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| 1 | 2016 Chinese expert consensus and guidelines for the diagnosis and treatment of papillary thyroid microcarcinoma显示文摘The incidence of papillary thyroid carcinoma(PTC)has exponentially increased in recent years.Papillary thyroid microcarcinoma(PTMC)accounts for the majority of the reported cases of PTC.The debates and crucial issues in PTMC management have received researchers'attention.To further improve the clinical management of PTMC in China, | Ming Gao Minghua Ge Qinghai Ji Ruochuan Cheng Hankui Lu Haixia Guan Li Gao Zhuming Guo Tao Huang Xiaoming Huang Xiaoming Li Yansong Lin Qinjiang Liu Xin Ni Yi Pan Jianwu Qin Zhongyan Shan Hui Sun Xudong Wang Zhengang Xu Yang Yu Daiwei Zhao Naisong Zhang ShengZhang Ying Zheng Jingqiang Zhu Dapeng Li Xiangqian Zheng 无 | 2017 | Cancer Biology & Medicine2017，14，3： | 23 |
| 2 | Responses of rice growth to copper stress under free-air CO_2 enrichment (FACE)显示文摘The responses of rice to the second degree contamination of copper were studied by pot experiments under free-air CO2 enrichment (FACE) with 570 μmol·mol-1 of CO2. The results showed that the content of copper in rice leaves was reduced with the CO2 concentration reaching 570 μmol·mol-1 and this happened more significantly under the second degree contamination of copper. Under FACE, activities of superoxide dismutase (SOD) enzyme in rice leaves treated by copper contamination were induced, whereas the contents of glutathione (GSH) and glutathione disulfide (GSSG) had no significant difference from the control. In the presence of ambient CO2, activities of SOD enzyme treated by copper pollution were suppressed during the whole rice growth, however, the contents of GSH and GSSG were induced at tillering and jointing stages, and then restored to the control levels in later growth under the second degree contamination of copper. With the rice growing, the content of malondialdehyde (MDA) rises continuously, but there had been no significant difference between the treatments at the same growth stage. Further studies are needed on the response mechanism of rice to Cu stress under elevated CO2. | JIA HaiXia GUO HongYan YIN Ying WANG Qiang SUN Qin WANG XiaoRong ZHU JianGuo | 2007 | Chinese Science Bulletin2007，52，19： | 10 |
| 3 | The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala显示文摘The short allele of the serotonin-transporter gene is associated with higher risk for anxiety and depression in Caucasians, but this association is still unclear in Asians. Here, we addressed this issue using behavioral and multi-modal MRI approaches in a large group of healthy Han Chinese participants (n = 233). In contrast to findings in Caucasians, we found that long-allele (L) carriers had higher anxiety scores. In another group (n = 64) experiencing significant levels of depression or anxiety, the L-allele frequency was also significantly higher. In healthy participants, L-carriers had reduced functional and anatomical connectivity between the amygdala and prefrontal cortex (PFC), which was correlated with anxiety or depression scores. Our findings demonstrated that in Chinese Han participants, in contrast to Caucasians, the L-allele confers vulnerability to anxiety or depression and weakens top-down emotional control between the PFC and amygdala. Therefore, ethnic background should be taken into account in gene-related studies and their potential clinical applications. | Haixia Long Bing Liu Bing Hou Chao Wang Jin Li Wen Qin Dawei Wang Yuan Zhou Keith M. Kendrick Chunshui Yu Tianzi Jiang | 2013 | Neuroscience Bulletin2013，29，1： | 9 |
| 4 | PDE-BASED MEDIAL AXIS EXTRACTION AND SHAPE MANIPULATION OF ARBITRARY MESHES显示文摘形状 skeletonization (即,中间的轴抽取) 在许多视觉计算应用程序是强大的例如模式识别,反对分割,登记,和动画。在这篇论文,作者扩展与距离地信息相结合到多角形的网孔基于他们的微分性质代表的任意的 3D 固体的近似中间的斧子的散开方程的使用。它为通常使用的 3D 为中间的轴抽取提供一个其他却自然的方法多角形的模型。由沿着时间轴解决 PDE,这个系统不能仅仅快速提取输入网孔的基于散开的中间的斧子,而且允许用户设想抽取进程在每次走。另外,建议模型提供用户雕刻提取中间的斧子的一套操作工具箱,然后使用基于散开的技术根据原来的输入数据集恢复相应使变形的形状。这基于骨骼的形状操作为复杂网孔对象的动画和变丑提供一个快、容易的方法。 | Haixia DU Terry YOO Hong QIN | 2008 | Journal of Systems Science & Complexity2008，21，4： | 3 |
| 5 | 2017 Chinese expert consensus on the clinical application ofserum marker for thyroid cancer显示文摘In recent years, the clinical incidence of thyroid cancer has been increasing year by year, and its risk assessment and clinical management methods have also been accordingly modified and constantly improved. There are great differences between the clinical diagnostic and therapeutic modes and disease management of thyroid cancer employed by various medical institutions in China, particularly with regard to the clinical application of serum marker of thyroid cancer. To this end, the China Anti-Cancer Association Thyroid Cancer Specialized Committee Chinese Association of Thyroid Oncology organized this compilation of ExpertConsensus on Clinical Application of Serum Marker of Thyroid Cancer to help and impel relevant clinical institutions and professionals to standardize clinical diagnosis, treatment, and long-term management of thyroid cancer, and to properly utilize the serum marker for scientific auxiliary clinical diagnosis and assessment of thyroid cancer before and after operation. | Ming Gao Minghua Ge Qinghai Ji Ruochuan Cheng Hankui Lu Haixia Guan Wei Cui Li Gao Zairong Gao Lin Guo Zhuming Guo Tao Huang Xiaoming Huang Yansong Lin Qinjiang Liu Xin Ni Jianwu Qin Li Ren Zhongyan Shan Hui Sun Xudong Wang Zhengang Xu Yang Yu Bin Zhang DaiweiZhao Ying Zheng Jingqiang Zhu Xiangqian Zheng 无 | 2018 | Cancer Biology & Medicine2018，15，4： | 3 |
| 6 | A new room temperature ionic liquid 1-butyl-3-trimethylsilylimidazolium hexafluorophosphate as a solvent for extraction and preconcentration of mercury with determination by cold vapor atomic absorption spectrometry显示文摘 | Zaijun Li Qin Wei Rui Yuan Xia Zhou Huizhen Liu Haixia Shan Qijun Song | 2006 | Talanta2006，，1： | 1 |
| 7 | Inhibition of voltage-gated sodium channels by bisphenol A in mouse dorsal root ganglion neurons显示文摘 | Qiang Wang Jie Cao Qin Zhu Chunye Luan Xiaodong Chen Xiaohua Yi Haixia Ding Jian Chen Jie Cheng Hang Xiao | 2011 | Brain Research2011，，： | 1 |
| 8 | An efficient strategy for generation of transgenic mice by lentiviral transduction of male germline stem cells in vivo显示文摘Background: Male germline stem cells(MGSCs) are a subpopulation of germ cells in the testis tissue. MGSCs are capable of differentiation into spermatozoa and thus are perfect targets for genomic manipulation to generate transgenic animals.Method: The present study was to optimize a protocol of production of transgenic mice through transduction of MGSCs in vivo using lentiviral-based vectors. The recombinant lentiviral vectors with either EF-1 or CMV promoter to drive the expression of enhanced green fluorescent protein(e GFP) transgene were injected into seminiferous tubules or inter-tubular space of 7-day-old and 28-day-old mouse testes. At 5 or 6 wk post-surgery, these pre-founders were mated with wild-type C57BL/6J female mice(1.5 to 2.0-month-old).Results: Sixty-seven percent of F1 generation and 55.56 % of F2 offspring were positive for eG FP transgene under the control of EF-1 promoter via PCR analysis. The transgenic pups were generated in an injection site-and age-independent manner. The expression of transgene was displayed in the progeny derived from lentiviral vector containing CMV promoter to drive transgene, but it was silenced or undetectable in the offspring derived from lentiviral vector with transgene under EF-1 promoter. The methylation level of g DNA in the promoter region of transgene was much higher in the samples derived lentiviral vectors with EF-1 promoter than that with CMV promoter,suggesting e GFP transgene was suppressed by DNA methylation in vivo.Conclusion: This research reported here an effective strategy for generation of transgenic mice through transduction of MGSCs in vivo using lentivirus vectors with specific promoters, and the transgenic offspring were obtained in an injection site-and age-independent manner. This protocol could be applied to other animal species, leading to advancement of animal transgenesis in agricultural and biomedical fields. | Jinzhou Qin Haixia Xu Pengfei Zhang Conghui Zhang Zhendong Zhu Rongfeng Qu Yuwei Qin Wenxian Zeng | 2016 | Journal of Animal Science and Biotechnology2016，7，2： | 1 |
| 9 | A new temperature ionic liquid 1-butyl-3-trimethylsilylimidazolium hexafluorophosphate as a solvent for extraction and preconcentration of mercury with determination by cold vapor atomic absorption spectrometry显示文摘 | Li zaijun Wei Qin Zhou Xia Yuan Rui Liu Huizhen Shan Haixia Song Qijun | 2007 | Talanta2007，71，1： | 1 |
| 10 | Comparisons of corneal biomechanical and tomographic parameters among thin normal cornea,forme fruste keratoconus,and mild keratoconus显示文摘Background:To compare the dynamic corneal response(DCR)and tomographic parameters of thin normal cornea(TNC)with thinnest corneal thickness(TCT)(≤500μm),forme fruste keratoconus(FFKC)and mild keratoconus(MKC)had their central corneal thickness(CCT)matched by Scheimpflug imaging(Pentacam)and corneal visualization Scheimpflug technology(Corvis ST).Methods:CCT were matched in 50 eyes with FFKC,50 eyes with MKC,and 53 TNC eyes with TCT≤500μm.The differences in DCR and tomographic parameters among the three groups were compared.The receiver operating characteristic(ROC)curve was used to analyze the diagnostic significance of these parameters.Back propagation(BP)neural network was used to establish the keratoconus diagnosis model.Results:Fifty CCT-matched FFKC eyes,50 MKC eyes and 50 TNC eyes were included.The age and biomechanically corrected intraocular pressure(bIOP)did not differ significantly among the three groups(all P>0.05).The index of height asymmetry(IHA)and height decentration(IHD)differed significantly among the three groups(all P<0.05).IHD also had sufficient strength(area under the ROC curves(AUC)>0.80)to differentiate FFKC and MKC from TNC eyes.Partial DCR parameters showed significant differences between the MKC and TNC groups,and the deflection amplitude of the first applanation(A1DA)showed a good potential to differentiate(AUC>0.70)FFKC and MKC from TNC eyes.Diagnosis model by BP neural network showed an accurate diagnostic efficiency of about 91%.Conclusions:The majority of the tomographic and DCR parameters differed among the three groups.The IHD and partial DCR parameters assessed by Corvis ST distinguished FFKC and MKC from TNC when controlled for CCT. | Lei Tian Di Zhang Lili Guo Xiao Qin Hui Zhang Haixia Zhang Ying Jie Lin Li | 2021 | Eye and Vision2021，8，1： | 1 |
| 11 | HighThyroglobulin Antibody Levels Increase the Risk ofDifferentiated Thyroid Carcinoma 显示文摘 | Qin Jing Yu Zhenqian Guan Haixia | 2015 | Disease markers2015，8，15： | 1 |
| 12 | Electrochemical bisphenol A sensor based on N-doped graphene sheets显示文摘 | Haixia Fan Yan Li Dan Wu Hongmin Ma Kexia Mao Dawei Fan Bin Du He Li Qin Wei | 2011 | Analytica Chimica Acta2011，，： | 1 |
| 13 | Microstructure and bending strength of liquid phase sintered 3 Y-TZP/12Ce-TZP at low temperature显示文摘 | QIN Haixia HUANG Xiaoxian | 2000 | J Am Ceram Soc2000，83，11： | 1 |
| 14 | Accumulation and bioavailability of copper and nickel in wheat plants grown in contaminated soils from the oasis, northwest China显示文摘 | Shengli Wang Zhongren Nan Xiaowen Liu Yuan Li Song Qin Haixia Ding | 2009 | Geoderma2009，，3： | 1 |
| 15 | A shape design system using volumetric implicit PDEs显示文摘 | Haixia Du Hong Qin | 2004 | Computer-Aided Design2004，，11： | 1 |
| 16 | A shape design system using volumetric implicit PDEs显示文摘 | Du Haixia Qin Hong | 2004 | Computer-Aided Design2004，36，11： | 1 |
| 17 | Analysis of Predictability of Local Rainstorm in Qinghai during August 19-20,2019显示文摘Based on conventional meteorological observation data,ECMWF model data,etc.,the causes of rainstorm in the northeast of Qinghai from the afternoon to the night of August 19,2019 were analyzed,and the causes and predictability of major forecast errors were discussed.The results show that there was high temperature,high humidity and high energy in the middle and low layers in the early period of rainstorm.As the subtropical high retreated eastwards,the high-altitude trough of the westerly belt and the vertical shear line of the plateau moved eastwards to make ground cold air move eastwards,and local short-term heavy precipitation appeared under the influence of this weather system.At the same time,the high-level dry and cold air moved into convective unstable areas.The wind speed at 700 hPa strengthened,and the low-level jet stream appeared to aggravate the instability of atmospheric stratification,which was more conducive to the generation of convection.The forecast results of precipitation based on various numerical models were significantly smaller,and the predicted western cold air was obviously weaker,which was also one of the reasons why the weak transportation of the western water vapor resulted in a small value of predicted precipitation.In the adjustment of model forecast,the proportion and amount of convective precipitation should be adjusted to be large,which has a certain indicating significance for the forecast of convective precipitation.In short-term nowcasting,the deviation of major weather systems predicted based on the model should be corrected in real time,and attention should be paid to the location of ground specific humidity and the convergence line.The falling area of heavy precipitation can be judged according to the high-value area of specific humidity,and the maximum of specific humidity appeared 1-2 h earlier than short-term heavy rainfall. | Qingping LI Liang XU Qin GUAN Yao HU Chenghong MEI Jinhai LI Chengzhen SHI Haixia QI | 2020 | Meteorological and Environmental Research2020，11，5： | 0 |
| 18 | Transfection of Nm23-H1 Gene Inhibited the Metastatic Potential of Human High-metastatic Large Cell Lung Cancer L9981显示文摘Background and objective Invasion and metastasis is not only the malignant phenotypes of lung cancer but also the main cause of death. Elucidating the molecular mechanism of | Haixia ZHENG Zhilin SUN Yang QIN Wen ZHU Li REN Jun CHEN Sen WEI Zhigang LI Hongyu LIU Haisu WAN Zhihao WU Ke XU Qinghua ZHOU | 2009 | 中国肺癌杂志2009，12，6： | 0 |
| 19 | Clinical Observation of Chuanbai Antipruritic Lotion'Water Film'Wet Compress Combined with Chloramphenicol Prednisone Liniment in the Treatment of Acute Eczema显示文摘[Objectives]To observe and analyze the clinical efficacy and possible mechanism of Chuanbai antipruritic lotion'water film'wet compress combined with chloramphenicol prednisone liniment in the treatment of acute eczema.[Methods]A total of 76 acute eczema cases admitted to Shiyan Taihe Hospital from January 2022 to March 2023 were divided into Western medicine treatment group and integrated traditional Chinese and Western medicine group.In the Western medicine treatment group,chloramphenicol and prednisone liniment was applied to the skin lesions and oral administration of cetirizine hydrochloride.The course of treatment in both groups was 2 weeks(w).The levels of interferon-γ(IFN-γ),interleukin-4(IL-4)and the ratio of IFN-γ/IL-4 in the peripheral blood of patients before and 2 weeks after treatment,as well as serum immunoglobulin E(IgE),anti-IgE antibody and histamine(HA)level,and with skin lesions disappearing time,skin oil,transepidermal water loss(TEWL),eczema area and severity index(EASI)score,total effective rate,degree of pruritus and traditional Chinese medicine quality of life scale(EPQOLS)score to evaluate the efficacy.[Results]Compared with the Western medicine treatment group at 2 w,the disappearance time of skin lesions in the integrated traditional Chinese and Western medicine group was shortened,TEWL,itching degree and EASI score,serum IgE and HA,and peripheral blood IL-4 levels were all decreased(P<0.05).IFN-γand IFN-γ/IL-4 ratio,anti-IgE antibody,EPQOLS score and total effective rate were all increased(P<0.05),and the difference was statistically significant.[Conclusions]Chuanbai antipruritic lotion'water film'wet compress combined with chloramphenicol prednisone liniment is an optimized and safe and efficient method for the treatment of acute eczema,which can quickly relieve the symptoms of inflammatory damage of eczema and restore the skin barrier function,dry dampness and relieve itch.Inhibition of the release of histamine active substances and regulation of immunity may be the main mechanisms. | Benlu QIN Haixia JING | 2023 | Medicinal Plant2023，14，6： | 0 |
| 20 | Fresh Processing Technology in Polygonatum odoratum Production Area and Its Comparison with Traditional Processing显示文摘[Objectives]To compare the effects of traditional processing and fresh processing on the quality of Polygonatum odoratum decoction piece.[Methods]The effects of fresh processing and traditional processing on the quality of P.odoratum decoction piece were compared and analyzed with appearance characteristics,total ash content,extract content,total polysaccharides content,and total flavonoids content as the evaluation indexes.[Results]Fresh processing method in different production areas has different effects on P.odoratum decoction piece.P.odoratum was dried in oven of 50℃.When moisture content was 41.44%-59.67%,it was cut.After complete drying at 50℃,the moisture content of dried P.odoratum was 8.94%-9.60%,and ethanol-soluble extract content was 77.29%-78.20%,and water-soluble extract was 77.7%-78.14%.At this time,the appearance characteristics of section of P.odoratum decoction piece were better than that of traditional processing,which was yellowish white.The total polysaccharide content was higher than that of traditional processing,and the content of total flavonoids was statistically significant different from that of traditional processing.[Conclusions]The quality of P.odoratum decoction piece by fresh processing is better than that of the traditional processing,and it is feasible to use fresh processing. | Miao YANG Chufan PENG Haixia LU Rufeng LIANG Hui TANG Zhongmei QIN Shengjiu GU | 2024 | Medicinal Plant2024，15，1： | 0 |
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