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| 1 | Contribution of the Compass satellite navigation system to global PNT users显示文摘As one of the four global satellite navigation systems,Compass not only enhances satellite visibility and availability for positioning,navigation and timing (PNT) for users in China and the surrounding areas,but also improves PNT precision for global users.The improvements in satellite visibility and the dilution of precision are analyzed under GNSS compatibility and interoperation conditions.The contribution of the Compass satellite navigation system to global users,especially the benefits that users can acquire from the combination of Compass,GPS,GLONASS,and Galileo navigation systems,is analyzed using simulation data. | YANG YuanXi LI JinLong XU JunYi TANG Jing GUO HaiRong HE HaiBo | 2011 | Chinese Science Bulletin2011，56，26： | 90 |
| 2 | One-step generation of knockout pigs by zygote injection of CRISPR/Cas system显示文摘 | Tang Hai Fei Teng Runfa Guo Wei Li Qi Zhou | 2014 | Cell Research2014，24，3： | 131 |
| 3 | RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings显示文摘在有前列腺癌症的不同赛跑的病人之中有显著不同;然而,位于这差别下面的机制仍然保持不清楚。这里,我们在场 transcriptome 的一处全面风景用 RNA-seq,越过关于基因熔化的前列腺癌症 transcriptomes 的揭示巨大的差异,长 noncoding RNA (长 ncRNA ) ,其他的拼接和体的变化从中国人口 14 主要前列腺癌症和他们的配对的正常对应物介绍。14 个肿瘤(21.4%) 中的三个在中国病人怀有 TMPRSS2 尔格熔化,和这熔化的低流行进一步在一个另外的肿瘤集合(10/54=18.5%) 被证实。尤其是,二新奇基因熔化, CTAGE5-KHDRBS3 (20/54=37%) 和 USP9Y-TTTY15 (19/54=35.2%) ,在我们的耐心的队经常发生了。介绍的进一步系统的 transcriptional 识别了是在肿瘤表示的差别的众多的长 ncRNAs。在长 ncRNA 和基因的表示之间的关联的分析建议长 ncRNAs 可以在 transcriptional 规定以外有功能。这研究在中国人口产出新卓见进前列腺癌症的致病。 | Shancheng Ren Zhiyu Peng Jian-Hua Mao Yongwei Yu Changjun Yin Xin Gao Zilian Cui Jibin Zhang Kang Yi Weidong Xu Chao Chen Fubo Wang Xinwu Guo Ji Lu Jun Yang Min Wei Zhijian Tian Yinghui Guan Liang Tang Chuanliang Xu Linhui Wang Xu Gao Wei Tian Jian Wang Huanming Yang Jun Wang Yinghao Sun | 2012 | Cell Research2012，22，5： | 66 |
| 4 | Clinical Features of Adult/Adolescent Atopic Dermatitis and Chinese Criteria for Atopic Dermatitis显示文摘 | Ping Liu Yan Zhao Zhang-Lei Mu Qian-Jin Lu Qian-Jin L U Li Zhang Xu Yao Min Zheng Yi-Wen Tang Xin-Xiano Lu Xiu-Juan xia You-Kun Lin Yu-Zhen Li Cai-Xia Tu Zhi-Rong Yao Jin-Hua Xu Wei Li Wei Lai Hui-Min Yang Hong-Fu Xie Xiu-Ping Han Zhi-Qiang Xie Xiang Nong Zai-Pei Guo Dan-Qi Deng Tong-Xin Shi Jian-Zhong Zhang | 2016 | Chinese Medical Journal2016，，7： | 64 |
| 5 | Wnt/b-catenin signaling plays an ever-expanding role in stem cell self-renewal,tumorigenesis and cancer chemoresistance显示文摘Wnt signaling transduces evolutionarily conserved pathways which play important roles in initiating and regulating a diverse range of cellular activities,including cell proliferation,calcium homeostasis,and cell polarity.The role of Wnt signaling in controlling cell proliferation and stem cell self-renewal is primarily carried out through the canonical pathway,which is the best-characterized the multiple Wnt signaling branches.The past 10 years has seen a rapid expansion in our understanding of the complexity of this pathway,as many new components of Wnt signaling have been identified and linked to signaling regulation,stem cell functions,and adult tissue homeostasis.Additionally,a substantial body of evidence links Wnt signaling to tumorigenesis of cancer types and implicates it in the development of cancer drug resistance.Thus,a better understanding of the mechanisms by which dysregulation of Wnt signaling precedes the development and progression of human cancer may hasten the development of pathway inhibitors to augment current therapy.This review summarizes and synthesizes our current knowledge of the canonical Wnt pathway in development and disease.We begin with an overview of the components of the canonical Wnt signaling pathway and delve into the role this pathway has been shown to play in stemness,tumorigenesis,and cancer drug resistance.Ultimately,we hope to present an organized collection of evidence implicating Wnt signaling in tumorigenesis and chemoresistance to facilitate the pursuit of Wnt pathway modulators that may improve outcomes of cancers in which Wnt signaling contributes to aggressive disease and/or treatment resistance. | Maryam K.Mohammed Connie Shao Jing Wang Qiang Wei Xin Wang Zachary Collier Shengli Tang Hao Liu Fugui Zhang Jiayi Huang Dan Guo Minpeng Lu Feng Liu Jianxiang Liu Chao Ma Lewis L.Shi Aravind Athiviraham Tong-Chuan He Michael J.Lee | 2016 | Genes & Diseases2016，3，1： | 70 |
| 6 | Berberine ameliorates renal injury in streptozotocin-induced diabetic rats by suppression of both oxidative stress and aldose reductase显示文摘背景 Berberine 是 Coptidis 根茎(CR ) 和外皮 phellodendri 的主要成分之一,在这研究,我们与糖尿病的 nephropathy (DN ) 在老鼠在肾的功能和它的可能的机制上调查了 berberine 的有益的效果。方法男 Wistar 老鼠被划分成三个组:正常,糖尿病的模型,和 berberine 处理组。在糖尿病的模型和 berberine 治疗组的老鼠被 intraperitonal 注射与 streptozotocin (STZ ) 导致到糖尿病。Glomerular 区域, glomerular 体积, fasting 血葡萄糖(FBG ) ,血脲氮(甜面包) ,浆液 creatinine (Cr ) 和为 24 个小时(UP24h ) 的尿蛋白质用商业地可得到的工具包被测量。同时, superoxide dismutase (草皮) 的活动,在浆液的 malondialdehyde (MDA ) 的内容, aldose reductase (AR ) 的活动和在肾的 AR mRNA 和蛋白质的表示被不同方法检测。结果显示出的结果 berberine 的那个口头的政府(200mg 牲汥瑡摥 ? ぐ?? | LIU Wei-hua HEI Zi-qing NIE Hong TANG Fu-tian HUANG He-qing LI Xue-juan DENG Yan-hui CHEN Shao-rui GUO Fen-fen HUANG Wen-ge CHEN Feng-ying LIU Pei-qing | 2008 | Chinese Medical Journal2008，，8： | 41 |
| 7 | New insights into the roles of CHOP-induced apoptosis in ER stress显示文摘Endoplasmic 蜂窝胃应力(嗯应力) 在 ER 由于动态平衡的损失被触发,在 ER 腔导致累积 ofmisfolded 蛋白质。嗯因为 ER 的展开的蛋白质 response.Perturbation 是抄写因素 C/EBP 相应蛋白质(砍) 的强大的 inducer,应力激活知道的一系列适应机制。尽管它过时的人或物证明到 ER 的过多或不利的应力触发 apoptosis,由砍位于这些 processesinduced 下面的特定的机制仍然保持不清楚。现在,导致砍的 apoptosis 在嗯应力在众多的人的疾病被含有例如 neurodegenerative 疾病,糖尿病, ischemic 疾病,肿瘤等等。在这评论,我们从实验室在几疾病的发展总结了砍的角色的 currentunderstanding 到诊所。 | Yiming Li Yunshan Guo Juan Tang Jianli Jiang Zhinan Chen | 2014 | Acta Biochimica et Biophysica Sinica2014，46，8： | 45 |
| 8 | Meta-analysis of defibrase in treatment of acute cerebral infarction显示文摘Background Fibrinogen-depleting agents are promising in the treatment of cerebral ischemic disease. They were studied by many trials, and the outcomes were different because of different regimens and different doses. In this study, we assessed the efficacy and safety of defibrase on acute cerebral infarction in China. Methods A search using Chinese hospital knowledge database (CHKD) and MEDLINE database for randomized controlled trials was carried out. A CHKD (1994 June 2005) search was performed with the keyword 'defibrase', then a second search for the keyword 'acute cerebral infarction'; a MEDLINE search (1950 June 2005) was performed with the following [(cerebral ischemia), OR (acute cerebral infarction), OR (stroke)], AND [defibrase]. Meta-analysis was performed with RevMan software 4.2. Results Included were 14 studies comparing the efficiency and safety of defibrase with other drugs in the treatment of acute cerebral infarction. Patients’ records were pooled (total 646 patients; defibrase, n=328, no defibrase n=318). Neurological deficit score (NDS) before treatment showed weighted mean differences (WMD)=0.95, 95% confidence interval (CI)= (-0.60, 2.50), P=0.23; NDS after treatment showed WMD=- 2.20, 95% CI= (-4.21, -0.18), P=0.03; Barthel index at 3 months showed WMD=4.45, 95% CI= (-0.13, 9.03), P=0.06; the plasma fibrinogen level before treatment showed WMD=0.02, 95% CI= (-0.16, 0.19), P=0.86; plasma fibrinogen level after treatment showed WMD=-1.51, 95% CI= (-1.88, -1.15), P<0.00 001. Conclusions With the given dose and regimen of defibrase in China, defibrase may play a role of anticoagulation. It might inhibit the progression of stroke and prevent the recurrence of stroke. | GUO Yi ZUO Yan-fang WANG Qi-zhang TANG Bing-shan LI Fu-kang SUN Yi | 2006 | Chinese Medical Journal2006，，8： | 35 |
| 9 | Positive and negative terrains on northern Shaanxi Loess Plateau显示文摘黄土积极、否定的地面(P-N 地面) 在黄土高原上广泛地分布式,被从高分辨率的数字举起模型介绍它的特征,分界以及抽取方法第一次讨论。把 5 m 决定 DEM 用作原来的测试数据,在 Shaanxi 黄土高原的不同部分的 48 个 geomorphological 单位的 P-N 地面精确地被提取。然后,为描绘 geomorphologic 风景和 P-N 地面的空间配置特征的六指示物被建议。在 P-N 地面和黄土地势之间的这些指示物和关系的空间分发规则为黄土地形的进一步的理解被讨论。与 P-N 地面和传统的地面索引的集成,最后,一系列无指导的分类方法被使用在北 Shaanxi 做一个合适的地形分类。结果证明 P-N 地面是效果线索在黄土高原上揭示精力和物质分发规则。到在 Shaanxi 黄土高原的北方的来自南方的 P-N 地面的一个连续变化证明黄土地形和积极地面区域的明显的空间差别仅仅在这个区域占了 60.5% 。P-N 地面参加者地形分类方法增加结果的有效性,特别在黄土台地,黄土台地山脉和黄土低山的区域。这研究在有数字地面分析方法的黄土地形的学习上是重要的。 | ZHOU Yi TANG Guo'an YANG Xin XIAO Chenchao ZHANG Yuan LUO Mingliang | 2010 | Journal of Geographical Sciences2010，20，1： | 35 |
| 10 | Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells显示文摘Spermatogonial 干细胞(SSC ) 能在移植以后生产众多的男配偶子进接受者睾丸,介绍为基因治疗和修改基因的动物的连续生产的一条珍贵途径。然而, SSC 的成功的基因操作被限制了,部分由于复杂性和当前可得到的基因编辑技术的低效率。这里,我们证明有效基因修正能用 CRISPR-Cas9 系统被介绍进 SSC。我们使用了 CRISPR-Cas9 系统变异在 SCC 的 EGFP transgene 或内长的 Crygc 基因。变异的 SSC 在移植以后经历了精子发生进不肥沃的老鼠睾丸的生精的小管。圆 spermatids 被产生并且在进成熟卵母细胞的注射以后,支持了显示相应变异的显型的异质接合的后代的生产。而且,在 Crygc 的一个引起疾病的变化(在 SSC 先存在的 Crygc −/−) 能乐意地到加入的 CRISPR-Cas9-induced nonhomologous 结束(NHEJ ) 或指导相同的修理(HDR ) 被修理,导致没有是的离开目标修正的证据带改正的基因的 SSC 线由整个染色体的定序出现。用从这些线产生的圆 spermatids 的授精在 100% 的效率与改正的显型产生了后代。我们的结果表明有效基因由 CRISPR-Cas9 系统在老鼠 SSC 编辑,并且提供在 SSC 经由基因修正治好基因疾病的原则的证明。 | Yuxuan Wu Hai Zhou Xiaoying Fan Ying Zhang Man Zhang Yinghua Wang Zhenfei Xie Meizhu Bai Qi Yin Dan Liang Wei Tang Jiaoyang Liao Chikai Zhou Wujuan Liu Ping Zhu Hongshan Guo Hong Pan Chunlian Wu Huijuan Shi Ligang Wu Fuchou Tang Jinsong Li | 2015 | Cell Research2015，25，1： | 37 |
| 11 | clusterProfiler 4.0:A universal enrichment tool for interpreting omics data显示文摘Functional enrichment analysis is pivotal for interpreting highthroughput omics data in life science.It is crucial for this type of tool to use the latest annotation databases for as many organisms as possible.To meet these requirements,we present here an updated version of our popular Bioconductor package,clusterProfiler 4.0.This package has been enhanced considerably compared with its original version published 9 years ago.The new version provides a universal interface for functional enrichment analysis in thousands of organisms based on internally supported ontologies and pathways as well as annotation data provided by users or derived from online databases.It also extends the dplyr and ggplot2 packages to offer tidy interfaces for data operation and visualization.Other new features include gene set enrichment analysis and comparison of enrichment results from multiple gene lists.We anticipate that clusterProfiler 4.0 will be applied to a wide range of scenarios across diverse organisms. | Tianzhi Wu Erqiang Hu Shuangbin Xu Meijun Chen Pingfan Guo Zehan Dai Tingze Feng Lang Zhou Wenli Tang Li Zhan Xiaocong Fu Shanshan Liu Xiaochen Bo Guangchuang Yu | 2021 | The Innovation2021，2，3： | 40 |
| 12 | Predictive factors and unfavourable prognostic factors of interstitial lung disease in patients with polymyositis or dermatomyositis: a retrospective study显示文摘背景空隙的肺疾病(ILD ) 是在 polymyositis (下午) 和影响预后并且在治疗要求一条更好攻击的途径的 dermatomyositis (DM ) 的严肃的肺复杂并发症。这研究在最新诊断的下午, DM 和 amyopathic DM (ADM ) 调查了流行,特征,预兆的因素和 ILD 的不利预示的因素。到 2008 年 12 月, 197 连续下午的医药记录和在孙中山大学的第二所隶属于的医院的 DM 病人的从 2000 年 1 月的方法被考察排除重叠,少年,和联系恶意的案例。病人被分到 ILD (69 个病人) 和一个 non-ILD 组(128 个病人) 。临床的特征,实验室调查结果,和预后被比较。结果 multivariate 分析在发作显示了那老年(或 1.033 , 95%CI 1.009-1.058 , P=0.007 ),发烧(或 4.109 , 95%CI 1.926-8.767 , P < 0.001 )并且关节炎/关节痛(或 2.274 , 95%CI 1.101-4.695 , P=0.026 )是为在排除 anti-Jo-1 以后在 PM/DM 开发 ILD 的独立预兆的因素。关于 anti-Jo-1,发烧(或 4.912, 95%CI 2.121-11.376, P < 0.001 ) 与 ILD 被联系。在 ILD 病人的差的幸存与 ILD 临床的子集被联系( RR 0.122 , 95%CI 0.049-0.399 , P < 0.001 ), ADM/DM/PM-ILD ( RR 0.140 , 95%CI 0.031-0.476 , P=0.002 ),心脏的参与( RR 4.654 , 95%CI 1.391-15.577 , P=0.013 )并且浆液白朊水平( RR 0.910 , 95%CI 0.831-0.997 , P=0.042 )。与发烧介绍了的结论病人趋于有 PM/DM-associated ILD 的更高的频率。一个 Hamman-Rich-like 演讲, ADM-ILD,心脏的参与和 hypoalbuminemia 是在 ILD-PM/DM 的差的预示的因素。 | JI Su-yun ZENG Fan-qin GUO Qing TAN Guo-zhen TANG Hong-feng LUO Yi-jin TANG Zeng-qi HAN Yan-fang | 2010 | Chinese Medical Journal2010，，5： | 33 |
| 13 | Positioning accuracy assessment for the 4GEO/5IGSO/2MEO constellation of COMPASS显示文摘Determined to become a new member of the well-established GNSS family,COMPASS(or BeiDou-2) is developing its capabilities to provide high accuracy positioning services.Two positioning modes are investigated in this study to assess the positioning accuracy of COMPASS' 4GEO/5IGSO/2MEO constellation.Precise Point Positioning(PPP) for geodetic users and real-time positioning for common navigation users are utilized.To evaluate PPP accuracy,coordinate time series repeatability and discrepancies with GPS' precise positioning are computed.Experiments show that COMPASS PPP repeatability for the east,north and up components of a receiver within China's Mainland is better than 2 cm,2 cm and 5 cm,respectively.Apparent systematic offsets of several centimeters exist between COMPASS precise positioning and GPS precise positioning,indicating errors remaining in the treatments of COMPASS measurement and dynamic models and reference frame differences existing between two systems.For common positioning users,COMPASS provides both open and authorized services with rapid differential corrections and integrity information available to authorized users.Our assessment shows that in open service positioning accuracy of dual-frequency and single-frequency users is about 5 m and 6 m(RMS),respectively,which may be improved to about 3 m and 4 m(RMS) with the addition of differential corrections.Less accurate Signal In Space User Ranging Error(SIS URE) and Geometric Dilution of Precision(GDOP) contribute to the relatively inferior accuracy of COMPASS as compared to GPS.Since the deployment of the remaining 1 GEO and 2 MEO is not able to significantly improve GDOP,the performance gap could only be overcome either by the use of differential corrections or improvement of the SIS URE,or both. | ZHOU ShanShi CAO YueLing ZHOU JianHua HU XiaoGong TANG ChengPan LIU Li GUO Rui HE Feng CHEN JunPing WU Bin | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，12： | 31 |
| 14 | Single-cell multi-omics sequencing of mouse early embryos and embryonic stem cells显示文摘定序技术的单个房间的 epigenome 最近被开发了。然而,在一个单个房间定序的 epigenome 的不同的层的联合还没被完成了。这里,我们开发了定序能分析染色质的技术(单个房间的 COOL-seq ) 的单个房间的 multi-omics 放的 state/nucleosome, DNA methylation,拷贝数字变化和 ploidy 同时从一样的单个哺乳动物的房间。我们使用了这个方法在老鼠 preimplantation 胚胎分析染色质状态和 DNA methylation 的 reprogramming。我们发现了那在以内 < 授精的 12 h,每个单个房间和母亲、父亲的染色体的快速、全球的 reprogramming 经历全球染色体 demethylation 到一个高度打开的染色质状态。这被减少的坦诚在迟了的接合子阶段以后跟随。而且,从迟了的接合子上演到 4 房间,剩余 DNA methylation 优先地在各单个的分裂球在父亲的等位基因的 intergenic 区域和母亲的等位基因的 intragenic 区域上被保存。然而,染色质可接近性在在从迟了的接合子的每个单个房间的父亲、母亲的等位基因之间是类似的到胚囊阶段。几个 pluripotency 管理者的有约束力的主题在远侧的 nucleosome 被充实弄空的区域从象 2 房间阶段一样早。这显示如此的目标基因的 cis 规章的元素从 2 房间阶段被告知到一个开的状态向前,在 pluripotency 最后在胚囊的 ICM 被建立以前,渴望。基因可以被分类进同类地开,同类地关门了并且分叉的状态基于他们在单个房间之中的倡导者区域的染色质可接近性。这能在 preimplantation 开发期间被跟踪到逐步的转变。我们的学习在早老鼠胚胎在单个底的分辨率提供染色体规模染色质状态和 DNA methylation 动力学的第一单个房间、父母的等位基因特定的分析并且提供新卓见进异构还高度在这个过程期间订了 epigenomic reprogramming 的特征。 | Fan Guo Lin Li Jingyun Li Xinglong Wu Boqiang Hu Ping Zhu Lu Wen Fuchou Tang | 2017 | Cell Research2017，27，8： | 34 |
| 15 | Terrestrial carbon sinks in China and around the world and their contribution to carbon neutrality显示文摘Enhancing the terrestrial ecosystem carbon sink(referred to as terrestrial C sink) is an important way to slow down the continuous increase in atmospheric carbon dioxide(CO_(2)) concentration and to achieve carbon neutrality target.To better understand the characteristics of terrestrial C sinks and their contribution to carbon neutrality,this review summarizes major progress in terrestrial C budget researches during the past decades,clarifies spatial patterns and drivers of terrestrial C sources and sinks in China and around the world,and examines the role of terrestrial C sinks in achieving carbon neutrality target.According to recent studies,the global terrestrial C sink has been increasing from a source of (-0.2±0.9) Pg C yr^(-1)(1 Pg=1015g)in the 1960s to a sink of (1.9±1.1) Pg C yr^(-1) in the 2010s.By synthesizing the published data,we estimate terrestrial C sink of 0.20–0.25 Pg C yr^(-1) in China during the past decades,and predict it to be 0.15–0.52 Pg C yr^(-1) by 2060.The terrestrial C sinks are mainly located in the mid-and high latitudes of the Northern Hemisphere,while tropical regions act as a weak C sink or source.The C balance differs much among ecosystem types:forest is the major C sink;shrubland,wetland and farmland soil act as C sinks;and whether the grassland functions as C sink or source remains unclear.Desert might be a C sink,but the magnitude and the associated mechanisms are still controversial.Elevated atmospheric CO_(2) concentration,nitrogen deposition,climate change,and land cover change are the main drivers of terrestrial C sinks,while other factors such as fires and aerosols would also affect ecosystem C balance.The driving factors of terrestrial C sink differ among regions.Elevated CO_(2) concentration and climate change are major drivers of the C sinks in North America and Europe,while afforestation and ecological restoration are additionally important forcing factors of terrestrial C sinks in China.For future studies,we recommend the necessity for intensive and long-term ecosystem C monitoring over broad geographic scale to improve terrestrial biosphere models for accurately evaluating terrestrial C budget and its dynamics under various climate change and policy scenarios. | Yuanhe Yang Yue Shi Wenjuan Sun Jinfeng Chang Jianxiao Zhu Leiyi Chen Xin Wang Yanpei Guo Hongtu Zhang Lingfei Yu Shuqing Zhao Kang Xu Jiangling Zhu Haihua Shen Yuanyuan Wang Yunfeng Peng Xia Zhao Xiangping Wang Huifeng Hu Shiping Chen Mei Huang Xuefa Wen Shaopeng Wang Biao Zhu Shuli Niu Zhiyao Tang Lingli Liu Jingyun Fang | 2022 | Science China(Life Sciences)2022，65，5： | 32 |
| 16 | Geochronology, geochemistry, and its geological significance of the Permian Mandula mafic rocks in Damaoqi, Inner Mongolia显示文摘The Hujierte-Chaganhadamiao volcanic-plutonic sequence is located in the Mandula area of northern Damaoqi, Inner Mongolia. It contains mainly mafic volcanics, with several ultramafic blocks in its central part and mafic-intermediate intrusions in the east. The zircon U-Pb ages of the gabbro and basalt samples are 278.5±3.0 Ma (MSWD=0.66) and 273.7±1.0 Ma (MSWD=0.36), respectively. These ages constrain the magmatism occurred in the Early Permian. The Mandula Permian mafic rocks are characterized by low abundances of REE and slightly LREE-enriched chondrite-normalized N-MORB-type REE patterns. And these mafic samples have high ( 143 Nd/ 144 Nd) i (0.51262-0.51270), relatively high positive ε Nd (t) (3.4-8.0), and high Mg # (49-54), suggesting derivation from the depleted asthenosphere mantle source. But they also show the enrichment in large ion lithophile elements (LILE, e.g. Rb, Ba and Sr), depletion in high field strength elements (HFSE); distinctly negative Nb, Ta anomalies and slightly negative P, Ti anomalies; high ( 87 Sr/ 86 Sr) i (0.70490-0.70537), low ( 206 Pb/ 204 Pb) i (17.39-17.93). All of these resemble the characteristics of the enriched mantle source or involvement of arc materials in the magma genesis. Furthermore, as shown in the correlation plots of ε Nd (t) vs ( 87 Sr/ 86 Sr) i , ( 206 Pb/ 204 Pb) i vs ( 207 Pb/ 204 Pb) i and ( 208 Pb/ 204 Pb) i , La/Ba La/Nb vs La/Nb, and La/Nb ratio, the magma source could have been experienced the contamination and metasomation from the previous subduction process. And the positive correlation between the selected major oxides and trace elements could be explained by the contamination from continental crust and arc materials during the magmatic emplacement. Combined with the distinct geochemistry features of Mandula mafic samples and many previous researches in the study area, the Early Permian magmatism in Mandula occurred under an extensional rift setting, and a juvenile ocean basin probably had already been formed after further development. | CHEN Chen ZHANG ZhiCheng GUO ZhaoJie LI JianFeng FENG ZhiShuo TANG WenHao | 2012 | Science China Earth Sciences2012，55，1： | 30 |
| 17 | Immunological synergistic mechanisms of trans-/cis-stilbene glycosides in Heshouwu-related idiosyncratic liver injury显示文摘Heshouwu is a traditional non-toxic Chinese medicine commonly used in the clinical setting;however,clinical cases of Heshouwu-induced hepatotoxicity have been frequently reported^([1]).Pharmacoepidemiological studies have found that Heshouwu-induced liver injury occurs only in a small fraction of individuals taking the drug;these patients presented with the typ- | Lanzhi He Ping Yin Yakun Meng Jinfa Tang Tingting He Ming Niu Yuming Guo Yun Zhu Jing Jing Chunyu Li Zhijie Ma Jiabo Wang Zhaofang Bai Xiaohe Xiao | 2017 | Science Bulletin2017，62，11： | 29 |
| 18 | Phosphorus Removal of High Phosphorus Iron Ore by Gas-Based Reduction and Melt Separation显示文摘A new method (gas-based separation plus melt separation) has been proposed to remove phosphorus of the high phosphorus iron ore which was 1.25% of phosphorus content and 50.0% of iron content.HSC chemistry package and the coexistence theory of slag structure were adopted for theoretical analysis.The gas-based reduction was carried out using a fixed bed reactor and the ore sample of 80 g with an average particle size of 2 mm were reduced using CO or H2 at temperature of 1073 K for 5 hours.50 g of the reduced sample with 3.0% CaO as additive was then subjected to melt separation in an electric furnace at temperature of 1873 K under Ar atmosphere.In each run,SEM,EDS,optical microscopic examination and chemical analysis of the reduced ore sample,the metal sample and the slag sample were conducted.Results of all gas-based reduction experiments showed that iron metallization ratios were some 65% and the phosphorus compounds in the ore remained unchanged.It was agreed well with the simulations except for the iron metallization rate being less than predicted value;this difference was attributed to kinetics.Results of melt separation experiments showed that P content in metal samples is 0.33% (metal sample from H2 reduction product) and 0.27 % (metal sample from CO reduction product).The phosphorus partition ratios of both cases were less than predicted values.Some P in the metal samples existed as slag inclusion was considered to be the reason for this discrepancy. | TANG Hui-qing GUO Zhan-cheng ZHAO Zhi-long | 2010 | Journal of Iron and Steel Research(International)2010，17，9： | 27 |
| 19 | Genome-wide Targeted Mutagenesis in Rice Using the CRISPR/Cas9 System显示文摘 | Lu, Yuming Ye, Xiao Guo, Renming Huang, Jing Wang, Wei Tang, Jiuyou Tan, Longtao Zhu, Jian-kang Chu, Chengcai Qian, Yangwen | 2017 | Molecular Plant2017，10，9： | 28 |
| 20 | High-Strength and High-Plasticity TWIP Steel for Modern Vehicle显示文摘In this paper new high-strength and high-plasticity twinning induced plasticity (TWIP) steel for modern automobile body was investigated. Some basic experimental results were given. The results indicate the TWlP steel has excellent properties. It exhibits high ultimate tensile strength (600~1100 MPa) and extremely large elongation of 60% to 90%. In the future it would be capable of satisfying the requirements of new generation of vehicle. | Zhenli MI Di TANG Ling YAN Jin GUO | 2005 | Journal of Materials Science & Technology2005，21，4： | 25 |
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