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| 1 | Visible light optical coherence tomography measures retinal oxygen metabolic response to systemic oxygenation显示文摘The lack of capability to quantify oxygen metabolism noninvasively impedes both fundamental investigation and clinical diagnosis of a wide spectrum of diseases including all the major blinding diseases such as age-related macular degeneration,diabetic retinopathy,and glaucoma.Using visible light optical coherence tomography(vis-OCT),we demonstrated accurate and robust measurement of retinal oxygen metabolic rate(rMRO2)noninvasively in rat eyes.We continuously monitored the regulatory response of oxygen consumption to a progressive hypoxic challenge.We found that both oxygen delivery,and rMRO2 increased from the highly regulated retinal circulation(RC)under hypoxia,by 0.2860.08 μL min(^-1)(p,0.001),and 0.2060.04 μL min(^-1)(p,0.001)per 100 mmHg systemic pO2 reduction,respectively.The increased oxygen extraction compensated for the deficient oxygen supply from the poorly regulated choroidal circulation.Results from an oxygen diffusion model based on previous oxygen electrode measurements corroborated our in vivo observations.We believe that vis-OCT has the potential to reveal the fundamental role of oxygen metabolism in various retinal diseases. | Ji Yi Wenzhong Liu Siyu Chen Vadim Backman Nader Sheibani Christine M.Sorenson Amani A.Fawzi Robert A.Linsenmeier Hao F.Zhang | 2015 | Light(Science & Applications)2015，4，1： | 8 |
| 2 | 查看详情显示文摘 | F.Zhang N.Huang P.Yang | | 0，，： | 1 |
| 3 | Karst rocky desertification in southwestern China: geomorphology, landuse, impact and rehabilitation显示文摘 | S.‐J.Wang Q.‐M.Liu D.‐F.Zhang | 2004 | Land Degrad Dev2004，，2： | 1 |
| 4 | Effects of Ureaplasma urealyticum infection on the male reproductive system in experimental rats显示文摘 | Y.Wang Z.‐W.Wu L.‐F.Zhang X.‐K.Wu L.Yi X.‐D.Han | 2010 | Andrologia2010，，5： | 1 |
| 5 | 查看详情显示文摘 | J.Xiang C.Chang F.Zhang J.Sun | | 0，，： | 1 |
| 6 | Pricing,resource allocation and quality of service in multi-class networks with competitive market model显示文摘 | F.Zhang PK Verma S.Cheng | | 0，，01： | 1 |
| 7 | Practical image quality metric applied to image coding显示文摘 | F.Zhang L.Ma S.N.Li | | 0，，04： | 1 |
| 8 | SIMULTANEOUS IMAGING OF A lacZ-MARKED TUMOR AND MICROVASCULATURE MORPHOLOGY IN VIVO BY DUAL-WAVELENGTH PHOTOACOUSTIC MICROSCOPY显示文摘Photoacoustic molecular imaging,combined with the reporter-gene technique,can provide a valuable tool for cancer research.The expression of the lacZ reporter gene can be imaged using photoacoustic imaging following the injection of X-gal,a colorimetric assay for the lacZ-encoded enzymeβ-galactosidase.Dual-wavelength photoacoustic microscopy was used to non-invasively image the detailed morphology of a lacZ-marked 9L gliosarcoma and its surrounding microvasculature simultaneously in vivo,with a superior resolution on the order of 10μm.Tumor-feeding vessels were found,and the expression level of lacZ in tumor was estimated.With future development of new absorption-enhancing reporter-gene systems,we anticipate this strategy can lead to a better understanding of the role of tumor metabolism in cancer initiation,progression,and metastasis,and in its response to therapy. | LI LI HAO F.ZHANG ROGER J.ZEMP KONSTANTIN MASLOV LIHONG V.WANG | 2008 | Journal of Innovative Optical Health Sciences2008，1，2： | 1 |
| 9 | 查看详情显示文摘 | Z. Wang J. Xia X. Qiang Y.Xia G.Shi F.Zhang G.Han L.Xia J.Tang | | 0，，： | 1 |
| 10 | FABRICATION AND PROPERTIES OF Al_2O_3 /Ni COMPOSITES显示文摘Ceramic matrix composites consisting of an alumina matrix containing 20 vol% nickel particles has been fabricated using hot pressing technique. It is found that fracture toughness of the composite is much higher than the alumina matrix. This is due to the energy dissipation of the nickel particles that bridge the propagating cracks. | L.X.Ding 1) ,F.Zhang 2) ,Z.J.Zhao 3) ,Y.M.Wang 1) and X.D.Sun 2) 1) Department of Materials, School of Mechanical Engineering, Shenyang University, Shenyang 110044, China 2) School of Materials and Metallurgy, Northeastern Univers | 1999 | Acta Metallurgica Sinica(English Letters)1999，12，5： | 1 |
| 11 | Symmetrically dispersed spectroscopic singlemolecule localization microscopy显示文摘Spectroscopic single-molecule localization microscopy(sSMLM)was used to achieve simultaneous imaging and spectral analysis of single molecules for the first time.Current sSMLM fundamentally suffers from a reduced photon budget because the photons from individual stochastic emissions are divided into spatial and spectral channels.Therefore,both spatial localization and spectral analysis only use a portion of the total photons,leading to reduced precisions in both channels.To improve the spatial and spectral precisions,we present symmetrically dispersed sSMLM,or SDsSMLM,to fully utilize all photons from individual stochastic emissions in both spatial and spectral channels.SDsSMLM achieved 10-nm spatial and 0.8-nm spectral precisions at a total photon budget of 1000.Compared with the existing sSMLM using a 1:3 splitting ratio between spatial and spectral channels,SDsSMLM improved the spatial and spectral precisions by 42% and 10%,respectively,under the same photon budget.We also demonstrated multicolour imaging of fixed cells and three-dimensional single-particle tracking using SDsSMLM.SDsSMLM enables more precise spectroscopic single-molecule analysis in broader cell biology and material science applications. | Ki-Hee Song Yang Zhang Benjamin Brenner Cheng Sun Hao F.Zhang | 2020 | Light(Science & Applications)2020，9，1： | 1 |
| 12 | Enhanced ultraviolet photoluminescence from V‐doped ZnO thin films prepared by a sol–gel process显示文摘 | LingWei LitingZhang YangZhang W. F.Zhang | 2007 | phys. stat. sol. (a)2007，，7： | 1 |
| 13 | Genomic expression profiles of blood and placenta reveal significant immune‐related pathways and categories in Chinese women with gestational diabetes mellitus显示文摘 | Y.‐H.Zhao D.‐P.Wang L.‐L.Zhang F.Zhang D.‐M.Wang W.‐Y.Zhang | 2011 | Diabetic Medicine2011，，2： | 1 |
| 14 | Observation of Lasing Emission from Carbon Nanodots in Organic Solvents显示文摘 | W. F.Zhang H.Zhu S. F.Yu H. Y.Yang | 2012 | Adv Mater2012，，17： | 1 |
| 15 | All-optical μ^- acceleration in the laser wakefield显示文摘Muons produced by the Bethe–Heitler process from laser wakefield accelerated electrons interacting with high Z materials have velocities close to the laser wakefield. It is possible to accelerate those muons with laser wakefield directly.Therefore for the first time we propose an all-optical ‘Generator and Booster’ scheme to accelerate the produced muons by another laser wakefield to supply a prompt, compact, low cost and controllable muon source in laser laboratories. The trapping and acceleration of muons are analyzed by one-dimensional analytic model and verified by two-dimensional particle-in-cell(PIC) simulation. It is shown that muons can be trapped in a broad energy range and accelerated to higher energy than that of electrons for longer dephasing length. We further extrapolate the dependence of the maximum acceleration energy of muons with the laser wakefield relativistic factor γ and the relevant initial energy E_0. It is shown that a maximum energy up to 15.2 GeV is promising with γ = 46 and E_0= 1.45 Ge V on the existing short pulse laser facilities. | F.Zhang Z.G.Deng L.Q.Shan Z.M.Zhang B.Bi D.X.Liu W.W.Wang Z.Q.Yuan C.Tian S.Q.Yang B.Zhang Y.Q.Gu | 2018 | High Power Laser Science and Engineering2018，6，4： | 0 |
| 16 | The design and performance of charged particle detector onboard the GECAM mission显示文摘Background The Gravitational wave highly energetic Electromagnetic Counterpart All-sky Monitor(GECAM)is dedicated to detecting gravitational wave gamma-ray bursts.It is capable of all-sky monitoring over and discovering gamma-ray bursts and new radiation phenomena.GECAM consists of two microsatellites,each equipped with 8 charged particle detectors(CPDs)and 25 gamma-ray detectors(GRDs).Purpose The CPD is used to measure charged particles in the space environment,monitor energy and flow intensity changes,and identify between gamma-ray bursts and space charged particle events in conjunction with GRD.Methods CPD uses plastic scintillator as the sensitive material for detection,silicon photomultiplier array as the optically readable device,and the inlaid Am-241 radioactive source as the onboard calibration means.Conclusion In this paper,we will present the working principle,physical design,functional implementation and preliminary performance test results of the CPD.As a result,the energy range of electron,gamma-ray detection efficiency and dead time are tested to be better than the indexes required through the ground calibration experiment. | Y.B.Xu X.Q.Li X.L.Sun S.Yang H.Wang W.X.Peng X.H.Liang K.Gong Y.Q.Liu D.Y.Guo X.Y.Zhao C.Y.Li Z.H.An J.J.He X.J.Liu X.Y.Wen S.L.Xiong Fan Zhang D.L.Zhang C.Y.Zhang C.Cai Z.Chang G.Chen C.Chen Y.Y.Du M.Gao R.Gao D.J.Hou Y.G.Li G.Li L.Li X.F.Li M.S.Li F.J.Lu H.Lu B.Meng F.Shi J.Z.Wang Y.S.Wang H.Z.Wang X.Wen S.Xiao Y.P.Xu J.W.Yang Q.B.Yi S.N.Zhang C.M.Zhang F.Zhang Y.Zhao X.Zhou | 2022 | Radiation Detection Technology and Methods2022，6，1： | 0 |
| 17 | High-Frequency 3D Photoacoustic Computed Tomography Using an Optical Microring Resonator显示文摘3D photoacoustic computed tomography(3D-PACT)has made great advances in volumetric imaging of biological tissues,with high spatial-temporal resolutions and large penetration depth.The development of 3D-PACT requires high-performance acoustic sensors with a small size,large detection bandwidth,and high sensitivity.In this work,we present a new high-frequency 3D-PACT system that uses a microring resonator(MRR)as the acoustic sensor.The MRR sensor has a size of 80μm in diameter and was fabricated using the nanoimprint lithography technology.Using the MRR sensor,we have developed a transmission-mode 3D-PACT system that has achieved a detection bandwidth of~23 MHz,an imaging depth of~8 mm,a lateral resolution of 114μm,and an axial resolution of 57μm.We have demonstrated the 3D PACT’s performance on in vitro phantoms,ex vivo mouse brain,and in vivo mouse ear and tadpole.The MRR-based 3D-PACT system can be a promising tool for structural,functional,and molecular imaging of biological tissues at depths. | Qiangzhou Rong Youngseop Lee Yuqi Tang Tri Vu Carlos Taboada Wenhan Zheng Jun Xia David A.Czaplewski Hao F.Zhang Cheng Sun Junjie Yao | 2022 | Biomedical Engineering Frontiers2022，3，1： | 0 |
| 18 | Reconstruction of Cherenkov image bymultiple telescopes of LHAASO-WFCTA显示文摘Introduction One of main scientific goals of the Large High Altitude Air Shower Observatory(LHAASO)is to accurately measure the energy spectra of different cosmic ray compositions around the‘knee’region.The Wide Field-of-View(FoV)Cherenkov Telescope Array(WFCTA),which is one of the main detectors of LHAASO and has 18 telescopes,is built to achieve this goal.Multiple telescopes are put together and point to connected directions for a larger FoV.Method Telescopes are deployed spatially as close as possible,but due to their own size,the distance between two adjacent telescopes is about 10 m.Therefore,the Cherenkov lateral distribution and the parallax between the two telescopes should be considered in the event building process for images crossing over the boundaries of FoVs of the telescopes.An event building method for Cherenkov images measured by multiple telescopes of WFCTA is developed.The performance of the shower measurements using the combined images is evaluated by comparing with showers that are fully contained by a virtual telescope in simulation.Results and conclusion It is proved that the developed event building process can help to increase the FoV of WFCTA by 30%while maintaining the same reconstruction quality,compared to the separate telescope reconstruction method. | F.Aharonian Q.An Axikegu L.X.Bai Y.X.Bai Y.W.Bao D.Bastieri X.J.Bi Y.J.Bi J.T.Cai Zhe Cao Zhen Cao J.Chang J.F.Chang E.S.Chen Liang Chen Liang Chen Long Chen M.J.Chen M.L.Chen Q.H.Chen S.H.Chen S.Z.Chen T.L.Chen Y.Chen H.L.Cheng N.Cheng Y.D.Cheng S.W.Cui X.H.Cui Y.D.Cui B.D’Ettorre Piazzoli B.Z.Dai H.L.Dai Z.G.Dai Danzengluobu Ddella Volpe K.K.Duan J.H.Fan Y.Z.Fan Z.X.Fan J.Fang K.Fang C.F.Feng L.Feng S.H.Feng X.T.Feng Y.L.Feng B.Gao C.D.Gao L.Q.Gao Q.Gao W.Gao W.K.Gao M.M.Ge L.S.Geng G.H.Gong Q.B.Gou M.H.Gu F.L.Guo J.G.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.Han H.H.He H.N.He S.L.He X.B.He Y.He M.Heller Y.K.Hor C.Hou X.Hou H.B.Hu Q.Hu S.Hu S.C.Hu X.J.Hu D.H.Huang W.H.Huang X.T.Huang X.Y.Huang Y.Huang Z.C.Huang X.L.Ji H.Y.Jia K.Jia K.Jiang Z.J.Jiang M.Jin M.M.Kang T.Ke D.Kuleshov K.Levochkin B.B.Li Cheng Li Cong Li F.Li H.B.Li H.C.Li H.Y.Li J.Li Jian Li Jie Li K.Li WLLi XRLi Xin Li Xin Li YZLi Zhe Li Zhuo Li E.W.Liang Y.F.Liang S.J.Lin B.Liu C.Liu D.Liu H.Liu H.D.Liu J.Liu J.L.Liu J.S.Liu J.Y.Liu M.Y.Liu R.Y.Liu S.M.Liu W.Liu Y.Liu Y.N.Liu W.J.Long R.Lu Q.Luo H.K.Lv B.Q.Ma L.L.Ma X.H.Ma J.R.Mao A.Masood Z.Min W.Mitthumsiri Y.C.Nan Z.W.Ou B.Y.Pang P.Pattarakijwanich Z.Y.Pei M.Y.Qi Y.Q.Qi B.Q.Qiao J.J.Qin D.Ruffolo A.Sáiz C.Y.Shao L.Shao O.Shchegolev X.D.Sheng J.Y.Shi H.C.Song Yu.V.Stenkin V.Stepanov Y.Su Q.N.Sun X.N.Sun Z.B.Sun P.H.T.Tam Z.B.Tang W.W.Tian B.D.Wang C.Wang H.Wang H.G.Wang J.C.Wang J.S.Wang L.P.Wang L.Y.Wang R.Wang R.N.Wang W.Wang X.G.Wang X.Y.Wang Y.Wang Y.D.Wang Y.J.Wang Y.P.Wang Z.H.Wang Z.X.Wang Zhen Wang Zheng Wang D.M.Wei J.J.Wei Y.J.Wei T.Wen C.Y.Wu H.R.Wu S.Wu X.F.Wu Y.S.Wu S.Q.Xi J.Xia J.J.Xia G.M.Xiang D.X.Xiao G.Xiao G.G.Xin Y.L.Xin Y.Xing Z.Xiong D.L.Xu R.X.Xu L.Xue D.H.Yan J.Z.Yan C.W.Yang F.F.Yang H.W.Yang J.Y.Yang L.L.Yang M.J.Yang R.Z.Yang S.B.Yang Y.H.Yao Z.G.Yao Y.M.Ye L.Q.Yin N.Yin X.H.You Z.Y.You Y.H.Yu Q.Yuan H.Yue H.D.Zeng T.X.Zeng W.Zeng Z.K.Zeng M.Zha X.X.Zhai B.B.Zhang F.Zhang H.M.Zhang H.Y.Zhang J.L.Zhang L.X.Zhang Li Zhang Lu Zhang P.F.Zhang P.P.Zhang R.Zhang S.B.Zhang S.R.Zhang S.S.Zhang X.Zhang X.P.Zhang Y.F.Zhang Y.L.Zhang Yi Zhang Yong Zhang B.Zhao J.Zhao L.Zhao L.Z.Zhao S.P.Zhao F.Zheng Y.Zheng B.Zhou H.Zhou J.N.Zhou P.Zhou R.Zhou X.X.Zhou C.G.Zhu F.R.Zhu H.Zhu K.J.Zhu X.Zuo | 2022 | Radiation Detection Technology and Methods2022，6，4： | 0 |
| 19 | Characterization of retinal ganglion cell damage at single axon bundle level in mice by visible-light optical coherence tomography fibergraphy显示文摘Retinal ganglion cells(RGCs)receive synaptic inputs through their dendritic trees in the inner plexiform layer(IPL)and convey the visual information via their axons which form the optic nerve to the brain(Sanes and Masland,2015).In glaucoma,RGCs and their axons degenerate and die,leading to irreversible vision loss and eventually blindness if left untreated(Quigley,2016). | Xiaorong Liu Hao F.Zhang | 2023 | Neural Regeneration Research2023，18，1： | 0 |
| 20 | PHOTOACOUSTIC GENERATION OF FOCUSED QUASI-UNIPOLAR PRESSURE PULSES显示文摘The photoacoustic effect was employed to generate short-duration quasi-unipolar acoustic pressure pulses in both planar and spherically focused geometries.In the focal region,the temporal profile of a pressure pulse can be approximated by the first derivative of the temporal profile near the front transducer surface,with a time-averaged value equal to zero.This approximation agreed with experimental results acquired from photoacoustic transducers with both rigid and free boundaries.For a free boundary,the acoustic pressure in the focal region is equal to the sum of a positive pressure that follows the spatial profile of the optical energy deposition in the medium and a negative pressure that follows the temporal profile of the laser pulse. | KONSTANTIN MASLOV HAO F.ZHANG LIHONG V.WANG | 2010 | Journal of Innovative Optical Health Sciences2010，3，4： | 0 |
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