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| 1 | Comparative Analysis of Leaf Trichomes, Epidermal Wax And Defense Enzymes Activities in Response to Puccinia horiana in Chrysanthemum and Ajania Species显示文摘White rust caused by Puccinia horiana is a destructive disease of chrysanthemum plants.To better understand the resistance mechanisms of composite species to this disease,the leaf cuticular traits,antioxidant and defensive enzymes activities of immune(Chrysanthemum makinoi var.wakasaense)and highly susceptible(Ajania shiwogiku var.kinokuniense)species were compared.Trichome density of two species was markedly different,negatively associated with plant resistance to P.horiana.Total wax load in C.makinoi var.wakasaense was two times more than that in A.shiwogiku var.kinokuniense.The wax composition in immune one was abundant in esters and primary alcohols.Superoxide dismutase(SOD,EC 1.15.1.1),peroxidase(POD,EC 1.11.1.7),polyphenoloxidase(PPO,EC 1.14.18.1 or EC 1.10.3.2)and phenylalanine ammonia lyase(PAL,EC 4.3.1.5)activitieswere investigated.In C.makinoi var.wakasaense,the activity of SOD and POD increased rapidly after inoculation,whichmight be non-host induced reactive oxygen species(ROS)activated antioxidant enzymes,however SOD and POD remained a low and steady level in the highly susceptible one after inoculation.Quick increase in PPO activities after inoculation was observed in both species,however it remained higher in C.makinoi var.wakasaense at the late period of inoculation.PAL in C.makinoi var.wakasaense was induced after pathogen inoculation,but not in A.shiwogiku var.kinokuniense,suggesting that these two enzymes might contribute to the resistance to P.horiana. | Yinjie Wang Jun Zeng Xiaolong Xia Yang Xu Jing Sun Jing Gu Hainan Sun Haini Lei Fadi Chen Jiafu Jiang Weiming Fang Sumei Chen | 2020 | Horticultural Plant Journal2020，6，3： | 8 |
| 2 | 美蓝染色放大电子结肠镜观察结肠息肉与组织病理学的关系显示文摘目的:研究美蓝染色后用放大电子结肠镜观察结肠息肉的微细结构类型与组织病理学的关系。方法:使用0.5%美蓝对电子结肠镜检查到有息肉的部位进行息肉及邻近的黏膜进行染色,然后用放大电子结肠镜观察。按Kudo’s标准记录正常结肠黏膜和息肉,然后行活检或息肉电切术,以便组织病理学评价。结果:本组共67人,普通电子结肠镜检查发现息肉180颗,经美蓝染色后又发现了1-3mm大小的息肉90颗,共计270颗息肉。放大结肠镜可明显提高腺瘤性病变的检出率,P<0.001。270颗病变的隐窝类型分为6种,呈Ⅱ型者2颗(0.7%);Ⅲ_s型203颗(75.2%);Ⅲ_L型49颗(18.1%),其中伴有轻、中度非典型增生者7颗;Ⅳ型11颗(4.1%),伴有轻度非典型增生者2颗、黏膜癌1颗(9.1%),Ⅴ_n共5颗(1.9%),伴有中度非典型增生者1颗,黏膜癌2颗(40%)。本组息肉均进行了电切术。结论:美蓝染色后用放大电子结肠镜可清晰地观察到结肠隐窝,其大小一致,呈圆形或椭圆形;诊断为腺瘤性息肉与病理组织学的符合率为96.7%,可明显提高息肉的检出率,并可鉴别电切息肉术后残留的基底部是否残留腺瘤组织或癌灶。 | Lu Su Hong-Zhen Pan Jing-Biao Weng Yi-Hua Xu Fang Chen Mei-Yan Hong Department of Digestive Endoscopy, The Worker’s Hospital of Hainan Province, Haikou 570311, Hainan Province, China | 2003 | 世界华人消化杂志2003，11，8： | 8 |
| 3 | Redundant CAMTA Transcription Factors Negatively Regulate the Biosynthesis of Salicylic Acid and N-Hydroxypipecolic Acid by Modulating the Expression of SARD1 and CBP60g显示文摘Two signal molecules, salicylic acid (SA) and N-hydroxypipecolic acid (NHP), play critical roles in plant immunity. The biosynthetic genes of both compounds are positively regulated by master immune-regulating transcription factors SARD1 and CBP60g. However, the relationship between the SA and NHP pathways is unclear. CALMODULIN-BINDING TRANSCRIPTION FACTOR 1 (CAMTA1), CAMTA2, and CAMTA3 are known redundant negative regulators of plant immunity, but the underlying mechanism also remains largely unknown. In this study, through chromatin immunoprecipitation and electrophoretic mobility shift assays, we uncovered that CBP60g is a direct target of CAMTA3, which also negatively regulates the expression of SARD1, presumably via an indirect effect. The autoimmunity of camta3-1 is suppressed by sard1 cbp60g double mutant as well as ald1 and fmo1, two single mutants defective in NHP biosynthesis. Interestingly, a suppressor screen conducted in the camta1/ 2/ 3 triple mutant background yielded various mutants blocking biosynthesis or signaling of either SA or NHP, leading to nearly complete suppression of the extreme autoimmunity of camta1/ 2/ 3, suggesting that the SA and NHP pathways can mutually amplify each other. Together, these results reveal that CAMTAs repress the biosynthesis of SA and NHP by modulating the expression of SARD1 and CBP60g, and that the SA and NHP pathways are coordinated to optimize plant immune response. | Tongjun Sun Jianhua Huang Yan Xu Vani Verma Beibei Jing Yulin Sun Alberto Ruiz Orduna Hainan Tian Xingchuan Huang Shitou Xia Laurel Schafer Reinhard Jetter Yuelin Zhang Xin Li | 2020 | Molecular Plant2020，13，1： | 5 |
| 4 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 5 | Eutrophication conditions and ecological status in typical bays of Lake Taihu in China显示文摘 | YE Chun XU Qiujin KONG Hainan | 2007 | Environmental Monitoring and Assessment2007，135，123： | 1 |
| 6 | Free cooling of data centers : A review 显示文摘 | Zhang Hainan Shao Shuangquan Xu Hongbo | 2014 | Renewable and Sustainable Energy Reviews2014，35，： | 1 |
| 7 | Eutrophica- tion conditions and ecological status in typical bays of Lake Taihu in China 显示文摘 | YE Chun XU Qiujin KONG Hainan | 2007 | Environ Monit Assess2007，135，13： | 1 |
| 8 | Integrated system of mechanical refrigeration and ther- mosyphon for free cooling of data centers 显示文摘 | Zhang Hainan Shao Shuangquan Xu Hongbo | 2015 | Applied Thermal Engineering2015，75，： | 1 |
| 9 | Experimental investigation on the photovoltaic-thermal solar heat pump air-conditioning system on water-heating mode显示文摘 | Guiyin Fang Hainan Hu Xu Liu | | 0，，： | 1 |
| 10 | PMD:A resource for archiving and analyzing protein microarray data显示文摘 | Xu Zhaowei Huang Likun Zhang Hainan | 2016 | Scientific Reports2016，，19： | 1 |
| 11 | Learning stratified 3D reconstruction显示文摘Stratified 3 D reconstruction, or a layer-by-layer 3 D reconstruction upgraded from projective to affine, then to the final metric reconstruction, is a well-known 3 D reconstruction method in computer vision. It is also a key supporting technology for various well-known applications, such as streetview, smart3 D, oblique photogrammetry. Generally speaking, the existing computer vision methods in the literature can be roughly classified into either the geometry-based approaches for spatial vision or the learning-based approaches for object vision. Although deep learning has demonstrated tremendous success in object vision in recent years,learning 3 D scene reconstruction from multiple images is still rare, even not existent, except for those on depth learning from single images. This study is to explore the feasibility of learning the stratified 3 D reconstruction from putative point correspondences across images, and to assess whether it could also be as robust to matching outliers as the traditional geometry-based methods do. In this study, a special parsimonious neural network is designed for the learning. Our results show that it is indeed possible to learn a stratified 3 D reconstruction from noisy image point correspondences, and the learnt reconstruction results appear satisfactory although they are still not on a par with the state-of-the-arts in the structurefrom-motion community due to largely its lack of an explicit robust outlier detector such as random sample consensus(RANSAC). To the best of our knowledge, our study is the first attempt in the literature to learn3 D scene reconstruction from multiple images. Our results also show that how to implicitly or explicitly integrate an outlier detector in learning methods is a key problem to solve in order to learn comparable3 D scene structures to those by the current geometry-based state-of-the-arts. Otherwise any significant advancement of learning 3 D structures from multiple images seems difficult, if not impossible. Besides, we even speculate that deep learning might be, in nature, not suitable for learning 3 D structure from multiple images, or more generally, for solving spatial vision problems. | Qiulei DONG Mao SHU Hainan CUI Huarong XU Zhanyi HU | 2018 | Science China(Information Sciences)2018，61，2： | 1 |
| 12 | Research of movingtable with aluminum foam-filled structure 显示文摘 | Xu ping Xiao zhen Tan hainan | 2013 | Advanced Ma-terials Research2013，19，： | 1 |
| 13 | Free cooling of data centers: a review 显示文摘 | Zhang Hainan Shao Shuangquan Xu Hongbo Zou Huiming Tian Changqing | 2014 | Renewable and Sustainable Energy Reviews2014，35，： | 1 |
| 14 | The binding epitope of sintilimab on PD-1 revealed by AbMap显示文摘PD-1 plays an important role as an immune checkpoint.Sintilimab is a newly approved PD-1 antibody for cancer immunotherapy with an unknown binding epitope on PD-1.In this study,to elucidate the molecular mechanism by which sintilimab blocks PD-1 activation,we applied Antibody binding epitope Mapping(AbMap)to identify the binding epitope of sintilimab.An epitope was successfully identified,i.e.SLAPKA,aa 127-132.By constructing a series of point mutations,the dominant residues S127,L128,A129,P130,and A132 of PD-1 were further validated by western blot analysis,biolayer interferometry,and flow cytometry.Structural analysis showed that the epitope is partially within the binding interface of PD-1 and PD-L1,and this epitope also partially overlaps with that of nivolumab and pembrolizumab.These results demonstrate that sintilimab can attenuate PD-1 activation by directly competing with the interaction between PD-1 and PD-L1 through binding with the key residues of the FG loop on PD-1.This study also demonstrates the high efficiency and accuracy of AbMap for determining the binding epitope of therapeutic antibodies. | Mingliang Ma Huan Qi Chuansheng Hu Zhaowei Xu Fanlin Wu Nan Wang Danyun Lai Yang Li Hainan Zhang Hewei Jiang Qingfeng Meng Shujuan Guo Yani Kang Xiaodong Zhao Hua Li Sheng-ce Tao | 2021 | Acta Biochimica et Biophysica Sinica2021，53，5： | 1 |
| 15 | Eutrophication conditions and ecological status in typical bays of Lake Taihu in China显示文摘 | Chun Ye Qiujin Xu Hainan Kong Zhemin Shen Changzhou Yan | 2007 | Environmental Monitoring and Assessment (-)2007，，1： | 1 |
| 16 | Modulating metal-organic frameworks for catalyzing acidic oxygen evolution for proton exchangemembrane water electrolysis显示文摘Proton exchangemembrane(PEM)water electrolysis represents one of the most promising technologies to achieve green hydrogen production,but currently its practical viability is largely affected by the slow reaction kinetics of the anodic oxygen evolution reaction(OER)in an acidic environment.While noble metal-based catalysts containing iridium or ruthenium are excellent catalysts for the acidic OER,their practical use in PEM electrolyzers is hindered due to their low abundance and high cost.Most recently,metal-organic frameworks(MOFs)have been demonstrated as a perfect platform to facilitate the design of acidic OER catalysts with both high efficiency and cost-effectiveness.Here,we pro-vide a timely and comprehensive overview of the recent progress on MOF-based acidic OER catalysts.The fundamental mechanisms of the acidic OER are first introduced,followed by a summary of the development of pristine MOFs and MOF derivatives as acidic OER catalysts.Importantly,a number of catalyst design strategies are discussed aiming at improving the acidic OER catalytic per-formance of MOF-based candidates.The integration of MOF-based catalysts into real PEM water electrolyzers is also included.Finally,future research directions are provided to achieve better MOF-based catalysts operational in acidic envi-ronments and PEM devices. | Xiaomin Xu Hainan Sun San Ping Jiang Zongping Shao | 2021 | SusMat2021，1，4： | 1 |
| 17 | An engineered xCas12i with high activity,high specificity,and broad PAM range显示文摘Dear Editor,The clustered regularly interspaced short palindromic repeats-Cas(CRISPR-Cas)systems,including type II Cas9 and type V Cas12 systems,which serve in the adaptive immunity of prokaryotes against viruses,have been developed into genome-editing tools(Anzalone et al.,2020;Doudna,2020).Compared with type II systems,the type V systems including V-A to V-K showed more functional diversity(Yan et al.,2019).Amongst them,Cas12i has a relatively smaller size(1,033-1,093 aa),compared to SpCas9 and Cas12a,and has a 5'-TTN protospacer adjacent motif(PAM)preference(Yan et al.,2019). | Hainan Zhang Xiangfeng Kong Mingxing Xue Jing Hu Zikang Wang Yinghui Wei Haoqiang Wang Jingxing Zhou Weihong Zhang Mengqiu Xu Xiaowen Shen Fengcai Yin Zhiyuan Ai Guangyan Huang Junhui Xia Xueqiong Song Hengbin Li Yuan Yuan Jinhui Li Na Zhong Meiling Zhang Yingsi Zhou Hui Yang | 2023 | Protein & Cell2023，14，7： | 0 |
| 18 | Wharton’s jelly MSC-derived extracellular vehicles-loaded hyaluronic acid-alginate adhesives for treatment of osteoarthritis显示文摘The repair of cartilage injury caused by osteoarthritis(OA)has long plagued clinicians.Mesenchymal stem cell(MSC)-derived small extracellular vesicles(sEVs)show great potential in cartilage regeneration and immunoregulation to realise cell-free therapy.However,unprotected sEVs are prone to be washed away by the flow of fluids and degraded in vivo.In this work,we successfully revealed that human Wharton’s jelly of umbilical cord-derived MSC(hWJMSC)sEVs promote proliferation,inhibit apoptosis,and attenuate the inflammation of chondrocytes in vitro.In light of the long period required for cartilage regeneration,we synthesised an injectable and adhesive aldehyded sodium alginate crosslinked acylhydrazide-modified hyaluronic acid(ALG-CHO/HHA)hydrogel loaded with sEVs to boost the reparative effect of the sEVs.The hydrogel-bearing sEVs was injected into cartilage defects where they adhered to the cartilage surface.In this configuration,the sEVs were delivered in a sustainable manner with the degradation of the hydrogel at the injury sites,thus contributing to highly efficient cartilage repair by regulating the regenerative and immune microenvironment.The ALG-CHO/HHA-sEV platform meets the clinical demand for long-lasting repair with a single injection.Thus,this work provides a new idea and theoretical basis for the clinical application of sEVs in the treatment of OA. | Yanhong Zhao Xige Zhao Hainan Xu Yi Xing Tengling Wu Xun Sun Mingjie Kuang Xinlong Ma Wenguang Liu Qiang Yang | 2023 | Journal of Materials Science & Technology2023，，11： | 0 |
| 19 | Clinical Features of Severe Tsutsugamushi Disease Complicated with Hemophagocytic Lymphohistiocytosis显示文摘The article discusses a case of severe tsutsugamushi disease complicated with hemophagocytic syndrome in Guangdong Maternal and Child Health Hospital and concludes that blood purification technology has significant therapeutic effect among children with severe HLH complicated with multiple organ dysfunction. | Linglong Lu Hainan Xu Dongping Huang Shumei Peng | 2021 | Proceedings of Anticancer Research2021，5，5： | 0 |
| 20 | Numerical and Experimental Investigation on the Performance of Battery Thermal Management System Based on Micro Heat Pipe Array显示文摘Battery thermal management is very crucial for the safe and long-term operation of electric vehicles or hybrid electric vehicles.In this study,numerical simulation method is adopted to simulate the temperature field of Li-ion battery cell and module.It is proved that the maximum temperature and maximum temperature difference of battery cell and module increase with the increase of charge/discharge rate(C-rate)of the battery.For battery module,it can reach a maximum temperature of 61.1℃at a C-rate of 2 under natural convection condition with the ambient temperature of 20.0℃.A battery thermal management system based on micro heat pipe array(BTMS-MHPA)is deeply investigated.Experiments are conducted to compare the cooling effect on the battery module with different cooling methods,which include natural cooling,only MHPA,MHPA with fan.The maximum temperature of battery module which is cooled by MHPA with a fan is 43.4℃at a C-rate of 2,which is lower than that in the condition of natural cooling.Meanwhile,the maximum temperature difference was also greatly reduced by the application of MHPA cooling.The experimental results confirm that the feasibility and superiority of the BTMS-MHPA for guaranteeing the working temperature range and temperature uniformity of the battery. | YANG Lulu XU Hongbo ZHANG Hainan CHEN Yiyu LIU Ming TIAN Changqing | 2022 | Journal of Thermal Science2022，31，5： | 0 |
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