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| 1 | Comparative study of the net exchange of CO_(2) in 3 types of vegetation ecosystems on the Qinghai-Tibetan Plateau显示文摘Using the eddy covariance method,from 1 July2003 to 30 June 2004, we conducted the observation andanalysis of ecosystem CO2 flux in 3 types of alpine meadowvegetation (Kobresia humilis, Potentilla fruticosa shrub andKobresia tibetica swamp meadows) on the Qinghai-TibetanPlateau. The results show that the Kobresia humilis meadow,the shrub meadow and the swamp meadow’s highest CO2uptake rates are 16.78, 10.42 and 16.57 μmol·m?2·s?1respectively, while their highest CO2 release rates are 8.22,7.73 and 18.67 μmol·m?2·s?1 respectively. The Kobresiahumilis meadow and shrub meadow’s annual atmosphericuptakes are 282 g CO2/m2 and 53 g CO2/m2, respectively,while swamp meadow’s annual atmospheric release is 478 gCO2/m2. This proves that the Kobresia humilis meadow andthe shrub meadow on the Qinghai-Tibetan Plateau haverelatively low potential for CO2 uptake and release comparedto C4 grasslands, a number of lowland grasslands, andforests. Moreover, swamp meadow has relatively high releasepotential. This, in turn, reveals clear differences in carbonsource/sink between different types of vegetation in theQinghai-Tibetan Plateau alpine meadow ecosystem. Thesedifferences are mainly brought by differences in thevegetations’ photosynthetic capacity and soil respiration. | ZHAO Liang LI Yingnian ZHAO Xinquan XU Shixiao TANG Yanhong YU Guirui GU Song DU Mingyuan WANG Qinxue | 2005 | Chinese Science Bulletin2005，50，16： | 34 |
| 2 | SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade显示文摘Tyrosine phosphatase SHP2 is a promising drug target in cancer immunotherapy due to its bidirectional role in both tumor growth promotion and T-cell inactivation. Its allosteric inhibitor SHP099 is known to inhibit cancer cell growth both in vitro and in vivo. However, whether SHP099-mediated SHP2 inhibition retards tumor growth in vivo via anti-tumor immunity remains elusive. To address this, a CT-26 colon cancer xenograft model was established in mice since this cell line is insensitive to SHP099.Consequently, SHP099 minimally affected CT-26 tumor growth in immuno-deficient nude mice, but significantly decreased the tumor burden in CT-26 tumor-bearing mice with intact immune system.SHP099 augmented anti-tumor immunity, as shown by the elevated proportion of CD8tIFN-γtT cells and the upregulation of cytotoxic T-cell related genes including Granzyme B andPerforin, which decreased the tumor load. In addition, tumor growth in mice with SHP2-deficient T-cells was markedly slowed down because of enhanced anti-tumor responses. Finally, the combination of SHP099 and antiPD-1 antibody showed a higher therapeutic efficacy than either monotherapy in controlling tumor growthin two colon cancer xenograft models, indicating that these agents complement each other. Our study suggests that SHP2 inhibitor SHP099 is a promising candidate drug for cancer immunotherapy. | Mingxia Zhao Wenjie Guo Yuanyuan Wu Chenxi Yang Liang Zhong Guoliang Deng Yuyu Zhu Wen Liu Yanhong Gu Yin Lu Lingdong Kong Xiangbao Meng Qiang Xu Yang Sun | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 18 |
| 3 | Dynamics of firing patterns,synchronization and resonances in neuronal electrical activities:experiments and analysis显示文摘在 neuronal 的动力学的试验性、理论的学习的最近的进展电的开火活动被考察。第一, neuronal 的一些试验性的现象不规则的开火模式,特别混乱、随机的开火的模式,被介绍,并且实际非线性的时间分析方法被介绍及时区分确定、随机的机制系列。第二,也就是,在一个单个神经原的电的开火的活动的动力学被担心为为发射模式的转变的各种各样的爆炸模式,一个参数或二参数的分叉分析的分类和机制的快慢动力学分析,和发射活动的随机的动力学(随机并且连贯回声,多重的整数和另外的开火的模式由噪音导致了,等等)。第三,有电、化学的触处的联合神经原的同步的不同类型被讨论。因为噪音和时间延期在神经系统是不可避免的,它被发现延期可以导致或提高发射联合神经原的模式的同步和变化的那噪音和时间。在联合 neuronal 网络的导致噪音的回声和空间与时间的模式也被表明。最后,一些前景为未来研究被介绍。在后果,非线性的动力学的想法和方法具有在动态进程的探索和神经系统的生理的函数的大意义。 | Qishao Lu Huaguang Gu Zhuoqin Yang Xia Shi Lixia Duan Yanhong Zheng | 2008 | Acta Mechanica Sinica2008，24，6： | 14 |
| 4 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 5 | Estimation of aboveground biomass using in situ hyperspectral measurements in five major grassland ecosystems on the Tibetan Plateau显示文摘Aims There are numerous grassland ecosystem types on the Tibetan Plateau.These include the alpine meadow and steppe and degraded alpine meadow and steppe.This study aimed at developing a method to estimate aboveground biomass(AGB)for these grasslands from hyperspectral data and to explore the feasibility of applying air/satellite-borne remote sensing techniques to AGB estimation at larger scales.Methods We carried out a field survey to collect hyperspectral reflectance and AGB for five major grassland ecosystems on the Tibetan Plateau and calculated seven narrow-band vegetation indices and the vegetation index based on universal pattern decomposition(VIUPD)from the spectra to estimate AGB.First,we investigated correlations between AGB and each of these vegetation indices to identify the best estimator of AGB for each ecosystem type.Next,we estimated AGB for the five pooled ecosystem types by developing models containing dummy variables.At last,we compared the predictions of simple regression models and the models containing dummy variables to seek an ecosystem type-independent model to improve prediction of AGB for these various grassland ecosystems from hyperspectral measurements.Important findings When we considered each ecosystem type separately,all eight vegetation indices provided good estimates of AGB,with the best predictor of AGB varying among different ecosystems.When AGB of all the five ecosystems was estimated together using a simple linear model,VIUPD showed the lowest prediction error among the eight vegetation indices.The regression models containing dummy variables predicted AGB with higher accuracy than the simple models,which could be attributed to the dummy variables accounting for the effects of ecosystem type on the relationship between AGB and vegetation index(VI).These results suggest that VIUPD is the best predictor of AGB among simple regression models.Moreover,both VIUPD and the soil-adjusted VI could provide accurate estimates of AGB with dummy variables integrated in regression models.Therefore,ground-based hyperspectral measurements are useful for estimating AGB,which indicates the potential of applying satellite/airborne remote sensing techniques to AGB estimation of these grasslands on the Tibetan Plateau. | Miaogen Shen Yanhong Tang Julia Klein Pengcheng Zhang Song Gu Ayako Shimono Jin Chen | 2008 | Journal of Plant Ecology2008，1，4： | 10 |
| 6 | SOME EXTENDED KNAPSACK PROBLEMS INVOLVING JOB PARTITION BETWEEN TWO PARTIES显示文摘一些新奇应用;背囊问题(KP ) 的实用变化被介绍;构造了,它被提出;从以二人的分离合作游戏从工作的分区在利润分配上在这篇论文开始的一个模型发展了。 | Gu Yanhong Chen Quanle | 2007 | Applied Mathematics(A Journal of Chinese Universities)2007，22，3： | 8 |
| 7 | Protonation induced high-T_c phases in iron-based superconductors evidenced by NMR and magnetization measurements显示文摘Chemical substitution during growth is a well-established method to manipulate electronic states of quantum materials, and leads to rich spectra of phase diagrams in cuprate and iron-based superconductors. Here we report a novel and generic strategy to achieve nonvolatile electron doping in series of(i.e.11 and 122 structures) Fe-based superconductors by ionic liquid gating induced protonation at room temperature. Accumulation of protons in bulk compounds induces superconductivity in the parent compounds, and enhances the Tclargely in some superconducting ones. Furthermore, the existence of proton in the lattice enables the first proton nuclear magnetic resonance(NMR) study to probe directly superconductivity. Using Fe S as a model system, our NMR study reveals an emergent high-Tcphase with no coherence peak which is hard to measure by NMR with other isotopes. This novel electric-fieldinduced proton evolution opens up an avenue for manipulation of competing electronic states(e.g.Mott insulators), and may provide an innovative way for a broad perspective of NMR measurements with greatly enhanced detecting resolution. | Yi Cui Gehui Zhang Haobo Li Hai Lin Xiyu Zhu Hai-Hu Wen Guoqing Wang Jinzhao Sun Mingwei Ma Yuan Li Dongliang Gong Tao Xie Yanhong Gu Shiliang Lie Huiqian Luo Pu Yu Weiqiang Yu | 2018 | Science Bulletin2018，63，1： | 7 |
| 8 | Altitudinal variation of ecosystem CO_(2) fluxes in an alpine grassland from 3600 to 4200 m显示文摘Aims Recent studies have recognized the alpine grasslands on the Qinghai-Tibetan plateau as a significant sink for atmospheric CO_(2).The carbon-sink strength may differ among grassland ecosystems at various altitudes because of contrasting biotic and physical environments.This study aims(i)to clarify the altitudinal pattern of ecosystem CO_(2) fluxes,including gross primary production(GPP),daytime ecosystem respiration(Redaytime)and net ecosystem production(NEP),during the period with peak above-ground biomass;and(ii)to elucidate the effects of biotic and abiotic factors on the altitudinal variation of ecosystem CO_(2) fluxes.Methods Ecosystem CO_(2) fluxes and abiotic and biotic environmental factors were measured in an alpine grassland at four altitudes from 3600 to 4200 m along a slope of the Qilian Mountains on the northwestern Qinghai-Tibetan Plateau during the growing season of 2007.We used a closed-chamber method combined with shade screens and an opaque cloth to measure several carbon fluxes,GPP,Redaytime and NEP,and factors,light-response curve for GPP and temperature sensitivity of Redaytime.Above-and below-ground biomasses and soil C and N contents at each measurement point were also measured.Important Findings(i)Altitudinal pattern of ecosystem CO_(2) fluxes:The maximum net ecosystem CO_(2) flux(NEPmax),i.e.the potential ecosystem CO_(2) sink strength,was markedly different among the four altitudes.NEPmax was higher at the highest and lowest sites,ap proximately7.460.9 and6.760.6 lmol CO_(2) m^(-2)s^(-1)(mean 6 standard error),respectively,but smaller at the intermediate altitude sites(3800 and 4000 m).The altitudinal pattern of maximum gross primary production was similar to that of NEPmax.The Redaytime,however,was significantly higher at the lowest altitude(3.460.3 lmol CO_(2) m^(-2)s^(-1))than at the other three altitudes.(ii)Altitudinal variation of vegetation biomass:The aboveground biomass was higher at the highest altitude(154627 g DW m2)than at the other altitudes,which we attribute mainly to the large biomass in cushion plants at the highest altitude.The small above-ground biomass at the lower altitudes was probably due to heavy grazing during the growing season.(iii)Features of ecosystem CO_(2) fluxes:Redaytime and GPP were positively correlated with above-ground biomass.The low ratio of Redaytime to GPP at either the measurement point or the site level suggests that CO_(2) uptake efficiency tends to be higher at higher altitudes,which indicates a high potential sink strength for atmospheric CO_(2) despite the low temperature at high altitudes.The results suggest that the effect of grazing intensity on ecosystem carbon dynamics,partly by decreasing vegetation biomass,should be clarified further. | Mitsuru Hirota Pengcheng Zhang Song Gu Mingyuan Du Ayako Shimono Haihua Shen Yingnian Li Yanhong Tang | 2009 | Journal of Plant Ecology2009，2，4： | 6 |
| 9 | Spatial distribution of IL4 controls iNKT cell-DC crosstalk in tumors显示文摘The spatiotemporal distribution of cytokines orchestrates immune responses in vivo,yet the underlying mechanisms remain to be explored.We showed here that the spatial distribution of interleukin-4(IL4)in invariant natural killer T(iNKT)cells regulated crosstalk between iNKT cells and dendritic cells(DCs)and controlled iNKT cell-mediated T-helper type 1(Th1)responses.The persistent polarization of IL4 induced by strong lipid antigens,that is,α-galactosylceramide(αGC),caused IL4 accumulation at the immunological synapse(IS),which promoted the activation of the IL4R-STAT6(signal transducer and activator of transcription 6)pathway and production of IL12 in DCs,which enhanced interferon-γ(IFNγ)production in iNKT cells.Conversely,the nonpolarized secretion of IL4 induced by Th2 lipid antigens with a short or unsaturated chain was incapable of enhancing this iNKT cell-DC crosstalk and thus shifted the immune response to a Th2-type response.The nonpolarized secretion of IL4 in response to Th2 lipid antigens was caused by the degradation of Cdc42 in iNKT cells.Moreover,reduced Cdc42 expression was observed in tumorinfiltrating iNKT cells,which impaired IL4 polarization and disturbed iNKT cell-DC crosstalk in tumors. | Lu Wang Zhilan Liu Lili Wang Qielan Wu Xiang Li Di Xie Huimin Zhang Yongdeng Zhang Lusheng Gu Yanhong Xue Ting Yue Gang Liu Wei Ji Haiming Wei Tao Xu Li Bai | 2020 | Cellular & Molecular Immunology2020，17，5： | 4 |
| 10 | Microstructure and tribological properties of W-implanted PVD TiN coatings on 316L stainless steel显示文摘 | Bin Tian Wen Yue Zhiqiang Fu Yanhong Gu Chengbiao Wang Jiajun Liu | 2014 | Vacuum2014，，： | 3 |
| 11 | Ultra-stable super-resolution fluorescence cryo-microscopy for correlative light and electron cryo-microscopy显示文摘Remarkable progress in correlative light and electron cryo-microscopy(cryo-CLEM) has been made in the past decade. A crucial component for cryo-CLEM is a dedicated cryo-fluorescence microscope(cryo-FM). Here, we describe an ultra-stable superresolution cryo-FM that exhibits excellent thermal and mechanical stability. The temperature fluctuations in 10 h are less than0.06 K, and the mechanical drift over 5 h is less than 200 nm in three dimensions. We have demonstrated the super-resolution imaging capability of this system(average single molecule localization accuracy of ~13.0 nm). The results suggest that our system is particularly suitable for long-term observations, such as single molecule localization microscopy(SMLM) and cryogenic super-resolution correlative light and electron microscopy(csCLEM). | Xiaojun Xu Yanhong Xue Buyun Tian Fengping Feng Lusheng Gu Weixing Li Wei Ji Tao Xu | 2018 | Science China(Life Sciences)2018，61，11： | 3 |
| 12 | DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS-STING pathway activation and contributed to the relief of CPT-11-induced intestinal mucositis显示文摘Gastrointestinal mucositis is one of the most debilitating side effects of the chemotherapeutic agent irinotecan(CPT-11). Andrographolide, a natural bicyclic diterpenoid lactone, has been reported to possess anti-colitis activity. In this study, andrographolide treatment was found to significantly relieve CPT-11-induced colitis in tumor-bearing mice without decreasing the tumor suppression effect of CPT-11. CPT-11 causes DNA damage and the release of double-stranded DNA(ds DNA) from the intestine, leading to cyclic-GMP-AMP synthase(c GAS)-stimulator of interferon genes(STING)-mediated colitis, which was significantly decreased by andrographolide both in vivo and in vitro. Mechanistic studies revealed that andrographolide could promote homologous recombination(HR) repair and downregulate ds DNA-c GAS-STING signaling and contribute to the improvement of CPT-11-induced gastrointestinal mucositis. These results suggest that andrographolide may be a novel agent to relieve gastrointestinal mucositis caused by CPT-11. | Yuanyuan Wang Bin Wei Danping Wang Jingjing Wu Jianhua Gao Haiqing Zhong Yang Sun Qiang Xu Wen Liu Yanhong Gu Wenjie Guo | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 3 |
| 13 | Analysis of Chang’e-5 lunar core drilling process显示文摘Chang’e-5 explorer successfully acquired lunar regolith core samples from depths of greater than 1 m of lunar surface.This study analyzed the lunar core drilling process based on the telemetry data,image information,and returned samples to optimize the sampling device design and enhance the understanding of the lunar regolith.In particular,a prediction method for the projected drilling path and local terrain fitting of drilling dip angle was proposed based on the flight events recorded during the core drilling process and the image information acquired before,during,and after sampling.The results revealed that the drilling dip angle of Chang’e-5 was approximately2.3.,and the deviation of the drilling length and depth was less than 2 mm.For continuous drilling,a fusion method based on telemetry data and image information was applied to determine the demarcation point of drilling with and without the lunar soil.The position of the demarcation point implied that the drilling point remained at approximately 6 mm loose soil,thereby lagging the action of the force response.Additionally,a characteristic parameter comparison method was proposed for the lunar and ground drilling to analyze the status of the lunar soil.Furthermore,the analysis results revealed that the majority of the Chang’e-5 drilling samples were derived from 0–73.8 cm below the lunar surface and few samples were extracted below 73.8 cm,as the drilling encountered several rocky regions.Moreover,the drilling point exhibited two prominent stratification variations at~28.7 cm and~70 cm below the lunar surface.Ultimately,the preliminary relationship between sample dissected position in soft tube and drilling displacement was analyzed.The segmented estimation results can support research on subsurface lunar soil. | Yanhong ZHENG Mengfei YANG Xiangjin DENG Shengyi JIN Jing PENG Yan SU Zheng GU Liping CHEN Yong PANG Nai ZHANG | 2023 | Chinese Journal of Aeronautics2023，36，2： | 3 |
| 14 | Energy exchange between the atmosphere and a meadowecosystem on the Qinghai-Tibetan Plateau显示文摘 | Song Gu Yanhong Tang Xiaoyong Cui | 2005 | Agricultural and Forest Meteorology2005，129，： | 1 |
| 15 | Expression and clinical significance of tyrosine phosphatase SHP-2 in colon cancer显示文摘 | Peifen Cai Wenjie Guo HuaQin Yuan Qian Li Weicheng Wang Yang Sun Xiaomin Li Yanhong Gu | 2013 | Biomedicine & Pharmacotherapy2013，，： | 1 |
| 16 | The biogeographical distribution of tree species-abundance and its relation to climatic factors in mass islands显示文摘Tree species-abundance in forests is a function of geographical area and climate, although it is not clear whether such relationships apply to mass islands. We examined the spatial pattern of tree species in mass islands along the coast of Zhejiang, East China Sea using the Preston model, to identify the relationships between tree communities and climatic conditions. The results show that:(1) the biogeographical distribution of tree species-abundance conformes to Preston's log-normal pattern, and is in accordance with the findings in both tropical rainforests and estuarine forests;(2) the climatic factors related to tree communities in mass islands are similar to that of the subtropical zone, including the major species of evergreen needle-leaf, broad-leaf and deciduous broad-leaf forests. We conclude that the Preston model can be applied to the trees of mass islands and thus facilitate the systematic ecological researches of vegetation species' composition in subtropical zone. | LI Xiaoming WU Chengzhen GU Wu YE Ran ZHANG Haibo QI Ping WANG Shengqiang ZHOU Siying WEI Yongjie CAI Yanhong | 2017 | Acta Oceanologica Sinica2017，36，9： | 1 |
| 17 | Controlled Synthesis of Conjugated Microporous Polymer Films: Versatile Platforms for Highly Sensitive and Label‐Free Chemo‐ and Biosensing显示文摘 | Cheng Gu Ning Huang Jia Gao Fei Xu Yanhong Xu Donglin Jiang | 2014 | Angew. Chem. Int. Ed2014，，19： | 1 |
| 18 | Analysis of a diverse global Pisum sp. collection and comparison to a Chinese local P. sativum collection with microsatellite markers显示文摘 | Xuxiao Zong Robert J. Redden Qingchang Liu Shumin Wang Jianping Guan Jin Liu Yanhong Xu Xiuju Liu Jing Gu Long Yan Peter Ades Rebecca Ford | 2009 | Theoretical and Applied Genetics2009，，2： | 1 |
| 19 | Analysis of a diverse global Pisum sp. collection and comparison to a Chinese local P. sativum collection with microsatellite markers显示文摘 | Xuxiao Zong Robert J. Redden Qingchang Liu Shumin Wang Jianping Guan Jin Liu Yanhong Xu Xiuju Liu Jing Gu Long Yan Peter Ades Rebecca Ford | 2009 | Theoretical and Applied Genetics2009，，2： | 1 |
| 20 | Maximum latency scheduling problem on two-person cooperative games显示文摘 | Yanhong Gu Jing Fan Guochun Tang Jiaofei Zhong | 2013 | Journal of Combinatorial Optimization2013，，1： | 1 |
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