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| 1 | Correlation between the coverage percentage of prosthesis and postoperative hidden blood loss in primary total knee arthroplasty显示文摘 | Gao Fuqiang Guo Wanshou Sun Wei Li Zirong Wang Weiguo Wang Bailiang Cheng Liming Kush Nepali | 2014 | Chinese Medical Journal2014，，12： | 18 |
| 2 | Synergistically Enhanced Mucoadhesive and Penetrable Polypeptide Nanogel for Efficient Drug Delivery to Orthotopic Bladder Cancer显示文摘Intravesical chemotherapy has been recommended after the gold standard of transurethral resection of the bladder tumor to prevent bladder cancer(BC)from local recurrence in the clinic.However,due to rapid urine excretion and barrier protection of the bladder wall,the clinical performances of chemotherapeutic drugs are severely compromised.In the present work,a smart positively charged disulfide-crosslinked nanogel of oligoarginine-poly(ethylene glycol)-poly(L-phenylalanine-co-L-cystine)(R_(9)-PEG-P(LP-co-LC))was prepared to prolong the retention period and enhance the penetration capability of chemotherapeutic agent toward the bladder wall.PEG significantly improved the aqueous dispersibility of the 10-hydroxycamptothecin(HCPT)-loaded R_(9)-PEG-P(LP-co-LC)(i.e.,R_(9)NG/HCPT)and enhanced the mucoadhesive capability by the nonspecific interaction between PEG chain and the bladder mucosa accompanied with the electrostatic interaction between the cationic R_(9)and negatively charged bladder mucosa.Besides,R_(9),as a cell-penetrating peptide,efficiently penetrated through the cell membrane and delivered carried cargo.The disulfide bond endowed the selective release behavior of HCPT triggered by the intracellular reductive microenvironment.As an advanced chemotherapeutic nanoformulation,the smart R_(9)NG/HCPT demonstrated superior cytotoxicity against human BC 5637 cells in vitro and remarkably enhanced tumor suppression activity toward orthotopic BC models of mouse and rat in vivo,indicating its great potential in the clinical intravesical BC chemotherapy. | Hui Guo Faping Li Heping Qiu Weiguo Xu Pengqiang Li Yuchuan Hou Jianxun Ding Xuesi Chen | 2020 | Research2020，，1： | 7 |
| 3 | Static recrystallization and grain growth during annealing of an extruded Mg-Zn-Zr-Er magnesium alloy显示文摘Microstructure stability is essential to maintain a fine grain structure for an alloy throughout its processing.The effects of Er addition and its existing form on the static recrystallization and grain growth during annealing of an extruded Mg-1.5Zn-0.6Zr magnesium alloy were studied in this paper.The results showed that microstructure stability was much improved by Er addition and the best thermability was obtained in 2 wt.%Er-containing alloy.For the incomplete dynamic recrystallization(DRX)microstructures extruded at a lower temperature of 350℃,Er addition increased the resistance of static recrystallization;and for the complete DRX microstructures extruded at a relatively high temperature of 420℃,Er addition suppressed grain growth.The difference in microstructure stability was then correlated with the microstructure features.Both the intermetallic phase and the solute atoms of Er inα-Mg matrix contributed to the microstructure stability.Moreover,it is believed that the existing form of Er-Zn atom pairs in theα-Mg solid solution favored the most to improve the thermal stability of the alloy. | Jing Zhang Weiguo Li Zhengxiao Guo | 2013 | Journal of Magnesium and Alloys2013，1，1： | 6 |
| 4 | The effect of phase transition on the compressional wave velocity for a trachybasalt at high temperature and high pressure显示文摘Compressional wave velocities in a trachybasalt, from Yichuan County, Henan Province, have been measured at 2.0 GPa and up to 1 350℃ in a YJ-3000 t cubic-anvil highpressure apparatus. The run products have been gained at the same pressure but different temperatures. The observation of the thin sections of the run products indicates that, corresponding to the variation of the compressional wave velocity in the trachybasalt, the phase transition has taken place. The relationship between the change of the compressional wave velocity and the hydrous mineral dehydration, solid-solid phase transformation and partial melting has been discussed. The experimental data presented here are of great importance to elucidating the geological process in the earth’s interior. | Wenge Zhou Hongsen Xie Zhidan Zhao Weiguo Zhu Jie Guo Ji’an Xu | 1999 | Chinese Science Bulletin1999，44，15： | 5 |
| 5 | Profiling and bioinformatics analysis of differentially expressed circular RNAs in human intervertebral disc degeneration显示文摘The functional changes of nucleus pulposus (NP) cells are considered to be the initiating factors of intervertebral disc degeneration (IDD), and the differentially expressed circRNAs in NP cells may play an important role in the process of IDD. To identify circular RNAs (circRNAs) associated with human IDD, we isolated the NP cells from human degenerated and non-degenerated intervertebral disc and identified NP cells by microscopy and cell proliferation. CircRNA microarray expression profiles were obtained from NP cells of degenerated and non-degenerated intervertebral disc and further validated by quantitative reverse transcription PCR (qRTPCR). The expression data were analyzed by bioinformatics. Microarray analysis identified 7294 circRNAs differentially expressed in degenerated human IDD NP cells. Among them, 3724 circRNAs were up-regulated and 3570 circRNAs were down-regulated by more than 2 folds. After validating by qRT-PCR, we predicted the possible miRNAs of the top dysregulated circRNAs using TargetScan, and miRanda. Furthermore, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that the most modulated circRNAs regulate the viability, degradation, apoptosis and oxidative stress in NP cells, and the possible mechanism underlying IDD was discussed. These results revealed that circRNAs may play a role in IDD and might be a promisi ng can didate molecular target for gene therapy. | Shunmin Wang Jingchuan Sun Haisong Yang Weiguo Zou Bing Zheng Yu Chen Yongfei Guo Jiangang Shi | 2019 | Acta Biochimica et Biophysica Sinica2019，51，6： | 4 |
| 6 | Fourth-generation ceramic-on-ceramic total hip arthroplasty in patients of 55 years or younger: short-term results and complications analysis显示文摘 | Wang Weiguo Guo Wanshou Yue Debo Shi Zhencai Zhang Nianfei Liu Zhaohui Sun Wei Wang Bailiang Li Zirong | 2014 | Chinese Medical Journal2014，，12： | 4 |
| 7 | High-performance all-polymer solar cells enabled by a novel low bandgap non-fully conjugated polymer acceptor显示文摘The non-fully conjugated polymer as a new class of acceptor materials has shown some advantages over its small molecular counterpart when used in photoactive layers for all-polymer solar cells(all-PSCs),despite a low power conversion efficiency(PCE)caused by its narrow absorption spectra.Herein,a novel non-fully conjugated polymer acceptor PFY-2TS with a low bandgap of~1.40 eV was developed,via polymerizing a largeπ-fused small molecule acceptor(SMA)building block(namely YBO)with a non-conjugated thioalkyl linkage.Compared with its precursor YBO,PFY-2TS retains a similar low bandgap but a higher LUMO level.Moreover,compared with the structural analog of YBO-based fully conjugated polymer acceptor PFY-DTC,PFY-2TS shows a similar absorption spectrum and electron mobility,but significantly different molecular crystallinity and aggregation properties,which results in optimal blend morphology with a polymer donor PBDB-T and physical processes of the device in all-PSCs.As a result,PFY-2TS-based all-PSCs achieved a PCE of 12.31%with a small energy loss of 0.56 eV enabled by the reduced non-radiative energy loss(0.24 eV),which is better than that of 11.08%for the PFY-DTC-based ones.Our work clearly demonstrated that non-fully conjugated polymers as a new class of acceptor materials are very promising for the development of high-performance all-PSCs. | Qunping Fan Ruijie Ma Tao Liu Jianwei Yu Yiqun Xiao Wenyan Su Guilong Cai Yuxiang Li Wenhong Peng Tao Guo Zhenghui Luo Huiliang Sun Lintao Hou Weiguo Zhu Xinhui Lu Feng Gao Ellen Moons Donghong Yu He Yan Ergang Wang | 2021 | Science China Chemistry2021，64，8： | 3 |
| 8 | Enhancement of potassium resistance of Ce-Ti oxide catalyst for NH_(3)-SCR reaction by modification with holmium显示文摘Alkali metal K in exhaust gas has a deactivation effect on NH_(3)-SCR catalysts.In this work,it is discovered that the addition of Ho on CeTi catalyst can remarkably strengthen its K tolerance.The conclusions of Brunauer-Emmett-Teller(BET),X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),NH_(3) temperature programmed desorption(NH_(3)-TPD)and H_(2)temperature programmed reduction(H_(2)-TPR)analyses demonstrate that the enhancement of K resistance mainly originates from its stronger surface acidity and redox capability,the higher concentration of Ce^(3+)species and surface chemisorbed oxygen.In situ DRIFT analysis reveals that the introduction of Ho on CeTi can remarkably improve the adsorption of NH_(3) and NO_(x) species on catalyst surface,accompanied by the intensified reactivity of ad-NH_(3) species,which should also administer to improve the K resistance. | Chaopeng Duan Ruitang Guo Yuanzhen Liu Guilin Wu Yufang Miao Jingwen Gu Weiguo Pan | 2022 | Journal of Rare Earths2022，40，1： | 3 |
| 9 | Low temperature catalytic oxidation of NO over different-shaped CeO2显示文摘To investigate the effect of CeO_2 nanomaterial morphology on its performance for NO catalytic oxidation.Three kinds of CeO_2 nanomaterials including CeO_2 nanorods,nanospheres and nanoparticles were prepared by hydrothermal method and used for catalytic oxidation of NO at low temperature. The experimental results show that CeO_2 nanorods are of the best catalytic performance. Characterization techniques including TEM, XRD, H_2-TPR, NO-TPD and XPS were used to determine the relationship between the morphology of CeO_2 nanomaterial and its catalytic performance. TEM images show that CeO_2 nanorods predominantly exposed(110) and(10 0) planes, while CeO_2 nanospheres and CeO_2 nanoparticles predominantly exposed(111) plane. The excellent catalytic performance of CeO_2 nanorods could be ascribed to the low crystallinity, high reducibility, strong NO adsorption ability and the presence of more surface chemisorbed oxygen. | Wenhuan Wang Ruitang Guo Weiguo Pan Guoxin Hu | 2018 | Journal of Rare Earths2018，36，6： | 3 |
| 10 | Effect of electropulsing treatment on static recrystallization behavior of cold-rolled magnesium alloy ZK60 with different reductions显示文摘Effect of electropulsing treatment(EPT) on recrystallization behavior of cold-rolled Mg alloy ZK60 strips was investigated. It was found that EPT significantly improved nucleation rate and migration ability of grain boundaries, leading to accelerated recrystallization of the deformed metals at relatively low temperature. After the recrystallization induced by EPT, the average grain size of 20% rolling reduction samples decreased from 113 um to around 10 um, meanwhile the typical basal-type texture of the coldrolled sample was weakened. EPT was normally accompanied with a thermal and an athermal effects. The athermal effect played a dominated role in increasing nucleation rate, while the thermal effect promoted grain growth. A fewer recrystallized grains originated along the grain boundaries in the 10% reduction samples, while most of the recrystallization took place inside the twins in the 20% reduction samples. | Huijun Guo Xun Zeng Jianfeng Fan Hua Zhang Qiang Zhang Weiguo Li Hongbiao Dong Bingshe Xu | 2019 | Journal of Materials Science & Technology2019，35，6： | 2 |
| 11 | Cdhl regulates craniofacial development via APC- dependent ubiquitination and activation of Goosecoid显示文摘 | Rui Shao Jia Liu Guang Yan Jinfang Zhang Yujiao Han Jianfeng Guo Zhan Xu Zhu Yuan Jiankang Liu Marcos Malumbres Lixin Wan Wenyi Wei Weiguo Zou | 2016 | Cell Research2016，26，6： | 2 |
| 12 | A critical review of mineral–microbe interaction and co-evolution:mechanisms and applications显示文摘Mineral–microbe interactions play important roles in environmental change,biogeochemical cycling of elements and formation of ore deposits.Minerals provide both beneficial(physical and chemical protection,nutrients,and energy)and detrimental(toxic substances and oxidative pressure)effects to microbes,resulting in mineral-specific microbial colonization.Microbes impact dissolution,transformation and precipitation of minerals through their activity,resulting in either genetically controlled or metabolism-induced biomineralization.Through these interactions,minerals and microbes co-evolve through Earth history.Mineral–microbe interactions typically occur at microscopic scale but the effect is often manifested at global scale.Despite advances achieved through decades of research,major questions remain.Four areas are identified for future research:integrating mineral and microbial ecology,establishing mineral biosignatures,linking laboratory mechanistic investigation to field observation,and manipulating mineral–microbe interactions for the benefit of humankind. | Hailiang Dong Liuqin Huang Linduo Zhao Qiang Zeng Xiaolei Liu Yizhi Sheng Liang Shi Geng Wu Hongchen Jiang Fangru Li Li Zhang Dongyi Guo Gaoyuan Li Weiguo Hou Hongyu Chen | 2022 | National Science Review2022，9，10： | 2 |
| 13 | Association between the Pro12Ala polymorphism of PPAR-γ gene and the non-alcoholic fatty liver disease: A meta-analysis显示文摘 | Jun Wang Xufeng Guo Pengbo Wu Jia Song Chuncui Ye Shijie Yu Jixiang Zhang Weiguo Dong | 2013 | Gene2013，，： | 2 |
| 14 | Arginine methylation of ribose-5-phosphate isomerase A senses glucose to promote human colorectal cancer cell survival显示文摘Cancer cells remodel their metabolic network to adapt to variable nutrient availability. Pentose phosphate pathway(PPP) plays protective and biosynthetic roles by oxidizing glucose to generate reducing power and ribose. How cancer cells modulate PPP activity in response to glucose supply remains unclear. Here we show that ribose-5-phosphate isomerase A(RPIA), an enzyme in PPP, directly interacts with co-activator associated arginine methyltransferase 1(CARM1) and is methylated at arginine 42(R42). R42 methylation up-regulates the catalytic activity of RPIA. Furthermore, glucose deprivation strengthens the binding of CARM1 with RPIA to induce R42 hypermethylation. Insufficient glucose supply links to RPIA hypermethylation at R42, which increases oxidative PPP flux. RPIA methylation supports ROS clearance by enhancing NADPH production and fuels nucleic acid synthesis by increasing ribose supply. Importantly, RPIA methylation at R42 significantly potentiates colorectal cancer cell survival under glucose starvation. Collectively, RPIA methylation connects glucose availability to nucleotide synthesis and redox homeostasis. | Jizheng Guo Qixiang Zhang Ying Su Xiaochen Lu Yiping Wang Miao Yin Weiguo Hu Wenyu Wen Qun-Ying Lei | 2020 | Science China(Life Sciences)2020，63，9： | 2 |
| 15 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 16 | Thymoquinone inhibits growth and augments 5-fluorouracil-induced apoptosis in gastric cancer cells both in vitro and in vivo显示文摘 | Xiaofei Lei Xiaoguang Lv Meng Liu Zirong Yang Mengyao Ji Xufeng Guo Weiguo Dong | 2011 | Biochemical and Biophysical Research Communications2011，，2： | 1 |
| 17 | Study on critical Point threshold of pollutant emission based on modified grey clustering model显示文摘 | Weiguo XU Qingyu ZHANG Hui GUO | 2006 | The 5th International Conference on Environmental Informatics (ISTP)2006，8，： | 1 |
| 18 | Compressive behavior and rate-controlling mechanisms of ultrafine grained copper over wide temperature and strain rate ranges显示文摘 | Tao Suo Yulong Li Feng Zhao Xueling Fan Weiguo Guo | 2013 | Mechanics of Materials2013，，： | 1 |
| 19 | Very high strainrate response of a NiTi shape-memory alloy 显示文摘 | Sia Nemat-nasser Choi Jeom-yong Guo Weiguo | 2005 | Mechanics of Materials2005，37，： | 1 |
| 20 | Superelastic and cyclic response of NiTi SMA at various strain rates and temperatures显示文摘 | Sia Nemat-nasser Guo Weiguo | 2006 | Meehanics of Materials2006，38，： | 1 |
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