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| 1 | A GmNINa-miR172c-NNC1 Regulatory Network Coordinates the Nodulation and Autoregulation of Nodulation Pathways in Soybean显示文摘Symbiotic root nodules are root lateral organs of plants in which nitrogen-fixing bacteria(rhizobia)convert atmospheric nitrogen to ammonia.The formation and number of nodules in legumes are precisely controlled by a rhizobia-induced signal cascade and host-controlled autoregulation of nodulation(AON).However,how these pathways are integrated and their underlying mechanisms are unclear.Here,we report that microRNA172c(miR172c)activates soybean(Glycine max)R hizobia-induced CLE1(GmRICI)and GmRIC2 by removing the transcriptional repression of these genes by Nodule Number Control 1(NNC1),leading to the activation of the AON pathway.NNC1 interacts with GmNINa,the soybean ortholog of Lotus NODULE INCEPTION(NIN),and hampers its transcriptional activation o i G m RICI and GmRIC2.Importantly,GmNINa acts as a transcriptional activator of miR172c.Intriguingly,NNC1 can transcriptionally repress miR172c expression,adding a negative feedback loop into the NNC1 regulatory network.Moreover,GmNINa interacts with NNC1 and can relieve the NNC1-mediated repression of miR172c transcription.Thus,the GmNINa-miR172c-NNC1 network is a master switch that coordinately regulates and optimizes NF and AON signaling,supporting the balance between nodulation and AON in soybean. | Lixiang Wang Zhengxi Sun Chao Su Yongliang Wang Qiqi Yan Jiahuan Chen Thomas Ott Xia Li | 2019 | Molecular Plant2019，12，9： | 7 |
| 2 | Digoxin Ameliorates Glymphatic Transport and Cognitive Impairment in a Mouse Model of Chronic Cerebral Hypoperfusion显示文摘The glymphatic system plays a pivotal role in maintaining cerebral homeostasis.Chronic cerebral hypoperfusion,arising from small vessel disease or carotid stenosis,results in cerebrometabolic disturbances ultimately manifesting in white matter injury and cognitive dysfunction.However,whether the glymphatic system serves as a potential therapeutic target for white matter injury and cognitive decline during hypoperfusion remains unknown.Here,we established a mouse model of chronic cerebral hypoperfusion via bilateral common carotid artery stenosis.We found that the hypoperfusion model was associated with significant white matter injury and initial cognitive impairment in conjunction with impaired glym・phatic system function.The glymphatic dysfunction was associated with altered cerebral perfusion and loss of aquaporin 4 polarization.Treatment of digoxin rescued changes in glymphatic transport,white matter structure,and cognitive function.Suppression of glymphatic functions by treatment with the AQP4 inhibitor TGN-020 abolished this protective effect of digoxin from hypoperfusion injury.Our research yields new insight into the relationship between hemodynamics,glymphatic transport,white matter injury,and cognitive changes after chronic cerebral hypoperfusion. | Jie Cao Di Yao Rong Li Xuequn Guo Jiahuan Hao Minjie Xie Jia Li Dengji Pan Xiang Luo Zhiyuan Yu Minghuan Wang Wei Wang | 2022 | Neuroscience Bulletin2022，38，2： | 5 |
| 3 | PDMS microchannel fabrication technique based on microwire-molding显示文摘Micro-flow channel is basic functional component of microfluidic chip,and every step-forward of its construction technique has been receiving concern all over the world.This article presents a not-complicated but flexible method for fabrication of micro-flow channels.This method mainly utilizes the conventional molding capability of polydimethylsiloxane(PDMS) and widespread commercial microwires as templates.We have fabricated out some conventional types of microchannels with different topological shapes,as examples for the demonstration of this flexible fabrication route which was not dependent on the stringent demands of photolithographical or microelectromechanical system(MEMS) techniques.The smooth surface,high-intensity,and high flexibility of the wires made it possible to create many types of topological structures of the two-dimensional or three-dimensional microchannel or channel array.The geometric shape of the cross-section of thus forming microchannel in PDMS was the negative of that of embedded-in microwire,in high-fidelity if suitable measures were taken.More-over,such a microchannel fabrication process can easily integrate the conductivity and low resistivity of the metal wire to create micro-flow devices that are suitable for the electromagnetic control of liquid or the temperature regulation in the microchannel.Furthermore some preliminary optical analysis was provided for the observation of thus forming rounded microchannel.Based on this molding strategy,we even made some prototypes for functional microflow application,such as microsolenoids chip and temperature control gadgets.And an experiment of forming a droplet in the cross channel further confirmed the feasibility and applicability of this flexible microchannel forming technique. | JIA YueFei JIANG JiaHuan MA XiaoDong LI Yuan HUANG HeMing CAI KunBao CAI ShaoXi WU YunPeng | 2008 | Chinese Science Bulletin2008，53，24： | 5 |
| 4 | Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver显示文摘Obesity is a major risk factor for cancers including hepatocellular carcinoma(HCC)that develops from a background of non-alcoholic fatty liver disease(NAFLD).Hypercholesterolemia is a common comorbidity of obesity.Although cholesterol biosynthesis mainly occurs in the liver,its role in HCC development of obese people remains obscure.Using high-fat high-carbohydrate diet-associated orthotopic and spontaneous NAFLD-HCC mouse models,we found that hepatic cholesterol accumulation in obesity selectively suppressed natural killer T(NKT)cell-mediated antitumor immunosurveillance.Transcriptome analysis of human liver revealed aberrant cholesterol metabolism and NKT cell dysfunction in NAFLD patients.Notably,cholesterol-lowering rosuvastatin restored NKT expansion and cytotoxicity to prevent obesogenic diet-promoted HCC development.Moreover,suppression of hepatic cholesterol biosynthesis by a mammalian target of rapamycin(mTOR)inhibitor vistusertib preceded tumor regression,which was abolished by NKT inactivation but not CD8^(+)T cell depletion.Mechanistically,sterol regulatory element-binding protein 2(SREBP2)-driven excessive cholesterol production from hepatocytes induced lipid peroxide accumulation and deficient cytotoxicity in NKT cells,which were supported by findings in people with obesity,NAFLD and NAFLD-HCC.This study highlights mTORC1/SREBP2/cholesterol-mediated NKT dysfunction in the tumor-promoting NAFLD liver microenvironment,providing intervention strategies that invigorating NKT cells to control HCC in the obesity epidemic. | Wenshu Tang Jingying Zhou Weiqin Yang Yu Feng Haoran Wu Myth T.S.Mok Lingyun Zhang Zhixian Liang Xiaoyu Liu Zhewen Xiong Xuezhen Zeng Jing Wang Jiahuan Lu Jingqing Li Hanyong Sun Xiaoyu Tian Philip Chun Yeung Yong Hou Heung Man Lee Candice C.H.Lam Howard H.W.Leung Anthony W.H.Chan Ka Fai To John Wong Paul B.S.Lai Kelvin K.C.Ng Simon K.H.Wong Vincent W.S.Wong Alice P.S.Kong Joseph J.Y.Sung Alfred S.L.Cheng | 2022 | Cellular & Molecular Immunology2022，19，7： | 3 |
| 5 | Elimination of CD4^low HLA-G^+ T cells overcomes castration- resistance in prostate cancer therapy显示文摘 | Chao Wang Jiahuan Chen Qianfei Zhang Wang Li Shengbo Zhang Yanjie Xu Fang Wang Bing Zhang Yan Zhang Wei-Qiang Gao | 2018 | Cell Research2018，28，11： | 3 |
| 6 | Rhodojaponin Ⅵ indirectly targets Cav2.2 channels via N-ethylmaleimide-sensitive fusion protein to alleviate neuropathic pain显示文摘Neuropathic pain is a chronic disease that severely afflicts the life and emotional status of patients,but currently available treatments are often ineffective.Novel therapeutic targets for the alleviation of neuropathic pain are urgently needed.Rhodojaponin Ⅵ,a grayanotoxin from Rhododendron molle,showed remarkable antinociceptive efficacy in models of neuropathic pain,but its biotargets and mechanisms are unknown.Given the reversible action of rhodojaponin Ⅵ and the narrow range over which its structure can be modified,we perforwmed thermal proteome profiling of the rat dorsal root ganglion to determine the protein target of rhodojaponin Ⅵ.N-Ethylmaleimide-sensitive fusion(NSF) was confirmed as the key target of rhodojaponin Ⅵ through biological and biophysical experiments.Functional validation showed for the first time that NSF facilitated trafficking of the Cav2.2 channel to induce an increase in Ca2+current intensity,whereas rhodojaponin Ⅵ reversed the effects of NSF.In conclusion,rhodojaponin Ⅵ represents a unique class of analgesic natural products targeting Cav2.2 channels via NSF. | Keliang Chen Tao Wang Yong Li Jun Wu Cheng-Xiao Zhao Sheng Liu Fengrun Sun Yehong Fang Jiahuan Hu Jinping Hu Chong-Jing Zhang Haibo Yu Chao Ma Shi-Shan Yu | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 2 |
| 7 | Lactobacillus plantarum KLDS1.0386 with antioxidant capacity ameliorates the lipopolysaccharide-induced acute liver injury in mice by NF-κB and Nrf2 pathway显示文摘The Lactobacillus is of great interest as a natural antioxidant to ameliorate liver injury for its antioxidant capacity.In a previous experiment,Lactobacillus plantarum KLDS 1.0386 was excellent in adhesion and anti-inflammation.This research assessed the antioxidant capacity of L.plantarum KLDS 1.0386 and how it ameliorates the LPS-induced acute liver injury.In vitro results showed that L.plantarum KLDS 1.0386 had potential antioxidant capacity with 27 genes,and it had better capacities in hydroxyl radicals scavenging and lipid antioxidant than the reference strain L.plantarum WCFS1 (P < 0.05).In vivo results,L.plantarum KLDS 1.0386 significantly reduced hepatic tissue injury,pro-inflammatory cytokines (TNF-α,IL-6),myeloperoxidase (MPO) activities and biochemical indicators of hepatotoxicity (ALT,AST,ALP) (P < 0.05),compared with the LPS-treated mice.Moreover,L.plantarum KLDS 1.0386 increased the relative abundance of the genera,including Lachnospiraceae_NK4A136_group,Muribaculaceae and Alistipes,which significantly increased the level of acetic acid and butyric acid (P < 0.05).The results also showed L.plantarum KLDS 1.0386 significantly adjusted the expression of HO-1,NQO1,CAT,NF-κB,TLR4 and IκB-α in the liver (P < 0.05).Overall,these results indicated that L.plantarum KLDS 1.0386 had great functionality in reducing LPS-induced acute liver injury. | Jiahuan Dong Lijun Ping Qinggang Xie Deyu Liu Li Zhao Smith Etareri Evivie Zhongjiang Wang Bailiang Li Guicheng Huo | 2022 | Food Bioscience2022，47，3： | 2 |
| 8 | Het- erogeneous Photo-Fenton Decolorization of Nethylene Blue Over LiFe(WO4 )2 Catalyst显示文摘 | JI FEI LI CHAOLIN ZHANG JIAHUAN | 2011 | Journal of Haz- ardous Materials2011，186，： | 1 |
| 9 | Ferroptosis is involved in deoxynivalenol-induced intestinal damage in pigs显示文摘Background Deoxynivalenol(DON)is a widespread issue for feed and food safety,leading to animal and human health risks.The objective of this study was to determine whether ferroptosis is involved in DON-induced intestinal injury in piglets.Three groups of 21-day-old male weanling piglets(n 4,serum and small intestines were=7/group)were fed a control diet,or diet adding 1.0 or 3.0 mg DON/kg.At week collected to assay for biochemistry,histology,redox status and ferroptosis-related genes expression.In addition,the involvement of ferroptosis and the role of FTL gene in DON-induced cell death were further verified in the IPEC-J2 cells.Results Compared to the control,dietary supplementation of DON at 1.0 and 3.0 mg/kg induced different degrees of damage in the duodenum,jejunum and ileum,and increased(P<0.05)serum lipopolysaccharide concentration by 46.2%-51.4%.Dietary DON supplementation at 1.0 and(or)3.0 mg/kg increased(P<0.05)concentrations of malondialdehyde(17.4%-86.5%)and protein carbonyl by 33.1%-92.3%in the duodenum,jejunum and ileum.In addition,dietary supplemented with DON upregulated(P<0.05)ferroptotic gene(DMT1)and anti-ferroptotic genes(FTL and FTH1),while downregulated(P<0.05)anti-ferroptotic genes(FPN,FSP1 and CISD1)in the duodenum of the porcine.Furthermore,the in vitro study has demonstrated that deferiprone,a potent ferroptotic inhibitor,mitigated(P<0.05)DON-induced cytotoxicity in porcine small intestinal IPEC-J2 cells.Additionally,deferiprone prevented or alleviated(P<0.05)the dysregulation of ferroptosis-related genes(ACSL4 and FTL)by DON in IPEC-J2 cells.Moreover,specific siRNA knockdown FTL gene expression compromised the DON-induced cell death in IPEC-J2 cells.Conclusions In conclusion,this study revealed that ferroptosis is involved in DON-induced intestinal damage in porcine,and sheds a new light on the toxicity of DON to piglets. | Meng Liu Lei Zhang Yixin Mo Jiahuan Li Jiacheng Yang Juan Wang Niel Alexander Karrow Hao Wu Lvhui Sun | 2023 | Journal of Animal Science and Biotechnology2023，14，4： | 1 |
| 10 | Development of a software platform for bridge modal and damage identification based on ambient excitation显示文摘Modal and damage identification based on ambient excitation can greatly improve the efficiency of high-speed railway bridge vibration detection.This paper first describes the basic principles of stochastic subspace identification,peak-picking,and frequency domain decomposition method in modal analysis based on ambient excitation,and the effectiveness of these three methods is verified through finite element calculation and numerical simulation,Then the damage element is added to the finite element model to simulate the crack,and the curvature mode difference and the curvature mode area difference square ratio are calculated by using the stochastic subspace identification results to verify their ability of damage identification and location.Finally,the above modal and damage identification techniques are integrated to develop a bridge modal and damage identification software platform.The final results show that all three modal identification methods can accurately identify the vibration frequency and mode shape,both damage identification methods can accurately identify and locate the damage,and the developed software platform is simple and efficient. | Jiahuan Li Li Zhu Wenyu Ji Sunfeng You | 2023 | High-Speed Railway2023，1，3： | 1 |
| 11 | Hydrogen inhibition effect of chitosan and sodium phosphate on ZK60 waste dust in a wet dust removal system:A feasible way to control hydrogen explosion显示文摘Wet dust removal systems used to control dust in the polishing or grinding process of Mg alloy products are frequently associated with potential hydrogen explosion caused by magnesium-water reaction.For purpose of avoiding hydrogen explosion risks,we try to use a combination of chitosan(CS)and sodium phosphate(SP)to inhibit the hydrogen evolution reaction between magnesium alloy waste dust and water.The hydrogen evolution curves and chemical kinetics modeling for ten different mixing ratios demonstrate that 0.4wt%CS+0.1wt%SP yields the best inhibition efficiency with hydrogen generation rate of almost zero.SEM and EDS analyses indicate that this composite inhibitor can create a uniform,smooth,tight protective film over the surface of the alloy dust particles.FTIR and XRD analysis of the chemical composition of the surface film show that this protective film contains CS and SP chemically adsorbed on the surface of ZK60 but no detectable Mg(OH)_(2),suggesting that magnesium-water reaction was totally blocked.Our new method offers a thorough solution to hydrogen explosion by inhibiting the hydrogen generation of magnesium alloy waste dust in a wet dust removal system. | Yuyuan Zhang Kaili Xu Jiahuan Li Bo Liu Ben Wang | 2023 | Journal of Magnesium and Alloys2023，11，8： | 0 |
| 12 | Gravity-Dependent Animacyy Perception in Zebrafish显示文摘Biological motion(BM),depicted by a handful of point lights attached to the major joints,conveys rich animacy information,which is significantly disrupted if BM is shown upside down.This well-known inversion effect in BM perception is conserved in terrestrial vertebrates and is presumably a manifestation of an evolutionarily endowed perceptual filter(i.e.,life motion detector)tuned to gravity-compatible BM.However,it remains unknown whether aquatic animals,living in a completely different environment from terrestrial animals,perceive BM in a gravity-dependent manner.Here,taking advantage of their typical shoaling behaviors,we used zebrafish as a model animal to examine the ability of teleosts to discriminate between upright(gravity-compatible)and inverted(gravity-incompatible)BM signals.We recorded their swimming trajectories and quantified their preference based on dwelling time and head orientation.The results obtained from three experiments consistently showed that zebrafish spent significantly more time swimming in proximity to and orienting towards the upright BM relative to the inverted BM or other gravity-incompatible point-light stimuli(i.e.,the non-BM).More intriguingly,when the recorded point-light video clips of fish were directly compared with those of human walkers and pigeons,we could identify a unique and consistent pattern of accelerating movements in the vertical(gravity)direction.These findings,to our knowledge,demonstrate for the first time the inversion effect in BM perception in simple aquatic vertebrates and suggest that the evolutionary origin of gravity-dependent BM processing may be traced back to ancient aquatic animals. | Xiaohan Ma Xiangyong Yuan Jiahuan Liu Li Shen Yiwen Yu Wen Zhou Zuxiang Liu Yi Jiang | 2023 | Research2023，，1： | 0 |
| 13 | Acid-Stable CoWO_(4)/WO_(3)-Microrod Coated by a Thin Carbon-Layer as Efficient Pt Co-Catalysts for Methanol Oxidation and Oxygen Reduction显示文摘Insufficient activity and instability(poisoning)of Pt-based electrocatalysts for methanol oxidation and oxygen reduction reactions(MOR/ORR)impede the development of direct methanol fuel cells.Here,CoWO_(4) nanoparticles-loaded WO_(3) microrods coated by a thin carbon-layer are used as Pt-supports/co-catalysts for MOR/ORR.WO_(3) grows along the(110)crystal plane to form microrod(diameter of~0.6 um),which is coated by a carbon-layer(~5 nm).Pt-CoWO_(4)/WO_(3)@NCL-mr(850℃)shows a higher mass activity(2208 mA mg^(-1)_(pt))than the commercial Pt/C(659.4 mA mg^(-1)_(pt)).CoWO_(4)/WO_(3) heterojunction on the microrod surface with abundant oxygen vacancies allows the generation of surface-adsorbed hydroxyl to facilitate CO elimination and regeneration of the occupied Pt active-sites(promising stability).PtCo WO_(4)/WO_(3)@NCL-mr(850℃)has higher half-wave(0.46 V)and onset(0.54 V)potentials than Pt/C(0.41 and 0.50 V)for ORR.The microrod structure of Co WO_(4)/WO_(3)@NCL facilitates the dispersibility of Pt NPs to increase the utilization of Pt active sites and relieve the self-aggregation of Pt to obtain a promising synergy between Pt and CoWO_(4)(Co^(2+))for ORR in acid media.This study provides insights not only into the synthesis of acid-resistant WO_(3)@NCL microrod as active Pt co-catalyst,but also into the effective utilization of surface oxygen vacancies and Co^(2+) for MOR/ORR. | Jiahuan Li Jiahao Xie Xinyu Wang Ying Dai Xiaoqin Xu Jin Liu Zhuang Cai Xin Meng Jinlong Zou | 2022 | Chinese Journal of Structural Chemistry2022，41，7： | 0 |
| 14 | Multi-omics analyses of G6PD deficiency variants in Chinese population显示文摘Glucose-6-phosphate dehydrogenase(G6PD)deficiency is one of the most prevalent hereditary and X-linked enzyme disorders caused by the pathogenetic G6PD(NM_001042351.2)variants(Yang et al.,2016).The clinical manifestations of G6PD deficiency offer a wide spectrum of diverse disease phenotypes(Hecker et al.,2013).Investigations of prevalence and molecular epidemiology demonstrate that G6PD deficiency affects over 400 milion individuals worldwide and leads to thousands of deaths annually(Mortality and Causes of Death,2015). | He Ji Jiahuan Chen Peide Huang Zhimin Feng Weining Hu Mengyao Dai Xiaohui Sun Xiao Jin Guangquan Chen Guang Ning Lin Li Weiqing Wang Yanan Cao | 2024 | Journal of Genetics and Genomics2024，51，1： | 0 |
| 15 | Prevalence and risk factors for minimal hepatic encephalopathy in cirrhotic patients with different etiologies显示文摘Aims:Minimal hepatic encephalopathy(MHE)significantly affects the prognosis of patients with cirrhosis.This study was performed to determine whether there is a difference in the prevalence of MHE among patients with cirrhosis of different etiologies and whether the etiology directly influences the occurrence of MHE.Methods:This multicenter,cross-sectional study enrolled 1879 patients with confirmed cirrhosis at 40 hospitals from October 25,2021,to January 10,2023(Trial registration:http://gffzzd3f38a9638994581spf0xu0cwuk5566cv.ffgz.tsg.suse.edu.cn/[NCT05140837]).The patients'demographics,etiologies of cirrhosis,and laboratory test results were collected.The psychometric hepatic encephalopathy score(PHES)was determined in all patients to screen for MHE.Multivariate logistic analyses were performed to identify the risk factors for MHE.Results:In total,736 patients with cirrhosis were analyzed.The prevalence of MHE was 42.0%(n=309).The primary etiology among all patients was hepatitis B virus(HBV)-related cirrhosis(71.9%[529/736]).The prevalence of MHE was significantly higher in patients with alcoholic cirrhosis(57.1%[40/70])than in those with HBV-related cirrhosis(40.6%[215/529],p=0.009)or hepatitis C virus(HCV)-related cirrhosis(38.2%[26/68],p=0.026).Age(odds ratio[OR],1.042;95%confidence interval[CI],1.024-1.059;p<0.001),duration of education(OR,0.935;95%CI,0.899-0.971;p=0.001),etiology(OR,1.740;95%CI,1.028-2.945;p=0.039),and high MELD-Na scores(OR,1.038;95%CI,1.009-1.067;p=0.009)were independent risk factors for MHE.When patients with cirrhosis of different etiologies were analyzed separately,the results showed that age(OR,1.035;95%CI,1.014-1.057;p=0.001)and duration of education(OR,0.924;95%CI,0.883-0.966;p=0.001)were risk factors for MHE among patients with HBV-related cirrhosis,whereas age(OR,1.138;95%CI,1.033-1.254;p=0.009)and creatinine concentration(OR,16.487;95%CI,1.113-244.160;p=0.042)were risk factors for MHE in patients with HCV-related cirrhosis.No risk factors for MHE were found in patients with autoimmune cirrhosis.For patients with alcoholic cirrhosis,the platelet count(OR,1.014;95%CI,1.000-1.027;p=0.045)was a risk factor for MHE.The PHES subtest results were inconsistent among patients who had MHE with cirrhosis of different etiologies.Patients with HBV-related cirrhosis performed better on Number Connection Test B and the serial dotting test than those with alcoholic cirrhosis(p=0.007 and p<0.001),better on Number Connection Test B than those with HCV-related cirrhosis(p=0.020),and better on the line tracing test than those with autoimmune cirrhosis(p=0.037).Conclusion:The etiology of cirrhosis affected the prevalence of MHE and risk factors for MHE.The domains of major cognitive impairment varied among patients with cirrhosis of different etiologies.Further studies are required to verify these findings. | Xiaoyan Li Shanghao Liu Huiling Xiang Qingge Zhang Ying Guo Hongmei Zu Jing Wang Jiaojian Lv Xiaoning Zhang Fanping Meng Jiahuan Li Jie Li Yangzhen Bianba Jia Shang Guo Zhang Fei Liu Zhaowei Tong Chuang Lei Wei Ye Qiaohua Yang Ningning Wang Ying Song Wei Fu Ziyue Li Yanjing Gao Yongping Zhang Jiafang Chen Caiyun Wu Qi Zheng Fang Wang Jiali Yu Lianjie Lin Chuanlong Yang Xiaoting Yang Xiaomin Ye Xiangmei Wang Xuelan Zhao Xiaolong Qi Fusheng Wang Junliang Fu | 2023 | Portal Hypertension & Cirrhosis2023，2，4： | 0 |
| 16 | Discrimination of background events in the PolarLight X-ray polarimeter显示文摘PolarLight is a space-borne X-ray polarimeter that measures the X-ray polarization via electron tracking in an ionization chamber.It is a collimated instrument and thus suffers from the background on the whole detector plane.The majority of background events are induced by high energy charged particles and show ionization morphologies distinct from those produced by X-rays of interest.Comparing on-source and off-source observations,we find that the two datasets display different distributions on image properties.The boundaries between the source and background distributions are obtained and can be used for background discrimination.Such a means can remove over 70%of the background events measured with PolarLight.This approaches the theoretical upper limit of the background fraction that is removable and justifies its effectiveness.For observations with the Crab nebula,the background contamination decreases from 25%to 8%after discrimination,indicative of a polarimetric sensitivity of around 0.2 Crab for PolarLight.This work also provides insights into future X-ray polarimetric telescopes. | Jiahuan Zhu Hong Li Hua Feng Jiahui Huang Xiangyun Long Qiong Wu Weichun Jiang Massimo Minuti Saverio Citraro Hikmat Nasimi Dongxin Yang Jiandong Yu Ge Jin Ming Zeng Peng An Luca Baldini Ronaldo Bellazzini Alessandro Brez Luca Latronico Carmelo Sgrò Gloria Spandre Michele Pinchera Fabio Muleri Paolo Soffitta Enrico Costa | 2021 | Research in Astronomy and Astrophysics2021，21，9： | 0 |
| 17 | Open-cell mullite ceramic foams derived from porous geopolymer precursors with tailored porosity显示文摘Porous geopolymer precursors were firstly prepared by the direct foaming method using bauxite,fly ash(FA),and metakaolin(MK)as raw materials,and porous mullite ceramics were prepared after ammonium ion exchange and then high-temperature sintering.The effects of chemical foaming agent concentration,ion-exchange time,and sintering temperature on porous geopolymerderived mullite ceramics were studied,and the optimal preparation parameters were found.Studies have shown that the concentration of blowing agent had great influence on open porosity(q)and porosity and cell size distributions of geopolymer samples,which in turn affected their compressive strength(σ).Duration of the ion exchange had no obvious effect on the sintered samples,and the amount of mullite phase increased with the increase in the sintering temperature.Mullite foams,possessing an open-celled porous structure,closely resembling that of the starting porous geopolymers produced by directly foaming,were obtained by firing at high temperatures.Stable mullite(3Al_(2)O_(3)·2SiO_(2))ceramic foams with total porosity(ε)of 83.52 vol%,high open porosity of 83.23 vol%,and compressive strength of 1.72 MPa were produced after sintering at 1400 for 2 h in℃ air without adding any sintering additives using commercial MK,bauxite,and FA as raw materials. | Jiahuan SHAO Chengying BAI Xinyu LI Kun YANG Ting ZHENG Yingjie QIAO Lili ZHANG Hongqiang LI Paolo COLOMBO | 2023 | Journal of Advanced Ceramics2023，12，2： | 0 |
| 18 | Gut microbiota bridges dietary nutrients and host immunity显示文摘Dietary nutrients and the gut microbiota are increasingly recognized to cross-regulate and entrain each other,and thus affect host health and immune-mediated diseases.Here,we systematically review the current understanding linking dietary nutrients to gut microbiota-host immune interactions,emphasizing how this axis might influence host immunity in health and diseases.Of relevance,we highlight that the implications of gut microbiota-targeted dietary intervention could be harnessed in orchestrating a spectrum of immune-associated diseases. | Lijuan Fan Yaoyao Xia Youxia Wang Dandan Han Yanli Liu Jiahuan Li Jie Fu Leli Wang Zhending Gan Bingnan Liu Jian Fu Congrui Zhu Zhenhua Wu Jinbiao Zhao Hui Han Hao Wu Yiwen He Yulong Tang Qingzhuo Zhang Yibin Wang Fan Zhang Xin Zong Jie Yin Xihong Zhou Xiaojun Yang Junjun Wang Yulong Yin Wenkai Ren | 2023 | Science China(Life Sciences)2023，66，11： | 0 |
| 19 | PPP-RTK considering the ionosphere uncertainty with cross-validation显示文摘With the high-precision products of satellite orbit and clock,uncalibrated phase delay,and the atmosphere delay corrections,Precise Point Positioning(PPP)based on a Real-Time Kinematic(RTK)network is possible to rapidly achieve centimeter-level positioning accuracy.In the ionosphere-weighted PPP–RTK model,not only the a priori value of ionosphere but also its precision afect the convergence and accuracy of positioning.This study proposes a method to determine the precision of the interpolated slant ionospheric delay by cross-validation.The new method takes the high temporal and spatial variation into consideration.A distance-dependent function is built to represent the stochastic model of the slant ionospheric delay derived from each reference station,and an error model is built for each reference station on a fve-minute piecewise basis.The user can interpolate ionospheric delay correction and the corresponding precision with an error function related to the distance and time of each reference station.With the European Reference Frame(EUREF)Permanent GNSS(Global Navigation Satellite Systems)network(EPN),and SONEL(Système d’Observation du Niveau des Eaux Littorales)GNSS stations covering most of Europe,the efectiveness of our wide-area ionosphere constraint method for PPP-RTK is validated,compared with the method with a fxed ionosphere precision threshold.It is shown that although the Root Mean Square(RMS)of the interpolated ionosphere error is within 5 cm in most of the areas,it exceeds 10 cm for some areas with sparse reference stations during some periods of time.The convergence time of the 90th percentile is 4.0 and 20.5 min for horizontal and vertical directions using Global Positioning System(GPS)kinematic solution,respectively,with the proposed method.This convergence is faster than those with the fxed ionosphere precision values of 1,8,and 30 cm.The improvement with respect to the latter three solutions ranges from 10 to 60%.After integrating the Galileo navigation satellite system(Galileo),the convergence time of the 90th percentile for combined kinematic solutions is 2.0 and 9.0 min,with an improvement of 50.0%and 56.1%for horizontal and vertical directions,respectively,compared with the GPS-only solution.The average convergence time of GPS PPP-RTK for horizontal and vertical directions are 2.0 and 5.0 min,and those of GPS+Galileo PPP-RTK are 1.4 and 3.0 min,respectively. | Pan Li Bobin Cui Jiahuan Hu Xuexi Liu Xiaohong Zhang Maorong Ge Harald Schuh | 2022 | Satellite Navigation2022，3，1： | 0 |
| 20 | PROPOSED INNOVATION REFORM MODEL FOR THE MINERAL NITROGEN FERTILIZER INDUSTRY IN CHINA TO REDUCE GREENHOUSE GAS EMISSIONS显示文摘Globally,the reduction of excessive N losses and greenhouse gas(GHG)emissions is a central environmental challenge in the 21 century.China has huge associated emissions during both production and land application phases.In addition,70%of N fertilizer in China is produced and land applied as urea,which has high associated emissions.This study utilized life cycle analysis to compare the carbon emission capacity of different N fertilizers and quantified GHG emissions from different N fertilizer chains within China.This enabled a new innovative reform model to be proposed,which aims to decrease the carbon footprint and increase the net ecosystem carbon budget of China.The results showed that the carbon footprint of the N fertilizer industry was about 229 Tg·yr^(-1)CO_(2)-eq in 2020.Through changes away from urea through the production and land application of a mix of newly emerging fertilizers,liquid fertilizers and standard fertilizer reductions to 174–182 Tg·yr^(-1)CO_(2)-eq.Through the upgrading of mineral N fertilizer production technology,the carbon footprint of N fertilizer chain can be reduced by34.8 Tg·yr^(-1)CO_(2)-eq.Such reductions would reduce China's total GHG emissions to 140–147 Tg·yr^(-1)CO_(2)-eq. | Dongjia LI Rui LIU Li CHEN Yu GAO Xuanyu GU Yu-hua SHI Jiahuan LIU Weifeng ZHANG | 2023 | Frontiers of Agricultural Science and Engineering2023，10，2： | 0 |
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