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| 1 | Preventive effect of chrysin on experimental autoimmune uveitis triggered by injection of human IRBP peptide 1-20 in mice显示文摘Uveitis is a common cause of blindness worldwide.Experimental autoimmune uveitis(EAU)is an animal model of noninfectious uveitis.Chrysin(5,7-dihydroxyflavone)is a member of the flavonoid family and has anti-inflammatory effects.We immunized C57BL/6J mice with human interphotoreceptor retinoid-binding protein peptide 1–20 to induce EAU.Chrysin was administered intragastrically at 25 mg/kg daily to the chrysin-treated mice from 3 days before immunization to 21 days after immunization.Vehicle was administered to the mice in the control group according to the same protocol.Lower clinical and histopathological scores,increased integrity of the blood–retinal barrier(BRB)and higher expression of tight junction proteins were observed in the chrysin-treated mice.Chrysin significantly decreased the proportions of Th1,Th17 and CD4^(+)CD3^(+)CD62L^(+)Th0 cells,and increased the proportion of Treg cells.Both macrophage infiltration and the expression of inducible nitric oxide synthase in the retina were efficiently inhibited by chrysin treatment.In chrysin-treated mice,the expression of interferon-γ,interleukin(IL)-17A,IL-6,IL-1βand tumor necrosis factor-αwas reduced in the retina,whereas higher levels of transforming growth factor-βwere detected.Furthermore,NF-κBp65 was downregulated after chrysin treatment.In conclusion,as an anti-inflammatory molecule,chrysin exerts a preventive effect on EAU by modulating the balance among helper T-cell subsets and suppressing ocular inflammation,thereby maintaining the integrity of the BRB. | Xiangda Meng Sijie Fang Zhuhong Zhang Yang Wang Caiyun You Jingkai Zhang Hua Yan | 2017 | Cellular & Molecular Immunology2017，14，8： | 3 |
| 2 | Nuclear proteome profile of C57BL/6J mouse liver显示文摘The liver proteome can serve as a reference to better understand both disease mechanisms and possible therapeutics,since the liver is an important organ in the body that performs a large number of tasks.Here we identify the organelle proteome of C57BL/6J mouse liver nuclei as a promising strategy to enrich low abundance proteins,in the sense that analysis of whole liver cells is rather complex for current techniques and may not be suitable for proteins with low abundance.Evaluation of nucleus integrity and purity was performed to demonstrate the effectiveness of the optimized isolation procedure.The extracted nuclear proteins were identified by 2-DE MS analyses,and a total of 748 proteins were identified.Bioinformatic analyses were performed to demonstrate the physicochemical properties,cellular locations and functions of the proteins. | ZHANG Yang FANG CaiYun BAO HuiMin FAN HuiZhi SHEN HuaLi YANG PengYuan | 2013 | Science China(Life Sciences)2013，56，6： | 3 |
| 3 | Phylogenetic and molecular characterization of coxsackievirus A24variant isolates from a 2010acute hemorrhagic conjunctivitis outbreak in Guangdong,China显示文摘 | Wu De Zheng Huanying Li Hui Monagin Corina Guo Xue Liu Leng Zeng Hanri Fang Ling Mo Yanling Zhou Huiqiong Zhang Huan Kou Jing Long Caiyun Hiromu Yoshida and Ke Changwen | 2012 | Virol J2012，9，41： | 1 |
| 4 | Controlling the morphology, size and phase of Nb_2O_5 crystals for high electrochemical performance显示文摘The morphology, size and phase of the material play a crucial role in its electrochemical performance.Herein, the nano-sized niobium pentoxide(Nb_2O_5) with different morphologies and phase structures are synthesized through a very simple thermal treatment method, including the pseudo hexagonal Nb_2O_5 nanosheets and pseudo hexagonal Nb_2O_5 nanoparticles, orthorhombic Nb_2O_5 nanoparticles. The synthesized pseudohexagonal Nb2O5 nanosheets and orthorhombic Nb_2O_5 nanoparticles exhibit better cycling and rate performance than the pseudohexagonal Nb2 O5 nanoparticles due to the different morphologies and phase structures. The T-Nb_2O_5-700 nanoparticles show the higher capacity(175 mAh/g) than that of TT-Nb_2O_5-500 nanosheets(127 mAh/g) and TT-Nb_2O_5-600 nanoparticles(39 mAh/g) at a current density of 50 mA/g and good rate performance with a capacity of 140 mAh/g at 1.0 A/g. The excellent rate capability and cycling stability of orthorhombic T-Nb_2O_5 may be ascribed to the dominant contribution of pseudocapacitive effect. This material has the great potential as a practical high-rate anode material for lithium-ion batteries. | Jiaqin Liao Rou Tan Zhixiang Kuang Chunyu Cui Zengxi Wei Xiaolan Deng Zhanheng Yan Yuezhan Feng Fang Li Caiyun Wang Jianmin Ma | 2018 | Chinese Chemical Letters2018，29，12： | 1 |
| 5 | Mapping urban land cover types using object-based multiple endmember spectral mixture analysis显示文摘 | Caiyun Zhang Hannah Cooper Donna Selch Xuelian Meng Fang Qiu Soe W. Myint Charles Roberts Zhixiao Xie | 2014 | Remote Sensing Letters2014，，6： | 1 |
| 6 | Relationship Between the Strengthening Effect and the Morphology of Precipitates in Al–7.4Zn–1.7Mg–2.0Cu Alloy显示文摘The morphological evolution of the precipitates in Al–7.4Zn–1.7Mg–2.0Cu(wt%) alloy was studied by highresolution transmission electron microscopy(HRTEM). Statistics reveal that the hardness of the alloy changes accordingly with the change of the average thickness–diameter ratio of precipitates. The GPII zones are mainly responsible for the first and also the highest hardness peak. They grow in diameter and keep 7-atomic-layer in thickness. Once the thickness changes, the phase transformation from GPII zone to g0 or g-precursor would occur. The resultant metastable g0 and g-precursor precipitates grow in both diameter and thickness, but much faster in the former. After the first hardness peak,the metastable g0 precipitates and g-precursor, coexisting with part of GPII zones, are counted as the main hardening precipitates. | Xiubo Yang Jizi Liu Jianghua Chen Caiyun Wan Lei Fang Ping Liu Cuilan Wu | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，6： | 0 |
| 7 | Discover the Post-Translational Modification Proteome Using Mass Spectrometry显示文摘Protein post-translational modifications(PTMs)are chemical modifications on proteins.PTMs play a key role in many cellular processes by influencing the structure of proteins and dynamically regulating their functions.Therefore,characterizing PTMs at proteome level is critical to provide invaluable insight into the functions of proteins underlying different biological processes.Advances in modern proteomics technologies including sample preparation,chromatography separation as well as mass spectrometry have propelled the PTMs proteome to further depths.During the past decade,to better examine the PTMs with high sensitivity and selectivity,our group have developed a series of MS-based novel analytical approaches to study the protein PTMs.Herein,we mainly introduce these approaches developed by our group and discuss how to overcome the technical obstacles of studying various protein PTMs with mass spectrometry. | Ying Zhang Caiyun Fang Huimin Bao Wenjuan Yuan Haojie Lu | 2021 | Chinese Journal of Chemistry2021，39，3： | 0 |
| 8 | Prevalence and risk factors for minimal hepatic encephalopathy in cirrhotic patients with different etiologies显示文摘Aims:Minimal hepatic encephalopathy(MHE)significantly affects the prognosis of patients with cirrhosis.This study was performed to determine whether there is a difference in the prevalence of MHE among patients with cirrhosis of different etiologies and whether the etiology directly influences the occurrence of MHE.Methods:This multicenter,cross-sectional study enrolled 1879 patients with confirmed cirrhosis at 40 hospitals from October 25,2021,to January 10,2023(Trial registration:http://gffzzd3f38a9638994581s0xnvq5fwnvwn6ncf.ffgz.tsg.suse.edu.cn/[NCT05140837]).The patients'demographics,etiologies of cirrhosis,and laboratory test results were collected.The psychometric hepatic encephalopathy score(PHES)was determined in all patients to screen for MHE.Multivariate logistic analyses were performed to identify the risk factors for MHE.Results:In total,736 patients with cirrhosis were analyzed.The prevalence of MHE was 42.0%(n=309).The primary etiology among all patients was hepatitis B virus(HBV)-related cirrhosis(71.9%[529/736]).The prevalence of MHE was significantly higher in patients with alcoholic cirrhosis(57.1%[40/70])than in those with HBV-related cirrhosis(40.6%[215/529],p=0.009)or hepatitis C virus(HCV)-related cirrhosis(38.2%[26/68],p=0.026).Age(odds ratio[OR],1.042;95%confidence interval[CI],1.024-1.059;p<0.001),duration of education(OR,0.935;95%CI,0.899-0.971;p=0.001),etiology(OR,1.740;95%CI,1.028-2.945;p=0.039),and high MELD-Na scores(OR,1.038;95%CI,1.009-1.067;p=0.009)were independent risk factors for MHE.When patients with cirrhosis of different etiologies were analyzed separately,the results showed that age(OR,1.035;95%CI,1.014-1.057;p=0.001)and duration of education(OR,0.924;95%CI,0.883-0.966;p=0.001)were risk factors for MHE among patients with HBV-related cirrhosis,whereas age(OR,1.138;95%CI,1.033-1.254;p=0.009)and creatinine concentration(OR,16.487;95%CI,1.113-244.160;p=0.042)were risk factors for MHE in patients with HCV-related cirrhosis.No risk factors for MHE were found in patients with autoimmune cirrhosis.For patients with alcoholic cirrhosis,the platelet count(OR,1.014;95%CI,1.000-1.027;p=0.045)was a risk factor for MHE.The PHES subtest results were inconsistent among patients who had MHE with cirrhosis of different etiologies.Patients with HBV-related cirrhosis performed better on Number Connection Test B and the serial dotting test than those with alcoholic cirrhosis(p=0.007 and p<0.001),better on Number Connection Test B than those with HCV-related cirrhosis(p=0.020),and better on the line tracing test than those with autoimmune cirrhosis(p=0.037).Conclusion:The etiology of cirrhosis affected the prevalence of MHE and risk factors for MHE.The domains of major cognitive impairment varied among patients with cirrhosis of different etiologies.Further studies are required to verify these findings. | Xiaoyan Li Shanghao Liu Huiling Xiang Qingge Zhang Ying Guo Hongmei Zu Jing Wang Jiaojian Lv Xiaoning Zhang Fanping Meng Jiahuan Li Jie Li Yangzhen Bianba Jia Shang Guo Zhang Fei Liu Zhaowei Tong Chuang Lei Wei Ye Qiaohua Yang Ningning Wang Ying Song Wei Fu Ziyue Li Yanjing Gao Yongping Zhang Jiafang Chen Caiyun Wu Qi Zheng Fang Wang Jiali Yu Lianjie Lin Chuanlong Yang Xiaoting Yang Xiaomin Ye Xiangmei Wang Xuelan Zhao Xiaolong Qi Fusheng Wang Junliang Fu | 2023 | Portal Hypertension & Cirrhosis2023，2，4： | 0 |
| 9 | A post-synthesis modification method of molecular sieve 13X for enriching hopanoids in petroleum显示文摘In this study,alkali/acid treatment and ion exchange post-synthesis modification methods to modify the pore diameter and structure of molecular sieve 13X(MS13X)were applied to obtain products,which could then be implemented to improve the enrichment recovery of hopanoids in petroleum.The modification products were analyzed by SEM with EDS,XRD and nitrogen physisorption.The results indicated that the product which had been prepared in the oxalic acid ethanol solution formed some mesopores,and also retained the initial framework of crystal.It was revealed that this product was able to remarkably increase the recovery rate of hopanoids in petroleum without leading to a significant isotope fractionation phenomenon.It is thus shown that this modification method of non-aqueous oxalic acid solution for MS13X can be used as an effective pretreatment tool in the application of compoundspecific isotope analysis of hopanes with low concentration. | Yu Fang Ling Huang Yanhua Shuai Bin Zhang Honggang Nie Jin Li Caiyun Wei Huajian Wang Wenlong Zhang | 2021 | Petroleum Research2021，6，3： | 0 |
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