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| 1 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 2 | An Interactive Intuitionistic Fuzzy Method for Multilevel Linear Programming Problems显示文摘In this paper, we propose an interactive method for solving the multilevel linear programming problems based on the intuitionistic fuzzy set theory. Firstly, the membership function and the non-membership function are introduced to describe the uncertainty of the decision makers. Secondly, a satisfactory solution is derived by updating the minimum satisfactory degrees with considerations of the overall satisfactory balance among all levels. In addition, the steps of the proposed method are given in this paper. Finally, numerical examples illustrate the feasibility of this method. | HUANG Chan FANG Debin WAN Zhongping | 2015 | Wuhan University Journal of Natural Sciences2015，20，2： | 1 |
| 3 | Effects of Different Dietary Lipid Contents on Growth and Lipase Activity of Eriocheir sinensis Larvae显示文摘The effects of different dietary lipid content on the growth and lipase activity of Eriocheir sinensis larvae were studied in the paper.The results showed that the survival,metamorphic rate and weight gain of E.sinensis larvae at different stages of growth all varied significantly with lipid content (P<0.05).Further,the survival and metamorphosis rates were the highest during the larval phases Z3 to Z4,and the weight gain was the highest during the larval phases Z5 to M.During the first 20 h after metamorphosis of every larval stage,the lipase activity increased over time at Z1,Z2,Z3 and M and declined at Z4 and Z5,and was influenced significantly by lipid content (P<0.05).In addition,lipase activity at each larval stage began to respond to dietary lipid contents 4 h after the larvae were fed,and tended to be stable after 12 h.The diets with higher lipase activity and lower lipid content were selected to give the suitable recipe of lipid requirements at each larval stage.It was concluded that the suitable lipid requirements at Z1,Z2,Z3,Z4,Z5 and M were 6%,4%,6%,8%,8% and 10%,respectively. | ZHENG Debin PAN Luqing FANG Bo | 2011 | Journal of Ocean University of China2011，10，1： | 1 |
| 4 | Experimental study on process of precision forging of an aluminium-alloy rotor显示文摘 | Shan Debin Liu Fang Xu Wenchen | 2005 | Journal of Materials Processing Technology2005，，170： | 1 |
| 5 | Genetic Algorithm for Solving Quadratic Bilevel Programming Problem显示文摘By applying Kuhn-Tucker condition the quadratic bilevel programming,a class of bilevel programming,is transformed into a single level programming problem,which can be simplified by some rule. So we can search the optimal solution in the feasible region,hence reduce greatly the searching space. Numerical experiments on several literature problems show that the new algorithm is both feasible and effective in practice. | WANG Guangmin WAN Zhongping WANG Xianjiai FANG Debin | 2007 | Wuhan University Journal of Natural Sciences2007，12，3： | 1 |
| 6 | A Chinese Sign Language Recognition System Based on SOFM/SRN/ HMM显示文摘 | Gao Wen Fang Gaolin Zhao Debin | 2004 | Pattern Recognition2004，37，12： | 1 |
| 7 | Large Vocabulary Sign Language Recognition Based on Fuzzy Decision Trees显示文摘 | Fang Gaolin Gao Wen Zhao Debin | 2004 | IEEE Transactions on System Man and Cybernetics2004，34，3： | 1 |
| 8 | A Chinese sign language recognition system based on SOFM/SRN/HMM显示文摘 | Wen Gao Gaolin Fang Debin Zhao YiqiangChen | | 0，，： | 1 |
| 9 | Power Coal Transportation and Storage:A Programming Analysis of Road and Rail Options显示文摘In this study,the transportation and storage problems for regional power coal allocation planning are formulated as transportation and storage problems to realize the minimization of the regional transportation and storage cost.An effective optimization model is proposed to solve transportation and storage problems for regional power coal allocation planning,which has interactive effect on multiple participants,such as regional power plants,coal transportation companies,logistics centers,and coal storage centers.A case study illustrates that the model and algorithm are more reasonable compared with the classic transportation model,and the sensitivity analysis improves transportation and storage strategies for regional power coal allocation planning.Results demonstrate that this model can not only satisfy more of the actual requirements of the integral system but also offer more information to the decision-makers(DMs) for reference in favor of exalting decision-making quality. | FANG Debin ZHANG Ming WANG Xianjia | 2011 | Wuhan University Journal of Natural Sciences2011，16，6： | 1 |
| 10 | Large-Vocabu- lary Continuous Sign Language Recognition Based on Transition-Movement Models 显示文摘 | FANG Gaolin GAO Wen ZHAO Debin | 2007 | IEEE Transactions on Systems Man and Cybernetics Part A: Systems and Humans2007，37，1： | 1 |
| 11 | Millimeter-wave wireless communications for home network in fiber-to-the-room scenario显示文摘Millimeter-wave(mmWave)technology has been well studied for both outdoor long-distance transmission and indoor short-range communication.In the recently emerging fiber-to-the-room(FTTR)architecture in the home network of the fifth generation fixed networks(F5G),mmWave technology can be cascaded well to a new optical network terminal in the room to enable extremely high data rate communication(i.e.,>10 Gb/s).In the FTTR+mmWave scenario,the rapid degradation of the mmWave signal in long-distance transmission and the significant loss against wall penetration are no longer the bottlenecks for real application.Moreover,the surrounding walls of every room provide excellent isolation to avoid interference and guarantee security.This paper provides insights and analysis for the new FTTR+mmWave architecture to improve the customer experience in future broadband services such as immersive audiovisual videos. | Chao HE Zhixiong REN Xiang WANG Yan ZENG Jian FANG Debin HOU Le KUAI Rong LU Shilin YANG Zhe CHEN Jixin CHEN | 2021 | Frontiers of Information Technology & Electronic Engineering2021，22，4： | 1 |
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