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| 1 | Ulva prolifera green-tide outbreaks and their environmental impact in the Yellow Sea, China显示文摘The Ulva prolifera green tides in the Yellow Sea, China, which have been occurring since 2007, are a serious environmental problem attracting worldwide attention. Despite extensive research, the outbreak mechanisms have not been fully understood. Comprehensive analysis of anthropogenic and natural biotic and abiotic factors reveals that human activities, regional physicochemical conditions and algal physiological characteristics as well as ocean warming and biological interactions(with microorganism or other macroalgae) are closely related to the occurrence of green tides. Dynamics of these factors and their interactions could explain why green tides suddenly occurred in 2007 and decreased abruptly in 2017.Moreover, the consequence of green tides is serious. The decay of macroalgal biomass could result in hypoxia and acidification, possibly induce red tide and even have a long-lasting impact on coastal carbon cycles and the ecosystem. Accordingly, corresponding countermeasures have been proposed in our study for future reference in ecosystem management strategies and sustainable development policy. | Yongyu Zhang Peimin He Hongmei Li Gang Li Jihua Liu Fanglue Jiao Jianheng Zhang Yuanzi Huo Xiaoyong Shi Rongguo Su Naihao Ye Dongyan Liu Rencheng Yu Zongling Wang Mingjiang Zhou Nianzhi Jiao | 2019 | National Science Review2019，6，4： | 17 |
| 2 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 3 | Investigation and experimental validation of curcumin-related mechanisms against hepatocellular carcinoma based on network pharmacology显示文摘Objective:To determine the potential molecular mechanisms underlying the therapeutic effect of curcumin on hepatocellular carcinoma(HCC)by network pharmacology and experimental in vitro validation.Methods:The predictive targets of curcumin or HCC were collected from several databases.the identified overlapping targets were crossed with Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)analyses using the Database for Annotation,Visualization,and Integrated Discovery(DAVID)platform.Two of the candidate pathways were selected to conduct an experimental verification.The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide tetrazolium(MTT)assay was used to determine the effect of curcumin on the viability of Hep G2 and LO2 cells.The apoptosis and autophagy of Hep G2 cells were respectively detected by flow cytometry and transmission electron microscopy.Besides,western blot and real-time polymerase chain reaction(PCR)were employed to verify the p53 apoptotic pathway and adenosine 5’-monophosphate(AMP)-activated protein kinase(AMPK)autophagy pathway.Hep G2 cells were pretreated with pifithrin-α(PFT-α)and GSK690693 for further investigation.Results:The 167 pathways analyzed by KEGG included apoptosis,autophagy,p53,and AMPK pathways.The GO enrichment analysis demonstrated that curcumin was involved in cellular response to drug,regulation of apoptotic pathway,and so on.The in vitro experiments also confirmed that curcumin can inhibit the growth of Hep G2 cells by promoting the apoptosis of p53 pathway and autophagy through the AMPK pathway.Furthermore,the protein and messenger RNA(m RNA)of the two pathways were downregulated in the inhibitor-pretreated group compared with the experimental group.The damage-regulated autophagy modulator(DRAM)in the PFT-α-pretreated group was downregulated,and p62 in the GSK690693-pretreated group was upregulated.Conclusions:Curcumin can treat HCC through the p53 apoptotic pathway and the AMPK/Unc-51-like kinase 1(ULK1)autophagy pathway,in which the mutual transformation of autophagy and apoptosis may occur through DRAM and p62. | Yang CHEN Qian LI Sisi REN Ting CHEN Bingtao ZHAI Jiangxue CHENG Xiaoyan SHI Liang SONG Yu FAN Dongyan GUO | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，8： | 3 |
| 4 | Enriched Opportunistic Pathogens Revealed by Metagenomic Sequencing Hint Potential Linkages between Pharyngeal Microbiota and COVID-19显示文摘As a respiratory tract virus,SARS-CoV-2 infected people through contacting with the upper respiratory tract first.Previous studies indicated that microbiota could modulate immune response against pathogen infection.In the present study,we performed metagenomic sequencing of pharyngeal swabs from eleven patients with COVID-19 and eleven Non-COVID-19 patients who had similar symptoms such as fever and cough.Through metagenomic analysis of the above two groups and a healthy group from the public data,there are 6502 species identified in the samples.Specifically,the Pielou index indicated a lower evenness of the microbiota in the COVID-19 group than that in the Non-COVID-19 group.Combined with the linear discriminant analysis(LDA)and the generalized linear model,eighty-one bacterial species were found with increased abundance in the COVID-19 group,where 51 species were enriched more than 8 folds.The top three enriched genera were Streptococcus,Prevotella and Campylobacter containing some opportunistic pathogens.More interestingly,through experiments,we found that two Streptococcus strains,S.suis and S.agalactiae,could stimulate the expression of ACE2 of Vero cells in vitro,which may promote SARS-CoV-2 infection.Therefore,these enriched pathogens in the pharynxes of COVID-19 patients may involve in the virus-host interactions to affect SARS-CoV-2 infection and cause potential secondary bacterial infections through changing the expression of the viral receptor ACE2 and/or modulate the host’s immune system. | Dongyan Xiong Caroline Muema Xiaoxu Zhang Xinming Pan Jin Xiong Hang Yang Junping Yu Hongping Wei | 2021 | Virologica Sinica2021，36，5： | 3 |
| 5 | Static behavior of multi-stud shear connectors for steel-concrete composite bridge显示文摘 | Dongyan Xue Yuqing Liu Zhen Yu Jun He | 2012 | Journal of Constructional Steel Research2012，，： | 2 |
| 6 | Static behavior of multi-stud shear connectors for steel-concrete composite bridge显示文摘 | XUE Dongyan LIU Yuqing YU Zhen | 2012 | Journal of Constructional Steel Research2012，74，： | 1 |
| 7 | Impacts of El Nino on the somatic condition of Humboldt squid based on the beak morphology显示文摘The Humboldt squid Dosidicus gigas has a short life span, and environmental variability plays a significant role in regulating its population dynamics and distribution. An analysis of 1 096 samples of D. gigas collected by the Chinese commercial fishing vessels during 2013, 2014, and 2016 off the Peruvian Exclusive Economic Zone, was conducted to evaluate the impacts of El Nino events on the somatic condition of D. gigas. This study indicates that the slopes of all beak variables in relation to mantle length (ML) for females were greater than those of males during 2013, 2014, and 2016, and slopes of the upper crest length and the lower rostrum length significantly differed between females and males in 2013 (P<0.05). Variation in the slopes for beak variables among years was studied;no significant difference was observed (ANCOVA, P>0.05). The Fulton's condition coefficients (K) of females and males in 2013 and 2014 were significantly greater than those in 2016 (P<0.01). The K values of females were greater than those of males in 2013, 2014, and 2016, and K values significantly differed between females and males in 2013. In normal years, the chlorophyll a (Chl a) concentration showed an N-shaped variability from January to December. However, in the El Nino period, it tended to weaken the upwelling coupled with warm and low Chl a concentration waters. We suggest that the poor somatic condition of D. gigas during the El Nino year was resulted from the low Chl a concentration in the waters, and the abundance of D. gigas would decrease due to the unfavourable environment and the lack of prey items in the El Nino year. | HU Guanyu YU Wei LI Bai HAN Dongyan CHEN Xinjun CHEN Yong LI Jianhua | 2019 | Journal of Oceanology and Limnology2019，37，4： | 1 |
| 8 | Transcriptional regulation of selenium-dependent glutathione peroxidase from Venerupis philippinarum in response to pathogen and contaminants challenge显示文摘 | Linbao Zhang Xiaoli Liu Leilei Chen Liping You Dong Pei Ming Cong Jianmin Zhao Chenghua Li Dongyan Liu Junbao Yu Huifeng Wu | 2011 | Fish and Shellfish Immunology2011，，6： | 1 |
| 9 | Static behavior of multi-stud shear connectors for steel-concrete composite bridge 显示文摘 | XUE Dongyan LIU Yuqing YU Zhen | 2012 | Journal of Constructional Steel Research2012，74，： | 1 |
| 10 | Transcriptional regulation of selenium-dependent glutathione peroxidase from Venerupis philippinarum in response to pathogen and contaminants challenge显示文摘 | Linbao Zhang Xiaoli Liu Leilei Chen Liping You Dong Pei Ming Cong Jianmin Zhao Chenghua Li Dongyan Liu Junbao Yu Huifeng Wu | 2011 | Fish and Shellfish Immunology2011，，6： | 1 |
| 11 | Antibody Response to COVID-19 Virus--Heilongjiang Province and Gansu Province,China,2020显示文摘What is already known about this topic?Coronavirus disease 2019(COVID-19)has become a global pandemic,while the profile of antibody response against the COVID-19 virus has not been well clarified.What is added by this report?In this study,210 serum samples from 160 confirmed COVID-19 cases with different disease severities were recruited.The IgM,IgA,IgG,and neutralizing antibodies(NAb)against COVID-19 virus were determined.Our findings indicated that four antibodies could be detectable at low levels within 2 weeks of disease onset,then rapidly increasing and peaking from the 3^(rd) to 5^(th) Weeks.NAb decreased between 5^(th) and 9^(th) Weeks,and a higher IgM/IgA level was observed in the groups with mild/moderate severity within 2 weeks(p<0.05),while all 4 types of antibodies were higher in the group with severe/critical severity after 4 weeks(p<0.05).What are the implications for public health practice?Our study on the dynamics of serological antibody responses against COVID-19 virus among COVID-19 patients complements the recognition regarding the humoral immune response to COVID-19 virus infection.The findings will help in the interpretation of antibody detection results for COVID-19 patients and be beneficial for the evaluation of vaccination effects. | Naiying Mao Zhen Zhu Shuangli Zhu Deshan Yu Jun Xu Aili Cui Lei Cao Jinyuan Guo Huiling Wang Dongyan Wang Dongmei Yan Yang Song Qian Yang Zhongyi Jiang Hui Zhang Chang Shu Ming Yang Yanhai Wang Jinbo Xiao Zhenzhi Han Yong Zhang Yan Zhang Wenbo Xu | 2020 | China CDC weekly2020，2，34： | 1 |
| 12 | Photolu mineseenee properties and energy transfer in color tunable BaY2Si3O10 :Ce,Tb phosphors显示文摘 | Zhanggen Xia Yujun Liang Dongyan Yu | 2014 | Optics & Laser Tech- nology2014，5，： | 1 |
| 13 | Advanced glycation end-products change placental barrier function and tight junction in rats with gestational diabetes mellitus via the receptor for advanced glycation end products/nuclear factor-κB pathway显示文摘The placenta plays an important role in nutrient transport to maintain the growth and development of the embryo.Gestational diabetes mellitus(GDM),the most common complication during pregnancy,highly affects placental function in late gestation.Advanced glycation end-products(AGEs),a complex and heterogeneous group of compounds engaged by the receptor for AGEs(RAGE),are closely associated with diabetes-related complications.In this study,AGEs induced a decrease in the expression of tight junction(TJ)proteins in BeWo cells and increased the paracellular permeability of trophoblast cells by regulating RAGE/NF-κB.Sprague-Dawley(SD)rats injected with 100 mg/kg AGEs-rat serum albumin(RSA)via the tail vein from embryo day 2 were set as the placental barrier dysfunction model group(n=10).The effect of AGEs on placental permeability was determined using the Evans-Blue dye extravasation method.The ultrastructure of the placenta samples was observed by transmission electron microscopy.The effects of AGEs on the placenta were confirmed by treating rats with RAGE antagonist FPS-ZM1 and soluble forms of RAGE(sRAGE).AGEs treatment increased placental permeability and disrupted the tight junctions in pregnant rat placenta,but has no effect on blood glucose.The expression of TJ-related proteins,including ZO-1,Occludin,and Claudin 5,were downregulated after AGEs treatment.Further,AGEs treatment increased the expression of RAGE and nuclear factor-κB in the placenta of rats and upregulated the levels of vascular endothelial growth factor.The effects of AGEs on the placenta were blocked by RAGE antagonist FPS-ZM1 and sRAGE.This study demonstrates the mechanism underlying AGEs-induced disturbance in placental function in pregnant rats and highlights the potential of AGEs in the treatment of GDM. | YUEHUA SHI QIUYING YAN QIN LI WEI QIAN DONGYAN QIAO DONGDONG SUN HONG YU | 2023 | BIOCELL2023，47，1： | 0 |
| 14 | Expression Regulation of Starch and Storage Protein Synthesis Related Genes in Rice Grains显示文摘Starch and the storage proteins are the main nutritious substances in crop grains,and their composition and content in grains play a decisive role in the grain quality of rice and other staple food crops.This review has mainly summarized the new advances in the expression regulation of starch and storage protein synthesis related genes in rice grains.Moreover,the challenges of the starch and storage protein synthesis substances in rice genetic improvement were also discussed.This review will provide important information for genetic improvement of grain quality in rice and,potentially,other staple cereals. | Bo PENG Dongyan KONG Yu PENG Lulu HE Yue JIANG Jingbo YU Mengshi SUN Qin DAI Yuchen LIU Qingqing XIN Ruihua PANG Yanfang SUN Xiaohua SONG Huilong LI Juan PENG Qiying ZHOU Jintao LI Quanxiu WANG Bin DUAN Shizhi SONG Hongyu YUAN | 2019 | Asian Agricultural Research2019，11，1： | 0 |
| 15 | Effects of Standardized Rehabilitation on Quality of Life of Stroke Patients at Convalescence and Sequelae Stages显示文摘Objective:To explore the effects of standardized rehabilitation on quality of life (QOL) of stroke patients at convalescence and sequelae stages. Method:A total of 251 stroke patients were randomly divided into a standardized rehabilitation group and a control group. The simplified Fugl-Meyer assessment(FMA) scale, the 36-item short-form health survey questionnaire (SF-36) and functional comprehensive assessment (FCA) were administered before as well as after 3, 6 and at 12 months a follow-up study respectively. Statistical analysis was conducted based on the evaluations at 4 testing time points. Result:There was no significant difference in FMA,SF-36 and FCA scores of the two groups before and after 3 months treatments, while FMA,SF-36 and FCA scores of the rehabilitation group were obviously higher than those of the control group either after 6 months treatments or of followup study. Moreover, after 6 months treatments FMA score was apparently higher than the score at the beginning and after 3 months treatments. The FMA, SF36 and FAC scores during the followup visit decreased when compared with scores after 6 months treatments, but increased significantly when compared with the scores at the beginning and after 3 months treatments. Conclusion:Standardized tertiary rehabilitation (STR) at convalescence and sequelae stages can significantly improve motor functions and QOL of stroke patients. | XU Dongyan JIA Jie WU Yi LI Mingfen XIE Hongyu YU Kewei GUO Zhenzhen | 2013 | 中国康复医学杂志2013，28，6： | 0 |
| 16 | Theory of the Solution of Inventive Problems (TRIZ) and Computer Aided Design (CAD) for Micro-electro-mechanical Systems (MEMS)显示文摘Satellite remote sensing technology[1] is widely used in all walks of life ,which plays an increasingly remarkable results in natural disasters(sudden and major).With more and more launch and application of high resolution satellite, the texture information in remote sensing imagery becomes much more abundant. In the age of big data, for the infrared remote sensor has short life, which annoys many people. In the packaging process, due to a difference in thermal expansion coefficients [2] between the flip-chip bonded MEMS device and the substrate, cooling after bonding can cause the MEMS to buckle. Combine TAIZ theory with the flexure design in CAD to solve the problem. It can be obtained that increasing fold length can reduce warpage. By solving the deformation problem of MEMS devices can facilitate the development of flip chip technology, and make for the further application of the TRIZ theory in the study of remote sensing equipment. | Huiling Yu Shanshan Cui Dongyan Shi Delin Fan Jie Guo | 2015 | 国际计算机前沿大会会议论文集2015，，1： | 0 |
| 17 | Knowledge Acquisition from Forestry Machinery Patent Based on the Algorithm for Closed Weighted Pattern Mining显示文摘The application of big data mining can create over a trillion dollars value. Patents contain a great deal of new technologies and new methods which have unique value in the product innovation. In order to improve the effectiveness of big data mining and aid the innovation of products of forestry machinery, the algorithm for closed weighted pattern mining is applied to acquire the function knowledge in the patents of forestry machinery. Compared with the other algorithms for mining patterns, the algorithm is more suitable for the characteristics of patent data. It not only takes into account the importance of different items to reduce the search space effectively, but also avoids achieving excessive uninteresting patterns below the premise that assures quality. The extensive performance study shows that the patterns which are mined by the closed weighted pattern algorithm are more representative and the acquired knowledge has more realistic application significance. | Huiling Yu Jie Guo Dongyan Shi Guangsheng Chen Shanshan Cui | 2015 | 国际计算机前沿大会会议论文集2015，，1： | 0 |
| 18 | Expression and Regulation of Plant Amino Acid Transporters and Their Application in Crop Genetic Improvement显示文摘Amino acid transporters( AATs) play an important role in transport process of various amino acids,which are indispensable in plant growth and development,while many putative AATs have been identified and the complete genomic sequences of the important plants have already been completed by splicing and assembling. There is still little knowledge about the expression,regulation and various biological functions of AATs in plants,including the major food crops. This study mainly reviewed the expression,regulation and various biological functions of AATs in plants,and the application of AATs in crop genetic improvement was also prospected. Thus,this review will provide important information for genetic improvement of staple food crops in plants. | Bo PENG Dongyan KONG Lulu HE Yu PENG Juan PENG Qingqing XIN Xiaohua SONG Yuchen LIU Yanfang SUN Ruihua PANG Huilong LI Guiying GUO Jintiao LI Quanxiu WANG Qiying ZHOU Shizhi SONG Bin DUAN Hongyu YUAN | 2019 | Agricultural Biotechnology2019，8，1： | 0 |
| 19 | Noninvasive Low-Frequency Pulsed Focused Ultrasound Therapy for Rheumatoid Arthritis in Mice显示文摘Rheumatoid arthritis(RA)is a common autoimmune disease characterized by chronic and progressive inflammation of the synovium.Focused ultrasound therapy is an increasingly attractive alternative for treating RA owing to its noninvasiveness;however,it remains unclear which immune subsets respond to ultrasound stimulation.In this study,we showed that spleen-targeted low-frequency pulsed focused ultrasound(LFPFU)effectively improved the severity of arthritis in an arthritis mouse model established in DBA/1J mice.Additionally,we performed in-depth immune profiling of spleen samples from RA mice,RA mice that underwent ultrasound therapy,and healthy controls using mass cytometry along with extensive antibody panels and identified the immune composition of 14 cell populations,including CD4^(+)/CD8^(+)T cells,B cells,natural killer cells,and dendritic cells.Moreover,multidimensional analysis according to cell-surface markers and phenotypes helped in identifying 4 and 5 cell subpopulations among T and myeloid cells,respectively,with 6 T cell subsets and 3 myeloid cell subsets responsive to ultrasound therapy among the 3 groups.Of these cell subsets,CD8^(+)T cell subsets showed a unique response to ultrasound stimulation in RA mice.Specifically,CD8^(+)T cells show a noticeable correlation with the degree of arthritis progression and could serve as an indicator for spleen-focused ultrasound-based therapy.Furthermore,single-cell RNA sequencing of spleen cells revealed the importance of T,B,and myeloid cell populations in the anti-inflammatory pathway.These results elucidated the unique cell subsets and transcriptome of splenic cells responsive to LFPFU and demonstrated the potential of spleen-focused ultrasound stimulation in the treatment of inflammatory diseases. | Xuqiao Hu Fei Li Jieying Zeng Zhenru Zhou Zhaoyang Wang Jing Chen Dongyan Cao Yifan Hong Laixin Huang Yongsheng Chen Jinfeng Xu Fajn Dong Rongmin Yu Harong Zhen | 2023 | Research2023，，3： | 0 |
| 20 | Research on the influence of contact surface constraint on mechanical properties of rock-concrete composite specimens under compressive loads显示文摘The contact form of rock-concrete has a crucial influence on the failure characteristics of the stability of rock-concrete engineering.To study the influence of contact surface on the mechanical properties of rock-concrete composite specimens under compressive loads,the two different contact forms of rock-concrete composite specimens are designed,the mechanical properties of these two different specimens are analyzed under triaxial compressive condition,and analysis comparison on the stress-strain curves and failure forms of the two specimens is carried out.The influence of contact surface constraint on the mechanical properties of rock-concrete composite specimens is obtained.Results show that the stress and strain of rock-concrete composite specimens with contact surface constraint are obviously higher than those without.Averagely,compared with composite specimens without the contact surface,the existence of contact surface constraint can increase the axial peak stress of composite specimens by 24%and the axial peak strain by 16%.According to the characteristics of the fracture surface,the theory of microcrack development is used to explain the contact surface constraint of rock-concrete composite specimens,which explains the difference of mechanical properties between the two rock-concrete composite specimens in the experiment.Research results cannot only enrich the research content of the mechanics of rock contact,but also can serve as a valuable reference for the understanding of the corresponding mechanics mechanism of other similar composite specimens. | Baoyun ZHAO Yang LIU Dongyan LIU Wei HUANG Xiaoping WANG Guibao YU Shu LIU | 2020 | Frontiers of Structural and Civil Engineering2020，14，2： | 0 |
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