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| 1 | China National Medical Products Administration approval summary:anlotinib for the treatment of advanced non-small cell lung cancer after two lines of chemotherapy显示文摘Background:On May 8,2018,the China National Medical Products Administration(NMPA)approved anlotinib,an orally administered anti-angiogenesis inhibitor,for the treatment of patients with advanced non-small cell lung can-cer(NSCLC)who have progressed after treatment with two or more lines of prior systemic chemotherapy.Main body of the abstract:China NMPA reviewed and inspected a regional double-blinded,placebo-controlled,Phase III trial comparing the overall survival(OS)of NSCLC patients between the anlotinib and placebo arms.A total of 437 patients were randomized(2:1)to receive either anlotinib(n=294)or placebo(n=143)once daily on a 2-week on and 1-week off schedule.Patients with epidermal growth factor receptor(EGFR)or activating anaplastic lymphoma kinase(ALK)genomic tumor aberrations should have disease progression on NMPA-approved therapy.Anlotinib is the first NMPA-approved drug for patients with advanced NSCLC who have progressed on at least two lines of prior systemic chemotherapies in China.The approval was based on a statistically and clinically significant improvement in median OS with anlotinib(9.46 months)compared with placebo[6.37 months;hazard ratio(HR])=0.70,95%confidence interval(CI)=0.55-0.89;two-sided log-rank P=0.002].The confirmed objective response rate(ORR)was 9.2%in the anlotinib arm and 0.7%in the placebo arm.The median duration of response(DoR)was 4.83 months,with a 95%CI of 3.31-6.97 months.The toxicity profile of anlotinib was consistent with that of known anti-angiogenesis inhibitors.Common adverse drug reactions(ADRs)in anlotinib-treated patients included hypertension(67.4%),hand-foot syndrome(43.9%),hemoptysis(14.0%),thyroid stimulating hormone(TSH)elevation(46.6%),and corrected QT interval(QTc)prolongation(26.2%).Short conclusion:Anlotinib demonstrated a clinically significant OS prolongation as a novel therapeutic option for advanced or metastatic NSCLC following at least two lines of chemotherapy. | Ming Zhou Xiaoyuan Chen Hong Zhang Lin Xia Xin Tong Limin Zou Ruimin Hao Jianhong Pan Xiao Zhao Dongmei Chen Yuanyuan Song Yueli Qi Ling Tang Zhifang Liu Rong Gao Yuankai Shi Zhimin Yang | 2019 | Cancer Communications2019，39，1： | 35 |
| 2 | Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients显示文摘 | Lu Wen Jingyi Li Huahu Guo Xiaomeng Liu Shengmin Zheng Dafang Zhang Weihua Zhu Jianhui Qu Limin Guo Dexiao Du Xiao Jin Yuhao Zhang Yun Gao Jie Shen Hao Ge Fuchou Tang Yanyi Huang Jirun Peng | 2015 | Cell Research2015，25，11： | 19 |
| 3 | Safety Research in Traditional Chinese Medicine: Methods, Applications, and Outlook显示文摘Traditional Chinese medicine (TCM) is a medical system that has collected and summarized abundant clinical experience over its long history of more than 2000 years. However, the frequent occurrence of TCM-induced adverse reactions has hindered the modernization and internationalization of TCM, while attracting increasing attention from around the world. Unlike chemical drugs and biological agents, the difficulties involved in research on the toxicity and safety of TCM mainly include the complexity of its components and the unpredictability of drug–body interactions. Much of TCM, which has overall therapeutic effects, has the typical mechanisms of multiple components, multiple pathways, and multiple targets. While considering the gradualness and unpredictability of TCM toxicity, the ambiguity of toxicants and safe dosage, and individual differences during long-term TCM administration, we have systematically established key techniques for the toxicity assessment of TCM. These techniques mainly include TCM toxicity discovery in an early phase, based on a combination of drug toxicology genomics and metabolomics;methods to identify dose–toxicity relationships in TCM;and integrated techniques for the exploration of TCM interactions, such as fast-screening tests based on drug-metabolizing enzymes and receptor pathways. In particular, we have developed a new technical system for TCM safety evaluation using molecular toxicology, which has been validated well in research on TCM compatibility contraindication, quality control, and allergen discovery. The application of this key technical platform is introduced here in detail. This application includes model organisms, toxicant biomarkers, a magnetic suspension technique, and the application of network toxicology and computational toxicology in research on the toxicity of Fructus toosendan, Semen cassiae, Polygonum multiflorum, and Fructus psoraleae. | Yue Gao Aihua Liang Xiaohui Fan Limin Hu Feiran Hao Yubo Li | 2019 | Engineering2019，5，1： | 19 |
| 4 | The GW2-WG1-OsbZIP47 pathway controls grain size and weight in rice显示文摘Regulation of seed size is a key strategy for improving crop yield and is also a basic biological question.However,the molecular mechanisms by which plants determine their seed size remain elusive.Here,we report that the GW2-WG1-OsbZIP47 regulatory module controls grain width and weight in rice.WG1,which encodes a glutaredoxin protein,promotes grain growth by increasing cell proliferation.Interestingly,WG1 interacts with the transcription factor OsbZIP47 and represses its transcriptional activity by associating with the transcriptional co-repressor ASP1,indicating that WG1 may act as an adaptor protein to recruit the transcriptional co-repressor.In contrary,OsbZIP47 restricts grain growth by decreasing cell proliferation.Further studies reveal that the E3 ubiquitin ligase GW2 ubiquitinates WG1 and targets it for degradation.Genetic analyses confirm that GW2,WG1,and OsbZIP47 function in a comm on pathway to control grain growth.Taken together,ourfindi ngs reveal a genetic and molecular framework for the control of grain size and weight by the GW2-WG1-OsbZIP47 regulatory module,providing new targets for improving seed size and weight in crops. | Jianqin Hao Dekai Wang Yingbao Wu Ke Huang Penggen Duan Na Li Ran Xu Dali Zeng Guojun Dong Baolan Zhang Limin Zhang Dirk Inze Qian Qian Yunhai Li | 2021 | Molecular Plant2021，14，8： | 14 |
| 5 | Ultrasensitive skin‐like wearable optical sensors based on glass micro/nanofibers显示文摘Electronic skin,a class of wearable electronic sensors that mimic the functionalities of human skin,has made remarkable success in applications including health monitoring,human-machine interaction and electronic-biological interfaces.While electronic skin continues to achieve higher sensitivity and faster response,its ultimate performance is fundamentally limited by the nature of low-frequency AC currents.Herein,highly sensitive skin-like wearable optical sensors are demonstrated by embedding glass micro/nanofibers(MNFs)in thin layers of polydimethylsiloxane(PDMS).Enabled by the transition from guided modes into radiation modes of the waveguiding MNFs upon external stimuli,the skin-like optical sensors show ultrahigh sensitivity(1870 k·Pa^-1),low detection limit(7 mPa)and fast response(10μs)for pressure sensing,significantly exceeding the performance metrics of state-of-the-art electronic skins.Electromagnetic interference(EMI)-free detection of high-frequency vibrations,wrist pulse and human voice are realized.Moreover,a five-sensor optical data glove and a 2×2-MNF tactile sensor are demonstrated.These initial results pave the way toward a new category of optical devices ranging from ultrasensitive wearable sensors to optical skins. | Lei Zhang Jing Pan Zhang Zhang Hao Wu Ni Yao Dawei Cai Yingxin Xu Jin Zhang Guofei Sun Liqiang Wang Weidong Geng Wenguang Jin Wei Fang Dawei Di Limin Tong | 2020 | Opto-Electronic Advances2020，3，3： | 12 |
| 6 | The diurnal and seasonal characteristics of urban heat island variation in Beijing city and surrounding areas and impact factors based on remote sensing satellite data显示文摘Based on the land surface temperature (LST), the land cover classification map,vegetation coverage, and surface evapotranspiration derived from EOS-MODIS satellite data, and by the use of GIS spatial analytic technique and multivariate statistical analysis method, the urban heat island (UHI) spatial distribution of the diurnal and seasonal variabilities and its driving forces are studied in Beijing city and surrounding areas in 2001. The relationships among UHI distribution and landcover categories, topographic factor, vegetation greenness, and surface evapotranspiration are analyzed. The results indicate that: (i) The significant UHI occur in Beijing city areas in the four seasons due to high heat capacity and multi-reflection of compression building, as well as with special topographic features of its three sides surrounded by mountains,especially in the summer. The UHI spatial distribution is corresponding with the urban geometry structure profile. The LST difference is approximately 4-6℃ between Beijing city and suburb areas, comparatively is 8- 10℃ between Beijing city area and outer suburb area in northwestern regions. (ii) The UHI distribution and intensity in daytime are different from nighttime in Beijing city area, the nighttime UHI is obvious. However, in the daytime, the significant UHI mainly appears in the summer, the autumn takes second place, and the UHI in the winter and the spring seem not obvious. The surface evapotranspiration in suburb areas is larger than that in urban areas in the summer, and high latent heat exchange is evident, which leads to LST difference between city area and suburb area. (iii) The reflection of surface landcover categories is sensitive to the UHI, the correlation between vegetation greenness and UHI shows obviously negative.The scatterplot shows that there is the negative correlation between NDVI and LST (R2 = 0.6481).The results demonstrate that the vegetation greenness is an important factor for reducing the UHI,and large-scale construction of greenbelts can considerably reduce the UHI effect. | ZHANG Jiahua, HOU Yingyu, LI Guicai, YAN Hao YANG Limin & YAO Fengmei The Chinese Academy of Meteorological Sciences, Beijing 100081, China The National Meteorological Center, Beijing 100081, China The National Satellite Meteorological Center, Beijing 100081, China Joint Laboratory for Geoinformation Science, The Chinese University of Hong Kong, Hong Kong, China Department of Geosciences, Graduate School of Chinese Academy of Sciences, Beijing 100039, China | 2005 | Science China Earth Sciences2005，48，z2： | 11 |
| 7 | Modifi cation of wheat bran insoluble and soluble dietary fibers with snail enzyme显示文摘Insoluble dietary fiber(IDF)and soluble dietary fiber(SDF)extracted from wheat bran were modifi ed by snail enzyme and their physicochemical properties(water retention capacity and oil retention capacity),functional properties(cholesterol adsorption capacity,glucose adsorption capacity and antioxidant activity)and structural characterizations were evaluated.The results showed that snail enzyme modification led to the significant increase in oil retention capacity of IDF,glucose adsorption capacity and cholesterol adsorption capacity of IDF and SDF.Enzymatic modification also markedly improved the DPPH radical scavenging capacity and reducing power of IDF and SDF.Meanwhile,scanning electron microscopy(SEM)analysis indicated the microstructures of IDF and SDF powders were signifi cantly changed.Fourier transfer-infrared spectrometry(FT-IR)showed that snail enzyme modifi cation could degrade the part of cellulose and hemicellulose of IDF and SDF.All these improved physicochemical and functional properties of IDF and SDF might depend on their structural changes.It suggested that snail enzyme modifi cation could effectively improve physicochemical and functional properties of IDF and SDF from wheat bran. | Xin Liu Keke Suo Pei Wang Xue Li Limin Hao Jiaqing Zhu Juanjuan Yi Qiaozhen Kang Jinyong Huang Jike Lu | 2021 | Food Science and Human Wellness2021，10，3： | 10 |
| 8 | Oxygen adsorption/desorption behavior of YBaCo4O7+δ and its application to oxygen removal from nitrogen显示文摘A new medium-temperature (200-400℃) adsorbent material for oxygen removal and air separation, YBaCo4O7+β, was prepared by the solid-state reaction method. This new adsorbent could adsorb a large quantity of oxygen in the temperature range of 200-370 ℃. Ad-sorbed oxygen could be released by raising temperature over 400 ℃ or by switching the atmosphere from oxygen to nitrogen. This oxygen adsorption and desorption process had good reproducibility. Taking advantage of this unique oxygen intake/release behavior, a nitrogen puri-fication process was investigated. The results showed that YBaCo4O7+δ material was a promising candidate for the oxygen sorption process and could be used to produce high-purity nitrogen or to remove trace oxygen from other gases. | HAO Haoshan ZHAO Limin FIU Jie HU Xing HOU Hongwei | 2009 | Journal of Rare Earths2009，27，5： | 8 |
| 9 | 中国国家药品监督管理局批准安罗替尼用于经两种系统化疗后疾病进展的晚期非小细胞肺癌的治疗显示文摘背景2018年5月8日,中国国家药品监督管理局(National Medical Products Administration,NMPA)批准了小分子多靶点抗血管抑制剂盐酸安罗替尼,用于既往经过至少两种系统化疗后疾病进展的晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的治疗。概要中国NMPA审查了一项随机双盲、安慰剂对照的III期临床试验,该临床试验的主要终点为总生存期(overall survival,OS)。试验共纳入437例患者随机分组(2∶1)接受安罗替尼(n=294)或安慰剂(n=143)治疗,每日1次,连服2周,停药1周。表皮生长因子受体(epidermal growth factor receptor,EGFR)基因敏感突变或间变性淋巴瘤激酶(activating anaplasticlymphomakinase,ALK)阳性的患者须经过NMPA已批准的药物治疗后出现疾病进展。安罗替尼为中国NMPA批准的用于治疗既往经过两种及以上系统化疗后疾病进展的晚期NSCLC患者的首个药物。安罗替尼组的中位OS(9.46个月)较安慰剂组[6.37个月;风险比(hazard ratio,HR)=0.70,95%置信区间(confidence Interval,CI):0.55–0.89;双侧log-rank P=0.002]显著延长。安罗替尼组的客观缓解率(objective responserate,ORR)为9.2%,安慰剂组为0.7%。安罗替尼组的中位缓解持续时间(durationofresponse,DoR)为4.83个月,95%CI为3.31–6.97个月。安罗替尼的常见不良反应(adverse drug reactions,ADRs)包括高血压(67.4%)、手足综合征(43.9%)、咳血(14.0%)、促甲状腺激素(thyroid stimulating hormone,TSH)升高(46.6%)、心电图QT间期(corrected QT Interval,QTc)延长(26.2%)。结论安罗替尼显著延长了患者的OS,可作为经二线及以上化疗后晚期或转移性非小细胞肺癌的一种新的治疗方案。 | Ming Zhou Xiaoyuan Chen Hong Zhang Lin Xia Xin Tong Limin Zou Ruimin Hao Jianhong Pan Xiao Zhao Dongmei Chen Yuanyuan Song Yueli Qi Ling Tang Zhifang Liu Rong Gao Yuankai Shi Zhimin Yang | 2019 | 癌症2019，38，12： | 7 |
| 10 | Mapping forest fire risk zones with spatial data and principal component analysis显示文摘By integrating forest inventory data with remotely sensed data, new data layers for factors that affect forest fire potentials were generated for Baihe Forestry Bureau in Jilin Province of China. The principle component analysis was used to sort out the relationships between forest fire potentials and environmental factors. The classifications of these factors were performed with GIS, generating three maps: a fuel-based fire risk map, a topography-based fire risk map, and an anthropogenic-factor fire risk map. These three maps were then synthesized to generate the final fire risk map. The linear regression method was used to analyze the relationship between an area-weighted value of forest fire risks and the frequency of historical forest fires at each forest farm. The results showed that the most important factor contributing to forest fire ignition was topography, followed by anthropogenic factors. | XU Dong, Guofan Shao, DAI Limin, HAO Zhanqing, TANG Lei & WANG Hui Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China Graduate University of Chinese Academy of Sciences, Beijing 100039, China Department of Forestry and Natural Resources, Purdue University, West Lafayette, IN 47907, USA Department of Management, Shenyang Institute of Aeronautical Engineering, Shenyang 110034, China Department of City Development, Jinan University, Jinan 250002, China | 2006 | Science China(Technological Sciences)2006，49，z1： | 3 |
| 11 | Mid-infrared chalcogenide microfiber knot resonators显示文摘A novel type of mid-IR microresonator,the chalcogenide glass(ChG)microfiber knot resonator(MKR),is demonstrated,showing easy fabrication,fiber-compatible features,resonance tunability,and high robustness.ChG micro fibers with typical diameters around 3μm are taper-drawn from As2S3 glass fibers and assembled into MKRs in liquid without surface damage.The measured Q factor of a typical 824μm diameter ChG MKR is about 2.84×104 at the wavelength of 4469.14 nm.The free spectral range(FSR)of the MKR can be tuned from2.0 nm(28.4 GHz)to 9.6 nm(135.9 GHz)by tightening the knot structure in liquid.Benefitting from the high thermal expansion coefficient of As2S3 glass,the MKR exhibits a thermal tuning rate of 110 pm·℃^-1 at the resonance peak.When embedded in polymethyl methacrylate(PMMA)film,a 551μm diameter MKR retains a Q factor of 1.1×10^4.The ChG MKRs demonstrated here are highly promising for resonator-based optical technologies and applications in the mid-IR spectral range. | YU XIE DAWEI CAI HAO WU JING PAN NING ZHOU CHENGUANG XIN SHAOLIANG YU PAN WANG XIAOSHUN JIANG JIANRONG QIU XIN GUO LIMIN TONG | 2020 | Photonics Research2020，8，4： | 3 |
| 12 | Research progress on properties of pre-gelatinized starch and its application in wheat flour products显示文摘Starch is the most abundant organic compound in nature,second only to cellulose.However,the conserved structure of native starches limits their properties and applications.Therefore,it is often necessary to modify them to obtain specific properties.As a common green and safe physical modification method,pre-gelatinization can improve the cold water solubility and swelling power of starch.The typical preparation methods of pre-gelatinized starch include spray drying,extrusion,and drum drying.Spray-dried pre-gelatinized starch still had good granule shape,but the increase of cold water solubility and cold paste viscosity was relatively small.Extruded and drum-dried pre-gelatinized starch showed serious structure destruction,significant increases in cold water solubility and cold paste viscosity,but relatively low hot paste viscosity.The properties of pre-gelatinized starch obtained by different methods are different,so do their effects on the quality of flour products.Wheat flour products,as one of the leading staple food for the people all over the world,play a vital role in people's daily life.With the improvement of people's living standards,more and more special flour products with unique features have received attentions of consumers and researchers.However,the sensory characteristics of special flour products are often inferior to traditional flour products,which limits its development.The unique functional characteristics of pre-gelatinized starch make it expected to play an essential role in the quality improvement of featured flour products.In this paper,the granule morphology,crystal structure,hydration and gelatinization properties of pre-gelatinized starch prepared by three common methods and their application in flour products were reviewed,which provides a theoretical basis for the application of pre-gelatinized starch in food industry. | Hao Ma Mei Liu Ying Liang Xueling Zheng Le Sun Wenqian Dang Jie Li Limin Li Chong Liu | 2022 | Grain & Oil Science and Technology2022，5，2： | 3 |
| 13 | Spray,atomization and combustion characteristics of oxygenated fuels in a constant volume bomb:A review显示文摘Biofuels have extensive available resources and have an immense potential as promising alternative fuels for automobile.The application advantages of biofuels are mainly reflected as particulate matter(PM)reduction,carbon neutral,greenhouse gases reduction,waste utilization,energy and economic security,and fuel pluralism.Based on the understanding of molecular structure effects of biofuels on soot formation and particles morphology,the effects of alcohols,ethers,esters and biodiesel on spray and combustion process in constant volume bomb in recent years are retrospectively analyzed in this paper.For the mixture,macromolecular ester fuels and polyoxymethylene dimethyl ether(PODE)are conducive to the improvement of liquid spray,while biodiesel,small molecules,dimethyl ether(DME)and alcohols are reversed.Alcohols are advantageous to the extension of mixing time and the increasing of vapor-phase mixture.Through the influence integrated assessment,alcohols show the best performance on the spray,atomization and combustion,while biodiesels show the worst.But in terms of combustion,PODE is the best choice without considering spray and atomization.For binary alternative-diesel fuel blends,methanol or butanol is the best additive based on synthetically considerations on spray,atomization and combustion.To meet the requirements of the fuel application of diesel engine,ternary fuel or even quaternary fuel have been proposed and explored.This review can help to form a systematic understanding on fuel recombining and obtain the guide of clean and efficient fuel formulation for diesel engine. | Peng Zhang Xin Su Chengshan Yi Hao Chen Hongming Xu Limin Geng | 2020 | Journal of Traffic and Transportation Engineering(English Edition)2020，7，3： | 2 |
| 14 | Vacuolar invertase genes SbVIN1 and SbVIN2 are differently associated with stem and grain traits in sorghum (Sorghum bicolor)显示文摘In higher plants, vacuolar invertases play essential roles in sugar metabolism, organ development, and sink strength. In sorghum(Sorghum bicolor), two vacuolar invertase genes,Sb VIN1(Sobic. 004 G004800) and Sb VIN2(Sobic. 006 G160700) have been reported, but their enzymatic properties and functional differences are largely unknown. We combined molecular, biochemical and genomic approaches to investigate their roles in sorghum stem and grain traits. Sb VIN1 and Sb VIN2 showed different expression levels in internodes,leaves, and panicles, indicating that their importance in each organ was different. In an in vitro sucrose hydrolysis assay, proteins of both genes heterologously expressed in Pichia pastoris displayed similar enzyme properties including the same optimum reaction p H(5)and similar Kmfor sucroe(49 mmol L-1 and 45 mmol L-1 for Sb VIN1 and Sb VIN2,respectively). The optimum reaction temperatures of Sb VIN1 and Sb VIN2 were 45 °C and65 °C, respectively. Sb VIN2 showed higher tolerance to high temperature than Sb VIN1. We characterized the sequence variation of these two vacuolar invertase genes in a panel of 216 diverse inbred lines of sweet and grain sorghum and performed gene-based association analysis. Sb VIN1 showed significant associations with stem traits including stem length,stem diameter, internode number, stem fresh weight, and Brix, as well as grain traits including hundred-grain weight and grain width. Significantly associated variation sites were mainly in 5′ upstream and intron regions. Sb VIN2 only associated with grain width and stem water-soluble carbohydrates(WSCs) content. We conclude that the vacuolar invertase genes Sb VIN1 and Sb VIN2 are differently associated with stem and grain traits in sorghum. | Yunhua Chi Kimani Wilson Zhiquan Liu Xiaoyuan Wu Li Shang Limin Zhang Haichun Jing Huaiqing Hao | 2020 | The Crop Journal2020，8，2： | 2 |
| 15 | Effects of water stress on light-harvesting comlex魭(LHC魭)and expression of a gene encoding LHC魭in Zea mays显示文摘 | HAO LIMIN LIANG HOUGUO | 1996 | J Plant Physiol1996，，149： | 1 |
| 16 | Upregulated FoxM1 expression induced by hepatitis B virus X protein promotes tumor metastasis and indicates poor prognosis in hepatitis B virus-related hepatocellular carcinoma显示文摘 | Limin Xia Wenjie Huang Dean Tian Hongwu Zhu Yongguo Zhang Hao Hu Daiming Fan Yongzhan Nie Kaichun Wu | 2012 | Journal of Hepatology2012，，3： | 1 |
| 17 | Performance simulation and optimization of new radiant floor heating based on micro heat pipe array显示文摘This paper proposes two new radiant floor heating structures based on micro heat pipe array(MHPA),namely cement-tile floor and keel-wood floor.The numerical models for these different floor structures are established and verified by experiments.The temperature distribution and heat transfer process of each part are comprehensively obtained,and the structure is optimized.The results show that the cement-tile floor has the better heat transfer performance of the two.When under the same inlet water temperature and flow rate,the keel-wood floor's surface temperature distribution is about 2℃ lower than that of the cement-tile floor.The inlet water temperature of cement-tile floor is about 10℃ lower than that of keel-wood structure when the floor surface temperature is the same.During a longitudinal heat transfer above MHPA,the floor surface temperature decreases by 0.5℃ for every 10 mm filling layer increase.In order to reduce the non-uniformity of the floor's surface temperature and improve the thermal comfort of the heated room,the optimal structure for a floor is given,with the maximum surface temperature difference reduced by 3.35℃.We used research focusing on new radiant floor heating,with advantages including high efficiency heat transfer,low water supply temperature,simple waterway structure,low resistance and leakage risk,to provide theory and data to support the application of an effective radiant floor heating based on MHPA. | Heran Jing Zhenhua Quan Ruixue Dong Limin Hao Yunhan Liu Yaohua Zhao | 2022 | Building Simulation2022，15，7： | 1 |
| 18 | Regional frequency analysis and spatio-temporal pattern characterization of rainfall extremes in the Pearl River Basin, China显示文摘 | Tao Yang Quanxi Shao Zhen-Chun Hao Xi Chen Zengxin Zhang Chong-Yu Xu Limin Sun | 2009 | Journal of Hydrology2009，，3： | 1 |
| 19 | Treatment of Irreducible Old Atlantoaxial Subluxation With Cable-Dragged Reduction and Cantilever Beam Internal Fixation显示文摘 | Xi Liu Hao Liu Tao Li Quan Gong Yueming Song Limin Liu Rui Shi Xiaodan Zhao Wenli Zhang Ganjun Feng Beiyu Wang | 2011 | Spine2011，，15： | 1 |
| 20 | Comprehensive analysis of gene expression patterns of hedgehog-related genes 显示文摘 | Limin Hao Robert Johnsen Gilbert Lauter | 2006 | BMC Genomics2006，7，： | 1 |
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