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| 1 | Antidiabetic Effects of Gegen Qinlian Decoction via the Gut Microbiota Are Attributable to Its Key Ingredient Berberine显示文摘Gegen Qinlian Decoction(GQD),a traditional Chinese medicine(TCM)formula,has long been used for the treatment of common metabolic diseases,including type 2 diabetes mellitus.However,the main limitation of its wider application is ingredient complexity of this formula.Thus,it is critically important to identify the major active ingredients of GQD and to illustrate mechanisms underlying its action.Here,we compared the effects of GQD and berberine,a hypothetical key active pharmaceutical ingredient of GQD,on a diabetic rat model by comprehensive analyses of gut microbiota,short-chain fatty acids,proinflammatory cytokines,and ileum transcriptomics.Our results show that berberine and GQD had similar effects on lowering blood glucose levels,modulating gut microbiota,inducing ileal gene expression,as well as relieving systemic and local inflammation.As expected,both berberine and GQD treatment significantly altered the overall gut microbiota structure and enriched many butyrate-producing bacteria,including Faecalibacterium and Roseburia,thereby attenuating intestinal inflammation and lowering glucose.Levels of short-chain fatty acids in rat feces were also significantly elevated after treatment with berberine or GQD.Moreover,concentration of serum proinflammatory cytokines and expression of immune-related genes,including Nfkb1,Stat1,and Ifnrg1,in pancreatic islets were significantly reduced after treatment.Our study demonstrates that the main effects of GQD can be attributed to berberine via modulating gut microbiota.The strategy employed would facilitate further standardization and widespread application of TCM in many diseases. | Xizhan Xu Zezheng Gao Fuquan Yang Yingying Yang Liang Chen Lin Han Na Zhao Jiayue Xu Xinmiao Wang Yue Ma Lian Shu Xiaoxi Hu Na Lyu Yuanlong Pan Baoli Zhu Linhua Zhao Xiaolin Tong Jun Wang | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 29 |
| 2 | Analysis of Typical Automakers’ Strategies for Meeting the Dual-Credit Regulations Regarding CAFC and NEVs显示文摘The parallel corporate average fuel consumption(CAFC)and new energy vehicle(NEV)credit schemes that have been introduced by the Ministry of Industry and Information Technology of China is an innovative attempt to simultaneously regulate conventional gasoline vehicles(CGVs)and NEVs in the passenger vehicle sector that is expected to function as a long-term management mechanism for CGVs to be more energy-efficient and NEVs to be well-promoted.This will have a significant impact on trends in China’s automotive industry and automakers’business decisions.Taking the cases of four typical automakers with different levels of average fuel economy in their CGVs and advanced NEV production,scenario analysis has been applied to generate these automakers’alternatives in relation to compliance with the dual-credit regulations in force from 2017 to 2020 based on the Interim Measures on the Joint Management of CAFC and NEV Credits(Draft).These automakers’alternative approaches to compliance are compared.Further,in view of the financial losses as a result of halted production if they fail to comply,the values of CAFC and NEV credits and corresponding influencing factors are analyzed from the automakers’perspective.Finally,the most cost-effective compliance strategies for these automakers are summarized and suggested improvements in the regulations are proposed for the government. | Yue Wang Fuquan Zhao Yinshuo Yuan Han Hao Zongwei Liu | 2018 | Automotive Innovation2018，1，1： | 14 |
| 3 | Abating transport GHG emissions by hydrogen fuel cell vehicles: Chances for the developing world显示文摘 | Han HAO Zhexuan MU Zongwei LIU Fuquan ZHAO | 2018 | Frontiers in Energy2018，12，3： | 12 |
| 4 | Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia显示文摘Dear Editor,Schizophrenia is a chronic and debilitating brain disorder,which has a strong genetic component with heritability ranging from 66%to 85%[1,2].Currently,antipsychotic drugs remain the most effective treatment for the psychotic symptoms of schizophrenia[3].Because of the severe sideeffects of first-generation antipsychotics(FGAs),secondgeneration antipsychotics(SGAs)have become more widely used in the treatment of schizophrenia. | Liansheng Zhao Huijuan Wang Yamin Zhang Jinxue Wei Peiyan Ni Hongyan Ren Gang Li Qiang Wang Gavin P Reynolds Weihua Yue Wei Deng Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Yinfei Li Hua Yu Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Jeremy Coid Dai Zhang Chao Chen Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 5 | Testing the role of genetic variation of the MC4R gene in Chinese population in antipsychotic-induced metabolic disturbance显示文摘Antipsychotic-induced metabolic disturbance(AIMD) is a common adverse effect of antipsychotics with genetics partly underpinning variation in susceptibility among schizophrenia patients. Melanocortin4 receptor(MC4 R) gene, one of the candidate genes for AIMD, has been under-studied in the Chinese patients. We conducted a pharmacogenetic study in a large cohort of Chinese patients with schizophrenia. In this study, we investigated the genetic variation of MC4 R in Chinese population by genotyping two SNPs(rs489693 and rs17782313) in 1,991 Chinese patients and examined association of these variants with the metabolic effects that were often observed to be related to AIMD. Metabolic measures, including body mass index(BMI), waist circumference(WC), glucose, triglyceride, high-density lipoprotein(HDL), and low-density lipoprotein(LDL) levels were assessed at baseline and after 6-week antipsychotic treatment. We found that interaction of SNP×medication status(drug-na?ve/medicated) was significantly associated with BMI, WC, and HDL change %, respectively. Both SNPs were significantly associated with baseline BMI and WC in the medicated group. Moderate association of rs489693 with WC, Triglyceride, and HDL change % were observed in the whole sample. In the drug-na?ve group, we found recessive effects of rs489693 on BMI gain more than 7%, WC and Triglyceride change %, with AA incurring more metabolic adverse effects. In conclusion, the association between rs489693 and the metabolic measures is ubiquitous but moderate. Rs17782313 is less involved in AIMD. Two SNPs confer risk of AIMD to patients treated with different antipsychotics in a similar way. | Yamin Zhang Hongyan Ren Qiang Wang Wei Deng Weihua Yue Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Dai Zhang Liansheng Zhao Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Science China(Life Sciences)2019，62，4： | 3 |
| 6 | Comparative analysis by simulating and testing pole impact for hot stamping front crossbeam of automobile显示文摘Hot stamping 22MnB5 steel plate with ultra-high strength has been widely used for body structural members in consideration of automobile safety and lightweight.This paper presents a verification program of simulating and testing pole impact in order to verify if the front crossbeam reinforcement assembly can meet the design requirements,reduce the overall vehicle simulation and test cost and shorten the operation period.In the same condition,the simulation proved conforming to the design requirements;however,the bumper cracked at the impacting point in the course of pole impact test.The analysis of the crack by optical microscope,Vickers and scanning electron microscope indicates that mixture of ferrite,bainite and martensite was produced in the weld heat-affected zone of the 340/590DP tow hook holder and the 22MnB5 front crossbeam;therefore,their hardness and mechanical property were reduced obviously,so that they fractured when impacted.No welding process with continuous weld but spot welding or other bonding method may be employed for the reason that the capacity of the 22MnB5 steel plate in the weld heat-affected zone was reduced obviously. | Ma Fangwu Yao Zaiqi Liu Qiang Wang Xiaona Zhao Fuquan Li Fangfang Lin Jianping | 2012 | Engineering Sciences2012，10，6： | 2 |
| 7 | Impact,Challenges and Prospect of Software-Defined Vehicles显示文摘Software-defined vehicles have been attracting increasing attentions owing to their impacts on the ecosystem of the automo-tive industry in terms of technologies,products,services and enterprise coopetition.Starting from the technology improve-ments of software-defined vehicles,this study systematically combs the impact of software-defined vehicles on the value ecology of automotive products and the automotive industrial pattern.Then,based on the current situation and demand of industrial development,the main challenges hindering the realization of software-defined vehicles are identified,including that traditional research and development models cannot adapt to the iterative demand of new automotive products;the transformation of enterprise capability faces multiple challenges;and many contradictions exist in the industrial division of labor.Finally,suggestions are put forward to address these challenges and provide decision-making recommendations for enterprises on strategy management. | Zongwei Liu Wang Zhang Fuquan Zhao | 2022 | Automotive Innovation2022，5，2： | 2 |
| 8 | The special shaped laser spot for driving indirect-drive hohlraum with multi-beam incidence显示文摘In indirect drive, reducing peak intensity of a single beam and controlling overlap of multi-beams are two opposite requirements for laser focal spot design. In this paper, an improved laser spot design technique for indirect drive built upon the geometric structures of laser propagation into hohlraum has been introduced. The proposed technique is able to generate appropriate continuous phase plate(CPP) producing a special shaped spot that can balance the opposite requirements. The corresponding CPP does not bring difficulties to the design and fabrication. Phase aberrations are more sensitive to the special shaped spot; however, it can be tolerable for the current beam control level. | Ping Li Sai Jin Runchang Zhao Wei Wang Fuquan Li Mingzhong Li Jingqin Su Xiaofeng Wei | 2017 | High Power Laser Science and Engineering2017，5，3： | 2 |
| 9 | Research on plastic fender development and key technologies显示文摘Automotive lightweight and safety performance come into play as key technologies to promote competiveness, and average applied amount of automotive plastics has become a significant sign for automotive industrial development level of a country.Various performances of a vehicle with plastic automotive fenders are analyzed in the paper.The research is emphasized on sinking-resistance and pedestrian protection performance of the plastic fenders by studying plastics characteristics and simulation analysis.It offers references for engineering design in which both automotive lightweight and safety performance are achieved and well balanced. | Yang Hao Li Li Liu Qiang Yang Anzhi Ma Fangwu Zhao Fuquan Guo Yihui Song Leifeng | 2012 | Engineering Sciences2012，10，6： | 1 |
| 10 | Identification of in-vivo induced genes of Streptococcus suis serotype 2 specially expressed in infected human显示文摘 | Shu Li Jie Song Hui Huang Wei Chen Ming Li Yan Zhao Yanguang Cong Junmin Zhu Xiancai Rao Xiaomei Hu Fuquan Hu | 2013 | Microbial Pathogenesis2013，，： | 1 |
| 11 | Magnetic properties of Fe_(3(1-x))Cr_(3x)C alloys显示文摘The magnetic properties of Fe3(1-x)Cr3xC alloys with x=0.05, 0.1, 0.15, and 0.2, which crystallize in the cementite Fe3C-type structure with space group Pnma, were investigated by means of magnetization measurements. These alloys show temperature-induced second-order magnetic phase transitions. The Curie temperature (Tc) of these alloys decreases with increasing x. The isothermal magnetic-entropy changes of these alloys were derived from the magnetic isotherms measured with increasing tem-perature and increasing field. The maximum values of the magnetic-entropy change are about 0.9 and 3.6 J·kg-1·K-1 at Tc =360 K for x = 0.05 in a magnetic field change from 0 to 1 T and 0 to 5 T, respectively. | Feng-qi Zhao O. Tegus B. Fuquan E. Brück | 2009 | International Journal of Minerals,Metallurgy and Materials2009，16，3： | 1 |
| 12 | Development Trends of Transmissions for Hybrid Electric Vehicles Using an Optimized Energy Management Strategy显示文摘Energy conservation and emissions reduction have become increasingly significant for automobiles due to the severity of the current energy situation.Hybrid electric vehicle(HEV)technology is one of the most promising solutions.This study investigated the total efficiency of a HEV powertrain.To improve the total efficiency,the engine should be regulated to work at its highest efficiency and drive the wheels directly as much as possible.To accomplish this,we developed an energy management strategy based on the direct drive area(DDA)of the engine’s efficiency map.Several typical HEV models were built to compare the fuel consumption using DDA and rule-based strategies.Furthermore,the function of the HEV transmission system with DDA was considered.The transmission in a HEV should regulate the engine to work at its highest efficiency as much as possible,which is rather different than the regulation in an internal combustion engine vehicle.The functional change may lead to transmission systems with fewer gears but optimal gear ratios.If this trend is realized,the manufacturing cost of HEVs could be largely reduced. | Tianze Shi Fuquan Zhao Han Hao Zongwei Liu | 2018 | Automotive Innovation2018，1，4： | 1 |
| 13 | Acyl-biotinyl Exchange Chemistry and Mass Spectrometry-Based Analysis of Palmitoylation Sites of In Vitro Palmitoylated Rat Brain Tubulin显示文摘 | Zhiqiang Zhao Junjie Hou Zhensheng Xie Jianwei Deng Xiaoming Wang Danfang Chen Fuquan Yang Weimin Gong | 2010 | The Protein Journal2010，，8： | 1 |
| 14 | The DNA concentration effect on DNA radiation damage induced by 7Li ions and γ rays显示文摘To evaluate the influence of the DNA concentration in the aqueous solution on DNA radiation damage, the plasmid DNA in the presence or absence of Mannitol (scavenger of free radical OH·) was irradiated by 7Li ions and γ rays at various DNA concentrations. Gel electrophoresis analysis revealed that the DNA damage of single and double strand breaks induced by irradiation became more severe at lower DNA concentration. In the condition of γ-ray irradiation, most of double strand breaks (DSB) damage was neutralized and less associated with DNA concentration in the presence of mannitol. However, under 7Li irradiation, DSB damage could not be cleared by mannitol but was gradually aggravated with decreasing DNA concentrations. These findings imply that under low-LET irradiation, most of the DSB damage is generated by free radical OH? diffusion, and thus may be counteracted by scavengers, while at higher-LET irradiation, quite a fraction of DSB induction is caused by direct ionizing energy deposi- tion of heavy ions, which cannot be eliminated. This work also indicates that the proportion between free radical damage and direct ionizing damage is a constant which is independent of DNA concentra- tion when the DNA concentration is under a certain value (50 ng/μL). Our study sheds light on the un- derlying mechanisms in the DNA radiation damage process. | KONG FuQuan WANG Xiao NI MeiNan SUI Li YANG MingJian ZHAO Kui | 2008 | Chinese Science Bulletin2008，53，18： | 1 |
| 15 | Aerosol optical properties and its direct radiative forcing over Tibetan Plateau from 2006 to 2017显示文摘Studies on optical properties of aerosols can reduce the uncertainty for modelling direct radiative forcing(DRF)and improve the accuracy for discussing aerosols effects on the Tibetan Plateau(TP)climate.This study investigated the spatiotemporal variation of aerosol optical and microphysical properties over TP based on OMI and MERRA2,and assessed the influence of aerosol optical properties on DRF at NamCo station(30°46.44′N,90°59.31′E,4730 m)in the central TP from 2006 to 2017 based on a long measurement of AERONET and the modelling of SBDART model.The results show that aerosol optical depth(AOD)exhibits obvious seasonal variation over TP,with higher AOD500nm(>0.75)during spring and summer,and lower value(<0.25)in autumn and winter.The aerosol concentrations show a fluctuated rising from 1980 to 2000,significant increasing from 2000 to 2010 and slight declining trend after 2013.Based on sensitivity experiments,it is found that AOD and single scattering albedo(SSA)have more important impact on the DRF compared withαvalues and ASY.When AOD440nm increases by 60%,DRF at the TOA and ATM is increased by 57.2%and 60.2%,respectively.When SSA440nm increases by 20%,DRF at the TOA and ATM decreases by 121%and 96.7%,respectively. | Hongru Bi Siyu Chen Dan Zhao Fuquan Lu Yu Chen Yawen Guan | 2023 | Particuology2023，，3： | 0 |
| 16 | Rice OsUBR7 modulates plant height by regulating histone H2B monoubiquitination and cell proliferation显示文摘Plant height is an important agronomic trait for lodging resistance and yield.Here,we report a new plantheight-related gene,OsUBR7 in rice(Oryza sativa L.);knockout of OsUBR7 caused fewer cells in internodes,resulting in a semi-dwarf phenotype.OsUBR7 encodes a putative E3 ligase containing a plant homeodomain finger and a ubiquitin protein ligase E3 component N-recognin 7(UBR7)domain.OsUBR7 interacts with histones and monoubiquitinates H2B(H2Bub1)at lysine148 in coordination with the E2 conjugase OsUBC18.OsUBR7 mediates H2Bub1 at a number of chromatin loci for the normal expression of target genes,including cell-cycle-related and pleiotropic genes,consistent with the observation that cell-cycle progression was suppressed in the osubr7 mutant owing to reductions in H2Bub1 and expression levels at these loci.The genetic divergence of OsUBR7 alleles among japonica and indica cultivars affects their transcriptional activity,and these alleles may have undergone selection during rice domestication.Overall,our results reveal a novel mechanism that mediates H2Bub1 in plants,and UBR7 orthologs could be utilized as an untapped epigenetic resource for crop improvement. | Yangyi Zheng Sensen Zhang Yanqiu Luo Fuquan Li Jiantao Tan Bin Wang Zhe Zhao Huifang Lin Tingting Zhang Jianhong Liu Xupeng Liu Jingxin Guo Xianrong Xie Letian Chen Yao-Guang Liu Zhizhan Chu | 2022 | Plant Communications2022，3，6： | 0 |
| 17 | Synthesizing an inorganic-rich solid electrolyte interphase by tailoring solvent chemistry in carbonate electrolyte for enabling high-voltage lithium metal batteries显示文摘High-voltage(>4.0 V)lithium metal battery(LBM)is considered to be one of the most promising candidates for next-generation high-energy batteries.However,the commercial carbonate electrolyte delivers a poor compatibility with Li metal anode,and its organic dominated solid electrolyte interphase(SEI)shows a low interfacial energy and a slow Li^(+)diffusion ability.In this work,an inorganic LiF-Li_(3)N rich SEI is designed to enable high-voltage LBM by introducing nano-cubic LiF and LiNO_(3)into1 M LiPF_(6)ethylene carbonate(EC)/dimethyl carbonate(DMC)(v:v=1:1)electrolyte.Specifically,the unique nano-cubic structure of as-synthetized LiF particles achieves its high concentration dissolution in carbonate electrolyte to enhance the interfacial energy of SEI.In addition,tetramethylene sulfolane(TMS)is used as a carrier solvent to dissolve LiNO_(3)in the carbonate electrolyte,thereby deriving a Li_(3)N-rich SEI.As a result,the as-designed electrolyte shows a high average Li plating/striping CE of 98.3%after 100 cycles at 0.5 m A cm^(-2)/0.5 mA h cm^(-2).Furthermore,it also enables the ultrathin Li(~50μm)‖LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM,4.4 mA h cm^(-2))full cell to deliver a high-capacity retention of 80.4%after 100 cycles with an outstanding average CE of 99.7%.Notably,the practical application prospect of the modified electrolyte is also estimated in LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)‖Li pouch cell with an energy density of 261.2 W h kg^(-1).This work sheds light on the internal mechanism of Li^(+)transport within the inorganic dominated SEI and provides a simple approach to stabilize the high-voltage LMBs. | Qiwen Ran Hongyuan Zhao Jintao Liu Lei Li Qiang Hu Fuquan Nie Xingquan Liu Sridhar Kormarneni | 2023 | Journal of Energy Chemistry2023，，7： | 0 |
| 18 | Protomer Roles in Chloroplast Chaperonin Assembly and Function显示文摘三叶绿体 CPN60 protomers (CPN60, CPN601,和 CPN602 ) 的单个角色并且他们是否并且怎么被装配进功能的 chaperonin 建筑群在 Chlamydomonas reinhardtii 被调查。包含所有三个潜在的子单元的蛋白质建筑群在 Chlamydomonas 被识别,并且他们在 Escherichia coli 的合作表示产出包含所有三个子单元(CPN6012 ) 的 oligomers 的一张同类的人口,与与 tetradecameric 结构一致的分子的重量。当 CPN60 的 homo-oligomers 能形成时,当 CPN60 是在场的, CPN602 的 homo-oligomers 乐意地面对 ATP 和另外的 protomers 被变成 hetero-oligomers 时,他们戏剧性地被减少。ATP 水解作用引起了 CPN60 oligomers 拆卸并且驱使净化的 protomers 重新组成 oligomers invitro,建议 CPN60 oligomers 的动态性质依赖于 ATP。在 5:6:3 比率的仅仅 hetero-oligomeric CPN6012,包含的 CPN60, CPN601,和 CPN602 子单元,与 GroES 机能上地合作了。CPN60 和 CPN60 子单元的联合,然而并非单个子单元在有子单元识别的 E.coli 的独自一个的、补充 GroEL 功能特性。在 Chlamydomonas 的 CPN60 子单元的下面规定导致了一个慢生长缺点和无能自造营养物质地成长,显示 CPN60 invivo 的必要角色。 | Cuicui Bai Peng Guo Qian Zhao Zongyang Lv Shijia Zhang Fei Gao Liyan Gao Yingchun Wang Zhixi Tian Jifeng Wang Fuquan Yang Cuimin Liu | 2015 | Molecular Plant2015，8，10： | 0 |
| 19 | 为交通低碳转型提供铂族金属资源保障显示文摘文章简介以锂、钴、镍、铂族金属等为代表的关键金属资源是重要的战略性矿产资源,在以纯电动汽车、燃料电池汽车为代表的下一代交通绿色低碳技术中发挥支撑作用。在全球绿色低碳转型的背景下,交通部门有望超越其他领域成为相关关键金属资源最大的需求方。由于相关资源储量相对有限且地理分布集中,交通部门的绿色低碳转型将对资源的可持续供应造成巨大挑战,其供应风险形成机制及应对策略亟待厘清。 | Han Hao 耿涌 James ETate Feiqi Liu Xin Sun Zhexuan Mu Dengye Xun Zongwei Liu Fuquan Zhao | 2020 | 科学新闻2020，，2： | 0 |
| 20 | Preface显示文摘We would like to present a new and high quality journal with great pleasure,Au tomotive Innovation,which provides a source of innova tive and scientific achievements for automo-tive engineers and scientists.As a top international journal,contributions are e welcome on methodologies,theoretical studies and cutting-edge technologies of ground vehicles.As an international medium of communication,it fosters the exchange of ideas among researchers in different parts of the world and also among scientists who emphasize various aspects of the vehicle field. | Jun Li Fuquan(Frank)Zhao Fangwu(Mike)Ma | 2018 | Automotive Innovation2018，1，1： | 0 |
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