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20篇 您的检索式:作者名="Haiming Tang"
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1Matrine attenuates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via maintaining AMPKα/UCP2 pathway显示文摘Oxidative stress and cardiomyocyte apoptosis are involved in the pathogenesis of doxorubicin(DOX)-induced cardiotoxicity. Matrine is well-known for its powerful anti-oxidant and anti-apoptotic capacities. Our present study aimed to investigate the effect of matrine on DOX-induced cardiotoxicity and try to unearth the underlying mechanisms. Mice were exposed with DOX to generate DOX-induced cardiotoxicity or normal saline as control. H9 C2 cells were used to verify the effect of matrine in vitro.DOX injection triggered increased generation of reactive oxygen species(ROS) and excessive cardiomyocyte apoptosis, which were significantly mitigated by matrine. Mechanistically, we found that matrine ameliorated DOX-induced uncoupling protein 2(UCP2) downregulation, and UCP2 inhibition bygenipin could blunt the protective effect of matrine on DOX-induced oxidative stress and cardiomyocyte apoptosis. Besides, 50-AMP-activated protein kinase α2(Ampkα2) deficiency inhibited matrine-mediated UCP2 preservation and abolished the beneficial effect of matrine in mice. Besides, we observed that matrine incubation alleviated DOX-induced H9 C2 cells apoptosis and oxidative stress level via activating AMPKα/UCP2, which were blunted by either AMPKα or UCP2 inhibition with genetic or pharmacological methods. Matrine attenuated oxidative stress and cardiomyocyte apoptosis in DOX-induced cardiotoxicity via maintaining AMPKα/UCP2 pathway, and it might be a promising therapeutic agent for the treatment of DOX-induced cardiotoxicity.Can Hu Xin Zhang Wenying Wei Ning Zhang Haiming Wu Zhenguo Ma Lingli Li Wei Deng Qizhu Tang 2019Acta Pharmaceutica Sinica B2019,9,4:25
26–100 GHz research progress and challenges from a channel perspective for fifth generation(5G)and future wireless communication显示文摘Radio frequency is a valuable resource for wireless communication systems. The high-frequency band from 6 GHz up to 100 GHz, where continuous and broad spectra exist, is promising to meet the high spectrum requirement of fifth generation(5G) mobile communication systems by 2020. To date, many groups from academia and industry have contributed to devising approaches to allocate and utilize frequency resources from 6 GHz to 100 GHz for 5G and future wireless communication systems. In this paper, we present global efforts to allocate potential frequency bands and field trial progress from 6 GHz to 100 GHz for 5G. From a channel perspective, we summarize research progress and challenges, including channel measurement platforms and channel parameter analysis, both of which are important to extract the inherent channel characteristics and use a high-frequency band for 5G and future wireless communication systems.Jianhua ZHANG Pan TANG Lei TIAN Zhixue HU Tan WANG Haiming WANG 2017Science China(Information Sciences)2017,60,8:14
3Research progress on aging of organic pollutants in geosorbents:a review显示文摘Geosorbents are the main host of anthropogenic organic pollutants and play a vital role in their fate and transport in the natural environment.Soil and sediment are the most common and abundant geosorbents in the natural environment;their interactions with organic pollutants,especially sorption and desorption processes,have been extensively studied from the perspectives of thermodynamics and kinetics.Recently,the aging of organic pollutants in geosorbents has drawn increased attention,leading to an improved understanding of interactions between organic pollutants and geosorbents and informing remediation criteria.Aging has been deemed important in accurately assessing ecologic and health risks of organic pollutants,and both positive and negative impacts have been reported in studies of natural and artificial sorbents.This paper summarizes recent research progress on organic pollutant aging in geosorbents,including related mechanism research,influence factors,bioavailability assessments,and biological and physicochemical remediation of aged organic pollutants.We also discuss issues in the current research and bring forward suggestions for future study.Xianjin An Baohua xiao Xinyue Di Hui Dong Haiming Tang 2017Acta Geochimica2017,36,1:3
4Clinical significance of interventional therapeutic bronchoscopy combined with bronchial arterial embolization in the treatment of hypervascular primary airway tumors in children显示文摘Importance Pediatric hypervascular primary airway tumors are progressive,fatal lesions with a low incidence,and the disease is often more serious than that in adults.Objective To evaluate the clinical efficacy and safety of interventional therapeutic bronchoscopy combined with conservative treatment and bronchial arterial embolization in children with primary airway tumors.Methods We retrospectively analyzed the clinical data of four pediatric patients with hypervascular primary airway tumor between 2017 and 2019 at Beijing Children’s Hospital.Results Two patients were low-grade bronchial mucoepidermoid carcinoma,one patient was pleomorphic adenoma,and one was bronchial leiomyoma.Interventional therapeutic bronchoscopy combined with bronchial arterial embolization was used for treatment(all four patients received general anesthesia).The tumors were safely resected in all patients via interventional bronchoscopy.There were no severe complications related to the procedures.All patients were followed up for 5–12 months,and one low-grade bronchial mucoepidermoid carcinoma recurred.Interpretation Interventional therapeutic bronchoscopy combined with bronchial arterial embolization appears to be a safe and efficient therapeutic method associated with less trauma and fewer complications,including no serious adverse events,in children with hypervascular primary airway tumors without bronchus wall infiltration.Haiming Yang Jie Yin Xiaolei Tang Gan Li Huimin Li Shunying Zhao 2021Pediatric Investigation2021,5,2:2
5Integration designs toward new-generation wearable energy supply-sensor systems for real-time health monitoring:A minireview显示文摘Wearable sensing systems,as a spearhead of artificial intelligence,are playing increasingly important roles in many fields especially health monitoring.In order to achieve a better wearable experience,rationally integrating the two key components of sensing systems,that is,power supplies and sensors,has become a desperate requirement.However,limited by device designs and fabrication technologies,the current integrated sensing systems still face many great challenges,such as safety,miniaturization,mechanical stability,energyefficiency,sustainability,and comfortability.In this review,the key challenges and opportunities in the current development of integrated wearable sensing systems are summarized.By summarizing the typical configurations of diverse wearable power supplies,and recent advances concerning the integrated sensing systems driven by such power supplies,the representative integrated designs,and micro/nanofabrication technologies are highlighted.Lastly,some new directions and potential solutions aiming at the device-level integration designs are outlooked.Yongchao Tang Xuejin Li Haiming Lv Wenlong Wang Chunyi Zhi Hongfei Li 2020InfoMat2020,2,6:2
6Giant Electrocaloric Response Over A Broad Temperature Range in Modified BaTiO<sub>3</sub> Ceramics显示文摘Xiao‐Shi Qian Hui‐Jian Ye Ying‐Tang Zhang Haiming Gu Xinyu Li C. A. Randall Q. M. Zhang 2014Adv Funct Mater2014,,9:1
7Shape evolution and thermal stability of Ag nanoparticleson spherical SiO2substrates显示文摘Shaochun Tang Shaopeng Zhu Haiming Lu XiangkangMeng 2008Journal of Solid State Chemis-try2008,181,3:1
8Deployment and Exploration of a Gas Storage Well Pattern Based on the Threshold Radius显示文摘To tackle the problem that wells that are deployed in a specific pattern based on the requirements of gas reservoir development are not suitable for gas storage,we have conducted concentrically circular injection and production simulation experiments for gas storage,discovered the existence of a threshold radius,denoted by Rt,and derived the expression for Rt.Based on the analysis and discussion results,we propose a strategy for deploying gas storage wells in specific patterns.The expression for Rt shows that it is affected by factors such as the gas storage gas production/injection time,the upper pressure limit,the lower pressure limit,the bottomhole flow pressure at the ends of injection and production,the and permeability.The analysis and discussion results show that the Rt of a gas storage facility is much smaller than the Rt for gas reservoir development.In the gas storage facilities in China,the Rt for gas production is less than the Rt for the gas injection,and Rt increases with the difference in the operating pressure and with permeability K.Based on the characteristics of Rt,we propose three suggestions for gas storage well pattern deployment:(1)calculate Rt according to the designed functions of the gas storage facility and deploy the well pattern according to Rt;(2)deploy sparser,large-wellbore patterns in high-permeability areas and denser,small-wellbore patterns in high-permeability areas;and(3)achieve the gas injection well pattern by new drilling,and the gas production well pattern through a combination of the gas injection well pattern and old wells.By assessing a gas storage facility with a perfect well pattern after a number of adjustments,we found that the Rt of the 12 wells calculated in this paper is basically close to the corresponding actual radius,which validates our method.The results of this study provide a methodological basis for well pattern deployment in new gas storage construction.TANG Ligen ZHU Weiyao ZHU Huayin SUN Chunhui YANG Fenglai WANG Yan Li Xiaorui Li Haiming CHU Guangzhen WANG Jieming KONG Debin YUE Ming LIU Yuwei HUANG Kun 2021Acta Geologica Sinica(English Edition)2021,95,2:1
9Hook Wire Localization of Pulmonary Pure Ground-Glass Opacities for Video-Assisted Thoracoscopic Surgery显示文摘Weizhao Huang Hongyu Ye Yingmeng Wu Wei Xu Xuan Tang Yi Liang Junmeng Zheng Haiming Jiang 2013Thorac cardiovasc Surg2013,,:1
10Direct Imaging of Molecular Orbitals of Metal Phthalocyanines on Metal Surfaces with an O2-Functionalized Tip of a Scanning Tunneling Microscope显示文摘Au (111 ) 上的铁酞毒和锌酞毒分子的高分辨率的扫描通道显微镜图象用一台扫描通道显微镜(STM ) 的一个 functionalized 尖端被获得了,并且显示出没用干净尖端被观察的富有的 intramolecular 特征。Ab initio 密度功能的理论计算和扩大 H?Zhihai Cheng Shixuan Du Wei Guo Li Gao Zhitao Deng Nan Jiang Haiming Guo Hao Tang H. J. Gao 2011Nano Research2011,4,6:1
11Interaction of Ca^(2+) and soil humic acid characterized by a joint experimental platform of potentiometric titration, UV–visible spectroscopy, and fluorescence spectroscopy显示文摘Rocky desertification has become a major environmental issue in the karst region of southwestern China.Karst rocky desertification was more severe in regions of limestone soil than in adjacent regions of other soils,despite the relatively higher soil organic matter(SOM)content in limestone soil.The underlying mechanism remains ambiguous.We speculated that the geochemical characteristics of limestone soils in the karst region plays an essential role,especially the high calcium content of limestone soil.To test this hypothesis,we collected limestone soil samples from a limestone soil profile in the southwestern China karst region and extracted humic acid(HA)from these limestone soil samples.We investigated the interaction of Ca^(2+)and three HA samples on a joint experimental platform,which consists of an automatic potentiometric titrator,a UV–visible spectrometer,and a Fluorescence spectrometer.HA solutions were titrated by Ca^(2+)and optical spectra of the HA solutions were monitored during the titration experiments.The results indicated that:(1)the interaction of Ca^(2+)and HA is a combined process of adsorption and complexation.Adsorption dominated the overall distribution behavior of Ca^(2+),which could be fit by Langmuir and Freundlich isotherm models.Complexation was distinguished only when the concentration of Ca2+is low;(2)the changes of UV–visible spectroscopy and excitation–emission matrix fluorescencespectroscopy spectra of HA samples when they were binding with Ca^(2+)implied the apparent molecular size and structure of HA became larger and more complex;(3)the combination of Ca^(2+)and HA plays an important role in the SOM preservation of limestone soils but the stability of the Ca–HA association was relatively weak.The present study draws attention to maintaining the relatively higher Ca^(2+)concentration in limestone soils in ecologic restoration attempts in karst regions.Haiming Tang Baohua Xiao Peiwen Xiao 2021Acta Geochimica2021,40,3:1
12The effects of soil sand contents on characteristics of humic acids along soil profiles显示文摘It is generally accepted that the compositions and properties of soil organic matter(SOM) are in?uenced by many factors. In order to reveal the effects of soil texture on characteristics and dynamics of SOM and its sub-fraction,humic acid(HA), along two soil pro?les, a yellow soil pro?le and a purplish soil pro?le, under the same climate and vegetation conditions were determined. Results indicate that the decomposition and humi?cation degrees of SOM and HA of the purplish soils are higher than those of the corresponding yellow soils indicated by A/O–A ratios of HAs, TOCs and HA yields of bulk soil samples, nevertheless, the development degree of the purplish soil is lower than that of the yellow soil. The variations of E_4/E_6 ratios of HAs along the soil pro?les indicate the overall molecular sizes of HAs decreased downward along the soil pro?les.A/O–A ratios of HAs decreased downward along both the soil pro?les indicate that humi?cation processes decrease downward along both the soil pro?les. Leaching of SOM shows signi?cant effects on the distribution and characteristics of HAs in the yellow soil pro?le but the purplish soil pro?le, which is consistent with the higher hydrophobicity of HAs in purplish soils, shows that the distribution characteristics of SOM along the soil pro?les are a complex result of the combination of soil texture and characteristics of SOM itself. The remarkably different sand contents are concluded tentatively as one of reasons to the different distributions and dynamics of HAs along the soil pro?les,however, to profoundly understand the evolution and transport of SOM along soil pro?les needs more researches.Xinyue Di Hui Dong Xianjin An Haiming Tang Baohua Xiao 2016Acta Geochimica2016,35,3:1
13A tree- based method of web service composition 显示文摘Haiming Tang Farong Zhongt Chang Yang 2008ICPCA2008,,2:1
14Design Rules of the Mixing Phase and Impacts on Device Performance in High-Efficiency Organic Photovoltaics显示文摘In nonfullerene acceptor-(NFA-)based solar cells,the exciton splitting takes place at both domain interface and donor/acceptor mixture,which brings in the state of mixing phase into focus.The energetics and morphology are key parameters dictating the charge generation,diffusion,and recombination.It is revealed that tailoringthe electronic properties of the mixing region by doping with larger-bandgap components could reduce the density of state but elevate the filling state level,leading to improved open-circuit voltage(V_(OC))and reduced recombination.The monomolecular and bimolecular recombinations are shown to be intercorrelated,which show a Gaussian-like relationship with V_(OC) and linear relationship with short-circuit current density(JSC)and fill factor(FF).The kinetics of hole transfer and exciton diffusion scale with JSC similarly,indicating the carrier generation in mixing region and crystalline domain are equally important.From the morphology perspective,the crystalline order could contribute to V_(OC) improvement,and the fibrillar structure strongly affects the FF.These observations highlight the importance of the mixing region and its connection with crystalline domains and point out the design rules to optimize the mixing phase structure,which is an effective approach to further improve device performance.Jingnan Song Ming Zhang Tianyu Hao Jun Yan Lei Zhu Guanqing Zhou Rui Zeng Wenkai Zhong Jinqiu Xu Zichun Zhou Xiaonan Xue Chun-Chao Chen Weihua Tang Haiming Zhu Zaifei Ma Zheng Tang Yongming Zhang Feng Liu 2022Research2022,,4:0
15Revealing alkali metal ions transport mechanism in the atomic channels of Au@a-MnO_(2)显示文摘Understanding alkali metal ions’(e.g.,Li^(+)/Na^(+)/K^(+))transport mechanism is challenging but critical to improving the performance of alkali metal batteries.Herein using a-MnO_(2)nanowires as cathodes,the transport kinetics of Li^(+)/Na^(+)/K^(+)in the 2×2 channels of a-MnO_(2)with a growth direction of[001]is revealed.We show that ion radius plays a decisive role in determining the ion transport and electrochemistry.Regardless of the ion radii,Li^(+)/Na^(+)/K^(+)can all go through the 2×2 channels of a-MnO_(2),generating large stress and causing channel merging or opening.However,smaller ions such as Li^(+)and Na^(+)cannot only transport along the[001]direction but also migrate along the<110>direction to the nanowire surface;for large ion such as K^(+),diffusion along the<110>direction is prohibited.The different ion transport behavior has grand consequences in the electrochemistry of metal oxygen batteries(MOBs).For Li-O_(2)battery,Li^(+)transports uniformly to the nanowire surface,forming a uniform layer of oxide;Na^(+)also transports to the nanowire surface but may be clogged locally due to its larger radius,therefore sporadic pearl-like oxides form on the nanowire surface;K^(+)cannot transport to the nanowire surface due to its large radius,instead,it breaks the nanowire locally,causing local deposition of potassium oxides.The study provides atomic scale understanding of the alkali metal ion transport mechanism which may be harnessed to improve the performance of MOBs.Jingzhao Chen Yong Su Hongjun Ye Yushu Tang Jitong Yan Zhiying Gao Dingding Zhu Jingming Yao Xuedong Zhang Tingting Yang Baiyu Guo Hui Li Qiushi Dai Yali Liang Jun Ma Bo Wang Haiming Sun Qiunan Liu Jing Wang Congcong Du Liqiang Zhang Yongfu Tang Jianyu Huang 2023Journal of Energy Chemistry2023,,7:0
16Direct transformation of n-alkane into all-trans conjugated polyene via cascade dehydrogenation显示文摘Selective C(sp^(3))-H activation is of fundamental importance in processing alkane feedstocks to produce high-value-added chemical products.By virtue of an on-surface synthesis strategy,we report selective cascade dehydrogenation of n-alkane molecules under surface constraints,which yields monodispersed all-trans conjugated polyenes with unprecedented length controllability.We are also able to demonstrate the generality of this concept for alkyl-substituted molecules with programmable lengths and diverse functionalities,and more importantly its promising potential in molecular wiring.Xuechao Li Kaifeng Niu Junjie Zhang Xiaojuan Yu Haiming Zhang Yuemin Wang Qing Guo Pengdong Wang Fangsen Li Zhengming Hao Chaojie Xu Yanning Tang Zhichao Xu Shuai Lu Peng Liu Guigu Xue Yen Wei Lifeng Chi 2021National Science Review2021,8,10:0
17Effect of Different Winter Cover Crops on Carbon Dioxide Emission in Paddy Field of Double Cropping Rice Area in Southern China显示文摘Haiming Tang Xiaoping Xiao WenguangTang Ouangli Yang 2013Journal of Environmental Science and Engineering(B)2013,2,9:0
18Geometric and Electronic Behavior of C60 on PTCDA Hydrogen Bonded Network显示文摘Self-assembled supramolecular networks are promising spacer layer for electronic decoupling from the metal substrate.However,the mechanism behind of how the intrinsic electronic structure of spacer layers affects the adsorbate is still unclear.Here a hydrogen bonded network composed of n-type semiconducting molecules 3,4,9,10-perylene-tetracarboxylic-dianhydride(PTCDA)is prepared under ultra-high vacuum to serve as a spacer layer for functional organics C60 on Au(111).The geometric and electronic information of C60 was investigated by scanning tunneling microscopy and scanning tunneling spectroscopy(STM/STS)at 5 K.Effective decoupling from the metal surface yields an energy gap of 3.67 eV for C602nd,merely considering the HOMO-LUMO peak separation.The broadening of resonance peaks in STS measurements however indicates unneglected interlayer interactions in this hetero-organic system.Moreover,we scrutinize the nucleation sites of C60 on PTCDA layer and attribute this to the decreased diffusion capability on a less dense molecular arrangement possessing inhomogeneous spatial distribution of unoccupied molecular orbitals.LI Ling LI Xuechao TANG Yanning XU Zhichao ZHANG Haiming CHI Lifeng 2020Chemical Research in Chinese Universities2020,36,1:0
19Targeting autophagy overcomes cancer-intrinsic resistance to CAR-T immunotherapy in B-cell malignancies显示文摘Background:Chimeric antigen receptor T(CAR-T)therapy has substantially revolutionized the clinical outcomes of patients with hematologic malignan-cies,but the cancer-intrinsic mechanisms underlying resistance to CAR-T cells remain yet to be fully understood.This study aims to explore the molecular deter-minants of cancer cell sensitivity to CAR-T cell-mediated killing and to provide a better understanding of the underlying mechanisms and potential modulation to improve clinical efficacy.Methods:The human whole-genome CRISPR/Cas9-based knockout screening was conducted to identify key genes that enable cancer cells to evade CD19 CAR-T-cell-mediated killing.The in vitro cytotoxicity assays and evaluation of tumor tissue and bone marrow specimens were further conducted to confirm the role of the key genes in cancer cell susceptibility to CAR-T cells.In addition,the specific mechanisms influencing CAR-T cell-mediated cancer clearance were elucidated in mouse and cellular models.Results:The CRISPR/Cas9-based knockout screening showed that the enrich-ment of autophagy-related genes(ATG3,BECN1,and RB1CC1)provided protec-tion of cancer cells from CD19 CAR-T cell-mediated cytotoxicity.These findings were further validated by in vitro cytotoxicity assays in cells with genetic and pharmacological inhibition of autophagy.Notably,higher expression of the three autophagy-related proteins in tumor samples was correlated with poorer respon-siveness and worse survival in patients with relapsed/refractory B-cell lymphoma after CD19 CAR-T therapy.Bulk RNA sequencing analysis of bone marrow samples from B-cell leukemia patients also suggested the clinical relevance of autophagy to the therapeutic response and relapse after CD19 CAR-T cell ther-apy.Pharmacological inhibition of autophagy and knockout of RB1CC1 could dramatically sensitize tumor cells to CD19 CAR-T cell-mediated killing in mouse models of both B-cell leukemia and lymphoma.Moreover,our study revealed that cancer-intrinsic autophagy mediates evasion of CAR-T cells via the TNF-α-TNFR1 axis-mediated apoptosis and STAT1/IRF1-induced chemokine signaling activation.Conclusions:These findings confirm that autophagy signaling in B-cell malig-nancies is essential for the effective cytotoxic function of CAR-T cells and thereby pave the way for the development of autophagy-targeting strategies to improve the clinical efficacy of CAR-T cell immunotherapy.Lu Tang Huan Zhang Fen Zhou Qiuzhe Wei Mengyi Du Jianghua Wu Chenggong Li Wenjing Luo Jie Zhou Xindi Wang Zhaozhao Chen Yinqiang Zhang Zhongpei Huang Zhuolin Wu Yuxi Wen Huiwen Jiang Danying Liao Haiming Kou Wei Xiong Heng Mei Yu Hu 2024Cancer Communications2024,44,3:0
20Saltwater intrusion into groundwater systems in the Mekong Delta and links to global change显示文摘In recent decades,changes in temperature,wind,and rainfall patterns of Southeast Asia induced by climate warming in the Tibetan Plateau result in many environmental changes that have serious impacts on the lower reach of the Mekong River basin,a region already battling severe water-related environmental problems such as pollution,saltwater intrusion,and intensified flooding.In the densely populated Mekong Delta located at the mouth of the Mekong River basin in southern Vietnam,the hydrogeological systems have been transformed from an almost undisturbed to a human-impacted state and saltwater intrusion into surface water and groundwater systems has grown to be a detrimental issue recently,seriously threatening freshwater supply and degrading the eco-environment.In this article,the impacts of human activities and climate change(e.g.,groundwater over-exploitation,relative sea-level rise,storm surge,changing precipitation and temperature regimes,uncontrolled drainage canals,operation of hydropower dams,and rapid development of aquaculture)on saltwater intrusion into groundwater systems in the Mekong Delta are briefly reviewed.Based on current status of research findings regarding saltwater intrusion and the subsequent groundwater quality degradation under the impacts of human activities and climate change,major knowledge gaps and challenges are identified and discussed,including thickness and permeability of the silt and clay aquitard,present-day highly heterogeneous 3D distribution of saline groundwater zones,dynamic variation of saltwater/freshwater transition zone,and the most effective and economical control measure.To bridge these gaps,future work should:1)apply environmental isotope techniques in combination with borehole tests to gain detailed hydrogeological information regarding spatial variation of permeability and thickness of the silt and clay aquitard;2)intensify regular groundwater monitoring and collect as much groundwater samples from multiple hydro-stratigraphic units at different depths as possible to visualize the present-day highly heterogeneous 3D distribution of saline groundwater;3)develop a series of variable-density coupled groundwater flow and salt transport models representing various scenarios of human activities and climate change for predicting future extent of saltwater intrusion;and 4)identify the dominant factor causing saltwater intrusion and determine the most effective and economical engineering technique to address saltwater intrusion problems in the Mekong Delta.XIAO Han TANG Yin LI Haiming ZHANG Lu NGO-DUC Thanh Deliang CHEN TANG Qiuhong 2021Advances in Climate Change Research2021,12,3:0
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