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| 1 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 2 | Tianwen-1 MINPA observations in the solar wind显示文摘The Mars Ion and Neutral Particle Analyzer(MINPA)is one of the three scientific instruments onboard the Tianwen-1 orbiter to investigate the Martian space environment.During Tianwen-1’s transfer orbit to Mars,the MINPA was switched on to measure the solar wind ions.Here,we present the first results of the MINPA observations in the solar wind.During cruise,nearly half of the MINPA ion field-of-view(FOV)was blocked by the lander capsule;thus only the solar-wind ions with azimuthal speeds pointing towards the unblocked FOV sectors could be detected.We perform a detailed comparison of the MINPA’s solar wind observations with data from Earth-based missions when MINPA reached its count-rate peak,finding a general consistency of the ion moments between them.The blocking effect due to the lander is evaluated quantitatively under varying solar-wind velocity conditions.Despite the blocking effect,the MINPA’s solar wind measurements during the transfer orbit suggest a good performance. | AiBing Zhang LingGao Kong WenYa Li Lei Li BinBin Tang ZhaoJin Rong Yong Wei JiJie Ma YiTeng Zhang LiangHai Xie YuXian Wang JianSen He Bin Liu WenJing Wang Bin Su JiaWei Li Xu Tan Fang Wang TaiFeng Jin FuHao Qiao Peter Wurz Yan Zhu YunFei Bai YiRen Li XinBo Zhu YueQiang Sun YongLiao Zou Chi Wang | 2022 | Earth and Planetary Physics2022，6，1： | 5 |
| 3 | Photostable and Biocompatible Fluorescent Silicon Nanoparticles for Imaging-Guided Co-Delivery of siRNA and Doxorubicin to Drug-Resistant Cancer Cells显示文摘The development of effective and safe vehicles to deliver small interfering RNA(siRNA) and chemotherapeutics remains a major challenge in RNA interference-based combination therapy with chemotherapeutics,which has emerged as a powerful platform to treat drug-resistant cancer cells.Herein,we describe the development of novel all-in-one fluorescent silicon nanoparticles(SiNPs)-based nanomedicine platform for imaging-guided co-delivery of siRNA and doxorubicin(DOX).This approach enhanced therapeutic efficacy in multidrug-resistant breast cancer cells(i.e.,MCF-7/ADR cells).Typically,the SiNP-based nanocarriers enhanced the stability of siRNA in a biological environment(i.e.,medium or RNase A) and imparted the responsive release behavior of siRNA,resulting in approximately 80% down-regulation of P-glycoprotein expression.Co-delivery of P-glycoprotein siRNA and DOX led to>35-fold decrease in the half maximal inhibitory concentration of DOX in comparison with free DOX,indicating the pronounced therapeutic efficiency of the resultant nanocomposites for drug-resistant breast cancer cells.The intracellular time-dependent release behaviors of siRNA and DOX were revealed through tracking the strong and stable fluorescence of SiNPs.These data provide valuable information for designing effective RNA interference-based co-delivery carriers. | Daoxia Guo Xiaoyuan Ji Fei Peng Yiling Zhong Binbin Chu Yuanyuan Su Yao He | 2019 | Nano-Micro Letters2019，11，2： | 5 |
| 4 | Gold Resources Potential Assessment in Eastern Kunlun Mountains of China Combining Weights-of-evidence Model with GIS Spatial Analysis Technique显示文摘Resources potential assessment is one of the fields in geosciences,which is able to take great advantage of GIS technology as a substitution of traditional working methods.The gold resources potential in the eastern Kunlun Mountains,Qinghai Province,China was assessed by combining weights-of-evidence model with GIS spatial analysis technique.All the data sets used in this paper were derived from an established multi-source geological spatial database,which contains geological,geophysical,geochemical and remote sensing data.Three multi-class variables,i.e.,structural intersection,Indosinian k-feldspar granite and regional fault,were used in proximity analysis to examine their spatial association with known gold deposits.A prospectivity map was produced by weights-of-evidence model based on seven binary evidential maps,all of which had passed a conditional independence test.The study area was divided into three target zones of high potential,moderate potential and low potential areas,among which high potential areas and moderate potential areas accounted for 20% of the total area and contained 32 of the 43 gold deposits.The results show that the gold resources potential assessment in the eastern Kunlun Mountains has a higher precision. | HE Binbin CHEN Cuihua LIU Yue | 2010 | Chinese Geographical Science2010，20，5： | 4 |
| 5 | Developmental Gerontology and Active Population Aging in China显示文摘Population aging is an irreversible process in the development of modern society,which brings challenges to comprehensive modernized social governance.Population aging is a“dualistic”development issue that not only leads to aging of the labor force structure but also creates new demographic dividends.This study describes the core thoughts of developmental gerontology(DG),which provides new insight into the relationship between active aging and comprehensive governance for modernized society.The development of DG will provide a feasible and sustainable path to integrate and coordinate the relationship between population aging,society,and economy. | Xiaoying Zheng Yanan Luo Binbin Su Ping He Chao Guo Yaohua Tian Shasha Han Chen Chen Yiran Wang Jufen Liu Jun Li | 2023 | China CDC weekly2023，5，8： | 4 |
| 6 | Effect of boron on bainitic transformation kinetics after ausforming in low carbon steels显示文摘The addition of boron(B) is frequently adopted to increase the hardenability of bainitic steels. Although it is well known that B can retard the bainitic transformation kinetics, it is still not clear how the B affects the bainitic transformation kinetics after ausforming. By systematic high-resolution dilatometry tests, the present work reveals that the bainitic transformation kinetics is accelerated in a low C steel with B addition after ausforming from all aspects including incubation time, transformation velocity and transformed volume fraction. In contrast, for the same steel without B addition, both transformation velocity and transformed volume fraction are retarded after ausforming. It is proposed that ausforming can reduce B segregation at prior austenite grain boundaries as some boron can interact with dislocations and therefore enhance bainite nucleation rate. Furthermore, auforming can refine the average volume of bainitic sheaf. Based on the competing mechanisms between increase of nucleation rate and refinement of bainitic sheaf, the effects of B and ausforming on the bainitic transformation kinetics are discussed. | Binbin He Wei Xu Mingxin Huang | 2017 | Journal of Materials Science & Technology2017，33，12： | 4 |
| 7 | Clemastine rescues behavioral changes and enhances remyelination in the cuprizone mouse model of demyelination显示文摘Increasing evidence suggests that white matter disorders based on myelin sheath impairment may underlie the neuropathological changes in schizophrenia.But it is unknown whether enhancing remyelination is a beneficial approach to schizophrenia.To investigate this hypothesis,we used clemastine,an FDA-approved drug with high potency in promoting oligodendroglial differentiation and myelination,on a cuprizone-induced mouse model of demyelination.The mice exposed to cuprizone(0.2%in chow) for 6 weeks displayed schizophrenia-like behavioral changes,including decreased exploration of the center in the open field test and increased entries into the arms of the Y-maze,as well as evident demyelination in the cortex and corpus callosum.Clemastine treatment was initiated upon cuprizone withdrawal at 10 mg/kg per day for3 weeks.As expected,myelin repair was greatly enhanced in the demyelinated regions with increased mature oligodendrocytes(APC-positive) and myelin basic protein.More importantly,the clemastine treatment rescued the schizophrenia-like behavioral changes in the open field test and the Y-maze compared to vehicle,suggesting a beneficial effect via promoting myelin repair.Our findings indicate that enhancing remyelination may be a potential therapy for schizophrenia. | Zhifang Li Yangtao He Shuangyi Fan Binbin Sun | 2015 | Neuroscience Bulletin2015，31，5： | 4 |
| 8 | Traditional Chinese medicine molecule-assisted chemical synthesis of fluorescent anti-cancer silicon nanoparUcles显示文摘 | Xiaoyuan Ji Daoxia Guo Bin Song Sicong Wu Binbin Chu Yuanyuan Su Yao He | 2018 | Nano Research2018，11，10： | 3 |
| 9 | The solar wind plasma upstream of Mars observed by Tianwen-1:Comparison with Mars Express and MAVEN显示文摘On the great journey to Mars,China’s first planetary exploration mission,the Tianwen-1 came within 26 million kilometers of Mars from 31 October 2020 to 25 January 2021 and was getting closer to its destination,the red planet,in search of answers to the cataclysmic climate change that occurred in Martian history.Both the escape of the Martian atmosphere and the loss of surface water were firmly influenced by solar activities.Tianwen-1 provided a unique chance to depict the solar wind streams between Earth and Mars during the minimum of Solar Cycle 25.During the three-month cruise phase of Tianwen-1,the solar wind flows were successively observed at Earth,Tianwen-1,and Mars.After the field of view correction and noise reduction,the solar wind velocity and density measured by Tianwen-1 show good agreement with those at Earth and Mars.The results indicate that the performance of the ion analyzer onboard the Tianwen-1 orbiter is reliable and stable.It is worth looking forward to the joint observations of ion escape with other Mars probes in the following Martian years. | Kai FAN Limei YAN Yong WEI Aibing ZHANG Linggao KONG Markus FRÄNZ Fei HE Lihui CHAI Chongjing YUAN Yuqi WANG Jun ZHONG Zhaojin RONG Zhonghua YAO Yongxin PAN Jun CUI Jiansen HE Wenya LI Binbin TANG Chi WANG | 2022 | Science China Earth Sciences2022，65，4： | 2 |
| 10 | Development of Bi/Er co-doped optical fibers for ultra-broadband photonic applications显示文摘 | Yanhua LUO Binbin YAN Jianzhong ZHANG Jianxiang WEN Jun HE Gang-Ding PENG | 2018 | Frontiers of Optoelectronics2018，11，1： | 2 |
| 11 | Highly fluorescent,photostable,and biocompatible silicon theranostic nanoprobes against Staphylococcus aureus infections显示文摘Human health is severely threatened by bacterial infections,which fuel urgent demand for the development of novel theranostic agents that are suitable for diagnosing and combating bacterial infections.To meet this goal,we synthesized a new kind of theranostic probes,made of vancomycin (Van)-modified fluorescent silicon nanoparticles (SiNPs-Van).The new probes feature good selectivity for Gram-positive bacterial infections,favorable fluorescence,strong resistance to photobleaching (e.g.,12%loss of fluorescence intensity during 40min continuous laser excitation in the presence of Staphylococcus aureus (S.aureus)),and good biocompatibility (e.g.,cell viability >95%during 24h treatment).Because of these benefits,the probes were effective at prolonged (i.e.,8-day)fluorescence tracking of S.aureus infections in vivo,thus providing a visible and accurate way to evaluate treatment efficacy.Moreover,the resultant SiNPs-Van with a minimum inhibitory concentration (MIC)of ca.0.5μg/mL exhibited high antibacterial efficiency of 92.5%,superior to that (76.5%)of free Van with higher MIC of ca.1μg/mL. | Xia Zhai Bin Song Binbin Chu Yuanyuan Su Houyu Wang Yao He | 2018 | Nano Research2018，11，12： | 2 |
| 12 | 3D printed biomimetic epithelium/stroma bilayer hydrogel implant for corneal regeneration显示文摘Corneal regeneration has always been a challenge due to its sophisticated structure and undesirable keratocyte-fibroblast transformation. Herein, we propose 3D printing of a biomimetic epithelium/stroma bilayer implant for corneal regeneration. Gelatin methacrylate (GelMA) and long-chain poly(ethylene glycol) diacrylate (PEGDA) are blended to form a two-component ink, which can be printed to different mechanically robust programmed PEGDA-GelMA objects by Digital Light Processing (DLP) printing technology, due to the toughening effect of crystalline crosslinks from long-chain PEGDA on GelMA hydrogel after photo-initiated copolymerization. The printed PEGDA-GelMA hydrogels support cell adhesion, proliferation, migration, meanwhile demonstrating a high light transmittance, and an appropriate swelling degree, nutrient permeation and degradation rate. A bi-layer dome-shaped corneal scaffold consisting of rabbit corneal epithelial cells (rCECs)-laden epithelia layer and rabbit adipose-derived mesenchymal stem cells (rASCs)-laden orthogonally aligned fibrous stroma layer can be printed out with a high fidelity and robustly surgical handling ability. This bi-layer cells-laden corneal scaffold is applied in a rabbit keratoplasty model. The post-operative outcome reveals efficient sealing of corneal defects, re-epithelialization and stromal regeneration. The concerted effects of microstructure of 3D printed corneal scaffold and precisely located cells in epithelia and stroma layer provide an optimal topographical and biological microenvironment for corneal regeneration. | Binbin He Jie Wang Mengtian Xie Miaoyi Xu Yahan Zhang Huijie Hao Xiaoli Xing William Lu Quanhong Han Wenguang Liu | 2022 | Bioactive Materials2022，7，11： | 2 |
| 13 | Overexpression of Sirt6 ameliorates sleep deprivation induced-cognitive impairment by modulating glutamatergic neuron function显示文摘Sleep benefits the restoration of energy metabolism and thereby suppo rts neuronal plasticity and cognitive behaviors.Sirt6 is a NAD+-dependent protein deacetylase that has been recognized as an essential regulator of energy metabolism because it modulates various transcriptional regulators and metabolic enzymes.The aim of this study was to investigate the influence of Sirt6 on cerebral function after chronic sleep deprivation(CSD).We assigned C57BL/6J mice to control or two CSD groups and subjected them to AAV2/9-CMV-EGFP or AAV2/9-CMV-Sirt6-EGFP infection in the prelimbic cortex(PrL).We then assessed cerebral functional connectivity(FC) using resting-state functional MRI,neuron/astrocyte metabolism using a metabolic kinetics analysis;dendritic spine densities using sparse-labeling;and miniature excitato ry postsynaptic currents(mEPSCs) and action potential(AP) firing rates using whole-cell patchclamp recordings.In addition,we evaluated cognition via a comprehensive set of behavioral tests.Compared with controls,Sirt6 was significantly decreased(P<0.05) in the PrL after CSD,accompanied by cognitive deficits and decreased FC between the PrL and accumbens nucleus,piriform cortex,motor co rtex,somatosensory co rtex,olfactory tubercle,insular cortex,and cerebellum.Sirt6 ove rexpression reve rsed CSD-induced cognitive impairment and reduced FC.Our analysis of metabolic kinetics using [1-13C] glucose and [2-13C] acetate showed that CSD reduced neuronal Glu4and GABA2synthesis,which could be fully restored via forced Sirt6 expression.Furthermore,Sirt6 ove rexpression reversed CSD-induced decreases in AP firing rates as well as the frequency and amplitude of mEPSCs in PrL pyramidal neurons.These data indicate that Sirt6 can improve cognitive impairment after CSD by regulating the PrL-associated FC network,neuronal glucose metabolism,and glutamatergic neurotransmission.Thus,Sirt6 activation may have potential as a novel strategy for treating sleep disorder-related diseases. | Jinpiao Zhu Chang Chen Zhen Li Xiaodong Liu Jingang He Ziyue Zhao Mengying He Binbin Nie Zili Liu Yingying Chen Kuanpin Su Xiang Li Juxiang Chen Hongbing Xiang Fuqiang Xu Kangguang Lin Zongze Zhang Jie Wang | 2023 | Neural Regeneration Research2023，18，11： | 1 |
| 14 | An overview of amphoteric ion exchange membranes for vanadium redox flow batteries显示文摘Vanadium redox flow battery(VRB),as the most promising large-scale electrical energy storage units,has attracted extensive attention.Amphoteric ion exchange membrane(AIEM),as the core part of VRB,separates electrolyte on both sides of electrolytic tank and conducts H+.The AIEM with cation and anion groups possesses excellent performances,such as high ion conductivity(σ),low vanadium ion permeability(Pvn+),relative stability and low cost.However,the performance of AIEM directly depends on the chemical structure of polymers.In addition to ensuring foundational physical performance,ion selectivity of AIEM is significant since the crossover of vanadium ion with various valences may reduce the battery capacity.In this paper,AIEMs for VRB and their chemical structures as well as synthesis approaches to realize all kinds of high-performing AIEMs are reviewed.The current trend and future direction of prospective materials for the VRB separators are documented in detail as well. | Lei Liu Chao Wang Zhenfeng He Rajib Das Binbin Dong Xiaofeng Xie Zhanhu Guo | 2021 | Journal of Materials Science & Technology2021，，10： | 1 |
| 15 | Recovery of iron oxide con- centrate rom high-sul显示文摘 | Binbin He Xike Tian Yan Sun | 2010 | Hydrometallurgy2010，，104： | 1 |
| 16 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 17 | Different salvents for the regeneration of the exhausted activated carbon used in the treatment of coking wastewater 显示文摘 | Guo Dongsheng Shi Qiantao He Binbin | 2011 | Journal of Hazardous Materials2011，186，23： | 1 |
| 18 | Juvenile hormone receptor Met regulates sleep and neuronal morphology via glial-neuronal crosstalk显示文摘Juvenile hormone(JH)is one of the most important hormones in insects since it is essential for insect development.The mechanism by which JH affects the central nervous system still remains a mystery.In this study,we demonstrate that one of the JH receptors,Methoprene-tolerant(Met),is important for the control of neurite development and sleep behavior in Drosophila.With the identification of Met-expressing glial cells,the mechanism that Met negatively controls the mushroom body(MB)b lobes fusion and positively maintains pigment-dispersing factor s LNvs projection pruning has been established.Furthermore,despite the developmental effects,Met can also maintain nighttime sleep in a developmentindependent manner through the a/b lobe of MB.Combining analyses of neuronal morphology and entomological behavior,this study advances our understanding of how the JH receptor regulates the nervous system. | Binbin Wu Lei He Yutong Xiao Juan Du Xiaoxiao Wang Zhangwu Zhao | 2021 | Journal of Genetics and Genomics2021，48，8： | 1 |
| 19 | Automated multi-scale classification of the terrain units of the Jiaxie Guyots and their mineral resource characteristics显示文摘Given the advances in satellite altimetry and multibeam bathymetry,benthic terrain classification based on digital bathymetric models(DBMs)has been widely used for the mapping of benthic topographies.For instance,cobaltrich crusts(CRCs)are important mineral resources found on seamounts and guyots in the western Pacific Ocean.Thick,plate-like CRCs are known to form on the summit and slopes of seamounts at the 1000–3000 m depth,while the relationship between seamount topography and spatial distribution of CRCs remains unclear.The benthic terrain classification of seamounts can solve this problem,thereby,facilitating the rapid exploration of seamount CRCs.Our study used an EM122 multibeam echosounder to retrieve high-resolution bathymetry data in the CRCs contract license area of China,i.e.,the Jiaxie Guyots in 2015 and 2016.Based on the DBM construted by bathymetirc data,broad-and fine-scale bathymetric position indices were utilized for quantitative classification of the terrain units of the Jiaxie Guyots on multiple scales.The classification revealed four first-order terrain units(e.g.,flat,crest,slope,and depression)and eleven second-order terrain units(e.g.,local crests,depressions on crests,gentle slopes,crests on slopes,and local depressions,etc.).Furthermore,the classification of the terrain and geological analysis indicated that the Weijia Guyot has a large flat summit,with local crests at the southern summit,whereas most of the guyot flanks were covered by gentle slopes.“Radial”mountain ridges have developed on the eastern side,while large-scale gravitational landslides have developed on the western and southern flanks.Additionally,landslide masses can be observed at the bottom of these slopes.The coverage of local crests on the seamount is∼1000 km^(2),and the local crests on the peak and flanks of the guyots may be the areas where thick and continuous plate-like CRCs are likely to occur. | Yong Yang Gaowen He Yonggang Liu Jinfeng Ma Zhenquan Wei Binbin Guo | 2022 | Acta Oceanologica Sinica2022，41，7： | 1 |
| 20 | Development of a UFLC–MS/MS method for simultaneous determination of six lignans of Schisandra chinensis (Turcz.) Baill. in rat plasma and its application to a comparative pharmacokinetic study in normal and insomnic rats显示文摘 | Binbin Wei Qing Li Dan Su Ronghua Fan Longshan Zhao Lulu Geng Bosai He Xiaohui Chen Ying Jia Kaishun Bi | 2013 | Journal of Pharmaceutical and Biomedical Analysis2013，，： | 1 |
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