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| 1 | Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer显示文摘Metastasis,the development of secondary malignant growths at a distance from a primary tumor,is the cause of death for 90%of cancer patients,but little is known about how metastatic cancer cells adapt to and colonize new tissue environments.Here,using clinical samples,patient-derived xenograft(PDX)samples,PDX cells,and primary/metastatic cell lines,we discovered that liver metastatic colorectal cancer(CRC)cells lose their colon-specific gene transcription program yet gain a liver-specific gene transcription program.We showed that this transcription reprogramming is driven by a reshaped epigenetic landscape of both typical enhancers and super-enhancers.Further,we identified that the liver-specific transcription factors FOXA2 and HNF1A can bind to the gained enhancers and activate the liver-specific gene transcription,thereby driving CRC liver metastasis.Importantly,similar transcription reprogramming can be observed in multiple cancer types.Our data suggest that reprogrammed tissue-specific transcription promotes metastasis and should be targeted therapeutically. | Shuaishuai Teng Yang Eric Li Ming Yang Rui Qi Yiming Huang Qianyu Wang Yanmei Zhang Shanwen Chen Shasha Li Kequan Lin Yang Cao Qunsheng Ji Qingyang Gu Yujing Cheng Zai Chang Wei Guo Pengyuan Wang Ivan Garcia-Bassets Zhi John Lu Dong Wang | 2020 | Cell Research2020，30，1： | 11 |
| 2 | GSH-sensitive polymeric prodrug: Synthesis and loading with photosensitizers as nanoscale chemo-photodynamic anti-cancer nanomedicine显示文摘Precisely delivering combinational therapeutic agents has become a crucial challenge for anti-tumor treatment. In this study, a novel redox-responsive polymeric prodrug(molecular weight,MW: 93.5 k Da) was produced by reversible addition-fragmentation chain transfer(RAFT) polymerization. The amphiphilic block polymer-doxorubicin(DOX) prodrug was employed to deliver a hydrophobic photosensitizer(PS), chlorin e6(Ce6), and the as-prepared nanoscale system [NPs(Ce6)] was investigated as a chemo-photodynamic anti-cancer agent. The glutathione(GSH)-cleavable disulfide bond was inserted into the backbone of the polymer for biodegradation inside tumor cells, and DOX conjugated onto the polymer with a disulfide bond was successfully released intracellularly. NPs(Ce6) released DOX and Ce6 with their original molecular structures and degraded into segments with low MWs of 41.2 k Da in the presence of GSH. NPs(Ce6) showed a chemo-photodynamic therapeutic effect to kill 4 T1 murine breast cancer cells, which was confirmed from a collapsed cell morphology, a lifted level in the intracellular reactive oxygen species, a reduced viability and induced apoptosis. Moreover, ex vivo fluorescence images indicated that NPs(Ce6) retained in the tumor, and exhibited a remarkable in vivo anticancer efficacy. The combinational therapy showed a significantly increased tumor growth inhibition(TGI,58.53%). Therefore, the redox-responsive, amphiphilic block polymeric prodrug could have a great potential as a chemo-photodynamic anti-cancer agent. | Lei Luo Yiming Qi Hong Zhong Shinan Jiang Hu Zhang Hao Cai Yahui Wu Zhongwei Gu Qiyong Gong Kui Luo | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 3 |
| 3 | Effects of antioxidants on homocysteine thiolactone-induced apoptosis in human umbilical vein endothelial cells显示文摘Background and objectives Hyperhomocysteinemia is an independent risk factor for cardiovascular disease. Homocysteine thiolactone (HcyT), one of the homocysteine metabolites in vivo, is toxic both in vivo and in vitro. The aim of this study was to investigate the effect of HcyT on apoptotic damage in human umbilical vein endothelial cells (HUVECs) and the role of antioxidants in the reduction of HcyT-induced apoptosis. Methods HUVECs were cultured in DMEM supplemented with 20% heat inactivated fetal bovine serum cell cultures were maintained in a humidified 5% CO2 atmosphere at 37 ℃. Cytotoxicity was determined by MTT assay,which consists of hypodiploid cells with propidium iodide labeling and intracellular reactive oxygen species levels using 2',7'-dichlorofluorescein diacetate as the probe by flow cytometry. Results HcyT (250-2000μM) induced HUVECs apoptosis in a time- and concentration-dependent manner. Reactive oxygen species levels rose in response to increasing HcyT concentrations at 24-h incubation.The reduction of cell apoptosis by N-acetylcysteine, vitamin E, or pyrrolidine dithiocarbamate, occurred simultaneously with a significant decrease in intracellular reactive oxygen species levels. Conclusion HcyT exerts its cytotoxic effects on endothelial cells through an apoptotic mechanism involving cellular reactive oxygen species production. The capacity of N-acetylcysteine, vitamin E, and pyrrolidine dithiocarbamate to scavenge HcyT-induced cellular reactive oxygen species correlates well with their efficiency to protect against HcyT-promoted apoptotic damage. The protective effect of pyrrolidine dithiocarbamate on cell apoptosis indicates HcyT-generated hydrogen peroxide may provoke cell apoptosis via activating nuclear factor-kappa binding protein. | Weijun GU Juming LU Guoqing YANG Qinghua GUO Baoan WANG Yiming MU Changyu PAN | 2006 | Journal of Geriatric Cardiology2006，3，2： | 3 |
| 4 | LHCGR and ALMS1 defects likely cooperate in the development of polycystic ovary syndrome indicated by double-mutant mice显示文摘Polycystic ovary syndrome(PCOS)is a heterogeneous disorder with evidence of polygenetic components,and obesity may be a risk factor for hyperandrogen ism.Previous studies have shown that LHCGR is en riched in the ovary and LHCGR deficiency causes infertility without typical PCOS phenotypes.ALMS1 is implicated in obesity and hyperandrogenism,the common phenotypes among PCOS patients.Through whole-exome sequencing of 22 PCOS families and targeted candidate gene sequencing of additional 65 sporadic PCOS patients,we identified potential causative mutations in LHCGR and ALMS1 in a sibling-pair PCOS family and three sporadic PCOS patients.The expression of LHCGRL638 P in granulosa-like tumor cell line(KGN)cells promoted cyclic adenosine monophosphate production and granulosa cell proliferation,indicating that LHCGRL638 P is an activating mutation.Lhcgr~(L642 P/L642 P)mice showed an irregular estrous cycle,reduced follicles with dynamic folliculogenesis,and increased testosterone(T),estradiol(E2),and dehydroepiandrosterone.Lhcgr~(+/L642 P)AIms1~(+/PB)mice displayed increased T and E2 but decreased late secondary and preovulatory follicles.We showed that activating mutation of LHCGR likely plays important roles in the pathophysiology of PCOS involving abnormal reproductive physiology,whereas ALMS1 deficiency may promote anovulatory infertility via elevated androgens,suggesting that the disturbed LHCGR and ALMS1 cooperatively induce PCOS phenotypes,characterized as anovulation and hyperandrogenemia frequently observed in PCOS patients with obesity. | Li Yu Lina Wang Wufan Tao Wenxiang Zhang Shuanghao Yang Jian Wang Jia Fei Rui Peng Yiming Wu Xiumei Zhen Hong Shao Weiyue Gu Rong Li Bai-Lin Wu Hongyan Wang | 2021 | Journal of Genetics and Genomics2021，48，5： | 3 |
| 5 | Terahertz spatial sampling with subwavelength accuracy显示文摘A simple terahertz(THz)spatial sampling method offers kilohertz(kHz)level sampling rates and greatly preserves the energy of a THz pulse,which enables THz imaging detection with a high signal-to-noise ratio,micron-grade accuracy,and subwavelength resolution. | Yan Peng Yiming Zhu Min Gu Songlin Zhuang | 2019 | Light(Science & Applications)2019，8，1： | 2 |
| 6 | Redevelopment of urban brownfield sites in China:Motivation,history,policies and improved management显示文摘Rapid urbanisation in China has resulted in an increased demand for land in towns and cities.To upgrade and modernise,China has also moved many major industries from urban centres to less populated areas.With the high economic value of urban land,the transformation and utilisation of brownfield areas have become important economically and socially.The Chinese government has recognised the need for strong frameworks to safeguard soil and groundwater quality,with brownfield sites a key category for management.Strong scientific,regulatory and decision-making frameworks are needed and being adopted to ensure practical,careful and wise use of central and localised government resources,to manage the reuse and regeneration of these brownfield sites.This paper reviews the context,policies and management procedures of developing brownfield sites in countries with a history of brownfield management and discusses China’s current situation and priorities for brownfield governance and redevelopment.These include(1)clarification of brownfield site soil contamination risk control standards and risk assessment procedures,(2)the responsibilities of different national and local agencies,(3)the establishment of a national expert committee to advise on best practices,policy and process,(4)the use of registered brownfield databases at national,provincial,municipal and county levels,and(5)the set up of soil pollution prevention fund at the provincial level. | Yiming Sun Hong Li Shuo Lei Kirk TSemple Frederic Coulon Qing Hu Jingyang Gao Guanlin Guo Qingbao Gu Kevin C.Jones | 2022 | Eco-Environment & Health2022，1，2： | 2 |
| 7 | Effect of Steam Explosion Technology Main Parameters on Moso Bamboo and Poplar Fiber显示文摘One of the large-scale industrial applications of Moso bamboo and poplar in China is the production of standardized fiberboard.When making fiberboard,a steam blasting pretreatment without the addition of traditional adhesives has become increasingly popular because of its environmental friendliness and wide applicability.In this study,the steam explosion pretreatment of Moso bamboo and poplar was conducted.The steam explosion pressure and holding time were varied to determine the influence of these factors on fiber quality by investigating the morphology of the fiber,the mass ratio of the unexploded specimen at the end face,the chemical composition,and the tensile strength.The following conclusions were drawn:As the steam burst pressure and holding time increased,more cellulose and hemicellulose degradation occurred(the degradation of hemicellulose was greater than that of cellulose),the lignin content rose,and the fiber bundle strength decreased.The degradation of bamboo cellulose was slightly higher than that of poplar,and the degradation of poplar hemicellulose was significantly faster than that of bamboo.Furthermore,increasing the steam explosion pressure and pressure holding time could not effectively increase the lignin content.It is recommended to use a steam blasting pressure of 2.5 MPa or 3.0 MPa and a holding time of 180 s to perform steam blasting on bamboo and poplar specimens. | Biqing Shu Qin Ren Lu Hong Zhongping Xiao Xiaoning Lu Wenya Wang Junbao Yu Naiqiang Fu Yiming Gu Jinjun Zheng | 2021 | Journal of Renewable Materials2021，9，3： | 1 |
| 8 | A non-contact method for determining junction temperature of phosphor-converte white LEDs显示文摘 | Gu Yiming Narendnan N | 2004 | Proc Spie2004，5187，： | 1 |
| 9 | Rhein Reduces Fat Weight in db/db Mouse and Prevents Diet-Induced Obesity in C57Bl/6 Mouse through the Inhibition of PPAR γ Signaling显示文摘 | Yu Zhang Shengjie Fan Na Hu Ming Gu Chunxiao Chu Yiming Li Xiong Lu Cheng Huang Beata Lecka-Czernik | 2012 | PPAR Research2012，，： | 1 |
| 10 | A non-contact method for determining junction temperature of phosphor-converte white LEDs显示文摘 | Gu Yiming Narendnan N | 2004 | Proc Spie2004，5187，： | 1 |
| 11 | ERP correlates of com- positionality in Chinese idiom comprehension显示文摘 | Zhang Hui Yang Yiming Gu Jiexin & Ji Feng | 2013 | Journal of Neurolin- guistics2013，，1： | 1 |
| 12 | Cooperative catalytic platinum species accelerating polysulfide redox reactions for Li-S batteries显示文摘The shuttle effect derived from diffusion of lithium polysulfides(LiPSs) and sluggish redox kinetic bring about poor cycling stability and low utilization of sulfur,which have always been the key challenging issues for the commercial application of lithium-sulfur(Li-S) batteries.Rational design of cathode materials to catalyze Li_(2)S dissociation/nucleation processes is an appealing and valid strategy to develop high-energy practical Li-S batteries.Herein,considering the synergistic effect of bidirectional catalysis on LiPSs conversion and enhanced chemical immobilization for LiPSs by heteroatom doping,Pt nanoparticles loaded on nitrogen-doped carbon spheres(Pt/NCS composites) were constructed as cathode materials.According to the dynamic evolution of Pt catalysts and sulfur species,Pt~0 and Pt^(2+) species were identified as active species for the accelerated dissociation and nucleation of Li_(2)S,respectively.Meanwhile,in-situ Raman results demonstrated the expedited conversion of sulfur species resulted from bidirectional catalysis of active Pt species,corresponding to boosted redox kinetics.Consequently,Pt/NCS cathode exhibited improved long-term cyclability with high initial capacity,along with enhanced rate capability.This work provides a facile approach to construct cathode materials with bidirectional catalysis on Li_(2)S dissociation/nucleation,and sheds light on a more global understanding of the catalytic mechanism of metal catalysts during LiPSs conversion. | Yujie Qi Ning Chai Qinhua Gu Junnan Chen Zhaofeng Zhai Ming Lu Yiming Niu Nan Huang Xia Zhang Bingsen Zhang | 2023 | Journal of Energy Chemistry2023，，12： | 0 |
| 13 | Neural stem cell-derived exosomes promote mitochondrial biogenesis and restore abnormal protein distribution in a mouse model of Alzheimer's disease显示文摘Mitochondrial dysfunction is a hallmark of Alzheimer’s disease.We previously showed that neural stem cell-derived extracellular vesicles improved mitochondrial function in the cortex of AP P/PS1 mice.Because Alzheimer’s disease affects the entire brain,further research is needed to elucidate alterations in mitochondrial metabolism in the brain as a whole.Here,we investigated the expression of several important mitochondrial biogenesis-related cytokines in multiple brain regions after treatment with neural stem cell-derived exosomes and used a combination of whole brain clearing,immunostaining,and lightsheet imaging to clarify their spatial distribution.Additionally,to clarify whether the sirtuin 1(SIRT1)-related pathway plays a regulatory role in neural stem cell-de rived exosomes interfering with mitochondrial functional changes,we generated a novel nervous system-SIRT1 conditional knoc kout AP P/PS1mouse model.Our findings demonstrate that neural stem cell-de rived exosomes significantly increase SIRT1 levels,enhance the production of mitochondrial biogenesis-related fa ctors,and inhibit astrocyte activation,but do not suppress amyloid-βproduction.Thus,neural stem cell-derived exosomes may be a useful therapeutic strategy for Alzheimer’s disease that activates the SIRT1-PGC1αsignaling pathway and increases NRF1 and COXIV synthesis to improve mitochondrial biogenesis.In addition,we showed that the spatial distribution of mitochondrial biogenesis-related factors is disrupted in Alzheimer’s disease,and that neural stem cell-derived exosome treatment can reverse this effect,indicating that neural stem cell-derived exosomes promote mitochondrial biogenesis. | Bo Li Yujie Chen Yan Zhou Xuanran Feng Guojun Gu Shuang Han Nianhao Cheng Yawen Sun Yiming Zhang Jiahui Cheng Qi Zhang Wei Zhang Jianhui Liu | 2024 | Neural Regeneration Research2024，19，7： | 0 |
| 14 | 2D VARIABLE FACTOR LEARNING CONTROLLER AND ITS APPLICATION IN PNEUMATIC SERVO SYSTEM显示文摘0INTRODUCTIONPneumaticsystemhasbeenwidelyusedinrobot,aircraftandotherequipmentbecauseofitssavingenergy,nopolution,highspeedan... | Lu, Lu Gu, Yiming Shi, Weixiang | 1998 | Chinese Journal of Mechanical Engineering1998，11，4： | 0 |
| 15 | Update cognition of nonalcoholic fatty liver disease/metabolism-associated fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD)is a clinicopathological syndrome characterized by hepatic steatosis,excluding alcohol and other clear liver damage factors,including NAFL. | Weijun Gu Yiming Mu | 2022 | Chronic Diseases and Translational Medicine2022，8，1： | 0 |
| 16 | Low-cost preferential different amine grafted silica spheres adsorbents for DAC CO_(2)removal显示文摘DAC CO_(2)capture is gaining wide attention as one of the most difficult carbon approaches to tackle climate change.In this work,different pore-size silica spheres were grafted using different amine groups such as APTES,APTMS,and Diamine.Herein,all samples based on the wet and dry grafting method were used for CO_(2)adsorption isotherm at room temperature and pressure(298 K and 1 bar).The sample based on the wet grafting(Silica-APTES-W)sample shows the highest CO_(2)uptake 1.67 mmol/g.Also,the adsorption isotherm of the Silica-APTES-W sample was showed a high capacity of CO_(2)1.2 mmol/g at 25℃,which describes the strong physical interaction between CO_(2)and amine.The isosteric adsorption of Silica-APTES-W also confirmed that the physical adsorption was dominant because of low adsorption heat ranging from 23 to 37 k J/mol.Also,the fixed bed experiment was conducted with 2000 ppm CO_(2)that obtains the optimal working capacity 4.5 m L/g with the lowest regeneration temperature 90℃.It was shown that Silica-APTES-W sample was superior performance for DAC CO_(2)capture in practical applications. | Salman Qadir Hongjiu Su Defu Li Yiming Gu Shengsheng Zhao Sheng Wang Shudong Wang | 2022 | Journal of Energy Chemistry2022，，12： | 0 |
| 17 | Multi-dimensional multiplexing optical secret sharing framework with cascaded liquid crystal holograms显示文摘Secret sharing is a promising technology for information encryption by splitting the secret information into different shares.However,the traditional scheme suffers from information leakage in decryption process since the amount of available information channels is limited.Herein,we propose and demonstrate an optical secret sharing framework based on the multi-dimensional multiplexing liquid crystal(LC)holograms.The LC holograms are used as spatially separated shares to carry secret images.The polarization of the incident light and the distance between different shares are served as secret keys,which can significantly improve the information security and capacity.Besides,the decryption condition is also restricted by the applied external voltage due to the variant diffraction efficiency,which further increases the information security.In implementation,an artificial neural network(ANN)model is developed to carefully design the phase distribution of each LC hologram.With the advantage of high security,high capacity and simple configuration,our optical secret sharing framework has great potentials in optical encryption and dynamic holographic display. | Keyao Li Yiming Wang Dapu Pi Baoli Li Haitao Luan Xinyuan Fang Peng Chen Yanqing Lu Min Gu | 2024 | Opto-Electronic Advances2024，7，1： | 0 |
| 18 | Integrated proteomic and phosphoproteomic data-independent acquisition data evaluate the personalized drug responses of primary and metastatic tumors in colorectal cancer显示文摘Mass spectrometry(MS)-based proteomics and phosphoproteomics are powerful methods to study the biological mechanisms,diagnostic biomarkers,prognostic analysis,and drug therapy of tumors.Dataindependent acquisition(DIA)mode is considered to perform better than data-dependent acquisition(DDA)mode in terms of quantitative reproducibility,specificity,accuracy,and identification of lowabundance proteins.Mini patient derived xenograft(MiniPDX)model is an effective model to assess the response to antineoplastic drugs in vivo and is helpful for the precise treatment of cancer patients.Kinases are favorable spots for tumor-targeted drugs,and their functional completion relies on signaling pathways through phosphorylating downstream substrates.Kinase-phosphorylation networks or edge interactions are considered more credible and permanent for characterizing complex diseases.Here,we provide a workflow for personalized drug response assessment in primary and metastatic colorectal cancer(CRC)tumors using DIA proteomic data,DIA phosphoproteomic data,and MiniPDX models.Three kinase inhibitors,afatinib,gefitinib,and regorafenib,are tested pharmacologically.The process mainly includes the following steps:clinical tissue collection,sample preparation,hybrid spectral libraries establishment,MS data acquisition,kinase-substrate network construction,in vivo drug test,and elastic regression modeling.Our protocol gives a more direct data basis for individual drug responses,and will improve the selection of treatment strategies for patients without the druggable mutation. | Xumiao Li Yiming Huang Kuo Zheng Guanyu Yu Qinqin Wang Lei Gu Jingquan Li Hui Wang Wei Zhang Yidi Sun Chen Li | 2023 | Biophysics Reports2023，9，2： | 0 |
| 19 | Preliminary exploration of the distribution characteristics and influencing factors of the intangible cultural heritage in Sichuan province based on GIS显示文摘This paper analyzed the distribution of the intangible cultural heritage in Sichuan province by using the nuclear density method in Arcgis 10.2,and obtained the provincial and nuclear density distribution maps of the intangible cultural heritage in Sichuan province,as well as the structural and spatial distribution characteristics of the intangible cultural heritage in Sichuan province.The authors analyzed and summarized the influencing factors of these characteristics and put forward the suggestions on strengthening the infrastructure construction in Western Sichuan province and encouraging exchanges and cooperation among the ethnic groups. | XU Yiming GU Siyang LIU Ying | 2019 | International English Education Research2019，，2： | 0 |
| 20 | Study of the packaging materials and the structural renewal of'Snow Bud'in Shutao Company显示文摘The improved'Snow Bud'packaging mainly includes the medium packing and the external packaging,with the cuboid as the main structure,and the paper as the main material.The inner packaging uses the tin foil paper bag.Because of the thin thickness of the carton used and the problems in colors,patterns,character design,structures and other aspects,the purpose of the improvement is to use the new structures to enhance the practical functions of the packaging and to explore the application of the new materials in the tea packaging. | XU Yiming GU Siyang LI Pinwu | 2019 | International English Education Research2019，，2： | 0 |
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