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| 1 | Altered regional homogeneity in post-traumatic stress disorder: a resting-state functional magnetic resonance imaging study显示文摘Objective Little is known about the brain systems that contribute to vulnerability to post-traumatic stress disorder (PTSD). Comparison of the resting-state patterns of intrinsic functional synchronization, as measured by functional magnetic resonance imaging (fMRI), between groups with and without PTSD following a traumatic event can help identify the neural mechanisms of the disorder and targets for intervention. Methods Fifty-four PTSD patients and 72 matched traumatized subjects who experienced the 2008 Sichuan earthquake were imaged with blood oxygen level-dependent (BOLD) fMRI and analyzed using the measure of regional homogeneity (ReHo) during the resting state. Results PTSD patients presented enhanced ReHo in the left inferior parietal lobule and right superior frontal gyrus, and reduced ReHo in the right middle temporal gyrus and lingual gyrus, relative to traumatized individuals without PTSD. Conclusion Our findings showed that abnormal brain activity exists under resting conditions in PTSD patients who had been exposed to a major earthquake. Alterations in the local functional connectivity of cortical regions are likely to contribute to the neural mechanisms underlying PTSD. | Yan Yin Changfeng Jin Lisa T. Eyler Hua Jin Xiaolei Hu Lian Duan Huirong Zheng Bo Feng Xuanyin Huang Baoci Shan Qiyong Gong Lingjiang Li | 2012 | Neuroscience Bulletin2012，28，5： | 9 |
| 2 | SETD8 induces stemness and epithelial–mesenchymal transition of pancreatic cancer cells by regulating ROR1 expression显示文摘Pancreatic cancer(PC)is one of the most deadly diseases,and its incidence is increasing year by year.The methyltransferase SETD8 has been demonstrated to play an important role in tumor cell proliferation and metastasis.However,little is known about whether SETD8 could affect the invasion and metastasis of PC and the mechanism underlying the regulation.Based on our previous report,here,we further found that SETD8 could promote the invasion and migration of PC cells by inducing the expression of receptor tyrosine kinase-like orphan receptor 1(ROR1).ROR1 was predominantly upregulated in PC tissues and was correlated with lymph node metastasis and worse prognosis.Mechanistically,SETD8 mediated ROR1 activity and regulated PC cells invasion and migration,although promoting the expression of stemness and epithelial–mesenchymal transition-related molecules.This promotion effect disappeared when the catalytically inactive mutant SETD8 was overexpressed,which could be counteracted by the SETD8-specific methyltransferase inhibitor UNC0379.Collectively,our results demonstrate that SETD8 may be a novel prognostic factor and a therapeutic target of PC. | Mengqi Liu Yihua Shi Qiangsheng Hu Yi Qin Shunrong Ji Wensheng Liu Qifeng Zhuo Guixiong Fan Zeng Ye Changfeng Song Xianjun Yu Xiaowu Xu Wenyan Xu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，12： | 2 |
| 3 | Effects of Kallistatin on Oxidative Stress and Inflammation on Renal Ischemia-Reperfusion Injury in Mice显示文摘 | Shuqin Zhou Yingying Sun Yugang Zhuang Wei Zhao Yuanzhuo Chen Bojie Jiang Changfeng Guo Zhonglin Zhang Hu Peng Yanqing Chen | 2015 | Current Vascular Pharmacology2015，，2： | 1 |
| 4 | Altered resting-state functional connectivity of thalamus in earthquake-induced posttraumatic stress disorder; A functional magnetic resonance imaging study显示文摘 | Yin Yan Jina Changfeng Hu Xiaolei | 2011 | Brail Research2011，1411，9： | 1 |
| 5 | Purification and identification of three novel antioxidant peptides from protein hydrolysate of bluefin leatherjacket(Navodon septentrionalis)skin显示文摘 | Chi Changfeng Wang Bin Hu Fayuan | 2014 | Food Research International2014，73，： | 1 |
| 6 | Bubbling solutions of fourth order mean field equations on S^(4)显示文摘In this paper,we first establish the existence of blow-up solutions with two antipodal points of the fourth order mean field equations on S^(4).Moreover,we construct non-axially symmetric solutions with blow-up points at the vertices of regular configurations,i.e.,equilateral triangles on a great circle,regular tetrahedrons,cubes,octahedrons,icosahedrons and dodecahedrons.The bubbling rates of these blow-up solutions rely on various bubbling configurations. | Changfeng Gui Yeyao Hu Weihong Xie | 2023 | Science China Mathematics2023，66，6： | 0 |
| 7 | Electrochemical oxidative cyclization of alkenes,boronic acids,and dichalcogenides to access chalcogenated boronic esters and 1,3-diols显示文摘A sustainable,environmentally benign electrochemical oxidative three-component cyclization of allylic alcohols,boronic acids,and dichalcogenides under metal-free and oxidant-free conditions has been developed,which provides an efficient approach for the formation of C–Se/S and C–O bonds together.A series of chalcogenated boronic esters were afforded with a broad substrate scope through a clean electrochemical system.The resulting chalcogenated cyclic boronic esters were easily converted to chalcogenated 1,3-diols in good yields under mild conditions. | Changfeng Huang Jijing Hu Guangxian Chen Minjian Wu Hua Cao Xiang Liu | 2022 | Organic Chemistry Frontiers2022，9，1： | 0 |
| 8 | A highly conserved amino acid in high molecular weight glutenin subunit 1Dy12 contributes to gluten functionality and processing quality in wheat显示文摘Bread wheat(Triticum aestivum L.)is one of the most commonly consumed staples worldwide,with widespread uses in foods such as breads,noodles,cakes,and cookies(Veraverbeke and Delcour,2002).The specific cooking properties of wheat products are mainly conferred by the gluten proteins contained in wheat grains(Delcour et al.,2012).High molecular weight glutenin subunits(HMW-GSs)are important constituents of wheat gluten proteins,largely determining gluten elasticity and processing quality(Branlard and Dardevet,1985;Payne et al.,1988). | Changfeng Yang Qian Chen Mingming Xin Zhenqi Su Jinkun Du Weilong Guo Zhaorong Hu Jie Liu Huiru Peng Zhongfu Ni Qixin Sun Yingyin Yao | 2023 | Journal of Genetics and Genomics2023，50，11： | 0 |
| 9 | An Environmentally Benign Catalytic Method for Versatile Synthesis of 1,4-Dihydropyridines via Multicomponent Reactions显示文摘The synthesis of diverse 1,4-dihydropyridines have been achieved via the multicomponent reactions of aldehydes,enaminones and amines.The reactions have been smoothly performed in water to provide all products with moderate to excellent yields by using lactic acid as a green catalyst. | Shuo Cao Shanshan Zhong Changfeng Hu Jie-Ping Wan Chengping Wen | 2015 | Chinese Journal of Chemistry2015，33，5： | 0 |
| 10 | Sequence and modified group analysis on C-terminal modified analogs of endomorphin-2 using electrospray ionization-Fourier transform ion cyclotron resonance mass spectrometer显示文摘In this paper, a series of C-terminal modified analogs of endomorphin-2 is investigated using ESI-FT-ICR-MS. Some b, y″, a, and internal ions are found in the CID spectra and slight mass differ- ences between the calculated and observed results are obtained. Moreover, if the C-terminal modified group is t-butyloxy, it can lose butene through McLafferty rearrangement. FT-ICR MS shows its power in peptide sequencing successfully helping us obtain the structure of peptide analogs. | ZHU ChuanJun HU ChangFeng SHAO Xuan YAO JinLong WANG ChangLin WANG Rui CUI YuXin | 2008 | Science China Chemistry2008，51，1： | 0 |
| 11 | Microwave Assisted Preparation of Monodisperse Polymeric Microspheres and Its Morphologies and Kinetics显示文摘The emulsifier-free emulsion polymerization of N-hydroxymethyl acrylamide (NMA), methyl methacrylate (MMA) and styrene (St) was successfully carried out under microwave irradiation, and monodisperse polymeric microspheres were prepared. The experimental results show that the emulsifier-free emulsion polymerization under microwave irradiation has more rapid reaction rate, higher conversion and shorter induction time than the copolymerization with conventional heating. The apparent activation energies are 61.04 and 83.75 kJ/mol, respectively; the microspheres have spherical morphology, and the microspheres prepared by emulsifier-free emulsion polymerization under microwave irradiation are smaller, more uniform than those obtained with conventional heating. | 严微 HU Xiaoxi ZHANG Gangshen DENG Min YI Changfeng 徐祖顺 | 2012 | Journal of Wuhan University of Technology(Materials Science)2012，27，6： | 0 |
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