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| 1 | Individualized prediction of perineural invasion in colorectal cancer: development and validation of a radiomics prediction model显示文摘Objective: To develop and validate a radiomics prediction model for individualized prediction of perineural invasion(PNI) in colorectal cancer(CRC).Methods: After computed tomography(CT) radiomics features extraction, a radiomics signature was constructed in derivation cohort(346 CRC patients). A prediction model was developed to integrate the radiomics signature and clinical candidate predictors [age, sex, tumor location, and carcinoembryonic antigen(CEA) level]. Apparent prediction performance was assessed. After internal validation, independent temporal validation(separate from the cohort used to build the model) was then conducted in 217 CRC patients. The final model was converted to an easy-to-use nomogram.Results: The developed radiomics nomogram that integrated the radiomics signature and CEA level showed good calibration and discrimination performance [Harrell's concordance index(c-index): 0.817; 95% confidence interval(95% CI): 0.811–0.823]. Application of the nomogram in validation cohort gave a comparable calibration and discrimination(c-index: 0.803; 95% CI: 0.794–0.812).Conclusions: Integrating the radiomics signature and CEA level into a radiomics prediction model enables easy and effective risk assessment of PNI in CRC. This stratification of patients according to their PNI status may provide a basis for individualized auxiliary treatment. | Yanqi Huang Lan He Di Dong Caiyun Yang Cuishan Liang Xin Chen Zelan Ma Xiaomei Huang Su Yao Changhong Liang Jie Tian Zaiyi Liu | 2018 | Chinese Journal of Cancer Research2018，30，1： | 23 |
| 2 | Source of major anions and cations of snowpacks in Hailuogou No.1 glacier, Mt. Gongga and Baishui No.1 glacier, Mt. Yulong显示文摘积雪场样品是从二条冰河的 colleted:在 2006 年 6 月的 Baishui No.1 冰河和 Hailuogou No.1 冰河。海盐离子 tracer。 | LI Zongxing HE Yuanqing PANG Hongxi YANG Xiaomei JIA Wenxiong ZHANG Ningning WANG Xufeng NING Baoying YUAN Lingling SONG Bo | 2008 | Journal of Geographical Sciences2008，18，1： | 13 |
| 3 | Generation of ready to use (RTU) products over China based on Landsat series data显示文摘Earth observation community has entered into the era of big data.Family of Landsat sensors have collected massive medium resolution satellite images,which are valuable for long-term land surface monitoring.In order to significantly reduce the magnitude of data processing for remote sensing data users,Landsat-based Ready to Use(RTU)products have been produced.Main RTU products,including orthorectified products,land surface reflectance,land surface temperature,large-area mosaic image,and standard image map products,are described.The resulting Landsat RTU products are hosted on the RSGS earth observation data sharing web site for free download(http://gffzz959b1a8e74bf485dhvk9n6npxwo9v6k0x.ffgz.tsg.suse.edu.cn/rtu/).These new products will provide consistent,standardized,multi-decadal image data for robust land cover change detection and monitoring across the Earth sciences.In the coming years,CASEarth DataBank system will be constructed,which is an intelligent data service platform for providing not only the RTU products from multi-source satellite data,but also big earth data analysis methods. | Guojin He Zhaoming Zhang Weili Jiao Tengfei Long Yan Peng Guizhou Wang Ranyu Yin Wei Wang Xiaomei Zhang Huichan Liu Bo Cheng Bo Xiang | 2018 | Big Earth Data2018，2，1： | 8 |
| 4 | Targeting PFKL with penfluridol inhibits glycolysis and suppresses esophageal cancer tumorigenesis in an AMPK/FOXO3a/BIM-dependent manner显示文摘As one of the hallmarks of cancer,metabolic reprogramming leads to cancer progression,and targeting glycolytic enzymes could be useful strategies for cancer therapy.By screening a small molecule library consisting of 1320 FDA-approved drugs,we found that penfluridol,an antipsychotic drug used to treat schizophrenia,could inhibit glycolysis and induce apoptosis in esophageal squamous cell carcinoma(ESCC).Gene profiling and Ingenuity Pathway Analysis suggested the important role of AMPK in action mechanism of penfluridol.By using drug affinity responsive target stability(DARTS)technology and proteomics,we identified phosphofructokinase,liver type(PFKL),a key enzyme in glycolysis,as a direct target of penfluridol.Penfluridol could not exhibit its anticancer property in PFKL-deficient cancer cells,illustrating that PFKL is essential for the bioactivity of penfluridol.High PFKL expression is correlated with advanced stages and poor survival of ESCC patients,and silencing of PFKL significantly suppressed tumor growth.Mechanistically,direct binding of penfluridol and PFKL inhibits glucose consumption,lactate and ATP production,leads to nuclear translocation of FOXO3a and subsequent transcriptional activation of BIM in an AMPK-dependent manner.Taken together,PFKL is a potential prognostic biomarker and therapeutic target in ESCC,and penfluridol may be a new therapeutic option for management of this lethal disease. | Cancan Zheng Xiaomei Yu Yiyao Liang Yidong Zhu Yan He Long Liao Dingkang Wang Yanming Yang Xingfeng Yin Ang Li Qingyu He Bin Li | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 4 |
| 5 | SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy显示文摘The global coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused severe morbidity and mortality in humans.It is urgent to understand the function of viral genes.However,the function of open reading frame 10(ORF10),which is uniquely expressed by SARS-CoV-2,remains unclear.In this study,we showed that overexpression of ORF10 markedly suppressed the expression of type I interferon(IFN-I)genes and IFN-stimulated genes.Then,mitochondrial antiviral signaling protein(MAVS)was identified as the target via which ORF10 suppresses the IFN-I signaling pathway,and MAVS was found to be degraded through the ORF10-induced autophagy pathway.Furthermore,overexpression of ORF10 promoted the accumulation of LC3 in mitochondria and induced mitophagy.Mechanistically,ORF10 was translocated to mitochondria by interacting with the mitophagy receptor Nip3-like protein X(NIX)and induced mitophagy through its interaction with both NIX and LC3B.Moreover,knockdown of NIX expression blocked mitophagy activation,MAVS degradation,and IFN-I signaling pathway inhibition by ORF10.Consistent with our observations,in the context of SARS-CoV-2 infection,ORF10 inhibited MAVS expression and facilitated viral replication.In brief,our results reveal a novel mechanism by which SARS-CoV-2 inhibits the innate immune response;that is,ORF10 induces mitophagy-mediated MAVS degradation by binding to NIX. | Xingyu Li Peili Hou Wenqing Ma Xuefeng Wang Hongmei Wang Zhangping Yu Huasong Chang Tiecheng Wang Song Jin Xue Wang Wenqi Wang Yudong Zhao Yong Zhao Chunqing Xu Xiaomei Ma Yuwei Gao Hongbin He | 2022 | Cellular & Molecular Immunology2022，19，1： | 4 |
| 6 | Development and validation of a CT-based radiomics nomogram for preoperative prediction of tumor histologic grade in gastric adenocarcinoma显示文摘Objectives:To develop and validate a radiomics nomogram for preoperative prediction of tumor histologic grade in gastric adenocarcinoma(GA).Methods:This retrospective study enrolled 592 patients with clinicopathologically confirmed GA(low-grade:n=154;high-grade:n=438)from January 2008 to March 2018 who were divided into training(n=450)and validation(n=142)sets according to the time of computed tomography(CT)examination.Radiomic features were extracted from the portal venous phase CT images.The Mann-Whitney U test and the least absolute shrinkage and selection operator(LASSO)regression model were used for feature selection,data dimension reduction and radiomics signature construction.Multivariable logistic regression analysis was applied to develop the prediction model.The radiomics signature and independent clinicopathologic risk factors were incorporated and presented as a radiomics nomogram.The performance of the nomogram was assessed with respect to its calibration and discrimination.Results:A radiomics signature containing 12 selected features was significantly associated with the histologic grade of GA(P<0.001 for both training and validation sets).A nomogram including the radiomics signature and tumor location as predictors was developed.The model showed both good calibration and good discrimination,in which C-index in the training set,0.752[95%confidence interval(95%CI):0.701-0.803];C-index in the validation set,0.793(95%CI:0.711-0.874).Conclusions:This study developed a radiomics nomogram that incorporates tumor location and radiomics signatures,which can be useful in facilitating preoperative individualized prediction of histologic grade of GA. | Jia Huang Huasheng Yao Yexing Li Mengyi Dong Chu Han Lan He Xiaomei Huang Ting Xia Zongjian Yi Huihui Wang Yuan Zhang Jian He Changhong Liang Zaiyi Liu | 2021 | Chinese Journal of Cancer Research2021，33，1： | 3 |
| 7 | Effect of organic carbon on nitrification effciency and community composition of nitrifying biofilms显示文摘The effects of organic carbon/inorganic nitrogen(C/N) ratio on the nitrification processes and the community shifts of nitrifying biofilms were investigated by kinetic comparison and denaturing gradient gel electrophoresis(DGGE) analysis.The results showed that the nitrification rate decreased with an increasing organic concentration.However,the effect became weak when the carbon concentration reached a suffciently high level.Denitrification was detected after organic carbon was added.The 12 h ammonium removal rate ranged from 85% to 30% at C/N = 0.5,1,2,4,8,and 16,as compared to the control(C/N = 0).The loss of nitrogen after 24 h at C/N = 0.5,1,2,4,8,and 16 was 31%,18%,24%,65%,59%,and 62%,respectively.The sequence analysis of 16S rRNA gene fragments revealed that the dominant populations changed from nitrifying bacteria(Nitrosomonas europaea and Nitrobacter sp.) to denitrifying bacteria(Pseudomonas sp.,Acidovorax sp.and Comamonas sp.) with an increasing C/N ratio.Although at high C/N ratio the denitrifying bacteria were the dominant populations,nitrifying bacteria grew simultaneously.Consequently,nitrification process coexisted with denitrification. | HU Jie LI Daping LIU Qiang TAO Yong HE Xiaohong WANG Xiaomei LI Xudong GAO Ping | 2009 | Journal of Environmental Sciences2009，21，3： | 3 |
| 8 | Finite element analysis of temperature and residual stress profiles of porous cubic Ti-6Al-4V titanium alloy by electron beam melting显示文摘The temperature and stress profiles of porous cubic Ti-6Al-4V titanium alloy grids by additive manufacturing via electron beam melting(EBM)based on finite element(FE)method were investigated.Three-dimensional FE models were developed to simulate the single-layer and five-layer girds under annular and lateral scanning.The results showed that the molten pool temperature in five-layer girds was higher than that in single-layer grids owing to the larger mass and higher heat capacity.More energies accumulated by the longer scanning time for annular path than lateral path led to the higher temperature and steeper temperature gradient.The thermal stress drastically fluctuated during EBM process and the residual stress decreased with the increase of powder layer where the largest stress appeared at the first layer along the build direction.The stress under lateral scanning was slightly larger but relatively more homogeneous distribution than those under annular scanning.The stress distribution showed anisotropy and the maximum Von Mises stress occurred around the central node.The stress profiles were explained by the temperature fields and grids structure. | Xiaochun He Yang Li Yongjie Bi Xiaomei Liu Bing Zhou Shangzhou Zhang Shujun Li | 2020 | Journal of Materials Science & Technology2020，44，9： | 2 |
| 9 | Contents Variation Analysis ofγ-Amino Butyric Acid in Semen sojae praeparatum Fermentation Using Online Pre-Column Derivatization-HPLC显示文摘This paper reported the contents variation analysis ofγ-amino butyric acid(GABA)in Semen sojae praeparatum(SSP)which is a famous traditional Chinese medicine.High performance liquid chromatography(HPLC)was used and GABA was derivatized by online pre-column derivatization with o-phthalaldehyde(OPA).To validate this method,the precision,stability,repeatability and recovery were discussed.In the concentration range from 0.0125 to 0.400 mg/m L,the calibration curve for GABA was linear and the regression equation was obtained with correlation coefficient(R2)of 0.9999.Relatively high levels of GABA exist in SSP and the content changes of GABA at different time points during the fermenting process were detected.At the'yellow cladding'stage,GABA level was very low or even undetectable;the'secondary fermentation'stage witnessed a rapid increase of GABA content to 1.39-5.52 mg/g,which remained stable after 18 days of'secondary fermentation'.This study demonstrated that GABA was generated at the'secondary fermentation'stage,revealing the significance and rationality of the'secondary fermentation'stage in the fermenting process of SSP.On the other hand,it suggested the downside of taking soy isoflavones as the only measurement in existing quality assessment and optimization approach for the fermenting process of SSP. | WENG Meizhi HE Jing REN Jiaxiu LIANG Yonghong CHEN Qingfeng SU Mingsheng WANG Liyuan XIE Xiaomei | 2021 | Wuhan University Journal of Natural Sciences2021，26，1： | 2 |
| 10 | Age-related Variation in Snake Venom: Evidence from Two Snakes (Naja atra and Deinagkistrodon acutus) in Southeastern China显示文摘In this study we explored electrophoretic profiles, enzymatic activities and immunoreactivity of neonate and adult venoms from two snakes(Naja atra and Deinagkistrodon acutus) coexisting in southeastern China. Age-related variation in electrophoretic profiles was found in both species and proteolytic and fibrinogenolytic activity was higher in neonate than adult venoms. Neonate D. acutus venom had higher 5'nucleotidase, PLA2, hyaluronidase and gelatinolytic activity, but lower esterolytic activity, than adult venom. Neonate and adult D. acutus venoms showed identical phosphomonoesterase, LAO and fibrinolytic activities. Neonate N. atra venom had higher phosphomonoesterase and LAO activity, but lower 5' nucleotidase, PLA2, hyaluronidase and AchE activities than adult venom. Neonate and adult N. atra venoms showed similar gelatinolytic activity. Further, age-dependent immunoreactivity was found in both species, and cross-reactions between homologous venoms and antiserums were closely related to venom composition. We speculate that age-related variation in venom characteristics is possibly driven by evolutionary forces associated with ontogenetic shifts in dietary habits, competition and predation pressure. | Ying HE Jianfang GAO Longhui LIN Xiaomei MA Xiang JI | 2014 | Asian Herpetological Research2014，5，2： | 2 |
| 11 | Duplication and transcriptional divergence of three Kunitz protease inhibitor genes that modulate insect and pathogen defenses in tea plant(Camellia sinensis)显示文摘Kunitz protease inhibitors(KPIs)are ubiquitous in plants and act as crucial compounds in defense responses against insect attack and pathogen infection.However,the influence of gene duplication on the postdivergence of the CsKPI genes involved in biotic stresses in tea plant is not well known.Here,we identified three CsKPI genes from tea plant(Camellia sinensis)and characterized their expression and evolutionary patterns among plant species.We found that CsKPI1,CsKPI2,and CsKPI3 diverged from their common ancestor 72.94 million years ago(MYA),and the tandem duplication of CsKPI2 and CsKPI3 occurred 26.78 MYA.An in vitro protein assay showed that the three CsKPI proteins were functional and inhibited the production of p-nitroanilide(PNA)from an artificial substrate.The three CsKPI-GFP fusion proteins localized to the cytoplasm.We showed that salicylic acid(SA)and transcripts of CsKPI2 and CsKPI3 significantly accumulated after infection with Glomerella cingulata.The application of exogenous SA stimulated the high expression of both CsKPI2 and CsKPI3 by activating cis-elements within their promoters.Under Ectropis oblique attack,CsKPI1 expression and jasmonic acid(JA)levels were more abundant in both insect-damaged leaf tissues and undamaged neighboring leaves.The application of jasmonic acid methyl ester elicited high expression levels of CsKPI1,suggesting that CsKPI1 accumulation requires JA production in tea plant.The overall findings suggest that the transcriptional divergence of KPI genes after duplication led to the specialized role of CsKPI1 in the physiological response to insect stress;the functional conservation between CsKPI2 and CsKPI3 confers resistance to pathogen infection in tea plant. | Junyan Zhu Yaxian He Xiaomei Yan Lu Liu Rui Guo Xiaobo Xia Daojie Cheng Xiaozeng Mi Lidiia Samarina Shenrui Liu Enhua Xia Chaoling Wei | 2019 | Horticulture Research2019，6，1： | 2 |
| 12 | Reduction of azides to amines or amides with zinc and ammonium chloride as reducing agent显示文摘 | Lin Wenqing Zhang Xiaomei He Ze | 2002 | Synth Commun2002，32，21： | 1 |
| 13 | Electroanalytieal characteristics of enoxacin and their analytical applieation显示文摘 | ZHANG ZHENGQI LI YANFEI HE XIAOMEI | 1996 | Talanta1996，43，： | 1 |
| 14 | Dynamic design theory and application of large vibrating screen显示文摘 | Zhao Yuemin Liu Chusheng He Xiaomei | 2009 | Procedia Earth and Planetary Science2009，1，1： | 1 |
| 15 | Petroleum Retention,Intraformational Migration and Segmented Accumulation within the Organic-rich Shale in the Cretaceous Qingshankou Formation of the Gulong Sag,Songliao Basin,Northeast China显示文摘In this study,organic geochemical and petrological analyses were conducted on 111 shale samples from a well to understand the retention,intraformational migration and segmented accumulation(shale oil enrichment in different intervals is unconnected)features of shale oil within the organic-rich shale in the Qingshankou Formation of the Gulong Sag.Our study shows that retained petroleum characteristics in the investigated succession are mainly influenced by three factors:organic richness,intraformational migration and segmented accumulation.Organic matter richness primarily controls the amount of retained petroleum,especially the‘live’component indicated by the S_(2)value rather than the total organic carbon(TOC)figure alone.The negative expulsion efficiencies determined by mass-balance calculations of hydrocarbons reveal that petroleum from adjacent organic-rich intervals migrates into the interval of about 2386-2408 m,which is characterized by high free hydrocarbon(S_(1)),OSI and saturated hydrocarbons content,along with a greater difference inδ^(13)C values between polar compounds(including resins and asphaltenes)and saturated hydrocarbons.The depth-dependent heterogeneity of carbon isotope ratios(δ^(13)C)of mud methane gas,δ^(13)C of extracts gross composition(SARA),δ^(13)C of kerogen and SARA content of extracts suggest that the studied succession can be subdivided into four intervals.The shale oil sealing enrichment character in each interval is further corroborated by the distinctδ^(13)C values of mud methane gas in different intervals.Due to the migration of petroleum into the 2386-2408 m interval,the S_(1),OSI and saturated hydrocarbons content of the interval show higher relative values.The maturity of organic matter in the 2471-2500 m interval is at the highest with the smaller size molecular components of the retained petroleum.Thus,favorable‘sweet spots’may be found in the 2386-2408 m interval and the 2471-2500 m interval,according to the experiment results in this study. | HUANGFU Yuhui ZHANG Jinyou ZHANG Shuichang WANG Xiaomei HE Kun GUAN Ping ZHANG Huanxu ZHANG Bin WANG Huajian | 2023 | Acta Geologica Sinica(English Edition)2023，97，5： | 1 |
| 16 | Improving Integrality of Detected Moving Objects Based on Image Matting显示文摘The integrality of moving objects is the basis for video-based object tracking and action analysis. But it often becomes unreliable as a result of shadow elimination when the object has similar properties with real shadow. The proposed methods manage to improve the integrality of detected moving objects as much as possible, by image matting operated on candidate shadow regions. Existing approaches for image matting require manual labeling of foreground and background. Considering the moving feature points in shadow may cause classification errors, we propose automatic scribbling methods based on Scale invariant feature transform(SIFT) and Speeded-up robust feature(SURF) respectively. Experiments demonstrate that our methods eliminate real shadow effectively and improve object segmentation in the case of object parts and shadows presenting similar characteristics. | ZHANG Liang WANG Haili DENG Tao HE Xiaomei | 2014 | Chinese Journal of Electronics2014，23，4： | 1 |
| 17 | Dynamic landscape mapping of humoral immunity to SARS-CoY-2 identifies non-structural protein antibodies associated with the survival of critical COVID-19 patients显示文摘A comprehensive analysis of the humoral immune response to the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is essential in understanding COVID-19 pathogenesis and developing antibody-based diagnostics and therapy.In this work,we performed a longitudinal analysis of antibody responses to SARS-CoV-2 proteins in 104 serum samples from 49 critical COVID-19 patients using a peptide-based SARS-CoV-2 proteome microarray.Our data show that the binding epitopes of IgM and IgG antibodies differ across SARS-CoV-2 proteins and even within the same protein. | Linlin Cheng Xiaomei Zhang Yu Chen Dan Wang Dong Zhang Songxin Yan Hongye Wang Meng Xiao Te Liang Haolong Li Meng Xu Xin Hou jiayu Dai Xian Wu Mingyuan Li Minya Lu Dong Wu Ran Tian Jing Zhao Yan Zhang Wei Cao Jinglan Wang Xiaowei Yan Xiang Zhou Zhengyin Liu Yingchun Xu Fuchu He Yongzhe Li Xiaobo Yu Shuyang Zhang | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 1 |
| 18 | Research of processing techniques used in fabrication of solid oxide fuel cells and study of their selected properties显示文摘 | Jiang Liu Zhe Lü Wei Liu Li Pei Xin Zhao Li Jia Yanbin Song Xiaomei Liu Lanying He Wenhui Su | 1998 | Science in China Series A: Mathematics1998，，5： | 1 |
| 19 | Influence of circulation types on temporal and spatial variations of ozone in Beijing显示文摘This study analyzes the impact of circulation types(CTs)on ozone(O_(3))pollution in Beijing.The easterly high-pressure(SWW)circulation occurred most frequently(30%;276 day),followed by northwesterly high-pressure(AN)circulation(24.3%;224 day).The SWW type had the highest O_(3) anomaly of+17.28μg/m^(3),which was caused by excellent photochemical reactions,poor diffusion ability and regional transport.Due to the higher humidity and precipitation in the low-pressure type(C),the O_(3) increase(+8.02μg/m^(3))was less than that in the SWW type.Good diffusion/wet deposition and weak formation ability contributed to O_(3) decrease in AN(-12.54μg/m^(3))and northerly high-pressure(ESN)CTs(-12.26μg/m^(3)).The intra-area transport of O_(3) was significant in polluted circulations(SWW-and C-CTs).In addition,higher temperature,radiation and less rainfall also contributed to higher O_(3) in northern Beijing under the SWW type.For the clean CTs(AN and ESN CTs),precursor amount and intra-area transport played a dominant role in O_(3) distribution.Under the northeasterly low-pressure CT,better formation conditions and higher precursor amount combined with the intra-area southerly transport to cause higher O_(3) values in the south than in the north.The higher O_(3) in the northwestern area under the northeasterly high-pressure type was influenced by weaker titration loss and high O_(3) concentration in previous day.Annual variation in the CTs contributed up to 86.1%of the annual variation in O_(3).About 78%-83%of the diurnal variation in O_(3) resulted from local meteorological factors. | Xiaowan Zhu JinWu Guiqian Tang Lin Qiao Tingting Han Xiaomei Yin Xiangxue Liu Ziming Li Yajun Xiong Di He Zhiqiang Ma | 2023 | Journal of Environmental Sciences2023，，8： | 1 |
| 20 | Intrusion Detection Using BP Optimized by PSO显示文摘 | Xiaomei YI Peng WU Dan DAI Lijuan LIU Xiong HE | 2012 | IJACT:International Journal of Advancements in Comput-ing Technology2012，，2： | 1 |
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