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| 1 | Stable classi?cation with limited sample: transferring a 30-m resolution sample set collected in 2015 to mapping 10-m resolution global land cover in 2017显示文摘As the world strives to reduce the impact of population growth, urbanization, agricultural expansion, and climate change on food security, energy and water shortage, resource over-exploration, biodiversity loss, environmental pollution, and ultimately human health, timely and higher resolution land cover information is urgently needed to achieve the sustainable development goals of the United Nations. | Peng Gong Han Liu Meinan Zhang Congcong Li Jie Wang Huabing Huang Nicholas Clinton Luyan Ji Wenyu Li Yuqi Bai Bin Chen Bing Xu Zhiliang Zhu Cui Yuan Hoi Ping Suen Jing Guo Nan Xu Weijia Li Yuanyuan Zhao Jun Yang Chaoqing Yu Xi Wang Haohuan Fu Le Yu Iryna Dronova Fengming Hui Xiao Cheng Xueli Shi Fengjin Xiao Qiufeng Liu Lianchun Song | 2019 | Science Bulletin2019，64，6： | 166 |
| 2 | Critical illness polyneuropathy and myopathy:a systematic review显示文摘Critical illness polyneuropathy and critical illness myopathy are frequent complications of severe illness that involve sensorimotor axons and skeletal muscles,respectively.Clinically,they manifest as limb and respiratory muscle weakness.Critical illness polyneuropathy/myopathy in isolation or combination increases intensive care unit morbidity via the inability or difficulty in weaning these patients off mechanical ventilation.Many patients continue to suffer from decreased exercise capacity and compromised quality of life for months to years after the acute event.Substantial progress has been made lately in the understanding of the pathophysiology of critical illness polyneuropathy and myopathy.Clinical and ancillary test results should be carefully interpreted to differentiate critical illness polyneuropathy/myopathy from similar weaknesses in this patient population.The present review is aimed at providing the latest knowledge concerning the pathophysiology of critical illness polyneuropathy/myopathy along with relevant clinical,diagnostic,differentiating,and treatment information for this debilitating neurological disease. | Chunkui Zhou Limin Wu Fengming Ni Wei Ji Jiang Wu Hongliang Zhang | 2014 | Neural Regeneration Research2014，9，1： | 15 |
| 3 | An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte–tumor cell crosstalk,local immunosuppression and tumor progression显示文摘Dissecting and understanding the cancer ecosystem,especially that around the tumor margins,which have strong implications for tumor cell infiltration and invasion,are essential for exploring the mechanisms of tumor metastasis and developing effective new treatments.Using a novel tumor border scanning and digitization model enabled by nanoscale resolution-SpaTial Enhanced REsolution Omics-sequencing(Stereo-seq),we identified a 500µm-wide zone centered around the tumor border in patients with liver cancer,referred to as“the invasive zone”.We detected strong immunosuppression,metabolic reprogramming,and severely damaged hepatocytes in this zone.We also identified a subpopulation of damaged hepatocytes with increased expression of serum amyloid A1 and A2(referred to collectively as SAAs)located close to the border on the paratumor side.Overexpression of CXCL6 in adjacent malignant cells could induce activation of the JAK-STAT3 pathway in nearby hepatocytes,which subsequently caused SAAs’overexpression in these hepatocytes.Furthermore,overexpression and secretion of SAAs by hepatocytes in the invasive zone could lead to the recruitment of macrophages and M2 polarization,further promoting local immunosuppression,potentially resulting in tumor progression.Clinical association analysis in additional five independent cohorts of patients with primary and secondary liver cancer(n=423)showed that patients with overexpression of SAAs in the invasive zone had a worse prognosis.Further in vivo experiments using mouse liver tumor models in situ confirmed that the knockdown of genes encoding SAAs in hepatocytes decreased macrophage accumulation around the tumor border and delayed tumor growth.The identification and characterization of a novel invasive zone in human cancer patients not only add an important layer of understanding regarding the mechanisms of tumor invasion and metastasis,but may also pave the way for developing novel therapeutic strategies for advanced liver cancer and other solid tumors. | Liang Wu Jiayan Yan Yinqi Bai Feiyu Chen Xuanxuan Zou Jiangshan Xu Ao Huang Liangzhen Hou Yu Zhong Zehua Jing Qichao Yu Xiaorui Zhou Zhifeng Jiang Chunqing Wang Mengnan Cheng Yuan Ji Yingyong Hou Rongkui Luo Qinqin Li Liang Wu Jianwen Cheng Pengxiang Wang Dezhen Guo Waidong Huang Junjie Lei Shang Liu Yizhen Yan Yiling Chen Sha Liao Yuxiang Li Haixiang Sun Na Yao Xiangyu Zhang Shiyu Zhang Xi Chen Yang Yu Yao Li Fengming Liu Zheng Wang Shaolai Zhou Huanming Yang Shuang Yang Xun Xu Longqi Liu Qiang Gao Zhaoyou Tang Xiangdong Wang Jian Wang Jia Fan Shiping Liu Xinrong Yang Ao Chen Jian Zhou | 2023 | Cell Research2023，33，8： | 1 |
| 4 | Organ-preserving surgery and classic surgery for pancreatic solid pseudopapillary neoplasms:a multicenter analysis from Central and Western China显示文摘Background:Pancreatic solid pseudopapillary neoplasms(SPNs)are low-grade malignant tumors of the pancreas.Organ-pre-serving surgery is being increasingly performed for these tumors,although there is little evidence to support its use.This retro-spective multicenter study aimed to determine the clinicopathologic characteristics of pancreatic SPNs in Central and Western China and to determine the efficacy of organ-preserving surgery.Methods:The clinicopathologic,treatment and follow-up data of 227 pancreatic SPN patients treated between July 2003 and December 2016 at 5 tertiary care centers were retrospectively reviewed.Results:Among the 227 patients(38 males,189 females;mean age 33.30±12.70 years),only 72(31.7%)had symptoms.The mean tumor size was 55.08±29.56 mm.Adjacent organ/lymphovascular invasion was present in 16(7.1%)patients and distant metastasis in 3(1.3%)patients;no patient had spread to distant lymph nodes.Surgery included organ-preserving surgery in 108(47.6%)patients,classic surgery in 115(50.7%)patients,and palliative surgery in 4(1.8%)patients.Tumor recurrence was seen in 8(3.6%)patients.Cox regression analysis showed positive surgical margin(P<.01)and metastasis(P=.03)to be independent predictors of recurrence.Tumor characteristics were comparable between patients receiving organ-preserving surgery and classic surgery.The risk of recurrence was also similar in both groups(P=.72).Conclusions:Organ-preserving surgery appears to be an effective procedure for the treatment of pancreatic SPNs.Resection surgery should aim for negative surgical margins. | Chunlu Tan Zhiqing Yang Jiang Li Fengming Ji Shanmiao Gou | 2023 | Journal of Pancreatology2023，6，2： | 0 |
| 5 | Research Progress on Production of Chlorophyll and Other Products with Silkworm Excrement and Industrial Development over the Past 50 Years显示文摘The development of sericultural industry in the Pearl River Delta has contributed greatly to good ecological environment and economic prosperity of the people’s livelihood.Comprehensive utilization of sericulture resources can turn waste into valuable resources and expand the development approaches of sericultural industry.For example,using abundant silkworm excrement to produce chlorophyll is one of the good practices in comprehensive utilization of sericulture resources,which has leading technologies and good economic benefits.In addition to chlorophyll,the products produced from silkworm excrement can be used as the main raw materials of medicine,food,plant growth regulator and cosmetics.For instances,phytol,the important raw material for synthesis of vitamin E and vitamin K,was extracted from silkworm excrement,enabling China to become an important production base of vitamin E and vitamin K.Triacontanol extracted from silkworm excrement is a new crop growth regulator,which can increase the yield of rice and vegetable.Pectin,dietary fiber and carotenoid extracted from silkworm excrement as well can be used as natural raw material in many fields.China is the biggest manufacturer and supplier of silkworm excrement products in the world,which has a development history of about 50 years and generated high export revenue.It is believed that close combination of academic research and industry development is the only way to promote the industrial development of silkworm excrement resources. | Huang Ziran Ji Pingxiong Feng Guodong Li Guangxue Cao Yongmin Shen Fengming Zhu Xiangrui Luo Quan Pang Guozhang | 2016 | Animal Husbandry and Feed Science2016，8，3： | 0 |
| 6 | Magnetized Micropillar-Enabled Wearable Sensors for Touchless and Intelligent Information Communication显示文摘The wearable sensors have recently attracted considerable attentions as communication interfaces through the information perception,decoding,and conveying process.However,it is still challenging to obtain a sensor that can convert detectable signals into multiple outputs for convenient,e cient,cryptic,and high-capacity information transmission.Herein,we present a capacitive sensor of magnetic field based on a tilted flexible micromagnet array(t-FMA)as the proposed interaction interface.With the bidirectional bending capability of t-FMA actuated by magnetic torque,the sensor can recognize both the magnitude and orientation of magnetic field in real time with non-overlapping capacitance signals.The optimized sensor exhibits the high sensitivity of over 1.3 T-1 and detection limit down to 1 mT with excellent durability.As a proof of concept,the sensor has been successfully demonstrated for convenient,e cient,and programmable interaction systems,e.g.,touchless Morse code and Braille communication.The distinguishable recognition of the magnetic field orientation and magnitude further enables the sensor unit as a high-capacity transmitter for cryptic information interaction(e.g.,encoded ID recognition)and multi-control instruction outputting.We believe that the proposed magnetic field sensor can open up a potential avenue for future applications including information communication,virtual reality device,and interactive robotics. | Qian Zhou Bing Ji Fengming Hu Jianyi Luo Bingpu Zhou | 2021 | Nano-Micro Letters2021，13，12： | 0 |
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