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1China's lakes at present:Number,area and spatial distribution显示文摘Based on 11004 satellite images from CBERS CCD and Landsat TM/ETM,changes in the spatial characteristics of all lakes in China were determined following pre-established interpretation rules.This dataset was supported by 6843 digital raster images(1:100000 and 1:50000),a countrywide digital vector dataset(1:250000),and historical literature.Comparative data were corrected for seasonal variations using precipitation data.There are presently 2693 natural lakes in China with an area greater than 1.0 km2,excluding reservoirs.These lakes are distributed in 28 provinces,autonomous regions and municipalities and have a total area of 81414.6 km2,accounting for-0.9% of China's total land area.In the past 30 years,the number of newly formed and newly discovered lakes with an area greater than 1.0 km2 is 60 and 131,respectively.Conversely,243 lakes have disappeared in this time period.MA RongHua YANG GuiShan DUAN HongTao JIANG JiaHu WANG SuMin FENG XueZhi LI AiNong KONG FanXiang XUE Bin WU JingLu LI ShiJie 2011Science China Earth Sciences2011,54,2:79
22018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up.Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu 2018Science Bulletin2018,63,23:54
3Berberine protects rat heart from ischemia/ reperfusion injury via activating JAK2/STAT3 signaling and attenuating endoplasmic reticulum stress显示文摘目的: Berberine (BBR ) ,从根茎 coptidis 孤立的导出 isoquinoline 的碱,施加 cardioprotective 效果。因为 endoplasmic 蜂窝胃(嗯)应力在导致的心肌的 ischemia/reperfusion ( MI/R )起一个枢轴的作用 apoptosis ,检验 BBR 的保护的效果是否源于 modulating 有趣嗯在 MI/R 损害期间强调层次,并且在这 process.Methods 定义发信号的机制:雄的老鼠与 BBR 被对待( 200 mg· ; kg −1·d−1, ig )为 2 个星期,然后使外科遭到了到 MI/R 。心脏的尺寸和功能用 echocardiography 被估计。心肌的梗塞尺寸和 apoptosis 被检验。在心织物的全部的浆液 LDH 层次和 CK 活动, superoxide 生产, MDA 层次和抗氧化剂草皮活动是坚定的。一在里面 vitro 学习在胚胎的导出心肌层的房间 H9C2 暴露了到模仿的 ischemia/reperfusion (先生) 的有教养的老鼠上被执行。apoptotic 的表达式,嗯压力相关、发信号的蛋白质用西方的污点 analyses.Results 被估计: 有 BBR 的预告的处理显著地减少了 MI/R-induced 心肌的梗塞尺寸,改进心脏的函数,和压制的心肌的 apoptosis 和氧化损坏。而且,有 BBR 的预告的处理压制了 MI/R-induced 嗯应力,证实了由下面调整心肌的津贴和 eIF2α 的 phosphorylation 层次;并且在心纸巾的 ATF4 和砍的表示。有 BBR 的预告的处理也激活与 AG490 在心纸巾,和合作处理表明小径的 JAK2/STAT3,一个特定的 JAK2/STAT3 禁止者,在 MI/R-induced 上堵住了 BBR 的 BBR,而且抑制的不仅保护的效果嗯应力。在 H9C2 房间,有 BBR 的处理(50 μ mol/L ) 显著地减少的导致先生的房间 apoptosis,氧化应力并且嗯应力,被 transfection 与 JAK2 siRNA.Conclusion 废除, BBR 改善在由激活表明小径和 attenuating 的 AK2/STAT3 的老鼠的 MI/R 损害嗯导致压力的 apoptosis。Guo-long ZHAO Li-ming YU Wen-li GAO Wei-xun DUAN Bo JIANG Xu-dong LIU Bin ZHANG Zhen-hua LIU Meng-en ZHAI Zhen-xiao JIN Shi-qiang YU Yun WANG 2016Acta Pharmacologica Sinica2016,37,3:47
4Noninvasive imaging of hepatocellular carcinoma: From diagnosis to prognosis显示文摘Hepatocellular carcinoma(HCC) is the most common primary liver cancer and a major public health problem worldwide. Hepatocarcinogenesis is a complex multistep process at molecular, cellular, and histologic levels with key alterations that can be revealed by noninvasive imaging modalities. Therefore, imaging techniques play pivotal roles in the detection, characterization, staging, surveillance, and prognosis evaluation of HCC. Currently, ultrasound is the first-line imaging modality for screening and surveillance purposes. While based on conclusive enhancement patterns comprising arterial phase hyperenhancement and portal venous and/or delayed phase wash-out, contrast enhanced dynamic computed tomography and magnetic resonance imaging(MRI) are the diagnostic tools for HCC without requirements for histopathologic confirmation. Functional MRI techniques, including diffusion-weighted imaging, MRI with hepatobiliary contrast agents, perfusion imaging, and magnetic resonance elastography, show promise in providing further important information regarding tumor biological behaviors. In addition, evaluation of tumor imaging characteristics, including nodule size, margin, number, vascular invasion, and growth patterns, allows preoperative prediction of tumor microvascular invasion and patient prognosis. Therefore, the aim of this article is to review the current state-of-the-art and recent advances in the comprehensive noninvasive imaging evaluation of HCC. We also provide the basic key concepts of HCC development and an overview of the current practice guidelines.Han-Yu Jiang Jie Chen Chun-Chao Xia Li-Kun Cao Ting Duan Bin Song 2018World Journal of Gastroenterology2018,24,22:37
5Structural changes of gut microbiota in Parkinson's disease and its correlation with clinical features显示文摘The aim of this study was to compare the structure of gut microbiota in Parkinson's disease(PD) patients and healthy controls;and to explore correlations between gut microbiota and PD clinical features. We analyzed fecal bacterial composition of 24 PD patients and 14 healthy volunteers by using 16 S rRNA sequencing. There were significant differences between PD and healthy controls, as well as among different PD stages. The putative cellulose degrading bacteria from the genera Blautia(P=0.018),Faecalibacterium(P=0.048) and Ruminococcus(P=0.019) were significantly decreased in PD compared to healthy controls.The putative pathobionts from the genera Escherichia-Shigella(P=0.038), Streptococcus(P=0.01), Proteus(P=0.022), and Enterococcus(P=0.006) were significantly increased in PD subjects. Correlation analysis indicated that disease severity and PD duration negatively correlated with the putative cellulose degraders, and positively correlated with the putative pathobionts. The results suggest that structural changes of gut microbiota in PD are characterized by the decreases of putative cellulose degraders and the increases of putative pathobionts, which may potentially reduce the production of short chain fatty acids, and produce more endotoxins and neurotoxins; and these changes is potentially associated with the development of PD pathology.Wei Li Xiaoli Wu Xu Hu Tao Wang Shan Liang Yunfeng Duan Feng Jin Bin Qin 2017Science China(Life Sciences)2017,60,11:26
6High salt primes a specific activation state of macrophages, M(Na)显示文摘Wu-Chang Zhang Xiao-Jun Zheng Lin-Juan Du Jian-Yong Sun Zhu-Xia Shen Chaoji Shi Shuyang Sun Zhiyuan Zhang Xiao-qing Chen Mu Qin Xu Liu Jun Tao Lijun Jia Heng-yu Fan Bin Zhou Ying Yu Hao Ying Lijian Hui Xiaolong Liu Xianghua Yi Xiaojing Liu Lanjing Zhang Sheng-Zhong Duan 2015Cell Research2015,25,8:15
7Progress of the key materials for organic solar cells显示文摘Organic solar cells have attracted academic and industrial interests due to the advantages like lightweight,flexibility and roll-to-roll fabrication.Nowadays,18%power conversion efficiency has been achieved in the state-of-the-art organic solar cells.The recent rapid progress in organic solar cells relies on the continuously emerging new materials and device fabrication technologies,and the deep understanding on film morphology,molecular packing and device physics.Donor and acceptor materials are the key materials for organic solar cells since they determine the device performance.The past 25 years have witnessed an odyssey in developing high-performance donors and acceptors.In this review,we focus on those star materials and milestone work,and introduce the molecular structure evolution of key materials.These key materials include homopolymer donors,D-A copolymer donors,A-D-A small molecular donors,fullerene acceptors and nonfullerene acceptors.At last,we outlook the challenges and very important directions in key materials development.Yang Tong Zuo Xiao Xiaoyan Du Chuantian Zuo Yuelong Li Menglan Lv Yongbo Yuan Chenyi Yi Feng Hao Yong Hua Ting Lei Qianqian Lin Kuan Sun Dewei Zhao Chunhui Duan Xiangfeng Shao Wei Li Hin-Lap Yip Zhengguo Xiaol Bin Zhang Qingzhen Bian Yuanhang Cheng Shengjian Liu Ming Cheng Zhiwen Jin Shangfeng Yang Liming Ding 2020Science China Chemistry2020,63,6:15
8Texture analysis on gadoxetic acid enhanced-MRI for predicting Ki-67 status in hepatocellular carcinoma: A prospective study显示文摘Objective: To investigate the value of whole-lesion texture analysis on preoperative gadoxetic acid enhanced magnetic resonance imaging(MRI) for predicting tumor Ki-67 status after curative resection in patients with hepatocellular carcinoma(HCC).Methods: This study consisted of 89 consecutive patients with surgically confirmed HCC. Texture features were extracted from multiparametric MRI based on whole-lesion regions of interest. The Ki-67 status was immunohistochemical determined and classified into low Ki-67(labeling index ≤15%) and high Ki-67(labeling index >15%) groups. Least absolute shrinkage and selection operator(LASSO) and multivariate logistic regression were applied for generating the texture signature, clinical nomogram and combined nomogram. The discrimination power, calibration and clinical usefulness of the three models were evaluated accordingly. Recurrence-free survival(RFS) rates after curative hepatectomy were also compared between groups.Results: A total of 13 texture features were selected to construct a texture signature for predicting Ki-67 status in HCC patients(C-index: 0.878, 95% confidence interval: 0.791-0.937). After incorporating texture signature to the clinical nomogram which included significant clinical variates(AFP, BCLC-stage, capsule integrity, tumor margin,enhancing capsule), the combined nomogram showed higher discrimination ability(C-index: 0.936 vs. 0.795,P<0.001), good calibration(P>0.05 in Hosmer-Lemeshow test) and higher clinical usefulness by decision curve analysis. RFS rate was significantly lower in the high Ki-67 group compared with the low Ki-67 group after curative surgery(63.27% vs. 85.00%, P<0.05).Conclusions: Texture analysis on gadoxetic acid enhanced MRI can serve as a noninvasive approach to preoperatively predict Ki-67 status of HCC after curative resection. The combination of texture signature and clinical factors demonstrated the potential to further improve the prediction performance.Zheng Ye Hanyu Jiang Jie Chen Xijiao Liu Yi Wei Chunchao Xia Ting Duan Likun Cao Zhen Zhang Bin Song 2019Chinese Journal of Cancer Research2019,31,5:11
9Isolated superior mesenteric artery dissection: case for conservative treatment and endovascular repair显示文摘WU Bin ZHANG Jian YIN Ming-di WANG Lei SONG Jin-qiu LI Xuan YANG Dong DUAN Zhi-quan XIN Shi-jie 2009Chinese Medical Journal2009,,2:10
10Two New Flavonoid Glycosides from Chrysanthemum morifolium显示文摘Two new flavonoid glycosides were isolated from the flowering heads of Chrysanthemum morifolium. Their structures were determined to be luteolin 4’-methoxy-7- O-(6'-O-acetyl)-β-D-glucopyranoside (1) and acacetin 7-O-(3'-O-acetyl)-β-D-glucopyranoside (2) by means of 1H and 13C NMR spectroscopic analysis, including 2D NMR technique.Jian ZHANG An Wei DING You Bin LI Da Wei QIAN Jin Ao DUAN Zhi Qi YIN 2006Chinese Chemical Letters2006,17,8:10
11Reversal of idiopathic hypogonadotropic hypogonadism: a cohort study in Chinese patients显示文摘尽管自发的 hypogonadotropic 性腺机能减退(IHH ) 传统地被看作了释放 gonadotropin 荷尔蒙神经原的缺乏引起的终生的疾病,病人的部分可以逐渐地在神经质的代替治疗期间重获正常的繁殖的轴功能。为潜在的 IHH 颠倒的预兆的因素大部分是未知的。我们的学习的目的是调查发生和颠倒了繁殖的轴功能的 IHH 男病人的临床的特征。在这回顾的队研究,男 IHH 病人被分类进一个颠倒组(n = 18 ) 并且一个 nonreversal 组(n = 336 ) 。gonadotropins 和睾丸激素的集中,以及睾丸尺寸和精子数,被决定。354 个 IHH 病人,(5.1%) 18 在治疗期间获得了正常繁殖功能。为颠倒的中部的年龄是 24 岁(范围 21-34 年) 。与 nonreversal 组相比,可逆的组有更高基础的 luteinizing 荷尔蒙(LH )(1.0 ±0.7 IU l -1 对 0.4 ±0.4 IU l −1, P <0.05 ) 并且刺激 LH (28.3 ±22.6 IU l −1 对 1.9 ±1.1 IU l −1, P <0.01 ) 层次,以及更大的睾丸尺寸(5.1 ±2.6 ml 对 1.5 ±0.3 ml, P <0.01 ) ,在起始的访问。在摘要,更大的睾丸尺寸和更高刺激的 LH 集中是为颠倒的喜爱的参数。我们发现建议可逆病人可以在起始的诊断保留部分活跃的繁殖的轴功能。Jiang-Feng Mao Hong-Li Xu Jin Duan Rong-Rong Chen Li Li Bin Li Min Nie Le Min Hong-Bing Zhang Xue-Yan Wu 2015Asian Journal of Andrology2015,17,3:9
12Epidemiology of Sepsis-3 in a sub-district of Beijing: secondary analysis of a population-based database显示文摘Background: With the publication of Sepsis-3 definition, epidemiological data based on Sepsis-3 definition from middle-income countries including China are scarce, which prohibits understanding of the disease burden of this newly defined syndrome in these settings. The purpose of this study was to describe incidence and outcome of Sepsis-3 in Yuetan sub-district of Beijing and to estimate the incidence rate of Sepsis-3 in China. Methods: The medical records of all adult residents hospitalized from July 1, 2012 to June 30, 2014 in Yuetan sub-district of Beijing were reviewed. Patients with sepsis-3 and severe sepsis/septic shock were identified. The incidence rates and mortality rate of sepsis-3 and sepsis/septic shock were calculated, incidence rates and in-hospital mortality rates were normalized to the population distribution in the 2010 National Census. Population incidence rate and case fatality rate between sexes were compared with the Z test, as the data conformed to Poisson distribution. Results: Of the 21,191 hospitalized patients, 935 patients were diagnosed with Sepsis-3, and 498 cases met severe sepsis/septic shock criteria. The crude annual incidence rate of Sepsis-3 in Yuetan sub-district was 363 cases per 100,000 population, corresponding to standardized incidence rates of 236 cases per 100,000 population per year, respectively. The overall case fatality rate of Sepsis-3 was 32.0%, the crude population mortality rates of Sepsis-3 was 116 cases per 100,000 population per year, the standardized mortality rate was 67 cases per 100,000 population per year, corresponding to a speculative extrapolation of 700,437 deaths in China. The incidence rate and mortality rate of Sepsis-3 were significantly higher in males, elderly people, and patients with more comorbidities. The 62.1% of patients with Sepsis-3 had community-acquired infections, compared with 75.3% of infected patients without Sepsis-3 (P < 0.001). The most common infection in patients with Sepsis-3 was lower respiratory tract infection. When compared with patients with Sepsis-3, patients diagnosed as severe sepsis/septic shock were more likely to have higher case fatality rate (53.4% vs. 32.0%, P < 0.001) Conclusions: This study found the standardized incidence rate of 236 cases per 100,000 person-year for Sepsis-3, which was more common in males and elderly population. This corresponded to about 2.5 million new cases of Sepsis-3 per year, resulting in more than 700,000 deaths in China.Hong-Cheng Tian Jian-Fang Zhou Li Weng Xiao-Yun Hu Jin-Min Peng Chun-Yao Wang Wei Jiang Xue-Ping Du Xiu-Ming Xi You-Zhong An Mei-Li Duan Bin Du 2019Chinese Medical Journal2019,,17:9
13A Retrospective Survival Analysis of Anatomic and Prognostic Stage Group Based on the American Joint Committee on Cancer 8th Edition Cancer Staging Manual in Luminal B Human Epidermal Growth Factor Receptor 2-negative Breast Cancer显示文摘Ling Xu Jiang-Hong Li Jing-Ming Ye Xue-Ning Duan Yuan-Jia Cheng Ling Xin Qian Liu Bin Zhou Yin-Hua Liu 2017Chinese Medical Journal2017,,16:9
14Establishing 1H nuclear magnetic resonance based metabonomics fingerprinting profile for spinal cord injury: a pilot study显示文摘背景针的绳索损害(SCI ) 是由包含的多重病理学的机制组成的一处复杂损伤细胞毒素,氧化应力并且免疫者内分泌。这研究试图建立用原子磁性的回声(NMR ) 基于的 1H 为 SCI 采指纹地图集的血浆 metabonomics metabonomics 方法论和主要部件分析 techniques.Methods 九 Sprague-Dawley (SD ) 男性老鼠随机被划分成 SCI,正常、假冒操作的控制组。血浆样品在操作以后被收集 1H NMR 光谱学 3 天。NMR 数据与 Matlab software.Results Metabonomics 分析用主要部件分析技术被分析能区分三个组(SCI,正常控制,假冒操作) 。没有 SCI,采指纹的地图集显示了那,与那些相比, SCI 组关于第二个主要部件表明了下列特征:它由丰满的酸组成,myc肌醇,精氨酸,很低密度的脂蛋白( VLDL ),低密度的脂蛋白( LDL ), triglyceride ( TG ),葡萄糖,并且数据显示了的 3-methyl-histamine .Conclusions SCI 很早在血浆新陈代谢导致几个重要变化并且一条 metabonomics 途径能基于 1H NMR 光谱学提供包括几个代谢物类的新陈代谢的侧面并且允许这的相对 quantification 变化。结果也为在一个个人以内分类损伤的程度为学习 SCI 并且为 multivariate 模型的利用为 metabonomics 技术的进一步的开发和申请提供了支持。JIANG Hua PENG Jin ZHOU Zhi-yuar DUAN Yu CHEN Wei CAI Bin YANG Hao ZHANG Wei 2010Chinese Medical Journal2010,,17:8
15Mechanisms underlying the promotion of functional recovery by deferoxamine after spinal cord injury in rats显示文摘Deferoxamine, a clinically safe drug used for treating iron overload, also repairs spinal cord injury although the mechanism for this action remains unknown. Here, we determined whether deferoxamine was therapeutic in a rat model of spinal cord injury and explored potential mechanisms for this effect. Spinal cord injury was induced by impacting the spinal cord at the thoracic T10 vertebra level. One group of injured rats received deferoxamine, a second injured group received saline, and a third group was sham operated. Both 2 days and 2 weeks after spinal cord injury, total iron ion levels and protein expression levels of the proinflammatory cytokines tumor necrosis factor-α and interleukin-1β and the pro-apoptotic protein caspase-3 in the spinal cords of the injured deferoxamine-treated rats were significantly lower than those in the injured saline-treated group. The percentage of the area positive for glial fibrillary acidic protein immunoreactivity and the number of terminal deoxynucleotidyl transferase d UTP nick end labeling-positive cells were also significantly decreased both 2 days and 2 weeks post injury, while the number of Neu N-positive cells and the percentage of the area positive for the oligodendrocyte marker CNPase were increased in the injured deferoxamine-treated rats. At 14–56 days post injury, hind limb motor function in the deferoxamine-treated rats was superior to that in the saline-treated rats. These results suggest that deferoxamine decreases total iron ion, tumor necrosis factor-α, interleukin-1β, and caspase-3 expression levels after spinal cord injury and inhibits apoptosis and glial scar formation to promote motor function recovery.Jian Hao Bo Li Hui-quan Duan Chen-xi Zhao Yan Zhang Chao Sun Bin Pan Chang Liu Xiao-hong Kong Xue Yao Shi-qing Feng 2017Neural Regeneration Research2017,12,6:8
16Myelin protein zero and its antibody in serum as biomarkers of n-hexane-induced peripheral neuropathy and neurotoxicity effects显示文摘Jia Xiaowei Liu Qingjun Zhang Yanshu Dai Yufei Duan Huawei Bin Ping Niu Yong Liu Jie Zhong Liuzhen Guo Jisheng Liu Xiaofeng Zheng Yuxin 2014Chinese Medical Journal2014,,8:8
17Do online reviews matter? — An empirical investigation of panel data显示文摘Wenjing Duan Bin Gu Andrew B. Whinston 2008Decision Support Systems2008,,4:8
18Tracking control for air-breathing hypersonic cruise vehicle based on tangent linearization approach显示文摘This paper is focused on developing a tracking controller for a hypersonic cruise vehicle using tangent linearization approach.The design of flight control systems for air-breathing hypersonic vehicles is a highly challenging task due to the unique characteristics of the vehicle dynamics.Motivated by recent results on tangent linearization control,the tracking control problem for the hypersonic cruise vehicle is reduced to that of a feedback stabilizing controller design for a linear time-varying system which can be accomplished by a standard design method of frozen-time control.Through a proper model transformation,it can be proven that the tracking error of the designed closed-loop system decays exponentially.Simulation studies are conducted for trimmed cruise conditions of 110000 ft and Mach 15 where the responses of the vehicle to step changes in altitude and velocity are evaluated.The effectiveness of the controller is demonstrated by simulation results.Guangbin Cai Guangren Duan Changhua Hu Bin Zhou 2010Journal of Systems Engineering and Electronics2010,21,3:7
193D printing of multilayered scaffolds for rotator cuff tendon regeneration显示文摘Repairing massive rotator cuff tendon defects remains a challenge due to the high retear rate after surgical intervention.3D printing has emerged as a promising technique that enables the fabrication of engineered tissues with heterogeneous structures and mechanical properties,as well as controllable microenvironments for tendon regeneration.In this study,we developed a new strategy for rotator cuff tendon repair by combining a 3D printed scaffold of polylactic-co-glycolic acid(PLGA)with cell-laden collagen-fibrin hydrogels.We designed and fabricated two types of scaffolds:one featuring a separate layer-by-layer structure and another with a tri-layered structure as a whole.Uniaxial tensile tests showed that both types of scaffolds had improved mechanical properties compared to single-layered PLGA scaffolds.The printed scaffold with collagen-fibrin hydrogels effectively supported the growth,proliferation,and tenogenic differentiation of human adipose-derived mesenchymal stem cells.Subcutaneous implantation of the multilayered scaffolds demonstrated their excellent in vivo biocompatibility.This study demonstrates the feasibility of 3D printing multilayered scaffolds for application in rotator cuff tendon regeneration.Xiping Jiang Shaohua Wu Mitchell Kuss Yunfan Kong Wen Shi Philipp N.Streubel Tieshi Li Bin Duan 2020Bioactive Materials2020,5,3:7
20The development in aqueous lithium-ion batteries显示文摘To meet the growing energy demands, it is urgent for us to construct grid-scale energy storage system than can connect sustainable energy resources. Aqueous Li-ion batteries(ALIBs) have been widely investigated to become the most promising stationary power sources for sustainable energy such as wind and solar power. It is believed that advantages of ALIBs will overcome the limitations of the traditional organic lithium battery in virtue of the safety and environmentally friendly aqueous electrolyte. In the past decades, plentiful works have been devoted to enhance the performance of different types of ALIBs.In this review, we discuss the development of cathode, anode and electrolyte for acquiring the desired electrochemical performance of ALIBs. Also, the main challenges and outlook in this field are briefly discussed.Duan Bin Yunping Wen Yonggang Wan Yongyao Xia 2018Journal of Energy Chemistry2018,27,6:7
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