|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade显示文摘Tyrosine phosphatase SHP2 is a promising drug target in cancer immunotherapy due to its bidirectional role in both tumor growth promotion and T-cell inactivation. Its allosteric inhibitor SHP099 is known to inhibit cancer cell growth both in vitro and in vivo. However, whether SHP099-mediated SHP2 inhibition retards tumor growth in vivo via anti-tumor immunity remains elusive. To address this, a CT-26 colon cancer xenograft model was established in mice since this cell line is insensitive to SHP099.Consequently, SHP099 minimally affected CT-26 tumor growth in immuno-deficient nude mice, but significantly decreased the tumor burden in CT-26 tumor-bearing mice with intact immune system.SHP099 augmented anti-tumor immunity, as shown by the elevated proportion of CD8tIFN-γtT cells and the upregulation of cytotoxic T-cell related genes including Granzyme B andPerforin, which decreased the tumor load. In addition, tumor growth in mice with SHP2-deficient T-cells was markedly slowed down because of enhanced anti-tumor responses. Finally, the combination of SHP099 and antiPD-1 antibody showed a higher therapeutic efficacy than either monotherapy in controlling tumor growthin two colon cancer xenograft models, indicating that these agents complement each other. Our study suggests that SHP2 inhibitor SHP099 is a promising candidate drug for cancer immunotherapy. | Mingxia Zhao Wenjie Guo Yuanyuan Wu Chenxi Yang Liang Zhong Guoliang Deng Yuyu Zhu Wen Liu Yanhong Gu Yin Lu Lingdong Kong Xiangbao Meng Qiang Xu Yang Sun | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 18 |
| 2 | Tolerance to low phosphorus in rice varieties is conferred by regulation of root growth显示文摘Phosphorus use efficiency(PUE)can be improved through cultivation techniques and breeding.However,little is known about rice(Oryza sativa L.)agronomic and physiological traits associated with high PUE.We characterized the agronomic and physiological traits of rice varieties with different tolerances to low phosphorus in nutrient solution.Two varieties with strong tolerance to low phosphorus(STVs)and two with weak tolerance(WTVs)were grown at normal(NP,control)and low phosphorus(LP,1/20 of NP)concentrations.Plants grown at LP produced significantly lower grain yield than those grown at NP.WTVs yields were lower than STVs yields.Compared to NP,LP significantly increased phosphorus translocation efficiency(PTE),internal phosphorus efficiency(IPE)and phosphorus harvest index(PHI).Under the LP condition,PTE and IPE were higher for STVs than for WTVs.LP also reduced tiller number,shoot biomass,leaf area index(LAI),leaf photosynthetic rate,and mean root diameter of both kinds of varieties at the main growth stages,but to a lower extent in STVs.LP significantly increased the number of productive tillers,root biomass,root-shoot ratio,root bleeding rate,and root acid phosphatase(RAP)activity.Total root length,root oxidation activity(ROA),and root total and active absorbing surface areas for STVs were significantly increased under LP,whereas the opposite responses were observed for WTVs.Total root length,ROA,root bleeding rate,root active absorbing surface area,and RAP activity were positively and significantly correlated with grain yield,PTE,and IPE.These results suggest that the tolerance of rice varieties to a low-phosphorus growth condition is closely associated with root growth with higher biomass and activity. | Yaping Deng Chuanbao Men Shengfeng Qiao Wenjie Wang Junfei Gu Lijun Liu Zujian Zhang Hao Zhang Zhiqin Wang Jianchang Yang | 2020 | The Crop Journal2020，8，4： | 8 |
| 3 | U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-control study in Chinese population显示文摘在由维持 chromosomal 正直并且阻止染色体的生物变老的一个关键角色结束的 Telomeres 玩熔化。流行病学的研究建议了 telomere 长度的内部个人的差别能影响倾向到多重癌症,但是关于食道的有鳞的房间癌(ESCC ) 的证据仍然是不明确的。几 telomere 在白种人的长度相关的单个核苷酸多型性(TLSNP ) 在染色体宽的协会研究被报导了。然而,在 ESCC 开发的 telomere 长度和 TL-SNPs 的效果是不清楚的。因此,我们进行了盒子控制研究(1045 个 ESCC 案例和 1433 控制) 在中国人口评估在 telomere 长度, TL-SNPs,和 ESCC 风险之间的协会。作为结果, ESCC 案例显示出全面更短的相对 telomere 长度(RTL )( 中部:1.34 ) 比控制(中部:1.50, P < 0.001 ) 。更有趣地,一个明显的非线性的U字形的协会在 RTL 和 ESCC 风险之间被观察( P < 0.001 )与比率(95%信心间隔)等于到 2.40 的机会( 1.843.14 ), 1.36 ( 1.031.79 ), 1.01 ( 0.761.35 ),并且 1.37 ( 1.031.82 )为个人在第一(最短),第二,第三,并且 第5 (最长) quintile 分别地,在是的 第4 quintile 与那些相比引用组。没有重要协会在八报导 TL-SNPs 和 ESCC 危险性之间被观察。这些调查结果建议短或极其长的 telomeres 可以是为在中国人口的 ESCC 的风险因素。 | Jiangbo Du Wenjie Xue Yong Ji Xun Zhu Yayun Gu Meng Zhu Cheng Wang Yong Gao Juncheng Dai Hongxia Ma Yue Jiang Jiaping Chen Zhibin Hu Guangfu Jin Hongbing Shen | 2015 | Frontiers of Medicine2015，9，4： | 4 |
| 4 | DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS-STING pathway activation and contributed to the relief of CPT-11-induced intestinal mucositis显示文摘Gastrointestinal mucositis is one of the most debilitating side effects of the chemotherapeutic agent irinotecan(CPT-11). Andrographolide, a natural bicyclic diterpenoid lactone, has been reported to possess anti-colitis activity. In this study, andrographolide treatment was found to significantly relieve CPT-11-induced colitis in tumor-bearing mice without decreasing the tumor suppression effect of CPT-11. CPT-11 causes DNA damage and the release of double-stranded DNA(ds DNA) from the intestine, leading to cyclic-GMP-AMP synthase(c GAS)-stimulator of interferon genes(STING)-mediated colitis, which was significantly decreased by andrographolide both in vivo and in vitro. Mechanistic studies revealed that andrographolide could promote homologous recombination(HR) repair and downregulate ds DNA-c GAS-STING signaling and contribute to the improvement of CPT-11-induced gastrointestinal mucositis. These results suggest that andrographolide may be a novel agent to relieve gastrointestinal mucositis caused by CPT-11. | Yuanyuan Wang Bin Wei Danping Wang Jingjing Wu Jianhua Gao Haiqing Zhong Yang Sun Qiang Xu Wen Liu Yanhong Gu Wenjie Guo | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 3 |
| 5 | ERCP with Retrieval Balloon-Assisted Enterography Using Traditional Duodenoscope in post-GI surgery patients显示文摘 | Ming Zhuang Wenjie Zhang Jun Gu Wei Gong Xuefeng Wang | 2012 | Gastrointestinal Endoscopy2012，，： | 2 |
| 6 | Online Adap- tive Least Squares Support Vector Machine and its Applica- tion In Utility Boiler Combustion Optimization Systems显示文摘 | GU Yanping ZHAO Wenjie WU Zhansong | 2011 | Journal of Process Control2011，21，7： | 1 |
| 7 | Memory access integrity:detecting fine-grained memory access errors in binary code显示文摘As one of the most notorious programming errors,memory access errors still hurt modern software security.Particularly,they are hidden deeply in important software systems written in memory unsafe languages like C/C++.Plenty of work have been proposed to detect bugs leading to memory access errors.However,all existing works lack the ability to handle two challenges.First,they are not able to tackle fine-grained memory access errors,e.g.,data overflow inside one data structure.These errors are usually overlooked for a long time since they happen inside one memory block and do not lead to program crash.Second,most existing works rely on source code or debugging information to recover memory boundary information,so they cannot be directly applied to detection of memory access errors in binary code.However,searching memory access errors in binary code is a very common scenario in software vulnerability detection and exploitation.In order to overcome these challenges,we propose Memory Access Integrity(MAI),a dynamic method to detect finegrained memory access errors in off-the-shelf binary executables.The core idea is to recover fine-grained accessing policy between memory access behaviors and memory ranges,and then detect memory access errors based on the policy.The key insight in our work is that memory accessing patterns reveal information for recovering the boundary of memory objects and the accessing policy.Based on these recovered information,our method maintains a new memory model to simulate the life cycle of memory objects and report errors when any accessing policy is violated.We evaluate our tool on popular CTF datasets and real world softwares.Compared with the state of the art detection tool,the evaluation result demonstrates that our tool can detect fine-grained memory access errors effectively and efficiently.As the practical impact,our tool has detected three 0-day memory access errors in an audio decoder. | Wenjie Li Dongpeng Xu WeiWu Xiaorui Gong Xiaobo Xiang Yan Wang Fangming gu Qianxiang Zeng | 2019 | Cybersecurity2019，2，1： | 1 |
| 8 | Evolution of microbial community diversity and enzymatic activity during composting显示文摘 | Yumei He Kaizhi Xie Peizhi Xu Xu Huang Wenjie Gu Fabao Zhang Shuanhu Tang | 2012 | Research in Microbiology2012，，： | 1 |
| 9 | A role for p21‐activated kinase 7 in the development of gastric cancer显示文摘 | Jun Gu Keqiang Li Maolan Li Xiangsong Wu Lin Zhang Qichen Ding Wenguang Wu Jiahua Yang Jiasheng Mu Hao Wen Qian Ding Jianhua Lu Yuan Hao Lei Chen Wenjie Zhang Songgang Li Yingbin Liu | 2012 | FEBS J2012，，1： | 1 |
| 10 | Expression and clinical significance of tyrosine phosphatase SHP-2 in colon cancer显示文摘 | Peifen Cai Wenjie Guo HuaQin Yuan Qian Li Weicheng Wang Yang Sun Xiaomin Li Yanhong Gu | 2013 | Biomedicine & Pharmacotherapy2013，，： | 1 |
| 11 | Online adaptive least squares support vector machine and its application in utility boiler combustion optimization systems显示文摘 | Gu Yanping Zhao Wenjie Wu Zhansong | 2011 | Journal of Process Control2011，21，7： | 1 |
| 12 | Online adaptive least squares support vector machine and its application in utility boiler combustion optimization systems显示文摘 | Yanping Gu Wenjie Zhao Zhansong Wu | 2011 | Journal of Process Control2011，，7： | 1 |
| 13 | Triband microstrip bandpass filter using Input/output cross coupling显示文摘 | Feng Wenjie Gu Liming Che Wenquan | 2014 | International Journal of Electronics2014，101，3： | 1 |
| 14 | Association of mitochondrial DNA copy number in peripheral blood leukocytes with risk of esophageal adenocarcinoma显示文摘 | Enping Xu Wenjie Sun Jian Gu Wong-Ho Chow Jaffer A. Ajani Xifeng Wu | 2013 | Carcinogenesis2013，，11： | 1 |
| 15 | Aerodynamic levitated laser annealing method to defective titanium dioxide with enhanced photocatalytic performance显示文摘因为它的缩小的乐队差距,有缺点的 TiO 2 在 photocatalytic 和电气化学的材料为使用吸引了增加的注意并且改进了可见光的 photocatalytic 活动。然而,为获得充满缺点的 TiO 2 的一条灵巧、有效的途径仍然是挑战。此处,我们表明如此的一条途径缩小它的 bandgap 并且通过由空气动力学的升在空中的激光退火植入丰富的缺点改进可见光的吸收(ALLA ) 处理。笔记 ALLA 方法不仅提供快速的退火,团结并且使过程凉下来,而且为同类、有缺点的 TiO 2 nanoparticles 展出高效率。退火激光的 TiO 2 完成 8.54 mmol 愠楮湯捩戠潬正挠灯汯浹牥洠捩汥敬瀠汯? 整瑲戭瑵汹愠牣汹瑡 ? 潣攭桴汹愠牣汹瑡 ? 潣洭瑥慨牣汹捩愠楣 ? 的高氢进化率 ? 呐 ?? 椠 ? 档獯湥愠 ?? 潭敬畣慬? 慣牲敩 ? 潦 ? 桴 ? 湩潣灲牯瑡潩 ? 景戠獩 ? 栭摹潲祸畱湩汯瑡 ? 稠湩 ? 娨煮猼'T 资 ? ??? 湡 ? 灯湥爭湩 ? 敭潲祣湡湩 ???? 敤潮整 ? 獡 ? 湚 ? ??? 猯'T??? 呐吗?? | Hehe Wei Xiaoguang Ma Liu Gu Jianqiang Li Wenjie Si Gang OU Wen Yu Chunsong Zhao Jiaying Li Mingjun Song Zhijian Peng Hui Wu | 2016 | Nano Research2016，9，12： | 1 |
| 16 | Impact of adverse childhood experiences on the symptom severity of different mental disorders: a cross-diagnostic study显示文摘Background Adverse childhood experiences have a significant impact on different mental disorders.Objective To compare differences in adverse childhood experiences among those with different mental disorders and their relationships in a cross-disorder manner.Methods The study included 1513 individuals aged≥18 years:339 patients with substance use disorders,125 patients with schizophrenia,342 patients with depression,136 patients with bipolar disorder,431 patients with obsessive-compulsive disorder(OCD),and 140 healthy controls.The Early Trauma Inventory Self Report-Short Form was used to investigate childhood traumatic experiences,and the Addiction Severity Index,Positive and Negative Syndrome Scale,Hamilton Depression Scale,Young Mania Rating Scale,and Yale-Brown Obsessive-Compulsive Scale were used to assess mental disorder severity.Correlation and multivariate logistic regression were analysed between adverse childhood experiences and clinical features.Results Levels of adverse childhood experiences were significantly different among different mental disorders.Moreover,25.8%of patients with substance use disorders reported childhood trauma,which was significantly higher than found in the other four psychiatric disorder groups.Emotional abuse scores were positively correlated with disease severity:the higher the total trauma score,the more severe the mental disorder.Conclusions Adverse childhood experiences are a common phenomenon in those with mental disorders,and the level of trauma affects mental disorder severity.Emotional abuse is closely related to many mental disorders.The incidence or severity of mental disorders can be reduced in the future by reducing the incidence of adverse childhood experiences or by timely intervention in childhood trauma. | Wenjie Gu Qing Zhao Chengmei Yuan Zhenghui Yi Min Zhao Zhen Wang | 2022 | General Psychiatry2022，35，2： | 1 |
| 17 | Cthrc1 Overexpression is an Independent Prognostic Marker in Gastric Cancer显示文摘 | Lina Gu Lei Liu Lili Zhong Yuxian Bai Hong Sui Xiaoli Wei Wenjie Zhang Peng Huang Dandan Gao Ying Kong Ge Lou | 2013 | Human Pathology2013，，： | 1 |
| 18 | A role for p21‐activated kinase 7 in the development of gastric cancer显示文摘 | Jun Gu Keqiang Li Maolan Li Xiangsong Wu Lin Zhang Qichen Ding Wenguang Wu Jiahua Yang Jiasheng Mu Hao Wen Qian Ding Jianhua Lu Yuan Hao Lei Chen Wenjie Zhang Songgang Li Yingbin Liu | 2012 | FEBS J2012，，1： | 1 |
| 19 | Online adaptive least squares support vector machine and its application in utility boiler combustion optimization systems显示文摘 | GU Yanping ZHAO Wenjie WU Zhansong | 2011 | Journal of Process Control2011，21，7： | 1 |
| 20 | Early Diagnosis of Bipolar Disorder Coming Soon:Application of an Oxidative Stress Injury Biomarker(BIOS)Model显示文摘Early distinction of bipolar disorder(BD)from major depressive disorder(MDD)is difficult since no tools are available to estimate the risk of BD.In this study,we aimed to develop and validate a model of oxidative stress injury for predicting BD.Data were collected from 1252 BD and 1359 MDD patients,including 64 MDD patients identified as converting to BD from 2009 through 2018.30 variables from a randomly-selected subsample of 1827(70%)patients were used to develop the model,including age,sex,oxidative stress markers(uric acid,bilirubin,albumin,and prealbumin),sex hormones,cytokines,thyroid and liver function,and glycolipid metabolism.Univariate analyses and the Least Absolute Shrinkage and Selection Operator were applied for data dimension reduction and variable selection.Multivariable logistic regression was used to construct a model for predicting bipolar disorder by oxidative stress biomarkers(BIOS)on a nomogram.Internal validation was assessed in the remaining 784 patients(30%),and independent external validation was done with data from 3797 matched patients from five other hospitals in China.10 predictors,mainly oxidative stress markers,were shown on the nomogram.The BIOS model showed good discrimination in the training sample,with an AUC of 75.1%(95%CI:72.9%–77.3%),sensitivity of 0.66,and specificity of 0.73.The discrimination was good both in internal validation(AUC 72.1%,68.6%–75.6%)and external validation(AUC 65.7%,63.9%–67.5%).In this study,we developed a nomogram centered on oxidative stress injury,which could help in the individualized prediction of BD.For better real-world practice,a set of measurements,especially on oxidative stress markers,should be emphasized using big data in psychiatry. | Zhiang Niu Xiaohui Wu Yuncheng Zhu Lu Yang Yifan Shi Yun Wang Hong Qiu Wenjie Gu Yina Wu Xiangyun Long Zheng Lu Shaohua Hu Zhijian Yao Haichen Yang Tiebang Liu Yong Xia Zhiyu Chen Jun Chen Yiru Fang | 2022 | Neuroscience Bulletin2022，38，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员