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| 1 | Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma显示文摘 | Andrew D. Rhim Paul E. Oberstein Dafydd H. Thomas Emily T. Mirek Carmine F. Palermo Stephen A. Sastra Erin N. Dekleva Tyler Saunders Claudia P. Becerra Ian W. Tattersall C. Benedikt Westphalen Jan Kitajewski Maite G. Fernandez-Barrena Martin E. Fernandez- | 2014 | Cancer Cell2014，，： | 5 |
| 2 | Lipocalin 2 stimulates bone fibroblast growth factor 23 production in chronic kidney disease显示文摘Bone-produced fibroblast growth factor 23(FGF23)increases in response to inflammation and iron deficiency and contributes to cardiovascular mortality in chronic kidney disease(CKD).Neutrophil gelatinase-associated lipocalin(NGAL or lipocalin 2;LCN2 the murine homolog)is a pro-inflammatory and iron-shuttling molecule that is secreted in response to kidney injury and may promote CKD progression.We investigated bone FGF23 regulation by circulating LCN2.At 23 weeks,Col4a3KO mice showed impaired kidney function,increased levels of kidney and serum LCN2,increased bone and serum FGF23,anemia,and left ventricular hypertrophy(LVH).Deletion of Lcn2 in CKD mice did not improve kidney function or anemia but prevented the development of LVH and improved survival in association with marked reductions in serum FGF23.Lcn2 deletion specifically prevented FGF23 elevations in response to inflammation,but not iron deficiency or phosphate,and administration of LCN2 increased serum FGF23 in healthy and CKD mice by stimulating Fgf23 transcription via activation of cAMP-mediated signaling in bone cells.These results show that kidney-produced LCN2 is an important mediator of increased FGF23 production by bone in response to inflammation and in CKD.LCN2 inhibition might represent a potential therapeutic approach to lower FGF23 and improve outcomes in CKD. | Guillaume Courbon Connor Francis Claire Gerber Samantha Neuburg Xueyan Wang Emily Lynch Tamara Isakova Jodie LBabitt Myles Wolf Aline Martin Valentin David | 2021 | Bone Research2021，9，3： | 4 |
| 3 | PREDICTING THE DEPTH OF EROSION IN RESERVOIRS FOLLOWING DAM REMOVAL USING BANK STABILITY ANALYSIS显示文摘Dam removal has emerged in the U.S. as a critical concern for river management. Of particular interest is predicting the quantity of sediment that will be eroded from a reservoir following dam removal, which necessitates predicting the geometry a channel will approach as it forms in the reservoir. The geometry and sediment characteristics of the Koshkonong River were measured as it adjusted to the removal of the Rockdale Dam. Bank stability modeling was used as a tool for predicting the maximum depth of the evolving channel and general agreement was found between depths predicted with the model and those observed up to one year following dam removal. Model sensitivity analysis showed strong control of bank heights by groundwater levels in the reservoir sediment, as well as some control by vegetation established on the sediment surface. Long-term monitoring is needed to assess the accuracy of the model, but preliminary agreement is encouraging for applying this model and similar models to future dam removals. | Martin W. DOYLE Emily H. STANLEY Andy R. SELLE John M. STOFLETH Jon M. HARBOR | 2003 | International Journal of Sediment Research2003，18，2： | 3 |
| 4 | Role of post-translational modification of the Y box binding protein 1 in human cancers显示文摘Y box binding protein-1(YBX1)belongs to a DNA-and RNA-binding family of transcription factors,containing the highly conserved cold shock domain(CSD).YBX1 is involved in a number of cellular functions including transcription,translation,DNA damage repair etc.,and it is upregulated during times of environmental stress.YBX1 is localized in both the cytoplasm and the nucleus.There,its nuclear translocation is observed in a number of cancers and is associated with poor prognosis and disease progression.Additionally,YBX1 expression is upregulated in a variety of cancers,pointing towards its role as a potential oncogene.Under certain circumstances,YBX1 also promotes the expression of multidrug resistance 1(MDR1)gene,which is involved in the development of drug resistance.Thus,it is critical to understand the mechanism of YBX1 regulation and its downstream effects on promoting cancer development.A number of recent studies have highlighted the mechanisms of YBX1 regulation.Mass spectrometric analyses have reported several post-translational modifications that possibly play an important role in modulating YBX1 function.Phosphorylation is the most widely occurring post-translational modification in YBX1.In vivo analyses of sites like S102 and more recently,S165 illustrate the relationship of post-translational regulation of YBX1 in promoting cell proliferation and tumor growth.This review provides a comprehensive and up-to-date account of post-translational modifications identified in YBX1.This knowledge is a key in allowing us to better understand the mechanism of YBX1 regulation,which will aid in development of novel therapeutic strategies to target YBX1 in many types of cancer in the future. | Lakshmi Prabhu Antja-Voy Hartley Matthew Martin Fadumo Warsame Emily Sun Tao Lu | 2015 | Genes & Diseases2015，2，3： | 3 |
| 5 | National Forest Inventories capture the multifunctionality of managed forests in Germany显示文摘Background:Forests perform various important ecosystem functions that contribute to ecosystem services.In many parts of the world,forest management has shifted from a focus on timber production to multi-purpose forestry,combining timber production with the supply of other forest ecosystem services.However,it is unclear which forest types provide which ecosystem services and to what extent forests primarily managed for timber already supply multiple ecosystem services.Based on a comprehensive dataset collected across 150 forest plots in three regions differing in management intensity and species composition,we develop models to predict the potential supply of 13 ecosystem services.We use those models to assess the level of multifunctionality of managed forests at the national level using national forest inventory data.Results:Looking at the potential supply of ecosystem services,we found trade-offs(e.g.between both bark beetle control or dung decomposition and both productivity or soil carbon stocks)as well as synergies(e.g.for temperature regulation,carbon storage and culturally interesting plants)across the 53 most dominant forest types in Germany.No single forest type provided all ecosystem services equally.Some ecosystem services showed comparable levels across forest types(e.g.decomposition or richness of saprotrophs),while others varied strongly,depending on forest structural attributes(e.g.phosphorous availability or cover of edible plants)or tree species composition(e.g.potential nitrification activity).Variability in potential supply of ecosystem services was only to a lesser extent driven by environmental conditions.However,the geographic variation in ecosystem function supply across Germany was closely linked with the distribution of main tree species.Conclusions:Our results show that forest multifunctionality is limited to subsets of ecosystem services.The importance of tree species composition highlights that a lack of multifunctionality at the stand level can be compensated by managing forests at the landscape level,when stands of complementary forest types are combined.These results imply that multi-purpose forestry should be based on a variety of forest types requiring coordinated planning across larger spatial scales. | Nadja K.Simons María R.Felipe-Lucia Peter Schall Christian Ammer Jürgen Bauhus Nico Blüthgen Steffen Boch François Buscot Markus Fischer Kezia Goldmann Martin M.Gossner Falk Hänsel Kirsten Jung Peter Manning Thomas Nauss Yvonne Oelmann Rodica Pena Andrea Polle Swen C.Renner Michael Schloter Ingo Schöning Ernst-Detlef Schulze Emily F.Solly Elisabeth Sorkau Barbara Stempfhuber Tesfaye Wubet Jörg Müller Sebastian Seibold Wolfgang W.Weisser | 2021 | Forest Ecosystems2021，8，1： | 2 |
| 6 | Does the spatial arrangement of urban landscape matter?Examples of urban warming and cooling in Phoenix and Las Vegas显示文摘This study examines the impact of spatial landscape configuration(e.g.,clustered,dispersed)on land-surface temperatures(LST)over Phoenix,Arizona,and Las Vegas,Nevada,USA.We classified detailed land-cover types via object-based image analysis(OBIA)using Geoeye-1 at 3-m resolution(Las Vegas)and QuickBird at 2.4-m resolution(Phoenix).Spatial autocorrelation(local Moran’s I)was then used to test for spatial dependence and to determine how clustered or dispersed points were arranged.Next,we used Advanced Spaceborne Thermal Emission and Reflection Radiometer(ASTER)data acquired over Phoenix(daytime on 10 June and nighttime on 17 October 2011)and Las Vegas(daytime on 6 July and nighttime on 27 August 2005)to examine day-and nighttime LST with regard to the spatial arrangement of anthropogenic and vegetation features.Local Moran’s I values of each land-cover type were spatially correlated to surface temperature.The spatial configuration of grass and trees shows strong negative correlations with LST,implying that clustered vegetation lowers surface temperatures more effectively.In contrast,clustered spatial arrangements of anthropogenic land-cover types,especially impervious surfaces and open soil,elevate LST.These findings suggest that city planners and managers should,where possible,incorporate clustered grass and trees to disperse unmanaged soil and paved surfaces,and fill open unmanaged soil with vegetation.Our findings are in line with national efforts to augment and strengthen green infrastructure,complete streets,parking management,and transit-oriented development practices,and reduce sprawling,unwalkable housing development. | Soe Win Myint Baojuan Zheng Emily Talen Chao Fan Shai Kaplan Ariane Middel Martin Smith Huei-Ping Huang Anthony Brazel | 2015 | Ecosystem Health and Sustainability2015，1，4： | 2 |
| 7 | Importance of Low Preoperative Platelet Count in Selecting Patients for Resection of Hepatocellular Carcinoma: A Multi-Institutional Analysis显示文摘 | Shishir K. Maithel Peter J. Kneuertz David A. Kooby Charles R. Scoggins Sharon M. Weber Robert C.G. Martin Kelly M. McMasters Clifford S. Cho Emily R. Winslow William C. Wood Charles A. Staley | 2011 | Journal of the American College of Surgeons2011，，4： | 2 |
| 8 | Retrospective evaluation of colistin versus tigecycline for the treatment of Acinetobacter baumannii and/or carbapenem-resistant Enterobacteriaceae infections显示文摘 | Kimberly Ku Jason M. Pogue Judy Moshos Suchitha Bheemreddy Yujing Wang Ashish Bhargava Michelle Campbell Namir Khandker Paul R. Lephart Teena Chopra Kayoko Hayakawa Emily T. Martin Odaliz Abreu-Lanfranco Sorabh Dhar Keith S. Kaye Dror Marchaim | 2012 | AJIC: American Journal of Infection Control2012，，10： | 1 |
| 9 | Potential for broad-scale transmission of Ebola virus disease during the West Africa crisis:lessons for the Global Health security agenda显示文摘Background:The 2014-2016 Ebola crisis in West Africa had approximately eight times as many reported deaths as the sum of all previous Ebola outbreaks.The outbreak magnitude and occurrence of multiple Ebola cases in at least seven countries beyond Liberia,Sierra Leone,and Guinea,hinted at the possibility of broad-scale transmission of Ebola.Main text:Using a modeling tool developed by the US Centers for Disease Control and Prevention during the Ebola outbreak,we estimated the number of Ebola cases that might have occurred had the disease spread beyond the three countries in West Africa to cities in other countries at high risk for disease transmission(based on late 2014 air travel patterns).We estimated Ebola cases in three scenarios:a delayed response,a Liberia-like response,and a fast response scenario.Based on our estimates of the number of Ebola cases that could have occurred had Ebola spread to other countries beyond the West African foci,we emphasize the need for improved levels of preparedness and response to public health threats,which is the goal of the Global Health Security Agenda.Our estimates suggest that Ebola could have potentially spread widely beyond the West Africa foci,had local and international health workers and organizations not committed to a major response effort.Our results underscore the importance of rapid detection and initiation of an effective,organized response,and the challenges faced by countries with limited public health systems.Actionable lessons for strengthening local public health systems in countries at high risk of disease transmission include increasing health personnel,bolstering primary and critical healthcare facilities,developing public health infrastructure(e.g.laboratory capacity),and improving disease surveillance.With stronger local public health systems infectious disease outbreaks would still occur,but their rapid escalation would be considerably less likely,minimizing the impact of public health threats such as Ebola.Conclusions:The Ebola outbreak could have potentially spread to other countries,where limited public health surveillance and response capabilities may have resulted in additional foci.Health security requires robust local health systems that can rapidly detect and effectively respond to an infectious disease outbreak. | Eduardo A.Undurraga Cristina Carias Martin I.Meltzer Emily B.Kahn | 2017 | Infectious Diseases of Poverty2017，6，1： | 1 |
| 10 | A comparison of parathyroid hormone‐related protein (1‐36) and parathyroid hormone (1‐34) on markers of bone turnover and bone density in postmenopausal women: The PrOP study显示文摘 | Mara J Horwitz Marilyn Augustine Leila Kahn Emily Martin Christine C Oakley Raquel M Carneiro Mary Beth Tedesco Angela Laslavic Susan M Sereika Alessandro Bisello Adolfo Garcia‐Oca?a Caren M Gundberg Jane A Cauley Andrew F Stewart | 2013 | J Bone Miner Res2013，，11： | 1 |
| 11 | Evaluating environmental influence of zoning in urban ecosystems with remote sensing显示文摘 | Jeffrey S W Michaun C Emily Martin | 2003 | Remote Sensing of Environment2003，86，3： | 1 |
| 12 | 4-Phenylbutyric Acid Treatment Rescues Trafficking and Processing of a Mutant Surfactant Protein-C显示文摘 | Stewart Gareth A Ridsdale Ross Martin Emily P Na Cheng-Lun Xu Yan Mandapaka Karunyakanth Weaver Timothy E | 2012 | EN2012，，3： | 1 |
| 13 | Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia显示文摘A gain-of-function mutation in the fibroblast growth factor receptor 3 gene(FGFR3)results in achondroplasia(ACH),the most frequent form of dwarfism.Constitutive activation of FGFR3 impairs bone formation and elongation and many signal transduction pathways.Identification of new and relevant compounds targeting the FGFR3 signaling pathway is of broad importance for the treatment of ACH,and natural plant compounds are prime drug candidate sources.Here,we found that the phenolic compound(-)-epicatechin,isolated from Theobroma cacao,effectively inhibited FGFR3’s downstream signaling pathways.Transcriptomic analysis in an Fgfr3 mouse model showed that ciliary mRNA expression was modified and influenced significantly by the Indian hedgehog and PKA pathways.(-)-Epicatechin is able to rescue mRNA expression impairments that control both the structural organization of the primary cilium and ciliogenesis-related genes.In femurs isolated from a mouse model(Fgfr3^(Y367C/+))of ACH,we showed that(-)-epicatechin eliminated bone growth impairment during 6 days of ex vivo culture.In vivo,we confirmed that daily subcutaneous injections of(-)-epicatechin to Fgfr3^(Y367C/+) mice increased bone elongation and rescued the primary cilium defects observed in chondrocytes.This modification to the primary cilia promoted the typical columnar arrangement of flat proliferative chondrocytes and thus enhanced bone elongation.The results of the present proof-of-principle study support(-)-epicatechin as a potential drug for the treatment of ACH. | Ludovic Martin Nabil Kaci Catherine Benoist-Lasselin Marine Mondoloni Suzanne Decaudaveine Valentin Estibals Maxence Cornille Léa Loisay Justine Flipo Benoît Demuynck Maria de la Luz Cádiz-Gurrea Florent Barbault Salvador Fernández-Arroyo Laurent Schibler Antonio Segura-Carretero Emilie Dambroise Laurence Legeai-Mallet | 2022 | Bone Research2022，10，1： | 1 |
| 14 | Retrospective evaluation of colistin versus tigecycline for the treatment of Acinetobacter baumannii and/or carbapenem-resistant Enterobacteriaceae infections显示文摘 | Kimberly Ku Jason M. Pogue Judy Moshos Suchitha Bheemreddy Yujing Wang Ashish Bhargava Michelle Campbell Namir Khandker Paul R. Lephart Teena Chopra Kayoko Hayakawa Emily T. Martin Odaliz Abreu-Lanfranco Sorabh Dhar Keith S. Kaye Dror Marchaim | 2012 | AJIC: American Journal of Infection Control2012，，10： | 1 |
| 15 | A snapshot of creativity: Evaluating a quick and simple method for assessing divergent thinking显示文摘 | Paul J. Silvia Christopher Martin Emily C. Nusbaum | 2009 | Thinking Skills and Creativity2009，，2： | 1 |
| 16 | Geochemistry of hydrothermal fluids from the PACMANUS, Northeast Pual and Vienna Woods hydrothermal fields, Manus Basin, Papua New Guinea显示文摘 | Eoghan P. Reeves Jeffrey S. Seewald Peter Saccocia Wolfgang Bach Paul R. Craddock Wayne C. Shanks Sean P. Sylva Emily Walsh Thomas Pichler Martin Rosner | 2010 | Geochimica et Cosmochimica Acta2010，，4： | 1 |
| 17 | Openness to experience, plasticity, and creativity: Exploring lower-order, high-order, and interactive effects显示文摘 | Paul J. Silvia Emily C. Nusbaum Christopher Berg Christopher Martin Alejandra O’Connor | 2009 | Journal of Research in Personality2009，，6： | 1 |
| 18 | IL28B polymorphism is associated with treatment response in patients with genotype 4 chronic hepatitis C显示文摘 | Tarik Asselah Simon De Muynck Philippe Bro?t Julien Masliah-Planchon Maud Blanluet Ivan Bièche Martine Lapalus Michelle Martinot-Peignoux Olivier Lada Emilie Estrabaud Qian Zhang Ahmed El Ray Dominique Vidaud Marie-Pierre Ripault Nathalie Boyer Pierre Bed | 2011 | Journal of Hepatology2011，，3： | 1 |
| 19 | Deletion 2q36.2q36.3 with multiple renal cysts and severe mental retardation显示文摘 | Martine Doco-Fenzy Emilie Landais Joris Andrieux Anouck Schneider Brigitte Delemer Véronique Sulmont Jean-Pierre Melin Dominique Ploton Jessica Thevenard Jean-Claude Monboisse Mohamed Belouadah Francis Lefebvre Anne Durlach Michel Goossens Juliette Albuis | 2008 | European Journal of Medical Genetics2008，，6： | 1 |
| 20 | Bile Salts Control the Antimicrobial Peptide Cathelicidin Through Nuclear Receptors in the Human Biliary Epithelium显示文摘 | Emilie D’Aldebert Marie–Jeanne Biyeyeme Bi Mve Martine Mergey Dominique Wendum Delphine Firrincieli Audrey Coilly Laura Fouassier Christophe Corpechot Raoul Poupon Chantal Housset Nicolas Chignard | 2009 | Gastroenterology2009，，4： | 1 |
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