guiling Wang | 2016 | Nano Research2016，9，11： | 5 |
| 3 | Reduced graphene oxide with a highly restored π-conjugated structure for inkjet printing and its use in all-carbon transistors显示文摘一部打印 inkjet 的 graphene 电影为下一代的灵活、低费用和高效是很重要的电子设备。由于打印过程的 inkjet 的限制,然而,打印 inkjet 的 graphene 电影的电的传导性被限制到 10 | Yang Su Jinhong Du Dongming Sun Chang Liu Huiming Cheng | 2013 | Nano Research2013，6，11： | 4 |
| 4 | Crystal structure of the African swine fever virus structural protein p35 reveals its role for core shell assembly显示文摘Dear Editor,The African swine fever(ASF)is a highly contagious hemorrhagic and lethal disease in domestic pigs.The ASF outbreaks of in many Asia countries,including China,Vietnam,Mongolia,and South Korea,have posed a huge threat to the pig indusry.In the attempt to stop ASF from spreading further in China's Mainland,more than 10 million pigs have been culled since August 2018.The causative agent for ASF is a DNA virus,African swine fever virus(ASFV).Although this deadly disease has been reported in Kenya nearly one hundred years ago,there has been no vaccine for protection from ASFV infection or effective treatments to cure ASF until now. | Guobang Li Dan Fu Guangshun Zhang Dongming Zhao Mingyu Li Xue Geng Dongdong Sun Yuhui Wang Cheng Chen Peng Jiao Lin Cao Yu Guo Zihe Rao | 2020 | Protein & Cell2020，11，8： | 3 |
| 5 | Structure of African swine fever virus p15 reveals its dual role for membrane-association and DNA binding显示文摘Dear Editor, African swine fever (ASF) is a highly contagious disease of domestic pigs caused by African swine fever virus (ASFV),with mortality rates approaching 90%-100%.The first ASF case was described in 1921 in Kenya.Over the past decades, ASF has spread from Sub-Saharan Africa to Europe and Asia, and pose a huge threat to global food safety.Since the first ASF case reported in August 2018, more than 10 million pigs had been culled in China at an enormous economic loss.The risk of ASFV mutating to infect humans is extremely low.However, ASF not only threatens food security but also severely strikes the world economy in many fields, such as the global supply of the blood thinner heparin,most of which is produced from pigs.Hence, ASF is a strictly monitored infectious animal disease by OIE (World Organization for Animal Health), unfortunately, there is no approved drug or vaccine against this lethal viral disease. | Dan Fu Dongming Zhao Wei Zhang Guangshun Zhang Mingyu Li Zheng Zhang Yuhui Wang Dongdong Sun Peng Jiao Cheng Chen Yu Guo Zihe Rao | 2020 | Protein & Cell2020，11，8： | 3 |
| 6 | Genomic and transcriptomic analysis unveils population evolution and development of pesticide resistance in fall armyworm Spodoptera frugiperda显示文摘The fall armyworm(FAW),Spodoptera frugiperda,is a destructive pest native to America and has recently become an invasive insect pest in China.Because of its rapid spread and great risks in China,understanding of FAW genetic background and pesticide resistance is urgent and essential to develop effective management strategies.Here,we assembled a chromosome-level genome of a male FAW(SFynMstLFR)and compared re-sequencing results of the populations from America,Africa,and China.Strain identification of 163 individuals collected from America,Africa and China showed that both C and R strains were found in the American pop-ulations,while only C strain was found in the Chinese and African populations.Moreover,population geno-mics analysis showed that populations from Africa and China have close relationship with significantly genetic differentiation from American populations.Taken toge-ther,FAWs invaded into China were most likely origi-nated from Africa.Comparative genomics analysis displayed that the cytochrome p450 gene family is extremely expanded to 425 members in FAW,of which 283 genes are specific to FAW.Treatments of Chinese populations with twenty-three pesticides showed the variant patterns of transcriptome profiles,and several detoxification genes such as AOX,UGT and GST spe-cially responded to the pesticides.These findings will be useful in developing effective strategies for manage-ment of FAW in China and other invaded areas. | Furong Gui Tianming Lan Yue Zhao Wei Guo Yang Dong Dongming Fang Huan Liu Haimeng Li Hongli Wang Ruoshi Hao Xiaofang Cheng Yahong Li Pengcheng Yang Sunil Kumar Sahu Yaping Chen Le Cheng Shuqi He Ping Liu Guangyi Fan Haorong Lu Guohai Hu Wei Dong Bin Chen Yuan Jiang Yongwei Zhang Hanhong Xu Fei Lin Bernard Slippers Alisa Postma Matthew Jackson Birhan Addisie Abate Kassahun Tesfaye Aschalew Lemma Demie Meseret Destaw Bayeleygne Dawit Tesfaye Degefu Feng Chen Paul K.Kuria Zachary M.Kinyua Tong-Xian Liu Huanming Yang Fangneng Huang Xin Liu Jun Sheng Le Kang | 2022 | Protein & Cell2022，13，7： | 2 |
| 7 | Rapid phenotypic evolution with shallow genomic differentiation during early stages of high elevation adaptation in Eurasian Tree Sparrows显示文摘Known as the‘third polar region’,the Qinghai-Tibet Plateau represents one of the harshest highland environments in the world and yet a number of organisms thrive there.Previous studies of birds,animals and humans have focused on well-differentiated populations in later stages of phenotypic divergence.The adaptive processes during the initial phase of highland adaptation remain poorly understood.We studied a human commensal,the Eurasian Tree Sparrow,which has followed human agriculture to the Qinghai-Tibet Plateau.Despite strong phenotypic differentiation at multiple levels,in particular in muscle-related phenotypes,highland and lowland populations show shallow genomic divergence and the colonization event occurred within the past few thousand years.In a one-month acclimation experiment investigating phenotypic plasticity,we exposed adult lowland tree sparrows to a hypoxic environment and did not observe muscle changes.Through population genetic analyses,we identified a signature of polygenic adaptation,whereby shifts in allele frequencies are spread across multiple loci,many of which are associated with muscle-related processes.Our results reveal a case of positive selection in which polygenic adaptation appears to drive rapid phenotypic evolution,shedding light on early stages of adaptive evolution to a novel environment. | Yanhua Qu Chunhai Chen Ying Xiong Huishang She Yong E Zhang Yalin Cheng Shane DuBay Dongming Li Per G P Ericson Yan Hao Hongyuan Wang Hongfeng Zhao Gang Song Hailin Zhang Ting Yang Chi Zhang Liping Liang Tianyu Wu Jinyang Zhao Qiang Gao Weiwei Zhai Fumin Lei | 2020 | National Science Review2020，7，1： | 2 |
| 8 | Oxygen vacancy engineering of calcium cobaltate:A nitrogen fixation electrocatalyst at ambient condition in neutral electrolyte显示文摘In order to sustainably transform N2 to ammonia(NRR)using electrocatalysts under mild ambient condition,it is urgent to design and develop non-nobel metal nanocatalysts that are inexpensive and suitable for mass-production.Herein,a calcium metalate catalyst CaCoO_(x)with oxygen vacancies was synthesized and used as an electrocatalyst for NRR for the first time,whose morphology can be controlled by the calcination temperature and the heating rate.Under the optimal conditions,the CaCoO_(x)catalyst achieved the yield of nitrogen conversion to ammonia of 16.25μg·h^(-1)·mg_(cat.)^(-1)at the potential of-0.3 V relative to the reversible hydrogen electrode(RHE)with a Faraday efficiency of 20.51%.The electrocatalyst showed good stability even after 12 times recyclability under environmental conditions and neutral electrolyte.Later,the electrocatalytic nitrogen reduction performance of CaFeO_(x),CaNiO_(x),CaCuO_(x)was investigated.These earth-rich transition metals also exhibited certain NRR electrocatalytic capabilities,which provided a door for further development of inexpensive and easily available transition metal as nitrogen reduction electrocatalysts. | Xinyu Chen Ke Li Xiaoxuan Yang Jiaqi Lv Sai Sun Siqi Li Dongming Cheng Bo Li Yang-Guang Li Hong-Ying Zang | 2021 | Nano Research2021，14，2： | 2 |
| 9 | A DNA length reducing computing model for maximum independent set problem显示文摘In this paper, a new molecular computing model is developed to solve the maximum independent set problem, based on the method of DNA length reducing. To solve the maximum independent set problem with n-vertices and m-edges, the time complexity is O(n+m). With the enlargement of the problem scale, the numbers of the required tubes will increase linearly. Two important methods in this experiment are single strand DNA (ssDNA) circularization and DNA length reducing. In addition, using reverse polymerase chain reaction (PCR) and circligase, the structure of DNA molecules is changed in each computing step, transforming from linear double strand DNA (dsDNA) to linear ssDNA and circular ssDNA. Using the circular DNA structure, the recombina-tion among DNA molecules is avoided. To verify this computing model, a small maximum independent set problem was solved. | Zhang Cheng Yang Jing Xu Jin Zhao DongMing | 2010 | Chinese Science Bulletin2010，55，9： | 1 |
| 10 | Anti-catalytic and zincophilic layers integrated zinc anode towards efficient aqueous batteries for ultra-long cycling stability显示文摘Aqueous zinc-based battery is usually plagued by serious dendrites and side reactions including Zn corrosion and water decomposition on the anode.To address the drawbacks,constructing coating layers with high conductivity and anti-catalytic effects on hydrogen evolution reaction has been considered as an efficient strategy.Herein,cheap and abundant twodimensional(2D)conductive graphite(KS-6)coating layer with high electronic conductivity(~106 S·m^(−1))could directly form strong bonding with Zn foil due to high zincophilicity,which correspondingly protects Zn metal from liquid electrolyte to inhibit parasitic hydrogen evolution and guide uniform Zn electrodeposition during cycling.The KS-6 layer owns a profitable charge redistribution effect to endow Zn anode with a lower nucleation energy barrier and a more uniformly distributed electric field compared with bare Zn.Therefore,such integrated Zn anode exhibits low voltage hysteresis(~38 mV)and excellent cycling stability with dendrite-free behaviors(1 mA·cm^(−2)and 2 mAh·cm^(−2))over 2,000 h,far outperforming many reported Zn metal anodes in aqueous systems.Encouragingly,in light of the superior Zn@KS-6 anode,VNOx powders and Prussian blue analogs Mn_(2)Fe(CN)_(6)are applied as the cathode materials to assemble full batteries,which show remarkable cycling stabilities and high Coulombic efficiencies(CEs)over 200 cycles with capacity retention of 81.5%for VNOx//Zn@KS-6 battery and over 400 cycles with capacity retention of 94.6%for Mn_(2)Fe(CN)_(6)//Zn@KS-6 battery,respectively. | Chunli Wang Yuxing Gao Lianshan Sun Yuan Zhao Dongming Yin Hairui Wang Jingchao Cao Yong Cheng Limin Wang | 2022 | Nano Research2022，15，9： | 1 |
| 11 | Plastic supported platinum modified nickel electrode and its high electrocatalytic activity for sodium borohydride electrooxidation显示文摘A novel plastic/multi-walled carbon nanotube(MWNTs)-nickel(Ni)-platinum(Pt) electrode(PMNP) is prepared by chemical-reducing Pt onto the surface of Ni film covered plastic/MWNTs(PM) substrate. The MWNTs are adhered by a piece of commercial double faced adhesive tape on the surface of plastic paper and the Ni film is prepared by a simple electrodeposition method. The morphology and phase structure of the PMNP electrode are characterized by scanning electron microscopy,transmission electron microscope and X-ray diffractometer. The catalytic activity of the PMNP electrode for Na BH4 electrooxidation is investigated by means of cyclic voltammetry and chronoamperometry. The catalyst combines tightly with the plastic paper and exhibits a good stability. MWNTs serve as both conductive material and hydrogen storage material and the Ni film and Pt are employed as electrochemical catalysts. The PMNP electrode exhibits a high electrocatalytic performance and the oxidation current density reaches to 10.76 A/(mg·cm) in 0.1 mol/dm3 Na BH4at0 V,which is much higher than those in the previous reports. The using of waste plastic reduces the discarding of white pollution and consumption of metal resources. | Bin Wang Dongming Zhang Ke Ye Kui Cheng Dianxue Cao Guiling Wang Xiaoli Cheng | 2015 | Journal of Energy Chemistry2015，24，4： | 1 |
| 12 | Restricted Representations of 显示文摘 | | 2000 | Algebra Colloquium2000，7，4： | 1 |
| 13 | Restricted Representations of Ut(sl2) 显示文摘 | Cheng Dongming | 2000 | Algebra Cooq2000，7，4： | 1 |
| 14 | Stabilization of high-voltage layered oxide cathode by utilizing residual lithium to form NASICON-type nanoscale functional coating显示文摘High-voltage medium-nickel low-cobalt lithium layered oxide cathode materials are becoming a popular development route for high-energy lithium-ion batteries due to their relatively high capacity,low cost,and improved safety.Unfortunately,capacity fading derived from surface lithium residue,electrode-electrolyte interfacial side reactions,and bulk structure degradation severely limits large-scale commercial utilization.In this work,an ultrathin and uniform NASICON-type Li_(3)V_(2)(PO_(4))_(3)(LVP)nanoscale functional coating is formed in situ by utilizing residual lithium to enhance the lithium storage performance of LiNi_(0.6)Co0.05Mn_(0.35)O_(2)(NCM)cathode.The GITT and ex-situ EIS and XPS demonstrate exceptional Li+diffusion and conductivity and attenuated interfacial side reactions,improving the electrode-electrolyte interface stability.The variable temperature in-situ XRD demonstrates delayed phase transition temperature to improve thermal stability.The battery in-situ XRD displays the singlephase H1-H2 reaction and weakened harmful H3 phase transition,minimizing the bulk mechanical degradation.These improvements are attributed to the removal of surface residual lithium and the formation of NASICON-type Li_(3)V_(2)(PO_(4))_(3)functional coatings with stable structure and high ionic and electronic conductivity.Consequently,the obtained NCM@LVP delivers a higher capacity retention rate(97.1%vs.79.6%)after 150 cycles and a superior rate capacity(87 mAh·g^(-1)vs.58 mAh·g^(-1))at a 5 C current density than the pristine NCM under a high cut-off voltage of 4.5 V.This work suggests a clever way to utilize residual lithium to form functional coatings in situ to improve the lithium storage performance of high-voltage medium-nickel low-cobalt cathode materials. | Yabin Shen Yingqiang Wu Dongyu Zhang Yao Liang Dongming Yin Limin Wang Licheng Wang Jingchao Cao Yong Cheng | 2023 | Nano Research2023，16，4： | 1 |
| 15 | Multidimensional regulation of Ti-Zr-Cr-Mn hydrogen storage alloys via Y partial substitution显示文摘High density and safe storage of hydrogen are the preconditions for the large-scale application of hydrogen energy.Herein,the hydrogen storage properties of Ti_(0.6)Zr_(0.4)Cr_(0.6)Mn_(1.4) alloys are systematically studied by introducing Y element instead of Ti element through vacuum arc melting.After the partial substitution of Y,a second phase of rare earth oxide is added in addition to the main suction hydrogen phase,C14 Laves phase.Thanks to the unique properties of rare earth elements,the partial substitution of Y can not only improve the activation properties and plateau pressure of the alloys,but also increase the effective hydrogen storage capacity of the alloys.The comprehensive properties of hydrogen storage alloys are improved by multidimensional regulation of rare earth elements.Among them,Ti_(0.552)Y_(0.048)Zr_(0.4)Cr_(0.6)Mn_(1.4) has the best comprehensive performance.The alloy can absorb hydrogen without activation at room temperature and 5 MPa,with a maximum hydrogen storage capacity of 1.98 wt.%.At the same time,it reduces the stability of the hydride and the enthalpy change value,making it easier to release hydrogen.Through theoretical analysis and first-principle simulation,the results show that the substitution of Y element reduces the migration energy barrier of hydrogen and the structural stability of the system,which is conducive to hydrogen evolution.The alloy has superior durability compared to the original alloy,and the capacity retention rate was 96.79%after 100 hydrogen absorption/desorption cycles. | Haixiang Xiu Wanqiang Liu Dongming Yin Nan Ding Wenfeng Qiao Shaolei Zhao Long Liang Cong Liu Shaohua Wang Qingshuang Wang Bingbing Chen Limin Wang Yong Cheng | 2024 | Nano Research2024，17，5： | 0 |
| 16 | Development of the cerebellar cortex in the mouse显示文摘The cerebellum is a highly conserved structure in the central nervous system of vertebrates,and is involved in the coordination of voluntary motor behavior.Supporting this function,the cerebellar cortex presents a layered structure which requires precise spatial and temporal coordination of proliferation,migration,differentiation,and apoptosis events.The formation of the layered structure in the developing cerebellum remains unclear.The present study investigated the development of the cerebellar cortex.The results demonstrate that the primordium of the cerebellum comprises the ependymal,mantle,and marginal layers at embryonic day 12(E12).Subsequently,the laminated cerebellar cortex undergoes cell proliferation,differentiation,and migration,and at about postnatal day 0(P0),the cerebellar cortex presents an external granular layer,a molecular layer,a Purkinje layer,and an internal granular layer.The external granular layer is thickest at P6/7 and disappears at P20.From P0 to P30,the internal granular cells and the Purkinje cells gradually differentiate and develop until maturity.Apoptotic neurons are evident in the layered structure in the developing cerebellar cortex.The external granular layer disappears gradually because of cell migration and apoptosis.The cells of the other layers primarily undergo differentiation,development,and apoptosis. | Xiangshu Cheng Jin Du Dongming Yu Qiying Jiang Yanqiu Hu Lei Wang Mingshan Li Jinbo Deng | 2011 | Neural Regeneration Research2011，6，4： | 0 |
| 17 | Investigation of the trajectory uniformity in water dissolution ultraprecision continuous polishing of large-sized KDP crystal显示文摘Large-sized potassium dihydrogen phosphate(KDP)crystals are an irreplaceable nonlinear optical component in an inertial confinement fusion project.Restricted by the size,previous studies have been aimed mainly at the removal principle and surface roughness of small-sized KDP crystals,with less research on flatness.Due to its low surface damage and high machining efficiency,water dissolution ultraprecision continuous polishing(WDUCP)has become a good technique for processing large-sized KDP crystals.In this technique,the trajectory uniformity of water droplets can directly affect the surface quality,such as flatness and roughness.Specifically,uneven trajectory distribution of water droplets on the surface of KDP crystals derived from the mode of motion obviously affects the surface quality.In this study,the material removal mechanism of WDUCP was introduced.A simulation of the trajectory of water droplets on KDP crystals under different eccentricity modes of motion was then performed.Meanwhile,the coefficient of variation(CV)was utilized to evaluate the trajectory uniformity.Furthermore,to verify the reliability of the simulation,some experimental tests were also conducted by employing a large continuous polisher.The results showed that the CV varied from 0.67 to 2.02 under the certain eccentricity mode of motion and varied from 0.48 to 0.65 under the uncertain eccentricity mode of motion.The CV of uncertain eccentricity is always smaller than that of certain eccentricity.Hence,the uniformity of trajectory was better under uncertain eccentricity.Under the mode of motion of uncertain eccentricity,the initial surface texture of the100 mm×100 mm×10 mm KDP crystal did achieve uniform planarization.The surface root mean square roughness was reduced to 2.182 nm,and the flatness was reduced to 22.013μm.Therefore,the feasibility and validity of WDUCP for large-sized KDP crystal were verified. | Zhipeng Cheng Hang Gao Ziyuan Liu Dongming Guo | 2020 | International Journal of Extreme Manufacturing2020，2，4： | 0 |
| 18 | Comparison between the Roles of Low-Level Jets in Two Heavy Rainfall Events over South China显示文摘Two heavy rainfall events occurred over the Pearl River Delta during 20-22 May 2020:the first was a warm-sector event and the second a frontal event.Based on ERA5 reanalysis data and observations from wind profilers and Doppler weather radars,the structures and roles of low-level jets(LLJs)during these two heavy rainfall events were analyzed.The results show that:(1)South China was affected by a low-level vortex and a low-level shear line during the two processes.The two heavy rainfall events were both associated with a synoptic-system-related low-level jet(SLLJ)and a boundary layer jet(BLJ).The coupling of the convergence at the exit of the BLJ and the divergence at the entrance of the SLLJ produced strong lifting for the warm-sector heavy rainfall,and the strong convergence between the LLJs and northerly winds as the cold front moved southwards was the main lifting reason for the frontal heavy rainfall.(2)The BLJ was the main transport of water vapor during the two processes.The coupling of the BLJ and SLLJ caused the water vapor convergence to be concentrated in the boundary layer during the first process,whereas the strong convergence between the LLJs and northerly winds led to the lower and middle troposphere having strong water vapor convergence during the second process.(3)During the period of these two heavy rainfall events,the lower and middle troposphere remained unstable.Further analysis show that the differences in the intensity,location,and direction between the BLJ and SLLJ resulted in the pseudo-equivalent potential temperature advection in the boundary layer being significantly larger than in the lower and middle troposphere,which compensated for the energy loss caused by heavy rainfall and maintained the convective instability.These findings add to our knowledge on the roles of LLJs in the pre-summer rainfall over South China. | Xinyu ZHOU Zhengquan CHENG Haowen LI Dongming HU | 2022 | Journal of Meteorological Research2022，36，2： | 0 |
| 19 | Recent Advances on Polyoxometalate-Based Ion-Conducting Electrolytes for Energy-Related Devices显示文摘Solid-state electrolytes have attracted considerable attention in new energyrelated devices due to their high safety and broad application platform.Polyoxometalates(POMs)are a kind of molecular-level cluster compounds with unique structures.In recent years,owing to their abundant physicochemical properties(including high ionic conductivity and reversible redox activity),POMs have shown great potential in becoming a new generation of solid-state electrolytes.In this review,an overview is investigated about how POMs have evolved as ion-conducting materials from basic research to novel solid-state electrolytes in energy devices.First,some expressive POM-based ion-conducting materials in recent years are introduced and classified,mainly inspecting their structural and functional relationship.After that,it is further focused on the application of these ionconducting electrolytes in the fields of proton exchange membranes,supercapacitors,and ion batteries.In addition,some properties of POMs(such as inherent dimension,capable of forming stable hydrogen bonds,and reversible bonding to water molecules)enable these functional POM-based electrolytes to be employed in innovative applications such as ion selection,humidity sensing,and smart materials.Finally,some fundamental recommendations are given on the current opportunities and challenges of POM-based ion-conducting electrolytes. | Dongming Cheng Ke Li Hongying Zang Jiajia Chen | 2023 | Energy & Environmental Materials2023，6，2： | 0 |
| 20 | Comparative transcriptomic and metabolomic analysis reveals pectoralis highland adaptation across altitudinal songbirds显示文摘Pectoralis phenotypic variation plays a fundamental role in locomotion and thermogenesis in highland birds.How-ever,its regulatory and metabolic mechanisms remain enigmatic to date.Here,we integrated phenomic,tran-scriptomic,and metabolomic approaches to determine muscle variation and its underpinning mechanisms across altitudinal songbirds.Phenomics confirmed that all highland birds had considerable increases in muscle oxidative capacity,capillarity,and mitochondrial abundance in our study.Correspondingly,transcriptomic analyses found that differentially expressed genes in phenotype-associated modules enriched for blood vessel,muscle structure development,and mitochondrial organization.Despite similar traits and functional enrichments across highland birds,different mechanisms drove their occurrence in high-altitude tree sparrow and 2 snowfinches.Importantly,a metabolic feature shared by all the 3 highland birds is the improvement in insulin sensitivity and glucose utilization through activating insulin signaling pathway,which is vital to increase muscle oxidative capacity and maintain metabolic homeostasis.Nevertheless,fatty acid biosynthesis and oxidation are enhanced in only 2 snowfinches which had a long evolutionary history on the high plateau,also differing from ketone body metabolism in recently introduced colonizer of the tree sparrow of the high plateau.Our study represents a vital contribution to reveal the regulatory and metabolic basis of pectoralis variation across altitudinal songbirds. | Ying XIONG Yan HAO Yalin CHENG Liqing FAN Gang SONG Dongming LI Yanhua QU Fumin LEI | 2022 | Integrative Zoology2022，17，6： | 0 |
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