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| 1 | Status and development of high-power laser facilities at the NLHPLP显示文摘In this paper, we review the status of the multifunctional experimental platform at the National Laboratory of High Power Laser and Physics(NLHPLP). The platform, including the SG-II laser facility, SG-II 9th beam, SG-II upgrade(SG-II UP) facility, and SG-II 5 PW facility, is operational and available for interested scientists studying inertial confinement fusion(ICF) and a broad range of high-energy-density physics. These facilities can provide important experimental capabilities by combining different pulse widths of nanosecond, picosecond, and femtosecond scales. In addition, the SG-II UP facility, consisting of a single petawatt system and an eight-beam nanosecond system, is introduced including several laser technologies that have been developed to ensure the performance of the facility. Recent developments of the SG-II 5 PW facility are also presented. | Jianqiang Zhu Jian Zhu Xuechun Li Baoqiang Zhu Weixin Ma Xingqiang Lu Wei Fan Zhigang Liu Shenlei Zhou Guang Xu Guowen Zhang Xinglong Xie Lin Yang Jiangfeng Wang Xiaoping Ouyang Li Wang Dawei Li Pengqian Yang Quantang Fan Mingying Sun Chong Liu Dean Liu Yanli Zhang Hua Tao Meizhi Sun Ping Zhu Bingyan Wang Zhaoyang Jiao Lei Ren Daizhong Liu Xiang Jiao Hongbiao Huang Zunqi Lin | 2018 | High Power Laser Science and Engineering2018，6，4： | 8 |
| 2 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 3 | Numerical calculation and influencing factors of the volume fraction of interfacial transition zone in concrete显示文摘The determination of volume fraction of interfacial transition zone(ITZ) is very important for investigating the quantitative relationship between the microstructure and macroscopical property of concrete.In this paper,based on Lu and Torquato's most nearest surface distribution function,a calculating process of volume fraction of ITZ is given in detail according to the actual sieve curve in concrete.Then,quantitative formulas are put forward to measure the influencing factors on the ITZ volume fraction.In order to validate the given model,the volume fractions of ITZ obtained by numerical calculation are compared with those by computer simulation.The results show that the two are in good agreement.The order of the factors influencing the ITZ volume fraction is the ITZ thickness,the volume fraction of aggregate and the maximum aggregate diameter for Fuller gradation in turn.The ITZ volume fraction obtained from the equal volume fraction(EVF) gradation is always larger than that from the Fuller gradation for a given volume fraction of aggregate. | SUN GuoWen SUN Wei ZHANG YunSheng LIU ZhiYong | 2012 | Science China(Technological Sciences)2012，55，6： | 3 |
| 4 | Experimental study of separation of ammonia synthesis vent gas by hydrate formation显示文摘Termodynamic data on methane hydrate formation in the presence of ammonia are very important for upgrading of ammonia synthesis vent gas using hydrate formation. This paper is focused on the formation conditions of methane hydrate in the presence of ammonia and the effects of gas-liquid ratio and temperature on the separation of vent gas by hydrate formation. Equilibrium data for methane hydrate within an ammonia mole concentration range from 1% to 5 % were obtained. The experimental results indicated that ammonia has an inhibitive effect on hydrate formation. The higher the ammonia concentration, the higher is the pressure reguired for methane hydrate formation would be. The primary experimental results showed that when volume ratio of gas to liquid was 80:1 and temperature was 283.15 K, total mole fraction of (H2+N2) in gas phase could reach 96.9 %. | Dong Taibin Wang Leiyan Liu Aixian Guo Xuqiang Ma Qinglan Li Guowen Sun Qiang | 2009 | Petroleum Science2009，6，2： | 3 |
| 5 | Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy——lysosomal pathway显示文摘Nonalcoholic fatty liver disease(NAFLD) is characterized by hepatic steatosis and insulin resistance and there are currently no approved drugs for its treatment.Hyperactivation of mTOR complex1(mTORCl) and subsequent impairment of the transcription factor EB(TFEB)-mediated autophagy-lysosomal pathway(ALP) are implicated in the development of NAFLD.Accordingly,agents that augment hepatic TFEB transcriptional activity may have therapeutic potential against NAFLD.The objective of this study was to investigate the effects of nuciferine,a major active component from lotus leaf,on NAFLD and its underlying mechanism of action.Here we show that nuciferine activated ALP and alleviated steatosis,insulin resistance in the livers of NAFLD mice and palmitic acid-challenged hepatocytes in a TFEB-dependent manner.Mechanistic investigation revealed that nuciferine interacts with the Ragulator subunit hepatitis B X-interacting protein and impairs the interaction of the Ragulator complex with Rag GTPases,thereby suppressing lysosomal localization and activity of mTORC1,which activates TFEB-mediated ALP and further ameliorates hepatic steatosis and insulin resistance.Our present results indicate that nuciferine may be a potential agent for treating NAFLD and that regulation of the mTORCl-TFEB-ALP axis could represent a novel pharmacological strategy to combat NAFLD. | Xiliang Du Chiara Di Malta Zhiyuan Fang Taiyu Shen Xiaodi Niu Meng Chen Bo Jin Hao Yu Lin Lei Wenwen Gao Yuxiang Song Zhe Wang Chuang Xu Zhijun Cao Guowen Liu Xinwei Li | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 2 |
| 6 | Stocking density effects on growth and stress response of juvenile turbot(Scophthalmus maximus) reared in land-based recirculating aquaculture system显示文摘Stocking density is widely recognized as a critical factor in aquaculture and a potential source of long-term stress.The influence of stocking density on growth and stress response of juvenile turbot(Scophthalmus maximus, ~3–75g, initial to final weight) was examined in fish held under low(LD, ~0.21–5.31 kg/m^2, initial to final density),medium(MD, ~0.42–10.81 kg/m^2) and high stocking density(HD, ~0.63–14.27 kg/m^2) for 120 days in a recirculating aquaculture system(RAS). In this trial, the growth curve for weight of juvenile turbot in RAS, all fitted by the Schnute model. No significant difference was found in growth performance among the three densities until at the final sampling(Day 120). The final weight and body weight increase(BWI) in the HD group were significantly lower than in other groups(P<0.05, weight:(75.83±2.49) g,(75.39±2.08) g,(65.72±2.86) g and BWI:(2 436.12±28.10)%,(2 421.29±4.64)%,(2 097.88±20.99)% in LD, MD and HD groups, respectively). Similarly, the specific growth rate(SGR), feed conversion ratio(FCR) and coefficient of variation for weight(CV_w) were adversely affected by high stocking density(P<0.05). However, there was no difference in survival and Fulton's condition factor(K) of turbot among the different groups. Physiological analyses demonstrated a clear increase in the plasma cortisol level and an obvious decrease in growth hormone(GH) concentration in the HD group on Day120(P<0.05). There was no significant effect of stocking density on plasma glucose, Cl– and protein levels. All these findings would provide a reference for selecting the optimal stocking density of juvenile turbot in RAS. | LIU Baoliang JIA Rui ZHAO Kuifeng WANG Guowen LEI Jilin HUANG Bin | 2017 | Acta Oceanologica Sinica2017，36，10： | 1 |
| 7 | SREBP-1c overexpression induces triglycerides accumulation through increasing lipid synthesis and decreasing lipid oxidation and VLDL assembly in bovine hepatocytes显示文摘 | Xinwei Li Wentao Yang Chong Xiao Shixin Fu Qinghua Deng Hongyan Ding Zhe Wang Guowen Liu Xiaobing Li | 2014 | Journal of Steroid Biochemistry and Molecular Biology2014，，： | 1 |
| 8 | The E3 ubiquitin ligase NEDD4-1 protects against acetaminophen-induced liver injury by targeting VDAC1 for degradation显示文摘Acetaminophen(APAP)overdose is a major cause of liver injury.Neural precursor cell expressed developmentally downregulated 4—1(NEDD4-1)is an E3 ubiquitin ligase that has been implicated in the pathogenesis of numerous liver diseases;however,its role in APAP-induced liver injury(AILI)is unclear.Thus,this study aimed to investigate the role of NEDD4-1 in the pathogenesis of AILI.We found that NEDD4-1 was dramatically downregulated in response to APAP treatment in mouse livers and isolated mouse hepatocytes.Hepatocyte-specific NEDD4-1 knockout exacerbated APAP-induced mitochondrial damage and the resultant hepatocyte necrosis and liver injury,while hepatocyte-specific NEDD4-1 overexpression mitigated these pathological events both in vivo and in vitro.Additionally,hepatocyte NEDD4-1 deficiency led to marked accumulation of voltage-dependent anion channel 1(VDAC1)and increased VDAC1 oligomerization.Furthermore,VDAC1 knockdown alleviated AILI and weakened the exacerbation of AILI caused by hepatocyte NEDD4-1 deficiency.Mechanistically,NEDD4-1 was found to interact with the PPTY motif of VDAC1 through its WW domain and regulate K48-linked ubiquitination and degradation of VDAC1.Our present study indicates that NEDD4-1 is a suppressor of AILI and functions by regulating the degradation of VDAC1. | Yiwei Zhu Lin Lei Xinghui Wang Linfang Chen Wei Li Jinxia Li Chenchen Zhao Xiliang Du Yuxiang Song Wenwen Gao Guowen Liu Xinwei Li | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 1 |
| 9 | MiR-196a2 rs11614913 T<ce:hsp sp='0.25'/>><ce:hsp sp='0.25'/>C polymorphism and risk of esophageal cancer in a Chinese population<!-- miRNA polymorphism and esophageal cancer risk -->显示文摘 | Jishu Wei Liang Zheng Shenghua Liu Jun Yin Liming Wang Xu Wang Yijun Shi Aizhong Shao Weifeng Tang Guowen Ding Chao Liu Suocheng Chen Haiyong Gu | 2013 | Human Immunology2013，，： | 1 |
| 10 | A colloidal gold probe-based silver enhancement immunochromatographic assay for rapid detection of abrin-a显示文摘 | Yang Wei Li Xiaobing Liu Guowen | 2011 | Biosensors and Bioelectronics2011，26，8： | 1 |
| 11 | A Novel Turn-on Fluorescent Probe for Highly Selective Detection of Phosphate Ion in Living Cell显示文摘A novel fluorescent probe was synthesized and studied.Fluorescent probe 1 undergoes a unique Pi induced hydrolytic reaction in DMSO-HEPES at physiological pH that produces a colorimetric change associated with a 76nm red-shift in the UV-vis absorption maximum and up to a 210-fold enhancement in the fluorescence intensity.It has successfully been used to stain and record microscopy images of HeLa cells.Moreover,the mechanistic proposal that these spectroscopic changes are associated with the reaction of Pi and probe 1 to form 2-(2-hydroxyphenyl)benzothiazole gains support from the results of mass spectrometry studied. | Jin Zhang Si Wang Changhui Liu Guowen He Tianying Peng | 2018 | Chinese Journal of Chemistry2018，36，12： | 1 |
| 12 | Interaction of AcMADS68 with transcription factors regulates anthocyanin biosynthesis in red-fleshed kiwifruit显示文摘In red-fleshed kiwifruit,anthocyanin pigmentation is a crucial commercial trait.The MYB-bHLH-WD40(MBW)complex and other transcription factors regulate its accumulation.Herein,a new SEP gene,AcMADS68,was identified as a regulatory candidate for anthocyanin biosynthesis in the kiwifruit by transcriptome data and bioinformatic analyses.AcMADS68 alone could not induce the accumulation of anthocyanin both in Actinidia arguta fruit and tobacco leaves.However,in combination with AcMYBF110,AcMYB123,and AcbHLH1,AcMADS68 co-overexpression increased anthocyanin biosynthesis,whereas its silencing reduced anthocyanin accumulation.The results of the dual-luciferase reporter,firefly luciferase complementation,yeast two-hybrid and co-immunoprecipitation assays showed that AcMADS68 could interact with both AcMYBF110 and AcMYB123 but not with AcbHLH1,thereby co-regulating anthocyanin biosynthesis by promoting the activation of the target genes,including AcANS,AcF3GT1,and AcGST1.Moreover,AcMADS68 also could activate the promoter of AcbHLH1 surported by dual-luciferase reporter and yeast one-hybrid assays,thereby further amplifying the regulation signals from the MBW complex,thus resulting in enhanced anthocyanin accumulation in the kiwifruit.These findings may facilitate better elucidation of various regulatory mechanisms underlying anthocyanin accumulation and contribute to the quality enhancement of red-fleshed kiwifruit. | Yanfei Liu Guowen Lv Yaqi Yang Kangxun Ma Xiaolin Ren Mingjun Li Zhande Liu | 2023 | Horticulture Research2023，10，2： | 0 |
| 13 | Molecular mechanisms of seasonal photoperiod effects of the pineal gland on the hippocampus in rats显示文摘Background:Based on the theory of“five Zang-organs corresponding to the seasons”in traditional Chinese medicine(TCM),physiological functions including emotions vary with the seasons.We aimed to investigate the seasonal photoperiod effects of melatonin(MT)released from the pineal gland on the MT receptor(MTR)-Gs/Gi-cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)-cAMP response element-binding protein(CREB)signaling pathway in the hippocampus.Methods:Rats were divided into three groups:control,operation(surgery with pineal gland removal),and pseudo-operation groups(same surgery as operation group but without removing pineal gland),and fed at specific time across the four seasons.The levels of MTR,adenylate cyclase(AC),cAMP,PKA,and CREB in the hippocampus were analyzed using ELISA.The concentrations of Gs and Gi were analyzed using Western blot.The expression of CREB mRNA was detected by PCR.Results:For intragroup comparisons,compared with spring,the levels of Gs/Gi in the control group were higher in summer,autumn,and winter(P=.009 in summer;P<.001 in autumn and winter);the levels of MTR,cAMP,PKA,and CREB in the control group were significantly higher in autumn and winter than in spring(all P<.001).The levels of MTR,cAMP,PKA,and CREB in each season were significantly lower in the operation group than in the control group(all P<.05).Significant differences were noted in Gs/Gi levels between the operation group and control group in spring,autumn,and winter(all P<.05).Conclusion:Our findings suggest that MTR-Gs/Gi-cAMP-PKA-CREB signaling pathway is involved in the seasonal photoperiod effects of the pineal gland on the hippocampus and may underpin seasonal changes in emotions.It can support the prevention and treatment of the seasonal onset of mental disorders,and enrich the theory of“five Zang-organs corresponding to the seasons”. | Qi Han Guowen Du Leilei Liu Lepeng Wang Wenna Li Hairong Zhang Yike Sun Pei Zhu Ruisen Hao Shuran Ma | 2021 | Journal of Traditional Chinese Medical Sciences2021，8，2： | 0 |
| 14 | EQUIAXED REFINEMENT OF GRAINS IN ALLOY TC11显示文摘The formation reason and elimination method of non-uniform microstructure defects in Ti al-loy TC11 bar have been studied.The coagulating and coarsening into block of the part ofgrain boundary α and secondary α seem to be caused by the ingot cogging and initial forgingtemperature in the β region as well as no more enough deformation and uneven distribution.The grain α,elongated α and blocky α may be finally eliminated by adopting the technique of(α+β)thermomechanical processing+β processing,W.Q.+recrystallization annealing,A.C.,thus the size of uniform and fine equiaxed α structure is believed to be reduced to 1.9258μm. | SU Zuwu MENG Guowen GUO Hongzhen LIU Jianchao YAO Zekun Northwestern Polytechnical University,Xi’an,ChinaYANG Zhaosu HU Zongshi Baoji Non-Ferrous Metals Mill,Baoji,China | 1992 | Acta Metallurgica Sinica(English Letters)1992，5，8： | 0 |
| 15 | Structural basis of sRNA RsmZ regulation of Pseudomonas aeruginosa virulence显示文摘Dear Editor,Pseudomonas aeruginosa is a ubiquitous Gram-negative opportunistic bacterium that notoriously causes infections with a high mortality rate in hospitalized patients,especially those with compromised immune systems.P.aeruginosa can cause acute infections that are typically associated with the cytotoxins secreted by the type Ⅲ secretion system(T3ss). | Xinyu Jia Zhiling Pan Yang Yuan Bingnan Luo Yongbo Luo Sunandan Mukherjee Guowen Jia Liu Liu Xiaobin Ling Xiting Yang Zhichao Miao Xiawei Wei Janusz M.Bujnicki Kelei Zhao Zhaoming Su | 2023 | Cell Research2023，33，4： | 0 |
| 16 | 非小细胞肺癌术中外周血CEA mRNA的检测及意义(英文)显示文摘Objective: To detect the expression of CEA mRNA in patients with non-small cell lung cancer (NSCLC) and to investigate it's significance. Methods: The blood samples were taken from peripheral veins of 70 patients with NSCLC and 18 patients with benign diseases at 3 intervals during the surgery. The transcription of carcinoembryonic antigen messenger ribonucleic acid (CEA mRNA) was assayed by means of nested reverse transcriptase polymerase chain reaction (RT-PCR) and micro-fluid chip. Results: The CEA mRNA positive rates at each of the 3 time spots were as follows: 50% at beginning of the surgery (group 1), 62.8% in the samples collected when ligating the pulmonary vein (group 2) and 57.1% in samples collected 1 h after ligation (group 3). A significant difference was found between groups 1 and 2 (χ2 = 7.114, P < 0.05). Con-clusion: Cancer cell dissemination during surgery is demonstrated indirectly in our study, when to ligate the pulmonary vein (earlier or later) may affect the quantity of tumor cells spread into the circulation. | Guowen Wang Zuyi Wang Xuegang Liu Zhen Tang Yiyao Liu Xiaojun Li Xiao Zhou Huiyuan Gong | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，11： | 0 |
| 17 | Variant TP53BP1 rs560191 G>C is associated with risk of gastric cardia adenocarcinoma in a Chinese Han population显示文摘Objective:To investigate the association between gastric cardia adenocarcinoma(GCA) and ten functional single nucleotide polymorphisms(SNPs),including TP53BP1 rs560191 G>C,CASP8 rsl035142 G>T,CASP7 rs3127075 G>C,CASP7 rs7907S19 C>A,and six C1orf10/CRNN variants.We performed a hospitalbased case-control study to evaluate the genetic effects of these SNPs.Methods:Two hundred and forty-three GCA cases and 476 controls were enrolled in this study.A customby-design 48-Plex SNPscan^(TM) Kit was used to determine their genotypes.Results:When the TP53BP1 rs560191 GG homozygote genotype was used as the reference group,the GC genotype was associated with a significantly increased risk of GCA.The CC genotype was not associated with the risk of GCA compared with the GG genotype.None of the CASP8 rs1035142 G>T,CASP7rs3127075 G>C,CASP7 rs7907519 C>A or the six C1orf10/CRNN polymorphisms showed a significant difference in genotype distributions between the cases and the controls.Conclusions:The results demonstrated that the functional polymorphism TP53BP1 rs560191 G>C might contribute to GCA susceptibility.However,the statistical power of our study was limited.Large,welldesigned stuthes and further functional investigations are needed to confirm our findings. | Sheng Zhang Weifeng Tang Guowen Ding Chao Liu Ruiping Liu Suocheng Chen Haiyong Gu Chunzhao Yu | 2015 | Chinese Journal of Cancer Research2015，27，2： | 0 |
| 18 | PROGRESSIVE FRACTURE MODELING OF THE FAILURE WAVE IN IMPACTED GLASS显示文摘失败波浪被观察了在自从 1991,装载的影响下面在玻璃里宣传。是一个连续破裂地区可以在冲击波的繁殖期间与损坏累积过程被联系。一个进步破裂模型被建议就它的 heterogeneousmeso 结构而言在震惊的玻璃里描述失败波浪形成和繁殖。原版并且。当装载的吃惊在 Hugoniot 有弹性的限制下面时,起核心作用的微裂缝将与伴随物膨胀沿着毛孔和另外的缺点膨胀。失败波浪的 Thegoverning 方程被无弹性的体积紧张与材料损坏和骨折描绘。并且无弹性的体积紧张从原来的毛孔的倒塌从微裂缝和压缩紧张的成核和扩大由膨胀紧张组成。免费表面速度的 Numericalsimulation 在设计物理的中国学院在对 K9 玻璃的平面影响实验的好同意被执行并且发现。并且纵的、侧面的 ands 听说在失败波浪的到达之上的应力历史被预言,它介绍减少砍在没有通过的层的强度和失去的裂片强度。 | Yao Guowen Liu Zhanfang Huang Peiyan | 2006 | Acta Mechanica Solida Sinica2006，19，1： | 0 |
| 19 | The effects of pH, surfactant, ion concentration,coformer, and molecular arrangement on the solubility behavior of myricetin cocrystals显示文摘Pharmaceutical cocrystals are a promising technology that can be used to improve the solubility of poor aqueous compounds. The objective of this study was to systematically investigate the solubility of myricetin(MYR) cocrystals, including their kinetic solubility, thermodynamic solubility, and intrinsic dissolution rate(IDR). The effects of pH, surfactant, ion concentration, and coformers on the cocrystal solubility were evaluated. Furthermore, single crystal structures of MYR, myricetin–isonicotinamide(MYR–INM) and myricetin–caffeine(MYR–CAF) cocrystals were analyzed to discuss the possible reasons for the enhancement of cocrystal solubility from the perspective of the spatial structure.The results indicated that the kinetic solubility of MYR cocrystals was modulated by pH and cocrystal coformer(CCF) ionization in buffer solution, while it primarily depended on the CCF solubility in pure water. In addition, the solubility of MYR cocrystals was increased in a concentration dependent fashion by the surfactant or ion concentration. The thermodynamic solubility of MYR–INM(1:3) cocrystals decreased with the increases of the pH value of the dissolution media. The IDR of MYR cocrystals was faster than that of MYR in the same medium and extremely fast in pH 4.5 buffer. The improved solubility of MYR cocrystals was probably related to the alternate arrangements of MYR and INM/CAF molecules and increased intermolecular distance. The present study provides some references to investigate the solubility behavior of pharmaceutical cocrystals. | Shuzhen Ren Mingyu Liu Chao Hong Guowen Li Jiabin Sun Jianying Wang Lei Zhang Yan Xie | 2019 | Acta Pharmaceutica Sinica B2019，9，1： | 0 |
| 20 | Real-world effectiveness and safety of goserelin 10.8-mg depot in Chinese patients with localized or locally advanced prostate cancer显示文摘Objective:Real-word data on long-acting luteinizing hormone-releasing hormone(LHRH)agonists in Chinese patients with prostate cancer are limited.This study aimed to determine the real-world effectiveness and safety of the LHRH agonist,goserelin,particularly the long-acting 10.8-mg depot formulation,and the follow-up patterns among Chinese prostate cancer patients.Methods:This was a multicenter,prospective,observational study in hormone treatment-na?ve patients with localized or locally advanced prostate cancer who were prescribed goserelin 10.8-mg depot every 12 weeks or 3.6-mg depot every 4 weeks with or without an anti-androgen.The patients had follow-up evaluations for 26 weeks.The primary outcome was the effectiveness of goserelin in reducing serum testosterone and prostate-specific antigen(PSA)levels.The secondary outcomes included testosterone and PSA levels,attainment of chemical castration(serum testosterone<50 ng/d L),and goserelin safety.The exploratory outcome was the monitoring pattern for serum testosterone and PSA.All analyses were descriptive.Results:Between September 2017 and December 2019,a total of 294 eligible patients received≥1 dose of goserelin;287 patients(97.6%)were treated with goserelin 10.8-mg depot.At week 24±2,the changes from baseline[standard deviation(95%confidence interval)]in serum testosterone(n=99)and PSA(n=131)were-401.0 ng/d L[308.4 ng/d L(-462.5,-339.5 ng/d L)]and-35.4 ng/m L[104.4 ng/m L(-53.5,-17.4 ng/m L)],respectively.Of 112 evaluable patients,100(90.2%)achieved a serum testosterone level<50 ng/d L.Treatment-emergent adverse events(TEAEs)and severe TEAEs occurred in 37.1%and 10.2%of patients,respectively.The mean testing frequency(standard deviation)was 1.6(1.5)for testosterone and 2.2(1.6)for PSA.Conclusions:Goserelin 10.8-mg depot effectively achieved and maintained castration and was well-tolerated in Chinese patients with localized and locally advanced prostate cancer. | Nanhui Chen Zengjun Wang Ming Chen Qi Ma Yi He Yujie Wang Xin Li Mingxing Qiu Lei Shi Shaoxing Zhu Qun Xie Xiuheng Liu Benkang Shi Guowen Lin Weizhong Yang Yongbin Liao Haibin Zhang Shusheng Wang Jiexian Li Shaogang Wang Lijun Dong Hui Chen Jiaju Lu YongyiCheng Xiaoping Zhang Lulin Ma Liqun Zhou He Wang Shen Li Dingwei Ye | 2023 | Cancer Biology & Medicine2023，20，12： | 0 |
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