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| 1 | Towards 6G wireless communication networks:vision,enabling technologies,and new paradigm shifts显示文摘The fifth generation(5G)wireless communication networks are being deployed worldwide from 2020 and more capabilities are in the process of being standardized,such as mass connectivity,ultra-reliability,and guaranteed low latency.However,5G will not meet all requirements of the future in 2030 and beyond,and sixth generation(6G)wireless communication networks are expected to provide global coverage,enhanced spectral/energy/cost efficiency,better intelligence level and security,etc.To meet these requirements,6G networks will rely on new enabling technologies,i.e.,air interface and transmission technologies and novel network architecture,such as waveform design,multiple access,channel coding schemes,multi-antenna technologies,network slicing,cell-free architecture,and cloud/fog/edge computing.Our vision on 6G is that it will have four new paradigm shifts.First,to satisfy the requirement of global coverage,6G will not be limited to terrestrial communication networks,which will need to be complemented with non-terrestrial networks such as satellite and unmanned aerial vehicle(UAV)communication networks,thus achieving a space-airground-sea integrated communication network.Second,all spectra will be fully explored to further increase data rates and connection density,including the sub-6GHz,millimeter wave(mmWave),terahertz(THz),and optical frequency bands.Third,facing the big datasets generated by the use of extremely heterogeneous networks,diverse communication scenarios,large numbers of antennas,wide bandwidths,and new service requirements,6G networks will enable a new range of smart applications with the aid of artificial intelligence(AI)and big data technologies.Fourth,network security will have to be strengthened when developing 6G networks.This article provides a comprehensive survey of recent advances and future trends in these four aspects.Clearly,6G with additional technical requirements beyond those of 5G will enable faster and further communications to the extent that the boundary between physical and cyber worlds disappears. | Xiaohu YOU Cheng-Xiang WANG Jie HUANG Xiqi GAO Zaichen ZHANG Mao WANG Yongming HUANG Chuan ZHANG Yanxiang JIANG Jiaheng WANG Min ZHU Bin SHENG Dongming WANG Zhiwen PAN Pengcheng ZHU Yang YANG Zening LIU Ping ZHANG Xiaofeng TAO Shaoqian LI Zhi CHEN Xinying MA Chih-Lin I Shuangfeng HAN Ke LI Chengkang PAN Zhimin ZHENG Lajos HANZO Xuemin(Sherman)SHEN Yingjie Jay GUO Zhiguo DING Harald HAAS Wen TONG Peiying ZHU Ganghua YANG Jun WANG Erik GLARSSON Hien Quoc NGO Wei HONG Haiming WANG Debin HOU Jixin CHEN Zhe CHEN Zhangcheng HAO Geoffrey Ye LI Rahim TAFAZOLLI Yue GAO HVincent POOR Gerhard P.FETTWEIS Ying-Chang LIANG | 2021 | Science China(Information Sciences)2021，64，1： | 122 |
| 2 | China National Medical Products Administration approval summary:anlotinib for the treatment of advanced non-small cell lung cancer after two lines of chemotherapy显示文摘Background:On May 8,2018,the China National Medical Products Administration(NMPA)approved anlotinib,an orally administered anti-angiogenesis inhibitor,for the treatment of patients with advanced non-small cell lung can-cer(NSCLC)who have progressed after treatment with two or more lines of prior systemic chemotherapy.Main body of the abstract:China NMPA reviewed and inspected a regional double-blinded,placebo-controlled,Phase III trial comparing the overall survival(OS)of NSCLC patients between the anlotinib and placebo arms.A total of 437 patients were randomized(2:1)to receive either anlotinib(n=294)or placebo(n=143)once daily on a 2-week on and 1-week off schedule.Patients with epidermal growth factor receptor(EGFR)or activating anaplastic lymphoma kinase(ALK)genomic tumor aberrations should have disease progression on NMPA-approved therapy.Anlotinib is the first NMPA-approved drug for patients with advanced NSCLC who have progressed on at least two lines of prior systemic chemotherapies in China.The approval was based on a statistically and clinically significant improvement in median OS with anlotinib(9.46 months)compared with placebo[6.37 months;hazard ratio(HR])=0.70,95%confidence interval(CI)=0.55-0.89;two-sided log-rank P=0.002].The confirmed objective response rate(ORR)was 9.2%in the anlotinib arm and 0.7%in the placebo arm.The median duration of response(DoR)was 4.83 months,with a 95%CI of 3.31-6.97 months.The toxicity profile of anlotinib was consistent with that of known anti-angiogenesis inhibitors.Common adverse drug reactions(ADRs)in anlotinib-treated patients included hypertension(67.4%),hand-foot syndrome(43.9%),hemoptysis(14.0%),thyroid stimulating hormone(TSH)elevation(46.6%),and corrected QT interval(QTc)prolongation(26.2%).Short conclusion:Anlotinib demonstrated a clinically significant OS prolongation as a novel therapeutic option for advanced or metastatic NSCLC following at least two lines of chemotherapy. | Ming Zhou Xiaoyuan Chen Hong Zhang Lin Xia Xin Tong Limin Zou Ruimin Hao Jianhong Pan Xiao Zhao Dongmei Chen Yuanyuan Song Yueli Qi Ling Tang Zhifang Liu Rong Gao Yuankai Shi Zhimin Yang | 2019 | Cancer Communications2019，39，1： | 35 |
| 3 | Distribution of polybrominated diphenyl ethers and decabromodiphenylethane in surface sediments from Fuhe River and Baiyangdian Lake,North China显示文摘Nineteen surface sediment samples collected from Baiyangdian Lake and its inflowing river (Fuhe River) in North China were analyzed for polybrominated diphenyl ethers (PBDEs) and decabromodiphenylethane (DBDPE).The concentrations of PBDEs and DBDPE in sediments ranged from 5.5 to 300.7 ng/g dry weight (dw) and 1.1 to 68.2 ng/g dw,respectively.Their levels in sediments in Fuhe River were significantly higher than those in Baiyandian Lake.Compared to data from other regions,the PBDE levels in surface sediments from Baiyangdian Lake and Fuhe River were in the medium to lower range.Among the PBDE congeners,BDE209 was predominant,with contributions to the total PBDEs ranging from 79.4% to 97.3% in sediment samples.For the lowly brominated congeners (tri-to hepta-BDE),BDE47 and BDE99 were the most abundant,which contributed 52.1% and 44.1% to the sum of tri-to hepta-BDEs in the sediments from Baiyangdian Lake and Fuhe River,respectively.The compositional patterns of PBDEs in Baiyangdian Lake sediments indicated that technical deca-BDE mixture was the major pollutant sources with a minor contribution of penta-BDE mixture.The present study suggested that the importance of Fuhe River as a possibly potential sources of PBDEs contamination in Baiyangdian Lake. | Guocheng Hu Zhencheng Xu Jiayin Dai Bixian Mai Hong Cao Jianshe Wang Zhimin Shi Muqi Xu | 2010 | Journal of Environmental Sciences2010，22，12： | 18 |
| 4 | 中国国家药品监督管理局批准安罗替尼用于经两种系统化疗后疾病进展的晚期非小细胞肺癌的治疗显示文摘背景2018年5月8日,中国国家药品监督管理局(National Medical Products Administration,NMPA)批准了小分子多靶点抗血管抑制剂盐酸安罗替尼,用于既往经过至少两种系统化疗后疾病进展的晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的治疗。概要中国NMPA审查了一项随机双盲、安慰剂对照的III期临床试验,该临床试验的主要终点为总生存期(overall survival,OS)。试验共纳入437例患者随机分组(2∶1)接受安罗替尼(n=294)或安慰剂(n=143)治疗,每日1次,连服2周,停药1周。表皮生长因子受体(epidermal growth factor receptor,EGFR)基因敏感突变或间变性淋巴瘤激酶(activating anaplasticlymphomakinase,ALK)阳性的患者须经过NMPA已批准的药物治疗后出现疾病进展。安罗替尼为中国NMPA批准的用于治疗既往经过两种及以上系统化疗后疾病进展的晚期NSCLC患者的首个药物。安罗替尼组的中位OS(9.46个月)较安慰剂组[6.37个月;风险比(hazard ratio,HR)=0.70,95%置信区间(confidence Interval,CI):0.55–0.89;双侧log-rank P=0.002]显著延长。安罗替尼组的客观缓解率(objective responserate,ORR)为9.2%,安慰剂组为0.7%。安罗替尼组的中位缓解持续时间(durationofresponse,DoR)为4.83个月,95%CI为3.31–6.97个月。安罗替尼的常见不良反应(adverse drug reactions,ADRs)包括高血压(67.4%)、手足综合征(43.9%)、咳血(14.0%)、促甲状腺激素(thyroid stimulating hormone,TSH)升高(46.6%)、心电图QT间期(corrected QT Interval,QTc)延长(26.2%)。结论安罗替尼显著延长了患者的OS,可作为经二线及以上化疗后晚期或转移性非小细胞肺癌的一种新的治疗方案。 | Ming Zhou Xiaoyuan Chen Hong Zhang Lin Xia Xin Tong Limin Zou Ruimin Hao Jianhong Pan Xiao Zhao Dongmei Chen Yuanyuan Song Yueli Qi Ling Tang Zhifang Liu Rong Gao Yuankai Shi Zhimin Yang | 2019 | 癌症2019，38，12： | 7 |
| 5 | Protective effects of human umbilical cord mesenchymal stem cell-derived conditioned medium on ovarian damage显示文摘Chemotherapeutic agents are extensively used to treat malignancies.However,chemotherapy-induced ovarian damage and reduced fertility are severe side effects.Recently,stem cell transplantation has been reported to be an effective strategy for premature ovarian insufficiency(POI)treatment,but safety can still be an issue in stem cell-based therapy.Here,we show the protective effects of human umbilical cord mesenchymal stem cell-derived conditioned medium(hUCMSC-CM)on a cisplatin(Cs)-induced ovarian injury model.hUCMSC-CM can relieve Cs-induced depletion of follicles and preserve fertility.In addition,hUCMSC-CM can decrease apoptosis of oocytes and granulosa cells induced by Cs.RNA sequencing analysis reveals the differentially expressed genes of ovaries after Cs and hUCMSC-CM treatments,including genes involved in cell apoptosis.Furthermore,we show that the granulocyte colony-stimulating factor(G-CSF)/phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt)pathway plays an important role in protecting granulosa cells from Cs-induced apoptosis.Together,we confirm the protective effects of hUCMSC-CM on ovarian reserve and fertility in mice treated with Cs,highlighting the remarkable therapeutic effects of hUCMSC-CM. | Liming Hong Long Yan Zhimin Xin Jie Hao Wenjing Liu Shuyu Wang Shujie Liao Hongmei Wang Xiaokui Yang | 2020 | Journal of Molecular Cell Biology2020，12，5： | 7 |
| 6 | Rare earth element geochemistry of hydrothermal deposits from Southwest Indian Ridge显示文摘The REE compositions of hydrothermal deposits and basalt samples from the Southwest Indian Ridge (SWIR) were determined with ICP-MS.The results show that there are significant differences between different types of samples although all samples show relative LREE enrichment.The contents of REE in hydrothermal sulfides and alterated rocks samples are lower (from 7.036 × 10 6 to 23.660 × 10 6),while those in the white chimney deposits are relatively higher (ranging from 84.496 × 10 6 to 103.511 × 10 6).Both of them are lower than basalts.Chondrite-normalized REE distribution patterns show that sulfides and alterated rocks samples are characterized by significant positive Eu anomalies.On the contrary,white chimney deposits have obvious negative Eu anomalies,which may be caused by abundant calcite existing in the white chimney samples.Both the content and distribution pattern of REE in sulfides suggest that REE most possibly is originally derived from hydrothermal fluids,but influenced by the submarine reducing ore-forming environment,seawater convection,mineral compositions as well as the constraint of mineral crystallizations. | CAO Zhimin CAO Hong TAO Chunhui LI Jun YU Zenghui SHU Liping | 2012 | Acta Oceanologica Sinica2012，31，2： | 6 |
| 7 | Large-area chemical vapor deposition-grown monolayer graphene-wrapped silver nanowires for broad-spectrum and robust antimicrobial coating显示文摘抗菌剂系统的新类型着急地由于获得抵抗到通常在日常生活和医疗保健使用的抗菌素的病原的微生物引起的种类的出现被需要。在这研究,我们第一次开发了用途广泛、柔韧的抗菌剂薄电影涂层基于大区域的化学蒸汽免职(CVD ) 种包 graphene 的银 nanowires (AgNWs ) 。抗菌剂 graphene/AgNW 混血儿涂层能在塑料由一个完整的 roll-to-roll 过程拍摄的商业灵活透明乙烯乙烯基 acetate/ 聚乙烯 terephthalate (EVA/PET ) 上被使用。graphene/AgNW 混血儿涂层显示出用途广泛的抗菌剂活动对克否定(Escherichia coli ) 并且克积极的细菌(葡萄球菌 aureus ) ,和真菌(Candida albicans ) 。这效果被归因于一个更弱的微生物引起的附件到极端光滑的 graphene 电影和 Ag+ 的消毒能力,它 sustainably 被免除 AgNWs 并且大概由 AgNWs 的电气化学的腐蚀提高了。而且, graphene/AgNW 涂层的柔韧的抗菌剂活动被 graphene 被 AgNW 封装增强。而且,抗菌剂效率能走水路百分之百被提高到 ~ 由把传导性的 graphene/AgNW 涂层用作阴极的电解。我们开发了用 graphene/AgNW/EVA/PET 和由 graphene/ AgNW 涂的一颗抗菌剂假牙做的一个透明、灵活的抗菌剂封面,到表演抗菌剂材料的潜在的应用程序。 | Chen Zhao Bing Deng Guanchu Chen Bo Lei Hong Hua Hailin Peng Zhimin Yan | 2016 | Nano Research2016，9，4： | 3 |
| 8 | Transition metal-mediated catalytic properties of gold nanoclusters in aerobic alcohol oxidation显示文摘Heteroatom 掺杂物能极大地修改电子、物理的性质和金 nanoclusters 的催化性能。在这研究,我们调查催化活动[Au 25x(PET)18x M ] NH 3( 宠物 = 2-phenylethanethiolate,和 M = Cu,公司, Ni,和 Zn ) 在氧气的白酒氧化的 nanoclusters。[Au 25x(PET)18x M ] NH 3 nanoclusters 被矩阵彻底地描绘帮助激光解吸附作用电离(MALDI ) 质量 spectrometry, X 光检查光电子光谱学(XPS ) , Fourier 变换红外线的光谱学(英尺红外) ,和诱导地联合的血浆团 spectrometry (ICPMS ) 。XPS 分析建议转变金属强烈与 nanoclusters 的金原子交往。CeO 2-supported nanoclusters 表演催化活动基于本甲基酒精的变换,在顺序,[Au 25x(PET)18x Ni ]>[Au 25x(PET)18x Cu ]>[Au 25x(PET)18x Zn ]>[Au 25x(PET)18x 公司] 。关于产品选择,[Au 25x(PET)18x Zn ] 并且[Au 25x(PET)18x 公司] 催化剂最好产出 benzaldehyde,[Au 25x(PET)18x Cu ] 收益 benzaldehyde 和本甲基酸,并且[Au 25x(PET)18x Ni ] 收益本甲基酸。暴露的金属原子被看作催化活跃地点。另外,催化表演(包括的活动和选择)[Au 25x(PET)18x M ] 催化剂被转变金属类型极大地转并且调停。 | Chaolei Zhang Yongdong Chen Hong Wang Zhimin Li Kai Zheng Shujun Li Gao Li | 2018 | Nano Research2018，11，4： | 3 |
| 9 | Augmented renal clearance in Chinese intensive care unit patients after traumatic brain injury: a cross-sectional study显示文摘To the Editor:Augmented renal clearance(ARC)refers to an enhanced elimination of circulating solutes,including drugs,by the kidneys at a rate statistically higher than normal.On the first day of intensive care unit(ICU)admission,ARC occurrence may predict continued creatinine clearance(CrCl)elevation for 1 day to several weeks.[1]ARC has a substantial adverse effect on renally cleared antibiotics'pharmacokinetics/pharmacodynamics.Treatment failure or worse outcomes are more frequent in ARC patients.Thus,a'one size fits all'approach to drug dosing in ARC patients is inappropriate;dosing requires adjustment for some variables. | Zilong Dang Hong Guo Bin Li Maohua Zhen Jian Liu Yuhui Wei Hongyan Qin Zhimin Dou Lei Zhang Lei Zhu Yongqiang Cao Fengjiao Li Xinan Wu | 2022 | Chinese Medical Journal2022，，6： | 3 |
| 10 | A non-metabolic function of hexokinase 2 in small cell lung cancer:promotes cancer cell stemness by increasing USP11-mediated CD133 stability显示文摘Background:Maintenance of cancer stem-like cell(CSC)stemness supported by aberrantly regulated cancer cell metabolism is critical for CSC self-renewal and tumor progression.As a key glycolytic enzyme,hexokinase 2(HK2)plays an instrumental role in aerobic glycolysis and tumor progression.However,whether HK2 directly contribute to CSC stemness maintenance in small cell lung cancer(SCLC)is largely unclear.In this study,we aimed to investgate whether HK2 independent of its glycolytic activity is directly involved in stemness maintenance of CSC in SCLC.Methods:Immunoblotting analyses were conducted to determine the expression of HK2 in SCLC CSCs and their differentiated counterparts.CSC-like properties and tumorigenesis of SCLC cells with or without HK2 depletion or overexpression were examined by sphere formation assay and xenograft mouse model.Immunoprecipitation and mass spectrometry analyses were performed to identify the binding proteins of CD133.The expression levels of CD133-associated and CSC-relevant proteins were evaluated by immunoblotting,immunoprecipitation,immunofluorescence,and immunohistochemistry assay.RNA expression levels of Nanog,POU5F1,Lin28,HK2,Prominin-1 were analyzed through quantitative reverse transcription PCR.Polyubiquitination of CD133 was examined by in vitro or in vivo ubiquitination assay.CD133+cells were sorted by flow cytometry using an anti-CD133 antibody.Results:We demonstrated that HK2 expression was much higher in CSCs of SCLC than in their differentiated counterparts.HK2 depletion inhibited CSC stemness and promoted CSC differentiation.Mechanistically,nonmitochondrial HK2 directly interacted with CD133 and enhanced CD133 expression without affecting CD133 mRNA levels.The interaction of HK2 and CD133 promoted the binding of the deubiquitinase ubiquitin-specific protease 11(USP11)to CD133,thereby inhibiting CD133 polyubiquitylation and degradation.HK2-mediated upregulation of CD133 expression enhanced the expression of cell renewal regulators,SCLC cell stemness,and tumor growth in mice.In addition,HK2 expression was positively correlated with CD133 expression in human SCLC specimens,and their expression levels were associated with poor prognosis of SCLC patients.Conclusions:These results revealed a critical non-metabolic function of HK2 in promotion of cancer cell stemness.Our findings provided new insights into the multifaceted roles of HK2 in tumor development. | Juhong Wang Fei Shao Yannan Yang Wei Wang Xueying Yang Renda Li Hong Cheng Sijin Sun Xiaoli Feng Yibo Gao Jie He Zhimin Lu | 2022 | Cancer Communications2022，42，10： | 2 |
| 11 | Comparison of Different Loading Dose of Celecoxib on Postoperative Anti-inflammation and Analgesia in Patients Undergoing Endoscopic Nasal Surgery—200 mg Is Equivalent to 400 mg显示文摘 | Hong Zhao Yi Feng Ying Wang Baxian Yang Zhimin Xing | 2011 | Pain Medicine2011，，8： | 1 |
| 12 | Estimation of mean in randomized response surveys when answers are incompletely truthful 显示文摘 | Hong Zhimin | 2006 | Model Assisted Statistics and Applications2006，1，4： | 1 |
| 13 | A one-model approach to congestion in data envelopment analysis显示文摘 | W.W.Cooper Hong hui Deng Zhimin M.Huang Su san X.Li | | 0，，04： | 1 |
| 14 | Effect of arotinolol on right ventricular function in patients with dilated cardiomyopathy显示文摘Objective Dilated cardiomyopathy(DCM) is generally considered to be accompanied by both left and right ventricular dysfunction,but most studies only analyze the left ventricular function. In this study,we evaluated the effect of arotinolol on right ventricular function in patients with DCM. Methods Right ventricular ejection fraction(RVEF) and right ventricular diameter(RVD) were measured by two-dimensional echocardiography(2-DE) in 33 DCM patients;RVEF measured by first-pass radionuclide angiography(FPRA) was compared with that by 2-DE. Results The treatment with arotinolol for one year resulted in a reduction in the right ventricular diameter(baseline,23.0 ± 8.3 mm vs after one-year treatment,20.7 ± 5.4 mm;P=0.004 ) and an associated increase in ejection fraction(baseline,36.9 ± 10.3% vs after one-year treatment,45.8 ± 9.6%;P < 0.001 ) ;there is a high correlation between the 2-DE method and radionuclide ventriculographic method. The correlation coefficient is 0.933(P<0.001) . Conclusion Arotinolol therapy could not only improve left ventricular function,but also improve right ventricular function in DCM patients. | Hong Yang Li Xu Yongkang Tao Zhimin Xu Xiuqing Du Naqiang Lu Kefei Dou Jinglin Zhao Xianqi Yuan Yanfen Zhao Rongfang Shi Chaomei Fan | 2007 | Journal of Geriatric Cardiology2007，4，3： | 1 |
| 15 | Electrochemical reduction of pyrite in aqueous NaCl solution 显示文摘 | Zhao Wei Zhu Hong Zong Zhimin | 2005 | Fuel2005，84，： | 1 |
| 16 | Soybean oil‐chitosan emulsion affects internal quality and shelf‐life of eggs stored at 25 and 4 °C显示文摘 | Wisdom Wardy Damir D. Torrico José A. Herrera Corredor Hong Kyoon No Xiumei Zhang Zhimin Xu Witoon Prinyawiwatkul | 2013 | Int J Food Sci Technol2013，，6： | 1 |
| 17 | Estimation of mean in randomized re-sponse surveys when answers are incompletely truthful显示文摘 | Hong Zhimin | | 0，，01： | 1 |
| 18 | Estimation of mean in randomized response surveys when answers are incompletely trutMul显示文摘 | Hong Zhimin | 2006 | Model Assisted Statistics and Applications2006，1，4： | 1 |
| 19 | Big Wave of the Intelligent Connected Vehicles显示文摘Internet of things is deemed as the one of the great revolution after the age of Industrial Revolution.With the development of the communication technology,more and more entities are connected to the communication network and become one of the elements in the network.Over recent decades,in the area of intelligent transportation,pedestrian and transport infrastructure are connected to the communication network to improve the driving safety and traffic efficiency which is known as the ICV(Intelligent Connected Vehicle).This paper summarizes the global ICV progresses in the past decades and the latest activities of ICV in China,and introduces various aspects regarding the recent development of the ICV,including industry development,spectrum and standard,at the same time. | Yan Li Yiqing Cao Hong Qiu Lu Gao Zhimin Du Shuping Chen | 2016 | China Communications2016，13，S2： | 1 |
| 20 | Finding the WDB's query interface in deep web automatically显示文摘 | LIN Peiguang XU Ruzhi HONG Zhimin | 2008 | IEEE Computer Society2008，，： | 1 |
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