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| 1 | Research on the dynamics of the South China Sea opening:Evidence from analogue modeling显示文摘Independent of Indochina extrusion, the South China Sea experienced a process from passive continental rifting to marginal sea drifting. According to the fault patterns in the Beibu Gulf basin and the Pearl River Mouth basin, the continental rifting and early spreading stage from 32 to 26 Ma were controlled by extensional stress field, which shifted clockwise from southeastward to south southeastward. From 24 Ma on, the sea spread in NW-SE direction and ceased spreading at around 15.5 Ma. Integrated geological information with the assumption that the South China Sea developed along a pre-Cenozoic weakness zone, we did analogue experiments on the South China Sea evolu- tion. Experiments revealed that the pre-existing weakness zone goes roughly along the uplift zone between the present Zhu-1 and Zhu-2 depression. The pre-existing weakness zone is composed of three segments trending NNE, roughly EW and NEE, respectively. The early opening of the South China Sea is accompanied with roughly 15° clockwise rotation, while the SE sub-sea basin opened with SE extension. Tinjar fault was the western boundary of the Nansha block (Dangerous Ground), while Lupar fault was the eastern boundary of the Indochina, NW-trending rift belt known as Zengmu basin developed between above two faults due to block divergent of Indochina from Nansha. In the experiment, transtensional flower structures along NW-trending faults are seen, and slight inversion occurs along some NE-dipping faults. The existence of rigid massifs changed the orientations of some faults and rift belt, and also led to deformation concentrate around the massifs. The rifting and drifting of the South China Sea might be caused by slab pull from the proto South China Sea subducting toward Borneo and/or mantle flow caused by India-Asia collision. | SUN Zhen1,2, ZHOU Di1, ZHONG Zhihong3, XIA Bin2, QIU Xuelin1, ZENG Zuoxun4 & JIANG Jianqun5 1. CAS Key Laboratory of Marginal Sea Geology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China 2. CAS Key Laboratory of Marginal Sea Geology, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China 3. Department of Technology, Shenzhen Branch of CNOOC, Guangzhou 510240, China 4. Faculty of Earth Sciences, China University of Geosciences, Wuhan 430074, China 5. Hainan Oil & Gas Exploration Company, Liaohe Oilfield PetroChina, Panjin 124010, China | 2006 | Science China Earth Sciences2006,49,10: | 45 |
| 2 | Comparative Analysis of Leaf Trichomes, Epidermal Wax And Defense Enzymes Activities in Response to Puccinia horiana in Chrysanthemum and Ajania Species显示文摘White rust caused by Puccinia horiana is a destructive disease of chrysanthemum plants.To better understand the resistance mechanisms of composite species to this disease,the leaf cuticular traits,antioxidant and defensive enzymes activities of immune(Chrysanthemum makinoi var.wakasaense)and highly susceptible(Ajania shiwogiku var.kinokuniense)species were compared.Trichome density of two species was markedly different,negatively associated with plant resistance to P.horiana.Total wax load in C.makinoi var.wakasaense was two times more than that in A.shiwogiku var.kinokuniense.The wax composition in immune one was abundant in esters and primary alcohols.Superoxide dismutase(SOD,EC 1.15.1.1),peroxidase(POD,EC 1.11.1.7),polyphenoloxidase(PPO,EC 1.14.18.1 or EC 1.10.3.2)and phenylalanine ammonia lyase(PAL,EC 4.3.1.5)activitieswere investigated.In C.makinoi var.wakasaense,the activity of SOD and POD increased rapidly after inoculation,whichmight be non-host induced reactive oxygen species(ROS)activated antioxidant enzymes,however SOD and POD remained a low and steady level in the highly susceptible one after inoculation.Quick increase in PPO activities after inoculation was observed in both species,however it remained higher in C.makinoi var.wakasaense at the late period of inoculation.PAL in C.makinoi var.wakasaense was induced after pathogen inoculation,but not in A.shiwogiku var.kinokuniense,suggesting that these two enzymes might contribute to the resistance to P.horiana. | Yinjie Wang Jun Zeng Xiaolong Xia Yang Xu Jing Sun Jing Gu Hainan Sun Haini Lei Fadi Chen Jiafu Jiang Weiming Fang Sumei Chen | 2020 | Horticultural Plant Journal2020,6,3: | 8 |
| 3 | Redundant CAMTA Transcription Factors Negatively Regulate the Biosynthesis of Salicylic Acid and N-Hydroxypipecolic Acid by Modulating the Expression of SARD1 and CBP60g显示文摘Two signal molecules, salicylic acid (SA) and N-hydroxypipecolic acid (NHP), play critical roles in plant immunity. The biosynthetic genes of both compounds are positively regulated by master immune-regulating transcription factors SARD1 and CBP60g. However, the relationship between the SA and NHP pathways is unclear. CALMODULIN-BINDING TRANSCRIPTION FACTOR 1 (CAMTA1), CAMTA2, and CAMTA3 are known redundant negative regulators of plant immunity, but the underlying mechanism also remains largely unknown. In this study, through chromatin immunoprecipitation and electrophoretic mobility shift assays, we uncovered that CBP60g is a direct target of CAMTA3, which also negatively regulates the expression of SARD1, presumably via an indirect effect. The autoimmunity of camta3-1 is suppressed by sard1 cbp60g double mutant as well as ald1 and fmo1, two single mutants defective in NHP biosynthesis. Interestingly, a suppressor screen conducted in the camta1/ 2/ 3 triple mutant background yielded various mutants blocking biosynthesis or signaling of either SA or NHP, leading to nearly complete suppression of the extreme autoimmunity of camta1/ 2/ 3, suggesting that the SA and NHP pathways can mutually amplify each other. Together, these results reveal that CAMTAs repress the biosynthesis of SA and NHP by modulating the expression of SARD1 and CBP60g, and that the SA and NHP pathways are coordinated to optimize plant immune response. | Tongjun Sun Jianhua Huang Yan Xu Vani Verma Beibei Jing Yulin Sun Alberto Ruiz Orduna Hainan Tian Xingchuan Huang Shitou Xia Laurel Schafer Reinhard Jetter Yuelin Zhang Xin Li | 2020 | Molecular Plant2020,13,1: | 5 |
| 4 | Geographic,Geometrical and Semantic Reconstruction of Urban Scene from High Resolution Oblique Aerial Images显示文摘An effective approach is proposed for 3D urban scene reconstruction in the form of point cloud with semantic labeling. Starting from high resolution oblique aerial images,our approach proceeds through three main stages: geographic reconstruction, geometrical reconstruction and semantic reconstruction. The absolute position and orientation of all the cameras relative to the real world are recovered in the geographic reconstruction stage. Then, in the geometrical reconstruction stage,an improved multi-view stereo matching method is employed to produce 3D dense points with color and normal information by taking into account the prior knowledge of aerial imagery.Finally the point cloud is classified into three classes(building,vegetation, and ground) by a rule-based hierarchical approach in the semantic reconstruction step. Experiments on complex urban scene show that our proposed 3-stage approach could generate reasonable reconstruction result robustly and efficiently.By comparing our final semantic reconstruction result with the manually labeled ground truth, classification accuracies from86.75% to 93.02% are obtained. | Xiaofeng Sun Shuhan Shen Hainan Cui Lihua Hu Zhanyi Hu | 2019 | IEEE/CAA Journal of Automatica Sinica2019,6,1: | 2 |
| 5 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023,66,5: | 2 |
| 6 | Numerical simulation of control ablation by transpiration cooling 显示文摘 | Wang Jianhua Wang Hainan SUN Jiguo | 2007 | Heat and Mass Transfer2007,43,: | 1 |
| 7 | Numerical simulation of control ablation by transpiration cooling显示文摘 | Jianhua Wang Hainan Wang Jiguo Sun Jue Wang | 2007 | Heat and Mass Transfer2007,,5: | 1 |
| 8 | Implantation of bone marrow mononuclear cells using injectable fibrin matrix enhances neovascularization in infarcted myocardium显示文摘 | Ju Hee Ryu Il-Kwon Kim Seung-Woo Cho Myeong-Chan Cho Kyung-Kuk Hwang Hainan Piao Shuguang Piao Sang Hyun Lim Yoo Sun Hong Cha Yong Choi Kyung Jong Yoo Byung-Soo Kim | 2004 | Biomaterials2004,,3: | 1 |
| 9 | Copper foam-derived electrodes as efficient electrocatalysts for conventional and hybrid water electrolysis显示文摘Electrochemical water splitting has been demonstrated as a promising technology for the renewable generation of green hydrogen from water.Despite the extensive progress in materials science,one particular challenge for further development towards industrial application lies in the rational design and exploitation of efficient and cost-effective materials,especially oxygen evolution reaction(OER)electrocatalysts at the anode.In addition,attempts to replace the OER with other more oxidizable anode reactions are being evaluated as a groundbreaking strategy for generating hydrogen at lower potentials and reducing overall energy costs while producing valuable chemicals simultaneously.Compared with Fe/Co/Ni-based compounds,Cu-based materials have not received extensive research attention for electrode designs despite their high conductivity and abundant earth reserves.In this review,combining with the advantages of a three-dimensional network structure of metal foams,we summarize recent progress on Cu foam(CF)-derived materials as efficient electrocatalysts towards pure water electrolysis and hybrid water electrolysis.The advantages of CF and design strategies to enhance the electrocatalytic activity and operational durability are presented first.Catalyst design and fabrication strategies are then highlighted and the structure-activity relationship is also discussed.Finally,we propose challenges and perspectives on self-supported electrodes beyond CF-derived materials. | Hainan Sun Hyunseung Kim Sanzhao Song WooChul Jung | 2022 | Materials Reports(Energy)2022,2,2: | 1 |
| 10 | Modulating metal-organic frameworks for catalyzing acidic oxygen evolution for proton exchangemembrane water electrolysis显示文摘Proton exchangemembrane(PEM)water electrolysis represents one of the most promising technologies to achieve green hydrogen production,but currently its practical viability is largely affected by the slow reaction kinetics of the anodic oxygen evolution reaction(OER)in an acidic environment.While noble metal-based catalysts containing iridium or ruthenium are excellent catalysts for the acidic OER,their practical use in PEM electrolyzers is hindered due to their low abundance and high cost.Most recently,metal-organic frameworks(MOFs)have been demonstrated as a perfect platform to facilitate the design of acidic OER catalysts with both high efficiency and cost-effectiveness.Here,we pro-vide a timely and comprehensive overview of the recent progress on MOF-based acidic OER catalysts.The fundamental mechanisms of the acidic OER are first introduced,followed by a summary of the development of pristine MOFs and MOF derivatives as acidic OER catalysts.Importantly,a number of catalyst design strategies are discussed aiming at improving the acidic OER catalytic per-formance of MOF-based candidates.The integration of MOF-based catalysts into real PEM water electrolyzers is also included.Finally,future research directions are provided to achieve better MOF-based catalysts operational in acidic envi-ronments and PEM devices. | Xiaomin Xu Hainan Sun San Ping Jiang Zongping Shao | 2021 | SusMat2021,1,4: | 1 |
| 11 | Wharton’s jelly MSC-derived extracellular vehicles-loaded hyaluronic acid-alginate adhesives for treatment of osteoarthritis显示文摘The repair of cartilage injury caused by osteoarthritis(OA)has long plagued clinicians.Mesenchymal stem cell(MSC)-derived small extracellular vesicles(sEVs)show great potential in cartilage regeneration and immunoregulation to realise cell-free therapy.However,unprotected sEVs are prone to be washed away by the flow of fluids and degraded in vivo.In this work,we successfully revealed that human Wharton’s jelly of umbilical cord-derived MSC(hWJMSC)sEVs promote proliferation,inhibit apoptosis,and attenuate the inflammation of chondrocytes in vitro.In light of the long period required for cartilage regeneration,we synthesised an injectable and adhesive aldehyded sodium alginate crosslinked acylhydrazide-modified hyaluronic acid(ALG-CHO/HHA)hydrogel loaded with sEVs to boost the reparative effect of the sEVs.The hydrogel-bearing sEVs was injected into cartilage defects where they adhered to the cartilage surface.In this configuration,the sEVs were delivered in a sustainable manner with the degradation of the hydrogel at the injury sites,thus contributing to highly efficient cartilage repair by regulating the regenerative and immune microenvironment.The ALG-CHO/HHA-sEV platform meets the clinical demand for long-lasting repair with a single injection.Thus,this work provides a new idea and theoretical basis for the clinical application of sEVs in the treatment of OA. | Yanhong Zhao Xige Zhao Hainan Xu Yi Xing Tengling Wu Xun Sun Mingjie Kuang Xinlong Ma Wenguang Liu Qiang Yang | 2023 | Journal of Materials Science & Technology2023,,11: | 0 |
| 12 | Contrasting responses to drought stress between Chrysanthemum japonense and C. nankingense显示文摘The response of Chrysanthemum japonense and C.nankingense to drought stress induced by polyethylene glycol was characterized at the level of leaf water status,leaf surface morphology and cuticular wax(quantity and composition),the activity of antioxidant enzymes,the extent of membrane lipid peroxidation,the accumulation of proline,photosynthesis performance and abscisic acid(ABA)accumulation.The more tolerant species C.japonense maintained its water status more effectively than C.nankingense,probably because its leaves form more cuticular wax and are able to accumulate higher levels of ABA.Superoxide dismutase activity was higher in C.japonense than in C.nankingense,as was that of catalase and ascorbate peroxidase during the later part of the stress episode,but levels of peroxidase were not differentiated at the end of the stress period.Membrane damage,as measured by electrolyte leakage and malondialdehyde accumulation,was less severe in C.japonense,which was also able to generate higher levels of free proline after a 10 h exposure to stress.Thus the superior response of C.japonense also reflects a more adapted system of osmoprotection and antioxidation.As a result,photosynthesis was compromised less by drought stress in C.japonense than in C.nankingense.That provides a scientific basis for the development and application of drought tolerance resources of chrysanthemum. | Yi Zhang Jing Gu Xiaolong Xia Jun Zeng Hainan Sun Fadi Chen Weimin Fang Jiafu Jiang Sumei Chen | 2022 | Ornamental Plant Research2022,2,1: | 0 |
| 13 | Exploration of sea anemone-inspired high-performance biomaterials with enhanced antioxidant activity显示文摘Antioxidant biomaterials have attracted much attention in various biomedical fields because of their effective inhibition and elimination of reactive oxygen species(ROS)in pathological tissues.However,the difficulty in ensuring biocompatibility,biodegradability and bioavailability of antioxidant materials has limited their further development.Novel bioavailable antioxidant materials that are derived from natural resources are urgently needed.Here,an integrated multi-omics method was applied to fabricate antioxidant biomaterials.A key cysteine-rich thrombospondin-1 type Ⅰ repeat-like(TSRL)protein was efficiently discovered from among 1262 adhesive components and then used to create a recombinant protein with a yield of 500 mg L^(-1).The biocompatible TSRL protein was able to self-assemble into either a water-resistant coating through Ca^(2+)-mediated coordination or redox-responsive hydrogels with tunable physical properties.The TSRL-based hydrogels showed stronger 1,1-diphenyl-2-picrylhydrazyl(DPPH)radical scavenging rates than glutathione(GSH)and ascorbic acid(Aa)and protected cells against external oxidative stress significantly more effectively.When topically applied to mice skin,TSRL alleviated epidermal hyperplasia and suppressed the degradation of collagen and elastic fibers caused by ultraviolet radiation B(UVB)irradiation,confirming that it enhanced antioxidant activity in vivo.This is the first study to successfully characterize natural antioxidant biomaterials created from marine invertebrate adhesives,and the findings indicate the excellent prospects of these biomaterials for great applications in tissue regeneration and cosmeceuticals. | Lulu Wang Xiaokang Zhang Pingping Xu Jicheng Yan Yuzhong Zhang Hainan Su Chengjun Sun Qiang Lu Weizhi Liu | 2022 | Bioactive Materials2022,7,4: | 0 |
| 14 | Evaluation of the Madden–Julian Oscillation in Fengyun-3B Polar-Orbiting Satellite Reprocessed OLR Data显示文摘The present study compares the spatial and temporal characteristics of the Madden-Julian Oscillation(MJO)in Fengyun-3B(FY-3B)polar-orbiting satellite reprocessed outgoing longwave radiation(OLR)data and NOAA OLR data during 2011-2020.The spatial distributions of climatological mean and intraseasonal standard deviation of FY-3B OLR during boreal winter(November-April)and boreal summer(May-October)are highly consistent with those of NOAA OLR.The FY-3B and NOAA OLRs display highly consistent features in the wavenumber-frequency spectra,the occurrence frequency of MJO active days,the eastward propagation of MJO along the equator,and the interannual variability of MJO according to diagnoses using the all-season multivariate EOF analysis.These results indicate that the FY-3B OLR produced by the polar-orbiting satellites is of high quality and worthy of global application. | Hainan GONG Wanchun ZHANG Ling SUN Zizhen DONG Peng ZHANG Lin WANG Wen CHEN Renguang WU | 2022 | Journal of Meteorological Research2022,36,6: | 0 |
| 15 | Advanced electrocatalysts with unusual active sites for electrochemical water splitting显示文摘Electrochemical water splitting represents a promising technology for green hydrogen production.To design advanced electrocatalysts,it is crucial to identify their active sites and interpret the relationship between their structures and performance.Materials extensively studied as electrocatalysts include noble-metal-based(e.g.,Ru,Ir,and Pt)and non-noble-metal-based(e.g.,3d transition metals)compounds.Recently,advancements in characterization techniques and theoretical calculations have revealed novel and unusual active sites.The present review highlights the latest achievements in the discovery and identification of various unconventional active sites for electrochemical water splitting,with a focus on state-of-the-art strategies for determining true active sites and establishing structure–activity relationships.Furthermore,we discuss the remaining challenges and future perspectives for the development of next-generation electrocatalysts with unusual active sites.By presenting a fresh perspective on the unconventional reaction sites involved in electrochemical water splitting,this review aims to provide valuable guidance for the future study of electrocatalysts in industrial applications. | Hainan Sun Xiaomin Xu Hyunseung Kim Zongping Shao WooChul Jung | 2024 | InfoMat2024,6,1: | 0 |
| 16 | On mathematical arbitrariness of some papers on the potential homologous linear rule investigation显示文摘The history of homologous linear rule investigation is reviewed simply. The author puts forward a problem worth paying attention to in the recent potential homologous linear rule investigation, especially some mistakes made in these investigations on mathematical foundations. The author also exposes the mathematical arbitrariness of some papers on their potential homologous linear rule investigation. | SUN YukunDepartment of Chemistry, Hainan Teachers College, Haikou 571158, China | 2000 | Chinese Science Bulletin2000,45,23: | 0 |
| 17 | Thin Films Fabricated by Pulsed Laser Deposition for Electrocatalysis显示文摘Advances in energy conversion and storage technologies,such as water electrolyzers,rechargeable metal-air batteries,and fuel cells,have enabled a renewable and sustainable future.The efficiency and effectiveness of these technologies largely relies on the physicochemical properties of the functional materials used,specifically electrocatalysts.Pulsed laser deposition(PLD)is a powerful technique for the synthesis of thin film materials,offering a unique platform for understanding electrochemical reaction mechanisms and searching for low-cost and high-performance electrocatalysts.In this mini-review,we present the latest studies in which thin film materials(mainly focused on perovskite oxide thin films)via PLD have been actively utilized in the field of electrocatalysis.The fundamentals and advantages of PLD in the synthesis of thin films are discussed first.Then,emerging types of thin films associated with electrochemical applications are presented.Special emphasis is placed on material design methods to reveal the reaction mechanisms and establish the structure–performance relationships by understanding structural variations in precatalysts and surface reconstruction under reaction conditions.Finally,we discuss remaining challenges and future perspectives. | Hainan Sun Hyunseung Kim Xiaomin Xu Liangshuang Fei WooChul Jung Zongping Shao | 2023 | Renewables2023,1,1: | 0 |
| 18 | SARS-CoV-2-specific antibody response characteristics in COVID-19 patients of different ages显示文摘Age has been found to be one of the main risk factors for the severity and outcome of COVID-19.However,differences in SARS-CoV-2 specific antibody responses among COVID-19 patients of different age groups remain largely unknown.In this study,we analyzed the IgG/IgM responses to 21 SARS-CoV-2 proteins and 197 peptides that fully cover the spike protein against 731 sera collected from 731 COVID-19 patients aged from 1 to 92 years.We show that there is no overall difference in SARS-CoV-2 antibody responses in COVID-19 patients in the 4 age groups.By antibody response landscape maps,we find that the IgG response profiles of SARS-CoV-2 proteins are positively correlated with age.The S protein linear epitope map shows that the immunogenicity of the S-protein peptides is related to peptide sequence,disease severity and age of the COVID-19 patients.Furthermore,the enrichment analysis indicates that low S1 IgG responses are enriched in patients aged<50 and high S1 IgG responses are enriched in mild COVID-19 patients aged>60.In addition,high responses of non-structural/accessory proteins are enriched in severe COVID-19 patients aged>70.These results suggest the distinct immune response of IgG/IgM to each SARS-CoV-2 protein in patients of different age,which may facilitate a deeper understanding of the immune responses in COVID-19 patients. | Linfang Lu Siqi Yu Min Liu Yang Li Qing Lei Mingxi Lin Danyun Lai Shujuan Guo Hewei Jiang Hongyan Hou Yunxiao Zheng Xuening Wang Mingliang Ma Bo Zhang Hong Chen Junbiao Xue Hainan Zhang Huan Qi Ziyong Sun Feng Wang Xionglin Fan Zhaowei Xu | 2022 | Acta Biochimica et Biophysica Sinica2022,54,4: | 0 |