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| 1 | Black carbon aerosols and their radiative properties in the Pearl River Delta region显示文摘The climatic and environmental effects of atmospheric aerosols are a hot topic in global science community, and radiative properties of the aerosols are one of the important parameters in assessing climatic change. Here we studied the black carbon concentration and absorption coefficient measured with aethalometers, scattering coefficient measured with nephelometers, and single scattering albedo derived at an atmospheric composition watch station in Guangzhou from 2004 to 2007. Our main results are as follows. The data of black carbon concentration and absorption coefficients measured with instruments cannot be directly used until they are measured in parallel with internationally accepted instruments for comparison, calibration, and reduction. After evaluation of the data, the result shows that the monthly mean of BC concentration varies 3.1―14.8 μg·m-3 and the concentration decreases by about 1 μg·m-3 in average over the four years; It is higher in the dry season with a multi-year mean of 8.9 μg/m3 and lower in the rainy season with a multi-year mean of 8.0 μg·m-3; The extreme maximum of monthly mean concentration occurred in December 2004 and extreme minimum in July 2007, and a 4-year mean is 8.4 μg·m-3. It is also shown that monthly mean scattering coefficient derived varies 129 -565 Mm-1, monthly mean absorption coefficient 32-139 Mm-1, and monthly mean single scattering albedo 0.71-0.91, with annual mean values of 0.80, 0.82, 0.79 and 0.84 for 2004, 2005, 2006 and 2007, respectively. Three instruments were used to take simultaneous measurements of BC in PM10, PM2.5, and PM1 and the results showed that PM2.5 took up about 90% of PM10 and PM1 accounted for about 68% of PM2.5, and BC aerosols are mainly present in fine particulates. The variability of BC concentrations is quite consistent between the Nancun station (141 m above sea level) and the Panyu station (13 m above sea level), which are 8 km apart from each other. The concentration in higher altitude station (Panyu) is consistently lower than the lower altitude station (Nancun), and the difference of annual mean is about 4 μg·m-3. | WU Dui MAO JieTai DENG XueJiao TIE XueXi ZHANG YuanHang ZENG LiMin LI Fei TAN HaoBo BI XueYan HUANG XiaoYing CHEN Jing DENG Tao | 2009 | Science China Earth Sciences2009，52，8： | 58 |
| 2 | Achieving over 16% efficiency for single-junction organic solar cells显示文摘To achieve high photovoltaic performance of bulk hetero-junction organic solar cells(OSCs), a range of critical factors including absorption profiles, energy level alignment, charge carrier mobility and miscibility of donor and acceptor materials should be carefully considered. For electron-donating materials, the deep highest occupied molecular orbital(HOMO) energy level that is beneficial for high open-circuit voltage is much appreciated. However, a new issue in charge transfer emerges when matching such a donor with an acceptor that has a shallower HOMO energy level. More to this point, the chemical strategies used to enhance the absorption coefficient of acceptors may lead to increased molecular crystallinity, and thus result in less controllable phase-separation of photoactive layer. Therefore, to realize balanced photovoltaic parameters, the donor-acceptor combinations should simultaneously address the absorption spectra, energy levels, and film morphologies. Here, we selected two non-fullerene acceptors, namely BTPT-4F and BTPTT-4F, to match with a wide-bandgap polymer donor P2F-EHp consisting of an imidefunctionalized benzotriazole moiety, as these materials presented complementary absorption and well-matched energy levels. By delicately optimizing the blend film morphology, we demonstrated an unprecedented power conversion efficiency of over 16% for the device based on P2F-EHp:BTPTT-4F, suggesting the great promise of materials matching toward high-performance OSCs. | Baobing Fan Difei Zhang Meijing Li Wenkai Zhong Zhaomiyi Zeng Lei Ying Fei Huang Yong Cao | 2019 | Science China Chemistry2019，62，6： | 38 |
| 3 | Heme oxygenase-1 protects donor livers from ischemia/reperfusion injury:The role of Kupffer cells显示文摘AIM:To examine whether heme oxygenase (HO)-1 overexpression would exert direct or indirect effects on Kupffer cells activation, which lead to aggravation of reperfusion injury.METHODS: Donors were pretreated with cobalt protoporphyrin (CoPP) or zinc protoporphyrin (ZnPP), HO-1 inducer and antagonist, respectively. Livers were stored at 4℃ for 24 h before transplantation. Kupffer cells were isolated and cultured for 6 h after liver reperfusion.RESULTS: Postoperatively, serum transaminases were significantly lower and associated with less liver injury when donors were pretreated with CoPP, as compared with the ZnPP group. Production of the cytokines tumor necrosis factor-α and interleukin-6 generated by Kupffer cells decreased in the CoPP group. The CD14 expression levels (RT-PCR/Western blots) of Kupffer cells from CoPP-pretreated liver grafts reduced.CONCLUSION: The study suggests that the potential utility of HO-1 overexpression in preventing ischemia/reperfusion injury results from inhibition of Kupffer cells activation. | Zeng, Zhong Huang, Han-Fei Chen, Ming-Qing Song, Fei Zhang, Yu-Jun | 2010 | World Journal of Gastroenterology2010，16，10： | 29 |
| 4 | Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer显示文摘渗入肿瘤的 Tregs 的起源,肿瘤免疫力的抑制的批评调停人,是不清楚的。这里,,我们证明在人的乳癌的渗入肿瘤的天真的 CD4 + T 房间和 Tregs 有重叠 TCR 全部剧目几乎别与传播 Tregs 重叠,建议 intratumoral Tregs 主要在 situ 而非从招募的 Tregs 从天真的 T 房间发展。而且,许多天真的 CD4 + T 房间和 Tregs 密切被相关,两个显示的穷人为乳癌病人的预后。天真的 CD4 + T 房间与许多生产 CCL18 巨噬细胞成比例遵守肿瘤片。而且,采纳地转移的人的天真的 CD4 + T 房间以一种 CCL18 依赖的方式渗入人的乳癌 orthotopic 异种皮移植。在在人性化的鼠标的人的乳癌异种皮移植,由将 PITPNM3 的表达式击倒堵住天真的 CD4 + T 房间的招募进肿瘤, CCL18 受体,显著地减少 intratumoral Tregs 并且禁止肿瘤前进。这些调查结果建议那个乳房渗入肿瘤的 Tregs 从在 situ 区分进 Tregs 的传播天真的 CD4 + T 房间的趋化性产生。由防碍 CCL18 的 PITPNM3 识别禁止天真的 CD4 + T 房间招募进肿瘤可以是为 anticancer 免疫疗法的吸引人的策略。 | Shicheng Su Jianyou Liao Jiang Liu Di Huang Chonghua He Fei Chen LinBing Yang Wei Wu Jianing Chen Ling Lin Yunjie Zeng Nengtai Ouyang Xiuying Cui Herui Yao Fengxi Su Jian-dong Huang Judy Lieberman Qiang Liu Erwei Song | 2017 | Cell Research2017，27，4： | 19 |
| 5 | The influence of stage at diagnosis and molecular subtype on breast cancer patient survival: a hospital.based multi.center study显示文摘Background: Stage at diagnosis and molecular subtype are important clinical factors associated with breast cancer patient survival. However, subgroup survival data from a large study sample are limited in China.To estimate the survival differences among patients with different stages and various subtypes of breast cancer, we conducted a hospital-based multi-center study on breast cancer in Beijing, China.Methods: All resident patients diagnosed with primary, invasive breast cancer between January 1,2006 and December 31,2010 from four selected hospitals in Beijing were included and followed up until December 31,2015. Hospitalbased data of stage at diagnosis, hormone receptor status, and selected clinical characteristics, including body mass index(BMI), menopausal status, histological grade, and histological type, were collected from the medical records of the study subjects. Overall survival(OS) and cancer-specific survival(CSS) were estimated. Cox proportional hazards models were employed to evaluate the associations of stage at diagnosis and molecular subtype with patient survival.Results: The 5-year OS and CSS rates for all patients were 89.4% and 90.3%. Survival varied by stage and molecular subtype. The 5-year OS rates for patients with stage I, Ⅱ, Ⅲ, and IV diseases were 96.5%, 91.6%, 74.8%, and 40.7%,respectively, and the corresponding estimates of 5-year CSS rates were 97.1%, 92.6%, 75.6%, and 42.7%, respectively.The 5-year OS rates for patients with luminal A, luminal B, HER2, and triple-negative subtypes of breast cancer were92.6%, 88.4%, 83.6%, and 82.9%, respectively, and the corresponding estimates of 5-year CSS rates were 93.2%, 89.1 %,85.4%, and 83.5%, respectively. Multivariate analysis showed that stage at diagnosis and molecular subtype were important prognostic factors for breast cancer.Conclusions: Survival of breast cancer patients varied significantly by stage and molecular subtype. Cancer screening is encouraged for the early detection and early diagnosis of breast cancer. More advanced therapies and health care policies are needed on HER2 and triple-negative subtypes. | Tingting Zuo Hongmei Zeng Huichao Li Shuo Liu Lei Yang Changfa Xia Rongshou Zheng Fei Ma Lifang Liu Ning Wang Lixue Xuan Wanqing Chen | 2017 | Chinese Journal of Cancer2017，36，11： | 18 |
| 6 | Capping CsPbBr3 with ZnO to improve performance and stability of perovskite memristors显示文摘技术与快信息存储为设备导致了迫切需要并且处理的信息的快速的发展,高密度,和低精力消费。Memristors 被认为是有所有上述的优点的下一代的记忆设备。最近,有机金属的卤化物 perovskites 被报导为 memristors 正在答应活跃材料,尽管他们有差的稳定性和低劣性能。此处,我们第一次基于无机的卤化物 perovskite (CsPbBr 3, CPB ) 报导稳定、高效的 memristors 的制造。设备有电导致地双极的抵抗切换(物件)并且有大开/关比率的存储器行为(> 10 5),低工作电压(< 1 V )并且精力消费,长数据保留(> 10 4 s ),并且高环境的稳定性,它经由在设备以内盖住的 ZnO 被完成。如此的一个图案能被使适应各种各样的设备。另外,在 CPB 和 ZnO 之间的异质接面以快速的反应速度赋予设备以超过 10 3 的导致光的物件效果(< 1 ms ) ,它使我们能由同时改变光和电场调节电阻状态。信息存储和处理能力的联合完成的如此的多功能的设备为超越传统的体系结构的未来计算有潜在的应用程序。 | Ye Wu Yi Wei Yong Huang Fei Cao Dejian Yu Xiaoming Li Haibo Zeng | 2017 | Nano Research2017，10，5： | 17 |
| 7 | Electroacupuncture preconditioning protects against focal cerebral ischemia/reperfusion injury via suppression of dynamin-related protein 1显示文摘Electroacupuncture preconditioning at acupoint Baihui(GV20) can reduce focal cerebral ischemia/reperfusion injury. However, the precise protective mechanism remains unknown. Mitochondrial fission mediated by dynamin-related protein 1(Drp1) can trigger neuronal apoptosis following cerebral ischemia/reperfusion injury. Herein, we examined the hypothesis that electroacupuncture pretreatment can regulate Drp1, and thus inhibit mitochondrial fission to provide cerebral protection. Rat models of focal cerebral ischemia/reperfusion injury were established by middle cerebral artery occlusion at 24 hours after 5 consecutive days of preconditioning with electroacupuncture at GV20(depth 2 mm, intensity 1 m A, frequency 2/15 Hz, for 30 minutes, once a day). Neurological function was assessed using the Longa neurological deficit score. Pathological changes in the ischemic penumbra on the injury side were assessed by hematoxylin-eosin staining. Cellular apoptosis in the ischemic penumbra on the injury side was assessed by terminal deoxyribonucleotidyl transferase-mediated d UTP-digoxigenin nick end labeling staining. Mitochondrial ultrastructure in the ischemic penumbra on the injury side was assessed by transmission electron microscopy. Drp1 and cytochrome c expression in the ischemic penumbra on the injury side were assessed by western blot assay. Results showed that electroacupuncture preconditioning decreased expression of total and mitochondrial Drp1, decreased expression of total and cytosolic cytochrome c, maintained mitochondrial morphology and reduced the proportion of apoptotic cells in the ischemic penumbra on the injury side, with associated improvements in neurological function. These data suggest that electroacupuncture preconditioning-induced neuronal protection involves inhibition of the expression and translocation of Drp1. | Gao-feng Zhang Pei Yang Zeng Yin Huai-long Chen Fu-guo Ma Bin Wang Li-xin Sun Yan-lin Bi Fei Shi Ming-shan Wang | 2018 | Neural Regeneration Research2018，13，1： | 16 |
| 8 | Influence of pH on short-cut denitrifying phosphorus removal显示文摘Through a series of experiments using denitrifying phosphorus-accumulating sludge in sequencing batch reactors(SBRs), the variations of the intracellular polymers during the anaerobic phosphorus release process at different pH values were compared, the probable reasons for different performances of phosphorus removal were examined, and system operations in a typical cycle were investigated. The results show that the phosphorus removal rate was positively correlated with pH values in a range of 6.5-8.5. When the pH value was 8.0, the anaerobic phosphorus release rate and anoxic phosphorus uptake rate of the activated sludge were 20.95 mg/(g?h) and 23.29 mg/(g?h), respectively; the mass fraction of poly-b-hydroxybutyrate(PHB) increased to 62.87 mg/g under anaerobic conditions; the mass fraction of polyphosphate was 92.67 mg/g under anoxic conditions; and the effluent concentration of total phosphorus(TP) was 1.47 mg/L. With the increase of pH, the mass fraction of acetic acid and PHB also increased, and the absorption rate of acetic acid was equal to the disintegration rate of polyphosphate. When the pH value was above 8.0, biological phosphorus removal was achieved by chemical phosphorus precipitation, and the phosphorus removal rate decreased. | Wei Li Hui-yan Zhang Hui-zhi Sun Fei Zeng Yu-nan Gao Lei Zhu | 2018 | Water Science and Engineering2018，11，1： | 14 |
| 9 | Characterization and fine mapping of the rice blast resistance gene Pia显示文摘Blast,caused by Magnaporthe oryzae,is one of the most widespread and destructive diseases of rice.Breeding durable resistant cultivars(cvs) can be achieved by pyramiding of various resistance(R) genes.Pia,carried by cv.Aichi Asahi,was evaluated against 612 isolates of M.oryzae collected from 10 Chinese provinces.The Pia gene expresses weak resistance in all the provinces except for Jiangsu.Genomic position-ready marker-based linkage analysis was carried out in a mapping population consisting of 800 F2 plants derived from a cross of Aichi Asahi×Kasalath.The locus was defined in an interval of approximately 90 kb,flanked by markers A16 and A21.Four candidate genes(Pia-1,Pia-2,Pia-3,and Pia-4) ,all having the R gene conserved structure,were predicted in the interval using the cv.Nipponbare genomic sequence.Four candidate resistance gene(CRG) markers(A17,A25,A26,and A27) ,derived from the four candidates,were subjected to genotyping with the recombinants detected at the flanking markers.The first three markers completely co-segregated with the Pia locus,and the fourth was absent in the Aichi Asahi genome and disordered with the Pia locus and its flanking markers,indicating that the fourth candidate gene,Pia-4,could be excluded.Co-segregation marker-based genotyping of the three sets of differentials with known R gene genotypes revealed that the genotype of A26(Pia-3) perfectly matched the R gene genotype of Pia,indicating that Pia-3 is the strongest candidate gene for Pia. | ZENG XiaoShan YANG XianFeng ZHAO ZhengHong LIN Fei WANG Ling PAN QingHua | 2011 | Science China(Life Sciences)2011，54，4： | 13 |
| 10 | Combination treatment with comprehensive cryoablation and immunotherapy in metastatic hepatocellular cancer显示文摘AIM: To retrospectively assess the effect of comprehensive cryosurgery (ablation of intraand extra-hepatic tumors) plus dendritic cell-cytokine-induced killer cell immunotherapy in metastatic hepatocellular cancer. METHODS: We divided 45 patients into cryo-immunotherapy (21 patients), cryotherapy (n = 12), immunotherapy (n = 5) and untreated (n = 7) groups. Overall survival (OS) after diagnosis of metastatic hepatocellular cancer was assessed after an 8-year follow-up. RESULTS: Median OS was higher following cryo-immu-notherapy (32 mo) or cryotherapy (17.5 mo; P < 0.05) than in the untreated group (3 mo) and was higher in the cryo-immunotherapy group than in the cryotherapy group (P < 0.05). In the cryo-immunotherapy group, median OS was higher after multiple treatments (36.5 mo) than after a single treatment (21 mo; P < 0.05). CONCLUSION: Cryotherapy and, especially, cryoimmunotherapy significantly increased OS in metastatic hepatocellular cancer patients. Multiple cryo-immunotherapy was associated with a better prognosis than single cryo-immunotherapy. | Li-Zhi Niu Jia-Liang Li Jian-Ying Zeng Feng Mu Meng-Tian Liao Fei Yao Li Li Chun-Yan Liu Ji-Bing Chen Jian-Sheng Zuo Ke-Cheng Xu | 2013 | World Journal of Gastroenterology2013，19，22： | 13 |
| 11 | The aldose reductase inhibitor epalrestat exerts nephritic protection on diabetic nephropathy in db/db mice through metabolic modulation显示文摘Epalrestat is an inhibitor of aldose reductase in the polyol pathway and is used for the management of diabetic neuropathy clinically.Our pilot experiments and accumulated evidences showed that epalrestat inhibited polyol pathway and reduced sorbitol production,and suggested the potential renal protection effects of epalrestat on diabetic nephropathy (DN).To evaluate the protective effect of epalrestat,the db/db mice were used and exposed to epalrestat for 8 weeks,both the physiopathological condition and function of kidney were examined.For the first time,we showed that epalrestatmarkedlyreduced albuminuria and alleviated the podocyte foot process fusion and interstitial fibrosis of db/db mice.Metabolomics was employed,and metabolites in the plasma,renal cortex,and urine were profiled using a gas chromatography-mass spectrometry (GC/MS)-based metabolomic platform.We observed an elevation of sorbitol and fructose,and a decrease of myo-inositol in the renal cortex of db/db mice. Epalrestat reversed the renal accumulation of the polyol pathway metabolites of sorbitol and fructose,and increased myo-inositol level.Moreover,the upregulation of aldose reductase,fibronectin,collagen Ⅲ,and TGF-β1 in renal cortex of db/db mice was downregulated by epalrestat.The data suggested that epalrestat has protective effects on DN,and the inhibition ofaldose reductas and the modulation of polyol pathway in nephritic cells be a potentially therapeutic strategy for DN. | Jun He Hao-xue Gao Na Yang Xiao-dong Zhu Run-bin Sun Yuan Xie Cai-hong Zeng Jing-wei Zhang Jian-kun Wang Fei Ding Ji-ye Aa Guang-ji Wang | 2019 | Acta Pharmacologica Sinica2019，40，1： | 13 |
| 12 | Synthesis and curing of a novel amino-containing phthalonitrile derivative显示文摘A novel phthalonitrile derivative containing an amino group, 3,5-bis(3,4-dicyanophenoxy)aniline (CPA), was synthesized via a nucleophilic displacement of 4-nitrophthalonitrile and 5-aminoresorcinol hydrochloride. The structure of CPA was confirmed by Fourier transform infrared spectra (FT-IR) and nuclear magnetic resonance (1H NMR). Thermal analysis performed on CPA revealed that the novel phthalonitrile derivative showed a self-promotion curing behavior and the resulting polymer exhibited outstanding heat-resistance. | Ke Zeng Ke Zhou Wen Rui Tang Yan Tang Hong Fei Zhou Tao Liu Yi Peng Wang Hai Bing Zhou Gang Yang | 2007 | Chinese Chemical Letters2007，18，5： | 12 |
| 13 | Nonvolatile resistive switching memories-characteristics,mechanisms and challenges | Feng PAN,Chao CHEN,Zhi-shun WANG,Yu-chao YANG,Jing YANG,Fei ZENG Laboratory of Advanced Materials,Department of Materials Science and Engineering, Tsinghua University,Beijing 100084,China | 2010 | Progress in Natural Science:Materials International2010，20，1： | 10 |
| 14 | Stochastic modeling the effect of wind gust on dust entrainment during sand storm显示文摘After the passage of a cold front,spring in northern China the outbreak of strong wind is often accompanied by dust emissions.Owing to the coherent structure of wind gust,dust particles can effectively overcome the systematic descending air motion and penetrate into the middle and upper levels of the atmospheric boundary layer,and then propagate further and diffuse into the troposphere where ascending air motion prevails.Here,we consider the coherent structure of wind gust in LS models,and construct a model suitable for the dust entrainment under the dust-storm canopy.With the parameter of gust,we simulate the dust entrainment during dust storms,and test that the coherent structures of wind gust make the sand particles to reach the upper of the boundary layer. | CHENG XueLing ZENG QingCun HU Fei | 2012 | Chinese Science Bulletin2012，57，27： | 10 |
| 15 | Radical treatment of stage Ⅳ pancreatic cancer by the combination of cryosurgery and iodine-125 seed implantation显示文摘AIM:To investigate the therapeutic effect of radical treatment and palliative treatment in stage Ⅳ pancreatic cancer patients.METHODS:81 patients were enrolled in the study.Radical treatment was performed on 51 patients,while 30 patients were put under palliative treatment.The procedural safety and interval survival for stage Ⅳ pancreatic cancer(IS-Ⅳ) was assessed by almost 2.5 years of follow-ups.The IS-Ⅳ of patients under the two kinds of treatment,and the effects of treatment timing and frequency on IS-Ⅳ,were compared.RESULTS:The IS-Ⅳ of patients who received radical treatment was significantly longer than those who received palliative treatment(P < 0.001).The IS-Ⅳ of patients who received delayed radical or palliative treatment was longer than those who received accordingly timely treatment(P = 0.0034 and 0.0415,respectively).Multiple treatments can play an important role in improving the IS-Ⅳ of patients who received radical treatment(P = 0.0389),but not for those who received palliative treatment(P = 0.99).CONCLUSION:The effect of radical treatment was significantly more obvious than that of palliative treatment,and multiple radical treatments may contribute more to patients than a single radical treatment. | Ji-Bing Chen Jia-Liang Li Li-Hua He Wei-Qun Liu Fei Yao Jian-Ying Zeng Yi Zhang Ke-Qiang Xu Li-Zhi Niu Jian-Sheng Zuo Ke-Cheng Xu | 2012 | World Journal of Gastroenterology2012，18，47： | 10 |
| 16 | Geographic variation of chloroplast DNA in Platycarya strobilacea (Juglandaceae)显示文摘摘要 monotypic 类 Platycarya (Juglandaceae ) 是在东亚的最普遍的适度的树种类之一。在这研究,我们实现了用叶绿体 DNA (cpDNA )(psbA-trnH 和 atpB-rbcL intergenic 分隔符) 的学习在 Platycarya strobilacea 上定序的 phylogeographical,主要 refugia 和移植发送以便识别种类的地点。P 的 180 个个人的一个总数。从从中国和 Jeju 岛(朝鲜) 的 27 张人口的 stobilacea 是镇定的。结果揭示了那 P。strobilacea 为二个 intergenic 分隔符和高基因差异有 35 haplotypes (hT= 0.926 ) 。haplotypes 的这令人惊讶地高的差异显示它的长进化的历史,它与以前的种系发生的分析和石块记录一致。重要 cpDNA 人口分被检测(GST= 0.720;NST= 0.862 ) ,通过在人口和重要 phylogeographical 之中的种子的周期性的基因流动的建议底层组织(NST > GST, P < 0.05 ) 。35 chlorotypes 的种系发生的关系的构造检测了四主要 cpDNA clades。用野兽的分叉标明日期分析建议主要 cpDNA clades 的分叉以前发生了中新世。人口统计的分析显示东方 clade 经历了局部性的人口统计的扩大。分子的种系发生的数据和 haplotypes 的地理分发,通过第四级的气候的摆动在中国在大多数它的当前的范围建议多重冰川的 refugia 的存在。 | Shi-Chao CHEN Li ZHANG Jie ZENG Fei SHI Hong YANG Yun-Rui MAO Cheng-Xin FU | 2012 | Journal of Systematics and Evolution2012，50，4： | 10 |
| 17 | Synthesis of a benzoxazine monomer containing maleimide and allyloxy groups显示文摘新奇 benzoxazine 单体 3-(4-allyloxy )phenyl-3,4-dihydro-2H-6-(N-maleimido )-1,3-benzoxazine (AMB ) 被综合,结构被英尺红外证实,(1 ) H NMR。AMB 的热分析(DSC ) 证明烯丙氧基组的介绍减少了熔点并且展出了一扇狭窄、对称的治好的发热的窗户。 | Yan Tang Qing Lai Zhao Ke Zeng Pei Kai Miao Ke Zhou Wen Rui Tang Hong Fei Zhou Tao Liu Yi Peng Wang Gang Yang | 2007 | Chinese Chemical Letters2007，18，8： | 10 |
| 18 | dentification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma显示文摘 | Fei Li Zhaoyuan Fang Jian Zhang Chen Li Hongyan Liu Jufeng Xia Hongwen Zhu Chenchen auo Zhen Qin Fuming Li Xiangkun Han Yuetong Wang Yan Feng Ye Wang Wenjing Zhang Zuoyun Wang Yujuan Jin Yihua Sun Wenyi Wei Rong Zeng Haiquan Chen Hongbin Ji | 2016 | Cell Research2016，26，10： | 9 |
| 19 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 20 | Induction of apoptosis by casticin in cervical cancer cells: reactive oxygen species-dependent sustained activation of Jun N-terminal kinase显示文摘Casticin,从 Fructus viticis 的 polymethoxyflavone 在中国传统的药用作一个反煽动性的代理人,被报导了有反癌症活动。这研究的目的是在人的颈的癌症房间和它的分子的机制上检验 casticin 的 apoptotic 活动。我们揭示了导致 casticin 的 apoptosis 由发生的新奇机制并且第一次证明 casticin 导致的 apoptosis 通过反应的氧种类(ROS ) 的产生被调停并且在 HeLa 细胞支撑了 c6 月 N 终端 kinase (JNK ) 的激活。Casticin 显著地增加了细胞内部的 ROS 的层次并且导致了 phosphorylated JNK 和 c6 月蛋白质的表示。有 N-acetylcysteine 和 SP600125 的预告的处理有效地在 HeLa 房间由 casticin 稀释了 apoptosis 的正式就职。而且, casticin 在另外的颈的癌症房间线导致了 ROS 生产和 apoptotic 房间死亡,例如 CasKi 和 SiHa。重要地, casticin 没在正常的人的外部血 mononuclear 房间和胚胎的肾上皮引起 ROS 的产生或 apoptosis 的正式就职 293 个房间。这些结果建议由 casticin 的 ROS 产生和持续 JNK 激活在导致 casticin 的 apoptosis 起一个作用并且提起有 casticin 的治疗可能作为对人的颈的癌症的新治疗有希望的可能性。 | Fanxiang Zeng Li Tian Fei Liu Jianguo Cao Meifang Quan Xifeng Sheng | 2012 | Acta Biochimica et Biophysica Sinica2012，44，5： | 9 |
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