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| 1 | The second natural gas hydrate production test in the South China Sea显示文摘Clayey silt reservoirs bearing natural gas hydrates(NGH)are considered to be the hydrate-bearing reservoirs that boast the highest reserves but tend to be the most difficult to exploit.They are proved to be exploitable by the first NGH production test conducted in the South China Sea in 2017.Based on the understanding of the first production test,the China Geological Survey determined the optimal target NGH reservoirs for production test and conducted a detailed assessment,numerical and experimental simulation,and onshore testing of the reservoirs.After that,it conducted the second offshore NGH production test in 1225 m deep Shenhu Area,South China Sea(also referred to as the second production test)from October 2019 to April 2020.During the second production test,a series of technical challenges of drilling horizontal wells in shallow soft strata in deep sea were met,including wellhead stability,directional drilling of a horizontal well,reservoir stimulation and sand control,and accurate depressurization.As a result,30 days of continuous gas production was achieved,with a cumulative gas production of 86.14×104 m3.Thus,the average daily gas production is 2.87×10^4 m^3,which is 5.57 times as much as that obtained in the first production test.Therefore,both the cumulative gas production and the daily gas production were highly improved compared to the first production test.As indicated by the monitoring results of the second production test,there was no anomaly in methane content in the seafloor,seawater,and atmosphere throughout the whole production test.This successful production test further indicates that safe and effective NGH exploitation is feasible in clayey silt NGH reservoirs.The industrialization of hydrates consists of five stages in general,namely theoretical research and simulation experiments,exploratory production test,experimental production test,productive production test,and commercial production.The second production test serves as an important step from the exploratory production test to experimental production test. | Jian-liang Ye Xu-wen Qin Wen-wei Xie Hai-long Lu Bao-jin Ma Hai-jun Qiu Jin-qiang Liang Jing-an Lu Zeng-gui Kuang Cheng Lu Qian-yong Liang Shi-peng Wei Yan-jiang Yu Chunsheng Liu Bin Li Kai-xiang Shen Hao-xian Shi Qiu-ping Lu Jing Li Bei-bei Kou Gang Song Bo Li He-en Zhang Hong-feng Lu Chao Ma Yi-fei Dong Hang Bian | 2020 | China Geology2020，3，2： | 22 |
| 2 | Evaluation of the Effects of Standard Rescue Procedure on Severe Trauma Treatment in China显示文摘 | Xiao-Feng Yin Tian-Bing Wang Pei-Xun Zhang Yu-Hui Kou Dian-Ying Zhang Kai Yu De-Cheng Lyu Mao-Zheng Liu Dong-Sheng Zhou Peng Zhang Jue-Hua Jing Wei-Wei Ge Li-Ying Cao Guo-Sheng Wang Shao-Jie Deng Weng-Hua Liu Mao Zhang Yong-An Xu Kun Zhang Bing Li Wei Wang Zhong-Li Gao Cheng-La Yi Bao-Guo Jiang | 2015 | Chinese Medical Journal2015，，10： | 18 |
| 3 | Characterization of naturally occurring pentacyclic triterpenes as novel inhibitors of deubiquitinating protease USP7 with anticancer activity in vitro显示文摘Deubiquitinating 朊酶 USP7 是为癌症治疗的一个有希望的治疗学的目标,并且对开发 USP7 禁止者的兴趣极大地增加了。在现在的学习,我们在 vitro 与 USP7 禁止的活动报导了一系列自然 pentacyclic triterpenes。在他们之中, ursane triterpenes 和 oleanane triterpenes 比贪吃的 triterpenes 更活跃,而 ursolic 酸是有 7.0 的 IC 50 | Bo JING Meng LIU Li YANG Hai-yan CAI Jie-bo CHEN Ze-xi LI Xi KOU Yun-zhao WU Dong-jun QIN Li ZHOU Jin JIN Hu LEI Han-zhang XU Wei-wei WANG Ying-li WU | 2018 | Acta Pharmacologica Sinica2018，39，3： | 5 |
| 4 | Viable mice produced from three-factor induced pluripotent stem (iPS) cells through tetraploid complementation显示文摘 | Lan Kang Tong Wu Yu Zao Ye Yuan Jing He Yu Zhang Tong Luo Zhaohui Kou Shaorong Gao | 2011 | Cell Research2011，21，3： | 5 |
| 5 | OsMPK4 promotes phosphorylation and degradation of IPA1 in response to salt stress to confer salt tolerance in rice显示文摘Salt stress adversely affects plant growth,development,and crop yield.Rice(Oryza sativa L.)is one of the most salt-sensitive cereal crops,especially at the early seedling stage.Mitogen-activated protein kinase(MAPK/MPK)cascades have been shown to play critical roles in salt response in Arabidopsis.However,the roles of the MPK cascade signaling in rice salt response and substrates of Os MPK remain largely unknown.Here,we report that the salt-induced Os MPK4-Ideal Plant Architecture 1(IPA1)signaling pathway regulates the salt tolerance in rice.Under salt stress,Os MPK4 could interact with IPA1 and phosphorylate IPA1 at Thr180,leading to degradation of IPA1.Genetic evidence shows that IPA1 is a negative regulator of salt tolerance in rice,whereas Os MPK4 promotes salt response in an IPA1-dependent manner.Taken together,our results uncover an Os MPK4-IPA1 signal cascade that modulates the salt stress response in rice and sheds new light on the breeding of salt-tolerant rice varieties. | Meiru Jia Nan Luo Xiangbing Meng Xiaoguang Song Yanhui Jing Liquan Kou Guifu Liu Xiahe Huang Yingchun Wang Jiayang Li Bing Wang Hong Yu | 2022 | Journal of Genetics and Genomics2022，49，8： | 2 |
| 6 | Low phosphorus promotes NSP1–NSP2 heterodimerization to enhance strigolactone biosynthesis and regulate shoot and root architecture in rice显示文摘Phosphorus is an essential macronutrient for plant development and metabolism,and plants have evolved ingenious mechanisms to overcome phosphate(Pi)starvation.However,the molecular mechanisms underlying the regulation of shoot and root architecture by low phosphorus conditions and the coordinated utilization of Pi and nitrogen remain largely unclear.Here,we show that Nodulation Signaling Pathway 1(NSP1)and NSP2 regulate rice tiller number by promoting the biosynthesis of strigolactones(SLs),a class of phytohormones with fundamental effects on plant architecture and environmental responses.We found that NSP1 and NSP2 are induced by Oryza sativa PHOSPHATE STARVATION RESPONSE2(OsPHR2)in response to low-Pi stress and form a complex to directly bind the promoters of SL biosynthesis genes,thus markedly increasing SL biosynthesis in rice.Interestingly,the NSP1/2–SL signaling module represses the expression of CROWN ROOTLESS 1(CRL1),a newly identified early SL-responsive gene in roots,to restrain lateral root density under Pi deficiency.We also demonstrated that GR24^(4DO) treatment under normal conditions inhibits the expression of OsNRTs and OsAMTs to suppress nitrogen absorption but enhances the expression of OsPTs to promote Pi absorption,thus facilitating the balance between nitrogen and phosphorus uptake in rice.Importantly,we found that NSP1p:NSP1 and NSP2p:NSP2 transgenic plants show improved agronomic traits and grain yield under low-and medium-phosphorus conditions.Taken together,these results revealed a novel regulatory mechanism of SL biosynthesis and signaling in response to Pi starvation,providing genetic resources for improving plant architecture and nutrient-use efficiency in low-Pi environments. | Kun Yuan Hao Zhang Chaoji Yu Nan Luo Jijun Yan Shuang Zheng Qingliang Hu Dahan Zhang Liquan Kou Xiangbing Meng Yanhui Jing Mingjiang Chen Xinwei Ban Zongyun Yan Zefu Lu Jian Wu Yu Zhao Yan Liang Yonghong Wang Guosheng Xiong Jinfang Chu Ertao Wang Jiayang Li Bing Wang | 2023 | Molecular Plant2023，16，11： | 2 |
| 7 | Soldering of Zr-based bulk metallic glass and copper by Au-12Ge eutectic alloy显示文摘Zr-based bulk metallic glass and copper with different surface roughness were soldered using low temperature eutectic Au-12 Ge(wt%) solder on a thermomechanical simulator. The cross-sectional microstructures of the brazed joints were analyzed by scanning electron microscopy(SEM) and transmission electron microscope(TEM) in detail, and the compositional distribution along the interface was analyzed by energy-dispersive spectrometer(EDS). Results show that the surface roughness of base metals plays an important role in the quality of the brazed joint because the surface roughness can enlarge the effective contact area, which can improve the brazing surface quality between two materials. A moderate roughness of treated Zr-based metallic glass of 18 μm is shown to be the best for the soldering, while the surface roughness has a weak effect on the soldering behavior of Au-12 Ge solder on copper. After soldering, long-range diffusion of atoms occurs between the base metal and solder, and five distinct regions are formed at the joint region. | Jun Wang Jing Cui Hong-Chao Kou Heng Guan Jin-Shan Li | 2019 | Rare Metals2019，38，1： | 2 |
| 8 | Application of wellhead suction anchor technology in the second production test of natural gas hydrates in the South China Sea显示文摘Traditional suction anchor technology is mainly used in the fields of subsea structure bearing foundations,single-point mooring systems and offshore wind power.It is characterized by providing sufficient lateral and vertical bearing capacities and lateral bending moment.The anchor structure of a traditional suction anchor structure is improved with wellhead suction anchor technology,where a central pipe is added as a channel for drilling and completion operations.To solve the technical problems of a low wellhead bearing capacity,shallow built-up depth,and limited application of conductor jetting in the second production test of natural gas hydrates(NGHs)in the South China Sea(SCS),the China Geological Survey(CGS)took the lead in independently designing and manufacturing a wellhead suction anchor,which fulfilled the requirements of the production test.This novel anchor was successfully implemented in the second production test for the first time,providing a stable wellhead foundation for the success of the second production test of NGHs in the SCS. | Bo Li Bei-bei Kou Bin Li Jing Li Jing Zeng Qing-lei Niu Yu-tao Shao Ke-wei Zhang Hao-yu Yu Ying-sheng Wang | 2022 | China Geology2022，5，2： | 2 |
| 9 | Hollow Al2O3 microspheres derived from Al/AlOOH-nH2O core-shell particles显示文摘 | KOU Huamin WANG Jing PAN Yubai | 2005 | Journal of the American Ceramic Society2005，88，： | 1 |
| 10 | Identification of Inonotus obliquus and Analysis of Antioxidation and Antitumor Activities of Polysaccharides显示文摘 | Yana Song Jing Hui Wei Kou Ru Xin Fei Jia Ning Wang Fengqing Hu Huili Zhang Hongsheng Liu | 2008 | Current Microbiology2008，，5： | 1 |
| 11 | Terahertz Spectroscopy for Accurate Identification of Panax quinquefolium Basing on Nonconjugated 24(R)-Pseudoginsenoside F_(11)显示文摘Panax quinquefolium is a perennial herbaceous plant that contains many beneficial ginsenosides with diverse pharmacological effects.24(R)-pseudoginsenoside F_(11)is specific to P.quinquefolium,a useful biomarker for distinguishing this species from other related plants.However,because of its nonconjugated property and the complexity of existing detection methods,this biomarker cannot be used as the identification standard.We herein present a stable 24(R)-pseudoginsenoside F_(11)fingerprint spectrum in the terahertz band,thereby proving that F_(11)can be detected and quantitatively analyzed via terahertz spectroscopy.We also analyzed the sample by high-performance liquid chromatography-triple quadrupole mass spectrometry.The difference between the normalized data for the two analytical methods was less than 5%.Furthermore,P.quinquefolium from different areas and other substances can be clearly distinguished based on these terahertz spectra with a standard principal component analysis.Our method is a fast,simple,and cost-effective approach for identifying and quantitatively analyzing P.quinquefolium. | Tianyi Kou Ji Ye Jing Wang Yan Peng Zefang Wang Chenjun Shi Xu Wu Xitian Hu Haihong Chen Ling Zhang Xiaohong Chen Yiming Zhu Huiliang Li Songlin Zhuang | 2021 | Plant Phenomics2021，3，1： | 1 |
| 12 | Preparation and properties of transparent Eu:YAG fluorescent ceramics with different doping concentrations显示文摘 | Qiang Liu Yong Yuan Jiang Li Jing Liu Chen Hu Min Chen Li Lin Huamin Kou Yun Shi Wenbin Liu Haohong Chen Yubai Pan Jingkun Guo | 2014 | Ceramics International2014，，： | 1 |
| 13 | Reinforcement of mullite matrix with multi-walled carbon nanotubes 显示文摘 | Wang Jing Kou Huamin Liu Xuejian | 2007 | Ceramics International2007，33，： | 1 |
| 14 | Phylogenetic and molecular characterization of coxsackievirus A24variant isolates from a 2010acute hemorrhagic conjunctivitis outbreak in Guangdong,China显示文摘 | Wu De Zheng Huanying Li Hui Monagin Corina Guo Xue Liu Leng Zeng Hanri Fang Ling Mo Yanling Zhou Huiqiong Zhang Huan Kou Jing Long Caiyun Hiromu Yoshida and Ke Changwen | 2012 | Virol J2012，9，41： | 1 |
| 15 | Hepatic stellate cells secreted hepatocyte growth factor contributes to the chemoresistance of hepatocellular carcinoma显示文摘 | Yu G Jing Y Kou X | 2013 | PloS One2013，8，73： | 1 |
| 16 | Simultaneous quantification of lopinavir and ritonavir in human plasma by high performance liquid chromatography coupled with UV detection显示文摘High performance liquid chromatography was coupled with UV detection for simultaneous quantification of lopinavir (LPV) and ritonavir (RTV) in human plasma. This assay was sensitive, accurate and simple, and only used 200 μL of plasma sample. Samples were liquid-liquid extracted, and diazepam was used as an internal standard. The chromatographic separation was achieved on a C18 reversed-phase analytic column with a mobile phase of acetonitrile-sodium dihydrogen phosphate buffer (10 mmol L 1, pH 4.80) (60:40, v/v). UV detection was conducted at 205 nm and the column oven was set at 40°C. Calibration curves were constructed between 0.5-20 μg mL 1 for LPV and 0.05-5 μg mL 1 for RTV. The relative standard deviations were 2.16%-3.20% for LPV and 2.12%-2.60% for RTV for intra-day analysis, and 2.34%-4.04% for LPV and 0.31%-4.94% for RTV for inter-day analysis. The accuracy was within 100%±10%. The mean extraction recoveries were 79.17%, 52.26% and 91.35% for RTV, LPV and diazepam, respectively. This method was successfully applied to human plasma samples from patients orally administered a salvage regimen of lopinavir-ritonavir tablets. | KOU HuiJuan YE Min FU Qiang HAN Yang DU XiaoLi XIE Jing ZHU Zhu LI TaiSheng | 2012 | Science China(Life Sciences)2012，55，4： | 1 |
| 17 | Synthesis of thiol-functionalized TiO_2 nanocomposite and photocatalytic degradation for PAH under visible light irradiation显示文摘In this paper,a thiol-functionalized nanophotocatalyst MPTES/TiO_2 was first synthesized by one-pot method using P123 as a template.X-ray diffraction confirms the complete anatase crystalline of thiol-functionalized TiO_2,N_2 adsorption-desorption isotherm demonstrated that these materials possess high surface area and mesoporous structure.The results of XPS show that MPTES has been successfully polymerized in mesoporous structured TiO_2.The photodegradation of phenanthrene(PHE) was investigated under visible light irradiation(λ>420 nm) to evaluate the photocatalytic activity of these materials.Based the experiment results of GC-Mass analysis,a possible mechanism was proposed. | Long Liu Jia Hui Kou Da Meng Guo Jing Yang Hong Lin Liu Hong Xia Yu Sheng Chu Ke Ren Jiang Ying Wang Zhi Gang Zou | 2009 | Chinese Chemical Letters2009，20，11： | 1 |
| 18 | Role of blood pressure on stroke-related mortality:a 45-year follow-up study in China显示文摘Background:Hypertension is associated with stroke-related mortality.However,the long-term association of blood pressure(BP)and the risk of stroke-related mortality and the influence path of BP on stroke-related death remain unknown.The current study aimed to estimate the long-term causal associations between BP and stroke-related mortality and the potential mediating and moderated mediating model of the associations.Methods:This is a 45-year follow-up cohort study and a total of 1696 subjects were enrolled in 1976 and 1081 participants died by the latest follow-up in 2020.COX proportional hazard model was used to explore the associations of stroke-related death with baseline systolic blood pressure(SBP)/diastolic blood pressure(DBP)categories and BP changes from 1976 to 1994.The mediating and moderated mediating effects were performed to detect the possible influencing path from BP to stroke-related deaths.E value was calculated in the sensitivity analysis.Results:Among 1696 participants,the average age was 44.38±6.10 years,and 1124 were men(66.3%).After a 45-year follow-up,a total of 201(11.9%)stroke-related deaths occurred.After the adjustment,the COX proportional hazard model showed that among the participants with SBP≥160 mmHg or DBP≥100 mmHg in 1976,the risk of stroke-related death increased by 217.5%(hazard ratio[HR]=3.175,95%confidence interval[CI]:2.297-4.388),and the adjusted HRs were higher in male participants.Among the participants with hypertension in 1976 and 1994,the risk of stroke-related death increased by 110.4%(HR=2.104,95%CI:1.632-2.713),and the adjusted HRs of the BP changes were higher in male participants.Body mass index(BMI)significantly mediated the association of SBP and stroke-related deaths and this mediating effect was moderated by gender.Conclusions:In a 45-year follow-up,high BP and persistent hypertension are associated with stroke-related death,and these associations were even more pronounced in male participants.The paths of association are mediated by BMI and moderated by gender. | Shengshu Wang Shanshan Yang Wangping Jia Ke Han Yang Song Jing Zeng Wenzhe Cao Shaohua Liu Shimin Chen Zhiqiang Li Xuehang Li Penggang Tai Fuyin Kou Yao He Miao Liu | 2022 | Chinese Medical Journal2022，，4： | 1 |
| 19 | Proteome of mouse oocytes at different developmental stages显示文摘 | WANG S F KOU Z H JING Z Y | 2010 | P Natl Acad Sci U S A2010，107，17： | 1 |
| 20 | Effects of Shengmai Yin(生脉饮)on pulmonary and cardiac function in coronavirus disease 2019 convalescent patients with cardiopulmonary symptoms:a randomized,double blind,multicenter control trial显示文摘OBJECTIVE:To evaluate the efficacy and safety of Shengmai Yin(生脉饮,SMY)on visual analogue scale(VAS)for cardiopulmonary symptoms in coronavirus disease 2019(COVID-19)convalescent patients.METHODS:In this randomized,double blind and multicenter controlled trial,a total of 200 COVID-19 convalescent patients who with cardiopulmonary symptoms were enrolled from three medical centers in Hubei,China.These patients were randomized divided into trial group and the control group,100 patients in each one,SMY and its placebo were applied to respectively,for two weeks.VAS of clinical symptoms included shortness of breath,hidrosis,chest distress,palpitation,and dry cough was performed at 0,1,2 weeks.Decrease in VAS of 30%or more was defined as effective,and a reduction in VAS of 0 was defined as curative.RESULTS:A total of 192 completed the study.The VAS of TCM symptoms showed there was no difference in baseline between the two groups.The VAS in both groups was down-regulated,and there was no significant difference in VAS and cure rates at the first and second week between the two groups.There was no significant difference in breath,hidrosis,palpitation,and dry cough between the two groups but SMY treatment for two weeks has remarkable therapeutic effects in chest distress than placebo.CONCLUSIONS:SMY could effectively ameliorate the symptoms of chest distress,and improve the quality of life of the COVID-19 convalescent patients. | AN Xuedong MAO Lina XIA Ping SU Wen WANG Beibei KOU Leiya ZHANG Zequan QI Meng HU Song CHEN Jing LI Xiujuan LIU Jinwei ZHOU Juan QIAO Jie LUO Dan LUO Guangwei YAN Youqin YANG Guiping DONG Dandan ZHOU Wei TAO Junxiu JIN De TONG Xiaolin WEI Li | 2023 | Journal of Traditional Chinese Medicine2023，43，1： | 1 |
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