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| 1 | Role of pyroptosis in inflammation and cancer显示文摘Pyroptosis is a form of programmed cell death mediated by gasdermin and is a product of continuous cell expansion until the cytomembrane ruptures,resulting in the release of cellular contents that can activate strong inflammatory and immune responses.Pyroptosis,an innate immune response,can be triggered by the activation of inflammasomes by various influencing factors.Activation of these inflammasomes can induce the maturation of caspase-1 or caspase-4/5/11,both of which cleave gasdermin D to release its N-terminal domain,which can bind membrane lipids and perforate the cell membrane.Here,we review the latest advancements in research on the mechanisms of pyroptosis,newly discovered influencing factors,antitumoral properties,and applications in various diseases.Moreover,this review also provides updates on potential targeted therapies for inflammation and cancers,methods for clinical prevention,and finally challenges and future directions in the field. | Xiang Wei Feng Xie Xiaoxue Zhou Yuchen Wu Haiyan Yan Ting Liu Jun Huang Fangwei Wang Fangfang Zhou Long Zhang | 2022 | Cellular & Molecular Immunology2022，19，9： | 11 |
| 2 | Ferroptosis in cancer and cancer immunotherapy显示文摘The hallmark of tumorigenesis is the successful circumvention of cell death regulation for achieving unlimited replication and immortality.Ferroptosis is a newly identified type of cell death dependent on lipid peroxidation which differs from classical programmed cell death in terms of morphology,physiology and biochemistry.The broad spectrum of injury and tumor tolerance are the main reasons for radiotherapy and chemotherapy failure.The effective rate of tumor immunotherapy as a new treatment method is less than 30%.Ferroptosis can be seen in radiotherapy,chemotherapy,and tumor immunotherapy;therefore,fer-roptosis activation may be a potential strategy to overcome the drug resistance mechanism of traditional cancer treatments.In this review,the characteristics and causes of cell death by lipid peroxidation in ferroptosis are briefly described.In addition,the three metabolic regulations of ferroptosis and its crosstalk with classical signaling pathways are summarized.Collectively,these findings sug-gest the vital role of ferroptosis in immunotherapy based on the interaction of ferroptosis with tumor immunotherapy,chemotherapy and radiotherapy,thus,indicating the remarkable potential of ferroptosis in cancer treatment. | Lei Zhao Xiaoxue Zhou Feng Xie Lei Zhang Haiyan Yan Jun Huang Chong Zhang Fangfang Zhou Jun Chen Long Zhang | 2022 | Cancer Communications2022，42，2： | 10 |
| 3 | Comparison of nonhuman primates identified the suitable model for COVID-19显示文摘Identification of a suitable nonhuman primate(NHP)model of COVID-19 remains challenging.Here,we characterized severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in three NHP species:Old World monkeys Macaca mulatta(M.mulatta)and Macaca fascicularis(M.fascicularis)and New World monkey Callithrix jacchus(C.jacchus).Infected M.mulatta and M.fascicularis showed abnormal chest radiographs,an increased body temperature and a decreased body weight.Viral genomes were detected in swab and blood samples from all animals.Viral load was detected in the pulmonary tissues of M.mulatta and M.fascicularis but not C.jacchus.Furthermore,among the three animal species,M.mulatta showed the strongest response to SARS-CoV-2,including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues.Collectively,these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M.mulatta as the most suitable for modeling COVID-19. | Shuaiyao Lu Yuan Zhao Wenhai Yu Yun Yang Jiahong Gao Junbin Wang Dexuan Kuang Mengli Yang Jing Yang Chunxia Ma Jingwen Xu Xingli Qian Haiyan Li Siwen Zhao Jingmei Li Haixuan Wang Haiting Long Jingxian Zhou Fangyu Luo Kaiyun Ding Daoju Wu Yong Zhang Yinliang Dong Yuqin Liu Yinqiu Zheng Xiaochen Lin Li Jiao Huanying Zheng Qing Dai Qiangming Sun Yunzhang Hu Changwen Ke Hongqi Liu Xiaozhong Peng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 4 | LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity显示文摘Den dritic cells(DCs)play a pivotal role in priming adaptive immunity.However,the in volveme nt of DCs in con trolling excessive and deleterious T cell responses remains poorly defined.Moreover,the metabolic dependenee and regulation of DC function are unclear.Here we show that LKB1 signaling in DCs functions as a brake to restrain excessive tumor-promoting regulatory T cell(Treg)and Th17 cell responses,thereby promoting protective anti-tumor immunity and maintaining proper immune homeostasis.LKB1 deficiency results in dysregulated metabolism and mTOR activation of DCs.Loss of LKB1 also leads to aberrant DC maturation and production of cytokines and immunoregulatory molecules.Blocking mTOR signaling in LKB1-deficient DCs partially rectifies the abno rmal phe no types of DC activation and Treg expansio n,whereas unc on trolled Th17 resp on ses depend upon IL-6-STAT3 signaling.By coordi nating metabolic and immune quiesce nee of DCs,LKB1 acts as a crucial signali ng hub in DCs to enforce protective anti-tumor immunity and normal immune homeostasis. | Yanyan Wang Xingrong Du Jun Wei Lingyun Long Haiyan Tan Cliff Guy Yogesh Dhungana Chenxi Qian Geoffrey Neale Yang-Xin Fu Jiyang Yu Junmin Peng Hongbo Chi | 2019 | Cell Research2019，29，5： | 3 |
| 5 | Tectonic Evolution of the North Depression of the South Yellow Sea Basin Since Late Cretaceous显示文摘On the basis of subsidence history analysis and balanced cross-section analysis, the vertical uplift/subsidence history and horizontal extension/compression history of the north depression of the south Yellow Sea basin are quantitatively studied. The results show that the tectonic evolution of the north depression of the south Yellow Sea basin since late Cretaceous can be divided into a rifting phase(late Cretaceous to Paleogene) and a post-rifting phase(Neogene to Quaternary). The rifting phase can be further subdivided into an initial rifting stage(late Cretaceous), an intensive rifting stage(Paleocene), a rifting termination stage(Eocene), and an inversion-uplifting stage(Oligocene). Together, this division shows the characteristics of an episodic-evolved intracontinental rift-depression basin. The deformation of the north depression of the south Yellow Sea basin since late Cretaceous was mainly fault-related. The horizontal extension and tectonic subsidence were controlled by the activity of faults. The differential evolution of faults also caused variations in local uplift/subsidence movements and the regional heterogeneity in extension. The late Cretaceous initial rifting of the north depression of the south Yellow Sea basin is related to the Pacific-Eurasia convergence. From the Paleocene intensive rifting stage to present, the Pacific-Eurasia convergence and India-Eurasia convergence have played important roles in the evolution of this region. | LI Nan LI Weiran LONG Haiyan | 2016 | Journal of Ocean University of China2016，15，6： | 3 |
| 6 | Compositional dependence of hydrogenation performance of Ti-Zr-Hf-Mo-Nb high-entropy alloys for hydrogen/tritium storage显示文摘A series of Ti-Zr-Hf-Mo-Nb high-entropy alloys with different Mo concentrations were developed as candidate materials for hydrogen/tritium storage in solid phase.The crystal structures and hydrogenation properties of the Ti-Zr-Hf-Mo-Nb alloys were investigated by X-ray diffraction and differential scanning calorimetry techniques.All the alloys have a body-centred cubic single phase structure.The results demonstrate that the cell volume of the Ti-Zr-Hf-Mo-Nb hydride decreases with increasing Mo concentration,which reduces their thermal stability.The theoretical calculation proposes that the lower binding energy of the Ti-Zr-Hf-Mo-Nb hydride decreases the thermal stability of Ti-Zr-Hf-Mo-Nb alloys with higher Mo content.The great hydrogenation performance for all the Ti-Zr-Hf-Mo-Nb alloys is owing to their reversible single-phase transformation during the hydrogen absorption-desorption cycle,which would be bene ficial to improving the hydrogen recycling rate and preventing the disproportionation.The compositional dependence of the hydrogenation performance of the Ti-Zr-Hf-Mo-Nb alloys was established and will be useful in designing novel hydrogen/tritium storage materials to satisfy the requirements of diffe rent application fields in hydrogen,solar thermal and nuclear energy. | Huahai Shen Jutao Hu Pengcheng Li Gang Huang Jianwei Zhang Jinchao Zhang Yiwu Mao Haiyan Xiao Xiaosong Zhou Xiaotao Zu Xinggui Long Shuming Peng | 2020 | Journal of Materials Science & Technology2020，52，20： | 2 |
| 7 | A 220 GHz dynamic frequency divider in 0.5μm InP DHBT technology显示文摘A high performance 3 inch 0.5 μm InP DHBT technology with three interconnecting layers has been developed.The epitaxial layer structure and geometry parameters of the device were carefully studied to get the required performances.The 0.5 × 5 μm^2 InP DHBTs demonstrated f_t = 350 GHz,f_(max) = 532 GHz and BV_(CEO) = 4.8 V,which were modeled using Agilent-IIBT large signal model.As a benchmark circuit,a dynamic frequency divider operating from 110 to 220 GHz has been designed,fabricated and measured with this technology.The ultra-high-speed 0.5 μm InP DHBT technology offers a combination of ultra-high-speed and high breakdown voltage,which makes it an ideal candidate for next generation 100 GHz+ mixed signal integrated circuits. | Wei Cheng Youtao Zhang Yuan Wang Bin Niu Haiyan Lu Long Chang Junling Xie | 2017 | Journal of Semiconductors2017，38，5： | 1 |
| 8 | Characterization and immunostimulatory activity of a polysaccharide from the spores of Ganoderma lucidum显示文摘 | Liang Guo Jianhui Xie Yuanyuan Ruan Lei Zhou Haiyan Zhu Xiaojing Yun Yan Jiang Long Lü Kangli Chen Zhihui Min Yumei Wen Jianxin Gu | 2009 | International Immunopharmacology2009，，10： | 1 |
| 9 | Effect of Zr/Ti ratio on the properties of PMMN-PZT ceramics near the morphotropic phase boundary 显示文摘 | Chen Haiyan Long Jiwen Meng Zhongyan | 2003 | Materials Science and Engineering2003，99，： | 1 |
| 10 | Resonance Rayleigh scattering determination of trace amounts of Al in natural waters and biological samples based on the formation of an Al( Ⅲ) - morin - surfactant complex显示文摘 | LONG Xiufen BI Shuping NI Haiyan | 2004 | Anal Chim Acta2004，501，1： | 1 |
| 11 | In Situ Generation of Oxazole Ylide and Interception with Sulfonamide: Construction of Amidines Using Two Diazo Molecules显示文摘 | Jijun Chen Wenhao Long Yanwei Zhao Haiyan Li Yonggao Zheng Pengcheng Lian Xiaobing Wan | 2018 | Chinese Journal of Chemistry2018，36，9： | 1 |
| 12 | ResonanceRayleigh scattering determination of trace amounts ofAl in natural waters and biological samples based onthe formation of an Al(Ⅲ)-morin-surfactant complex显示文摘 | Long Xiufen Bi Shuping Ni Haiyan | 2004 | Anal Chim Acta2004，501，1： | 1 |
| 13 | Effects of compositions and Nb-doping on microstructure and piezoelectric properties of PMS-PZ-PT system显示文摘 | Long Jiwen Chen Haiyan | 2003 | Mater Sci Eng2003，99，： | 1 |
| 14 | The way of SARS-CoV-2 vaccine development:success and challenges显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the causative agent of coronavirus disease 2019(COVID-19).To halt the pandemic,multiple SARS-CoV-2 vaccines have been developed and several have been allowed for emergency use and rollout worldwide.With novel SARS-CoV-2 variants emerging and circulating widely,whether the original vaccines that were designed based on the wild-type SARS-CoV-2 were effective against these variants has been a contentious discussion.Moreover,some studies revealed the long-term changes of immune responses post SARS-CoV-2 infection or vaccination and the factors that might impact the vaccine-induced immunity.Thus,in this review,we have summarized the influence of mutational hotspots on the vaccine efficacy and characteristics of variants of interest and concern.We have also discussed the reasons that might result in discrepancies in the efficacy of different vaccines estimated in different trials.Furthermore,we provided an overview of the duration of immune responses after natural infection or vaccination and shed light on the factors that may affect the immunity induced by the vaccines,such as special disease conditions,sex,and pre-existing immunity,with the aim of aiding in combating COVID-19 and distributing SARS-CoV-2 vaccines under the prevalence of diverse SARS-CoV-2 variants. | Yetian Dong Tong Dai Bin Wang Lei Zhang Ling-hui Zeng Jun Huang Haiyan Yan Long Zhang Fangfang Zhou | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 1 |
| 15 | Reservoir Characteristics of Fine-grained Sedimentary Rocks in Saline Lakes in the Cenozoic Upper Ganchaigou Formation,Southwestern Qaidam Basin,NW China显示文摘Cenozoic fine-grained sedimentary rocks in the southwestern Qaidam Basin,as typical salinized lacustrine sediments,are significantly different from those in other freshwater lakes under the impact of the high salinity in the lake.Many fine-grained sedimentary rock samples were selected from the lower member of Neogene(N_(1))in the Gaskule Oilfield,Qaidam Basin,northwest China,with the aim to analyze and test their petrology,pore structure,and organic geochemical characteristics and determine its genesis and geological significance.Based on previous results,a new genesis of mixed sedimentary rocks is proposed.The Cenozoic lacustrine fine-grained sedimentary rocks in SW Qaidam Basin belong to mixed sedimentary rocks,which can be divided into three types,including carbonate and terrigenous clastic-bearing mudstone,carbonate-bearing to terrigenous clastic mixed sedimentary rocks,and carbonate-terrigenous clastic mixed sedimentary rocks.The geneses of mixing are quite different from that of mixed marine rocks.According to the sedimentary characteristics of the salinized lakes,three new geneses of mixed deposits are proposed:syn-sedimentary mixing,varve interbedded mixing,and biogenic mixing.The reservoir spaces of the Cenozoic lacustrine fine-grained sedimentary rocks in SW Qaidam Basin include residual intergranular pores,intercrystalline pores,microfractures,and minor dissolved pores.The reservoirs have super-low porosity and ultra-low permeability,with a porosity of 1.82%-21.04%,averaging 7.71%,and permeability of(0.0028-254.86)×10^(−3)μm^(2),averaging 2.82×10^(−3)μm^(2).The test results of total organic carbon(TOC)content show that the highest content of organic carbon reached 1.41%,and those of vitrinite reflectance show that Ro ranges from 0.525%-0.824%,with an average of 0.806%.The organic geochemical characteristics show that the fine-grained mixed sedimentary rocks of SW Qaidam Basin have the potential for self-generation and self-storage.As an unconventional reservoir,it has potential industrial value.This is the first study of fine-grained sedimentary rocks in the Qaidam Basin,which offers certain theoretical and practical values. | SHENG Jun LIU Jincheng LI Yunlong ZOU Haiyan LONG Anlin WANG Lin LI Jiyong QI Qingshan YANG Xiaojing LI Yanan | 2022 | Acta Geologica Sinica(English Edition)2022，96，3： | 1 |
| 16 | Electrochemical behavior of gallic acid interaction with DNA and detection of damage to DNA显示文摘 | Yang Zhousheng Zhang Dapeng Long Haiyan | 2008 | Journal of Electroanalytical Chemistry2008，624，12： | 1 |
| 17 | The unique morphology role of thorn surface in determining electrochemical performance of polyaniline nano-fibers via one-step method显示文摘 | Wang Haiyan Li Lan Zhang Long | 2015 | Journal of Applied Polymer Science2015，132，42： | 1 |
| 18 | Foundry manufacturing of tight-confinement,dispersion-engineered,ultralow-loss silicon nitride photonic integrated circuits显示文摘The foundry development of integrated photonics has revolutionized today’s optical interconnect and datacenters.Over the last decade,we have witnessed the rising of silicon nitride(Si_(3)N_(4)) integrated photonics,which is currently transferring from laboratory research to foundry manufacturing.The development and transition are triggered by the ultimate need for low optical loss offered by Si_(3)N_(4),which is beyond the reach of silicon and III-V semiconductors.Combined with modest Kerr nonlinearity,tight optical confinement,and dispersion engineering,Si_(3)N_(4) has today become the leading platform for linear and Kerr nonlinear photonics,and it has enabled chip-scale lasers featuring ultralow noise on par with table-top fiber lasers.However,so far all the reported fabrication processes of tight-confinement,dispersion-engineered Si_(3)N_(4) photonic integrated circuits(PICs)with optical loss down to few dB/m have only been developed on 4-inch(100 mm diameter)or smaller wafers.Yet,to transfer these processes to established CMOS foundries that typically operate 6-inch or even larger wafers,challenges remain.In this work,we demonstrate the first foundry-standard fabrication process of Si_(3)N_(4) PICs with only 2.6 dB/m loss,thickness above 800 nm,and near 100%fabrication yield on 6-inch(150 mm diameter)wafers.Such thick and ultralow-loss Si_(3)N_(4) PIC enables low-threshold generation of soliton frequency combs.Merging with advanced heterogeneous integration,active ultralow-loss Si_(3)N_(4) integrated photonics could pave an avenue to addressing future demands in our increasingly information-driven society. | ZHICHAO YE HAIYAN JIA ZHANGJUN HUANG CHEN SHEN JINBAO LONG BAOQI SHI YI-HAN LUO LAN GAO WEI SUN HAIRUN GUO JIJUN HE JUNQIU LIU | 2023 | Photonics Research2023，11，4： | 1 |
| 19 | Size-dependent microstructure and europium site preference influence fluorescent properties of Eu 3+ -doped Ca 10 (PO 4 ) 6 (OH) 2 nanocrystal显示文摘 | Mei Long Fashui Hong Wei Li Fuchun Li Haiyan Zhao Yuanqi Lv Huixin Li Feng Hu Lingdong Sun Chunhua Yan Zhenggui Wei | 2007 | Journal of Luminescence2007，，3： | 1 |
| 20 | AI based colorectal disease detection using real-time screening colonoscopy显示文摘Colonoscopy is an effective tool for early screening of colorectal diseases.However,the application of colonoscopy in distinguishing different intestinal diseases still faces great challenges of efficiency and accuracy.Here we constructed and evaluated a deep convolution neural network(CNN)model based on 117055 images from 16004 individuals,which achieved a high accuracy of 0.933 in the validation dataset in identifying patients with polyp,colitis,colorectal cancer(CRC)from normal.The proposed approach was further validated onmulti-center real-time colonoscopy videos and images,which achieved accurate diagnostic performance on detecting colorectal diseases with high accuracy and precision to generalize across external validation datasets.The diagnostic performance of the model was further compared to the skilled endoscopists and the novices.In addition,our model has potential in diagnosis of adenomatous polyp and hyperplastic polyp with an area under the receiver operating characteristic curve of 0.975.Our proposed CNN models have potential in assisting clinicians in making clinical decisions with efficiency during application. | Jiawei Jiang Qianrong Xie Zhuo Cheng Jianqiang Cai Tian Xia Hang Yang Bo Yang Hui Peng Xuesong Bai Mingque Yan Xue Li Jun Zhou Xuan Huang Liang Wang Haiyan Long Pingxi Wang Yanpeng Chu Fan-Wei Zeng Xiuqin Zhang Guangyu Wang Fanxin Zeng | 2021 | Precision Clinical Medicine2021，4，2： | 0 |
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