|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Long-term follow-up of the effects of fecal microbiota transplantation in combination with soluble dietary fiber as a therapeutic regimen in slow transit constipation显示文摘As some studies have reported that strategies targeting the gut microbiota such as fecal microbiota transplantation(FMT) with or without other microecological therapy might have efficacy in treating slow transit constipation(STC), we conducted a singlecenter, open-label trial to study the long-term effect of FMT combined with soluble dietary fiber(pectin) on STC. Thirty-one adult patients with STC were enrolled into the trial. Patients received 6-day FMT procedures repeatedly for the first 3 months and soluble dietary fiber(pectin) daily during the follow-up. The rate of clinical remission and improvement, stool consistency, the Wexner constipation scale, and assessment of constipation-related symptoms were evaluated at week 4 and 1 year later. The clinical remission and improvement rates at week 4 were 69.0%(20/29) and 75.9%(22/29), respectively. At the end of the study,48.3%(14/29) of patients continued to have at least three complete spontaneous bowel movements per week and 58.6%(17/29)of patients showed clinical improvements. Stool consistency, the Wexner constipation scale, and constipation symptoms improved both at short-term and long-term follow-up. The results indicated that FMT in combination with soluble dietary fiber(pectin) had both short-term and long-term efficacy in treating STC. | Xueying Zhang Hongliang Tian Lili Gu Yongzhan Nie Chao Ding Xiaolong Ge Bo Yang Jianfeng Gong Ning Li | 2018 | Science China(Life Sciences)2018，61，7： | 33 |
| 2 | Insights into the role of gut microbiota in obesity: pathogenesis, mechanisms, and therapeutic perspectives显示文摘 | Lijuan Sun Lanjing Ma Yubo Ma Faming Zhang Changhai Zhao Yongzhan Nie | 2018 | Protein & Cell2018，9，5： | 29 |
| 3 | DDIT4 promotes gastric cancer proliferation and tumorigenesis through the p53 and MAPK pathways显示文摘Background:Gastric cancer(GC)is one of the most common malignancies worldwide,particularly in China.DNA damage-inducible transcript 4(DDIT4)is a mammalian target of rapamycin inhibitor and is induced by various cellular stresses;however,its critical role in GC remains poorly understood.The present study aimed to investigate the poten-tial relationship and the underlying mechanism between DDIT4 and GC development.Methods:We used western blotting,real-time polymerase chain reaction,and immunohistochemical or immunoflu-orescence to determine DDIT4 expression in GC cells and tissues.High-content screening,cell counting kit-8 assays,colony formation,and in vivo tumorigenesis assays were performed to evaluate cell proliferation.Flow cytometry was used to investigate cell apoptosis and cell cycle distribution.Results:DDIT4 was upregulated in GC cells and tissue.Furthermore,downregulating DDIT4 in GC cells inhibited proliferation both in vitro and in vivo and increased 5-fluorouracil-induced apoptosis and cell cycle arrest.In contrast,ectopic expression of DDIT4 in normal gastric epithelial cells promoted proliferation and attenuated chemosensitivity.Further analysis indicated that the mitogen-activated protein kinase and p53 signaling pathways were involved in the suppression of proliferation,and increased chemosensitivity upon DDIT4 downregulation.Conclusion:DDIT4 promotes GC proliferation and tumorigenesis,providing new insights into the role of DDIT4 in the tumorigenesis of human GC. | Feng Du Lina Sun Yi Chu Tingyu Li Chao Lei Xin Wang Mingzuo Jiang Yali Min Yuanyuan Lu Xiaodi Zhao Yongzhan Nie Daiming Fan | 2018 | Cancer Communications2018，38，1： | 10 |
| 4 | Evolution of sedimentary environments of the middle Jiangsu coast, South Yellow Sea since late MIS 3显示文摘沉积环境的一个进化模型后来迟了的海洋的同位素舞台 3 (迟了的 MIS 3,即, ca。39 cal ka BP ) 沿着中间的江苏,海岸被介绍在核心 07SR01,在邻近的出版核心之间的新关联,和在 Xiyang 潮汐的隧道和邻近的北海区域恢复的浅地震侧面的解释之上基于。地形学, sedimentology ,标明日期的放射性碳并且地震并且顺序地层学被联合证实自从在学习区域的迟了的 MIS 3 ,环境变化首先被海平面的变化,进南方黄海( SYS )的paleo河的沉积分泌物,和次要的构造沉淀控制,所有哪个影响了地区性的似地球形状、沉积的环境的前进(即,沿海的障碍岛,淡水湖的沼泽地,河泛滥平原,沿海的沼泽地, ti 这导致了第五顺序的顺序地层学的形成,最后间冰段( Para-Sq2 )的迟了的阶段的 parasequence 包括了包括 highstand 和强迫的回归的楔系统道( HST 和 FRWST ),并且冰期后的时期( Para-Sq1 )的 parasequence ,包括 transgressive 和 highstand 系统道( TST 和 HST )。当海平面的上升在 ca 盖住中间的江苏海岸,潮汐的沙山脉多半开始在冰期后的违反期间发展。9.0 cal ka BP。这些开始沉没的潮汐的沙山脉常常在广告 1128 ~ 1855 期间正在移居直到黄河嘴的向南方的迁居到北江苏海岸。paleo-Xiyang 由 paleo 潮汐的当前的地并且显著地被决定的潮汐的隧道与现代的不同,在 Holocene transgressive 最大值期间在存在并且持续了直到广告 1128。在由黄河的广告 1128 跟随 Huaihe 河的俘获,潮汐的隧道是的 paleo-Xiyang 有从广告 1128 ~ 1855 的大量导出河的沉积的 infilled,引起一些以前沉没的潮汐的沙的出现隆起。从到礼品的广告 1855,潮汐的隧道经历了搜索的 infilled paleo-Xiyang,导致它的现代表格。现代 Xiyang 潮汐的隧道继续拓宽并且加深,对强壮的潮汐的电流搜索和人为的活动到期。 | XIA Fei ZHANG Yongzhan WANG Qiang YIN Yong Karl W. WEGMANN J. Paul LIU | 2013 | Journal of Geographical Sciences2013，23，5： | 10 |
| 5 | 粪菌移植应用于慢传输型便秘的临床疗效及疗效影响因素:一项前瞻性研究的长期随访结果显示文摘背景和目的肠道菌群参与结肠动力的调控,菌群失调是便秘是病因之一。粪菌移植被证实可以恢复肠道平衡。本研究旨在评估粪菌移植治疗慢传输型便秘(STC)的临床疗效和预后影响因素。方法:52例STC患者接受标准的粪菌移植入组研究,对其进行至少6个月的随访。记录入组患者的排便习惯、结肠传输时间、便秘相关的症状(PAC-SYM评分)、生活质量(PAC-QOL评分)、治疗满意度和不良反应。主要疗效指标是平均每周完全自主排便≥3次的患者比例。结果:治疗后34周、912周、2124周,每周完全自主排便≥3次患者的比例分别为50.0%、38.5%和32.7%,均较治疗前显著提高(均P<0.01)。其他排便情况、结肠传输时间、便秘相关症状和生活质量方面,治疗后亦有显著改善;但这些短期改善在治疗后12周和24周逐渐减小。治疗前排便不尽是唯一的疗效影响因素。治疗和随访期间未发现任何治疗相关的不良反应。结论:本研究显示粪菌移植治疗STC安全有效,但远期疗效有所降低。治疗前排便不尽感较少甚至没有的患者接受粪菌移植的治疗效果更佳。 | Chao Ding Wenting Fan Lili Gu Hongliang Tian Xiaolong Ge Jianfeng Gong Yongzhan Nie Ning Li | 2018 | Gastroenterology Report2018，6，2： | 7 |
| 6 | Coastal plain evolution in southern Hainan Island,China显示文摘The coast of southern Hainan Island is characterized by wide sandy embayments, which consist of ( i) drowned valleys bounded by steep bedrock hills and only locally receiving sediments, and embayments of various dimensions covered either by (ii) alluvial-deltaic deposits or by (iii) sands of coastal beach ridges/barriers and associated elongated lagoons. During the late Tertiary-Pleistocene the area has experienced isostatic and eustatic movements associated with neotectonics and climatic changes. Such history isrecorded in terraces at various altitudes (SO, 40, 20 m asl) and sequences of coastal sand ridges/baymouth bars. The Holocene variations in sea level and climate are recorded in the dated coastal ridges, coral reef and beachrock. Conditions suitable for reef development started about 8000 a BP. The GPR profiles also show that the internal structures of the sand ridges have composite nature being formed by several superimposed secondary ridges. | WANG Ying MARTINI I.Peter ZHU Dakui ZHANG Yongzhan TANG Wenwu | 2001 | Chinese Science Bulletin2001，46，S1： | 3 |
| 7 | Proteomics provides individualized options of precision medicine for patients with gastric cancer显示文摘While precision medicine driven by genome sequencing has revolutionized cancer care,such as lung cancer,its impact on gastric cancer(GC)has been minimal.GC patients are routinely treated with chemotherapy,but only a fraction of them receive the clinical benefit.There is an urgent need to develop biomarkers or algorithms to select chemo-sensitive patients or apply targeted therapy.Here,we carried out retrospective analyses of 1,020 formalin-fixed,paraffin-embedded GC surgical resection samples from 5 hospitals and developed a mass spectrometry-based workflow for proteomic subtyping of GC.We identified two proteomic subtypes:the chemo-sensitive group(CSG)and the chemo-insensitive group(CIG)in the discovery set.The 5-year overall survival of CSG was significantly improved in patients who had received adjuvant chemotherapy after surgery compared with those who received surgery only(64.2%vs.49.6%;Cox P-value=0.002),whereas no such improvement was observed in CIG(50.0%vs.58.6%;Cox P-value=0.495).We validated these results in an independent validation set.Further,differential proteome analysis uncovered 9 FDA-approved drugs that may be applicable for targeted therapy of GC.A prospective study is warranted to test these findings for future GC patient care. | Wenwen Huang Dongdong Zhan Yazhuo Li Nairen Zheng Xin Wei Bin Bai Kecheng Zhang Mingwei Liu Xuefei Zhao Xiaotian Ni Xia Xia Jinwen Shi Cheng Zhang Zhihao Lu Jiafu Ji Juan Wang Shiqi Wang Gang Ji Jipeng Li Yongzhan Nie Wenquan Liang Xiaosong Wu Jianxin Cui Yongsheng Meng Feilin Cao Tieliu Shi Weimin Zhu Yi Wang Lin Chen Qingchuan Zhao Hongwei Wang Lin Shen Jun Qin | 2021 | Science China(Life Sciences)2021，64，8： | 3 |
| 8 | Association of systemic inflammation and body mass index with survival in patients with resectable gastric or gastroesophageal junction adenocarcinomas显示文摘Objective:The systemic inflammation index and body mass index(BMI)are easily accessible markers that can predict mortality.However,the prognostic value of the combined use of these two markers remains unclear.The goal of this study was therefore to evaluate the association of these markers with outcomes based on a large cohort of patients with gastric cancer.Methods:A total of 2,542 consecutive patients undergoing radical surgery for gastric or gastroesophageal junction adenocarcinoma between 2009 and 2014 were included.Systemic inflammation was quantified by the preoperative neutrophil-to-lymphocyte ratio(NLR).High systemic inflammation was defined as NLR≥3,and underweight was defined as BMI<18.5 kg/m2.Results:Among 2,542 patients,NLR≥3 and underweight were common[627(25%)and 349(14%),respectively].In the entire cohort,NLR≥3 or underweight independently predicted overall survival(OS)[hazard ratio(HR):1.236,95%confidence interval(95%CI):1.069–1.430;and HR:1.600,95%CI:1.350–1.897,respectively]and recurrence-free survival(RFS)(HR:1.230,95%CI:1.054–1.434;and HR:1.658,95%CI:1.389–1.979,respectively).Patients with both NLR≥3 and underweight(vs.neither)had much worse OS(HR:2.445,95%CI:1.853–3.225)and RFS(HR:2.405,95%CI:1.802–3.209).Furthermore,we observed similar results in subgroup analyses according to pathological stage,age,and postoperative chemotherapy.Conclusions:Our results showed that preoperative elevated NLR and decreased BMI had a significant negative effect on survival.Underweight combined with severe inflammation could enhance prognostication.Taking active therapeutic measures to reduce inflammation and increase nutrition may help improve outcomes. | Xianchun Gao Yanan Pan Weili Han Caie Hu Chenchen Wang Ling Chen Yong Guo Yupeng Shi Yan Pan Huahong Xie Liping Yao Jianjun Yang Jianyong Zheng Xiaohua Li Xiaonan Liu Liu Hong Jipeng Li Mengbin Li Gang Ji Zengshan Li Jielai Xia Qingchuan Zhao Daiming Fan Kaichun Wu Yongzhan Nie | 2021 | Cancer Biology & Medicine2021，18，1： | 2 |
| 9 | MicroRNA-19a/b regulates multidrug resistance in human gastric cancer cells by targeting PTEN显示文摘 | Fang Wang Ting Li Bin Zhang Hong Li Qiong Wu Li Yang Yongzhan Nie Kaichun Wu Yongquan Shi Daiming Fan | 2013 | Biochemical and Biophysical Research Communications2013，，3： | 2 |
| 10 | USP33, a new player in lung cancer, mediates Slit-Robo signaling显示文摘Ubiquitin 特定的朊酶(USP33 ) 33 是调整多样的细胞的过程的多功能的蛋白质。在肺癌症的 USP33 的表示和角色仍然保持未经勘探。在这研究,我们证明 USP33 在肺癌症病人的多重队是下面调整的, USP33 的那低表情与差的预后被联系。USP33 调停 Slit-Robo 在肺癌症房间移植发信号。USP33 的 Downregulation 在肺癌症房间减少 Robo1 的蛋白质稳定性,提供为在调停的 USP33 功能的以前未知的机制在肺癌症房间的裂缝活动。一起拿, USP33 是在调整 Slit-Robo 发信号的肺癌症的一个新播放器。我们的数据建议 USP33 可以作为一个预示的标记是为有潜力的肺癌症的候选人肿瘤 suppressor。 | Pushuai Wen Ruirui Kong Jianghong Liu Li Zhu Xiaoping Chen Xiaofei Li Yongzhan Nie Kaichun WU Jane Y. Wu | 2014 | Protein & Cell2014，5，9： | 2 |
| 11 | Silencing of ER-resident oxidoreductase PDIA3 inhibits malignant biological behaviors of multidrug-resistant gastric cancer显示文摘Glycosylation is a common posttranslational modification of proteins,which plays a role in the malignant transformation,growth,progression,chemoresistance,and immune response of tumors.Disulfide isomerase family A3(PDIA3)specifically acts on newly synthesized glycoproteins to promote the correct folding of sugar chains.Studies have shown that PDIA3 participates in multidrug-resistant gastric cancer(MDR-GC).In this study,we performed western blot analysis and immunohistochemistry to identify PDIA3 expression.Cell proliferation was assessed by CCK-8 assay.Transwell assays were used to detect the migration and invasion abilities of cells.Immunoprecipitation coupled to mass spectrometry(IP-MS)analysis was employed to identify PDIA3-interacting proteins and the associated pathways in MDR-GC cells.Glycoprotein interactions and translocation were detected by immunofluorescence assay.The results showed that PDIA3 knockdown significantly inhibited the proliferation,invasion,and migration abilities of MDR-GC cells.Kyoto Encyclopedia of Genes and Genomes analysis of the IP-MS results showed that PDIA3 was closely associated with focal adhesion pathways in MDR-GC cells.Additionally,important components of focal adhesion pathways,including fibronectin-1(FN1)and integrinα5(ITGA5),were identified as pivotal PDIA3-binding glycoproteins.Knockdown of PDIA3 altered the cellular locations of FN1 and ITGA5,leading to abnormal accumulation.In conclusion,our results suggest that knockdown of PDIA3 inhibited the malignant behaviors of MDR-GC cells and influenced the translocation of FN1 and ITGA5. | Danyang Song Meng Guo Kaichu Wu Jianyu Hao Yongzhan Nie Daiming Fan | 2021 | Acta Biochimica et Biophysica Sinica2021，53，9： | 2 |
| 12 | Phosphorus fractions and matrix-bound phosphine in coastal surface sediments of the Southwest Yellow Sea显示文摘 | Yuning Hong Jinju Geng Song Qiao Yongzhan Zhang Lili Ding Xiaorong Wang Hongqiang Ren | 2010 | Journal of Hazardous Materials2010，，1： | 1 |
| 13 | Thesand ridge field of the South Yellow Sea:origin by river-sea interaction 显示文摘 | WANG Ying ZHANG Yongzhan ZOU Xinqing | 2012 | Marine Geology2012，29，1292： | 1 |
| 14 | Upregulated FoxM1 expression induced by hepatitis B virus X protein promotes tumor metastasis and indicates poor prognosis in hepatitis B virus-related hepatocellular carcinoma显示文摘 | Limin Xia Wenjie Huang Dean Tian Hongwu Zhu Yongguo Zhang Hao Hu Daiming Fan Yongzhan Nie Kaichun Wu | 2012 | Journal of Hepatology2012，，3： | 1 |
| 15 | Mesenchymal Stem Cells Promote Epithelial to Mesenchymal Transition and Metastasis in Gastric Cancer Though Paracrine Cues and Close Physical Contact显示文摘 | Zengfu Xue Xiumin Wu Xiong Chen Yali Liu Xin Wang Kaichun Wu Yongzhan Nie Daiming Fan | 2015 | Biochem2015，，4： | 1 |
| 16 | Molecular basis of therapeutic approaches to gastric cancer 显示文摘 | Kaichun Wu Yongzhan Nie Changcun Guo | 2009 | Journal of Gastroenterology and Hepatology2009，24，： | 1 |
| 17 | Transcriptional up-regulation of RhoE by hypoxia-inducible factor (HIF)-1 promotes epithelial to mesenchymal transition of gastric cancer cells during hypoxia显示文摘 | Jinfeng Zhou Kai Li Yong Gu Bin Feng Gui Ren Liyun Zhang Yafang Wang Yongzhan Nie Daiming Fan | 2011 | Biochemical and Biophysical Research Communications2011，，2： | 1 |
| 18 | The sand ridge field of the South Yellow Sea: Origin by river - sea in- teraction显示文摘 | Wang Ying Zhang Yongzhan Zou Xinqing | 2012 | Marine Geology2012，2914，13： | 1 |
| 19 | Effect of black and white sesame on lowering blood lipids of rats with hyperlipidemia induced by high-fat diet显示文摘Sesamum indicum has various biological effects,and this study aimed to investigate its hypolipidemic effect.A hyperlipidemia rat model was established by feeding rats with high-fat diets in this study,then the hyperlipidemia rats were fed with different doses of black and white sesame seeds and black and white sesame kernels.The serum and liver biochemical indicators of the rats were determined,and liver pathology analysis was conducted to evaluate the hypolipidemic effect of sesame.The results showed that the blood lipid of SD(Sprague-Dawley)rats fed with high-fat diet for three weeks was higher than 200 mg/d L,indicating that the hyperlipidemia rat model was successfully established.At the same dose,the final body weights of the rats of white sesame seed and kernel groups were higher than those of the black sesame seed and kernel groups;and the weights of the black and white sesame seed groups were lower than those of the black and white sesame kernel groups.The liver indexes of the normal control group and the experimental groups were significantly lower than the model control group(P<0.05),indicating that black and white sesame seed and kernel could reduce the lipid accumulation on the liver.The malondialdehyde(MDA)values of the liver in the normal control group and the experimental groups were significantly lower than that in the model control group(P<0.05).The total antioxidant capacity(T-AOC),high density lipoprotein cholesterol(HDL-C),glutathione peroxidase(GSH-Px)and total superoxide dismutase(T-SOD)in the liver of each experimental group were significantly higher than those in the model control group(P<0.05).Based on the above results as well as pathological observation and analysis,we found that the black and white sesame seeds and kernels could improve fatty liver lesions and lipid metabolism disorder and could reduce lipid accumulation on the liver,thereby protecting the liver from damage and reducing the risk of fatty liver.Moreover,black and white sesame seeds,black and white sesame kernels can reduce the levels of total cholesterol(TC)and triglyceride(TG)in serum,and high dose of black sesame seeds(30%black sesame seeds)and low dose of black sesame kernels(10%black sesame kernels)were more beneficial for the recovery of hyperlipidemia and fatty liver.The above results indicated that black and white sesame has hypolipidemic effect. | Chenxi Li Yahui Li Yuxiang Ma Dongying Wang Yongzhan Zheng Xuede Wang | 2020 | Grain & Oil Science and Technology2020，3，2： | 1 |
| 20 | Osteopontin Contributes to TGF-β1 Mediated Hepatic Stellate Cell Activation显示文摘 | Xiao Xiao Yi Gang Yong Gu Lina Zhao Jindong Chu Jinfeng Zhou Xiqiang Cai Hui Zhang Li Xu Yongzhan Nie Kaichun Wu Zhiguo Liu Daiming Fan | 2012 | Digestive Diseases and Sciences2012，，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员