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| 1 | A Genome-Wide Transcription Analysis Reveals a Close Correlation of Promoter INDEL Polymorphism and Heterotic Gene Expression in Rice Hybrids显示文摘杂种优势,或混合活力,指二个生来的变化的混合子孙在展出提高的生长或农学的性能的现象。尽管研究的世纪长的历史关于杂种优势的基因基础产生了几个假设,位于杂种优势和 heterotic 基因表示下面的分子的机制留下逃犯。这里,我们在米饭报导二个 heterotic 十字的染色体宽的基因表示分析,利用它的充分定序的染色体。约 79% 基因是从 heterotic 十字的二个集合在幼苗射击表示的差别,包括许多抄写因素基因,并且展出了基因行动的多重模式。在生来的父母之间的 ortholog 基因的通常认为的倡导者区域的比较揭示了广泛的顺序变化,特别地小的插入 / 删除(INDEL ) ,许多哪个在通常认为的 cis 规章的元素的形成 / 混乱的结果。一起,这些结果建议那在抄写因素和多态的倡导者的表示之间的组合相互影响在混血儿的 cis 规章的元素是位于 heterotic 基因行动下面的一嘴巧的分子的机制并且这样在米饭的杂种优势。 | Hui-Yong Zhang Hang He Liang-Bi Chen Lei Li Man-Zhong Liang Xiang-Feng Wang Xi-Gang Liu Guang-Ming He Run-Sheng Chen Li-Geng Ma Xing Wang Deng | 2008 | Molecular Plant2008，1，5： | 25 |
| 2 | Analysis on Factors Related to Rabies Epidemic in China from 2007-2011显示文摘To analyze features of the rabies epidemic in China between 2007 and 2011, identify factors influencing the epidemic and to provide a scientific basis for further control and prevention of rabies, Descriptive epidemiological methods and statistical analysis was used on data collected from the National Disease Reporting Information System between 2007 to 2011 and the National Active Surveillance System between 2007 and 2010. Our analysis shows that while the number of human rabies cases decreased year by year, the number of districts reporting cases did not show significant change. The situations in Guangdong, Guangxi, Guizhou and Hunan provinces clearly improved over the period but they remain provinces with high-incidence, and consequently influence the epidemic situation of surrounding provinces and possibly the whole country. Summer and autumn were high-incidence seasons. Farmers, students and pre-school children represent the high-risk populations, and rates of cases in farmers increased, those for students decreased, and pre-school children remained unchanged. Provinces with active surveillance programs reported a total of 2346 individual cases, of which 88.53% were associated with canines. Postexposure prophylaxis (PEP) of rabies cases was not significantly improved, whereas PEP in post-exposure population was good. In rural regions of China, canine density was reduced somewhat, and the immunization rate increased slightly. Finally we show that while the epidemic decreased 2007 to 2011 in China, cases continued to be diffused in certain regions. Lack of standardization of PEP on rabies cases was the main reason of morbidity. The high density and low immunization of dog in rural areas and the defective situation of PEP are still continuous occurrences in China and remain a cause for concern. | Cui-ping Yin Hang Zhou Hui Wu Xiao-yan Tao Simon Rayner Shu-mei Wang Qing Tang Guo-dong Liang | 2012 | Virologica Sinica2012，27，2： | 22 |
| 3 | The second natural gas hydrate production test in the South China Sea显示文摘Clayey silt reservoirs bearing natural gas hydrates(NGH)are considered to be the hydrate-bearing reservoirs that boast the highest reserves but tend to be the most difficult to exploit.They are proved to be exploitable by the first NGH production test conducted in the South China Sea in 2017.Based on the understanding of the first production test,the China Geological Survey determined the optimal target NGH reservoirs for production test and conducted a detailed assessment,numerical and experimental simulation,and onshore testing of the reservoirs.After that,it conducted the second offshore NGH production test in 1225 m deep Shenhu Area,South China Sea(also referred to as the second production test)from October 2019 to April 2020.During the second production test,a series of technical challenges of drilling horizontal wells in shallow soft strata in deep sea were met,including wellhead stability,directional drilling of a horizontal well,reservoir stimulation and sand control,and accurate depressurization.As a result,30 days of continuous gas production was achieved,with a cumulative gas production of 86.14×104 m3.Thus,the average daily gas production is 2.87×10^4 m^3,which is 5.57 times as much as that obtained in the first production test.Therefore,both the cumulative gas production and the daily gas production were highly improved compared to the first production test.As indicated by the monitoring results of the second production test,there was no anomaly in methane content in the seafloor,seawater,and atmosphere throughout the whole production test.This successful production test further indicates that safe and effective NGH exploitation is feasible in clayey silt NGH reservoirs.The industrialization of hydrates consists of five stages in general,namely theoretical research and simulation experiments,exploratory production test,experimental production test,productive production test,and commercial production.The second production test serves as an important step from the exploratory production test to experimental production test. | Jian-liang Ye Xu-wen Qin Wen-wei Xie Hai-long Lu Bao-jin Ma Hai-jun Qiu Jin-qiang Liang Jing-an Lu Zeng-gui Kuang Cheng Lu Qian-yong Liang Shi-peng Wei Yan-jiang Yu Chunsheng Liu Bin Li Kai-xiang Shen Hao-xian Shi Qiu-ping Lu Jing Li Bei-bei Kou Gang Song Bo Li He-en Zhang Hong-feng Lu Chao Ma Yi-fei Dong Hang Bian | 2020 | China Geology2020，3，2： | 22 |
| 4 | Collagen type Ⅱ suppresses articular chondrocyte hypertrophy and osteoarthritis progression by promoting integrin β1-SMAD1 interaction显示文摘Hypertrophic differentiation is not only the terminal process of endochondral ossification in the growth plate but is also an important pathological change in osteoarthritic cartilage.Collagen type II(COL2A1)was previously considered to be only a structural component of the cartilage matrix,but recently,it has been revealed to be an extracellular signaling molecule that can significantly suppress chondrocyte hypertrophy.However,the mechanisms by which COL2A1 regulates hypertrophic differentiation remain unclear.In our study,a Col2a1 p.Gly1170Ser mutant mouse model was constructed,and Col2a1 loss was demonstrated in homozygotes.Loss of Col2a1 was found to accelerate chondrocyte hypertrophy through the bone morphogenetic protein(BMP)-SMAD1 pathway.Upon interacting with COL2A1,integrinβ1(ITGB1),the major receptor for COL2A1,competed with BMP receptors for binding to SMAD1 and then inhibited SMAD1 activation and nuclear import.COL2A1 could also activate ITGB1-induced ERK1/2 phosphorylation and,through ERK1/2-SMAD1 interaction,it further repressed SMAD1 activation,thus inhibiting BMP-SMAD1-mediated chondrocyte hypertrophy.Moreover,COL2A1 expression was downregulated,while chondrocyte hypertrophic markers and BMP-SMAD1 signaling activity were upregulated in degenerative human articular cartilage.Our study reveals novel mechanisms for the inhibition of chondrocyte hypertrophy by COL2A1 and suggests that the degradation and decrease in COL2A1 might initiate and promote osteoarthritis progression. | Chengjie Lian Xudong Wang Xianjian Qiu Zizhao Wu Bo Gao Lei Liu Guoyan Liang Hang Zhou Xiaoming Yang Yan Peng Anjing Liang Caixia Xu Dongsheng Huang Peiqiang Su | 2019 | Bone Research2019，7，1： | 17 |
| 5 | Three hours continuous injection of adenosine improved left ventricular function and infarct size in patients with ST-segment elevation myocardial infarction显示文摘 | ZHANG Hang TIAN Nai-liang HU Zuo-ying WANG Feng CHEN Liang ZHANG Yao-jun CHEN Shao-liang | 2012 | Chinese Medical Journal2012，，10： | 12 |
| 6 | Expression Analysis of miRNAs and Highly-expressed Small RNAs in Two Rice Subspecies and their Reciprocal Hybrids显示文摘Heterosis,or hybrid vigor,is the phenomenon whereby progeny of two inbred lines exhibit superior agronomic performance compared with either parent.We analyzed the expression of miRNAs and highly expressed small RNAs (defined according to Solexa sequencing results) in two rice (Oryza sativa) subspecies (japonica cv.Nipponbare and indica cv.93-11) and their reciprocal hybrids using microarrays.We found that of all the 1141 small RNAs tested,140 (12%,140 of 1141) and 157 (13%,157 of 1141) were identified being significantly differentially expressed in two reciprocal hybrids,respectively.All possible modes of action,including additive,high-and low-parent,above high-and below low-parent modes were exhibited.Both F1 hybrids showed non-additive expression patterns,with downregulation predominating.Interestingly,15 miRNAs displayed stark opposite expression trends relative to midparent in reciprocal hybrids.Computational prediction of targets of differentially expressed miRNAs showed that they participated in multifaceted developmental pathways,and were not distinguishable from the targets of non-differentially expressed miRNAs.Together,our findings reveal that small RNAs play roles in heterosis and add a new layer in the understanding and exploitation of molecular mechanisms of heterosis. | Fangfang Chen Guangming He Hang He Wei Chen Xiaopeng Zhu Manzhong Liang Liangbi Chen Xing Wang Deng | 2010 | Journal of Integrative Plant Biology2010，52，11： | 10 |
| 7 | Protein A immunoadsorption combined with rituximab in highly sensitized kidney transplant recipients显示文摘背景高度敏化的病人的数字正在升起,并且促进感受性能导致肾移植学习试图调查 immunoadsorption 在肾 transplants.Methods 的高度敏化的接受者与 rituximab ( RTX )相结合的蛋白质的安全和功效的在场的 failure.The 七个高度敏化的接受者生活相关肾移植( 4 个男人和 3 个女人, 42.5 岁(范围 33-51 )的平均数)是有这联合的 pretreated 。人的白血球抗原(HLA ) 失配数字是 2-5。班 1 的面板反应抗体(PRA ) 在 2 种情况中高,班的在 1 种情况中高。所有病人是有 immunoadsorption 2-10 时间的 pretreated。免疫球蛋白和 PRA 变化在吸收前后被监视。当 PRA 或免疫球蛋白层次在或下面正常的 levels.Immunosuppressive 药是如果在操作前的 3-5 天,和 RTX (375 mg/m^2 ) 的一剂量在操作的日子与 polyclonal 抗体被灌输时,操作被进行。手术后的 creatinine (Cr ) , creatinine 清理率(Ccr ) , PRA 比率,和免疫球蛋白变化都是 monitored.Results 没有推迟的接枝功能, 7 个病人有好恢复。尖锐拒绝在手术后的天发生在 3 种情况中 8, 10,和 14 分别地。Banff 07 活体检视等级是在 1 种情况中的 la,在 2 cases.Successful 回复的 lla C4d0 在给 methylprednisolone 或 antithymocyte 免疫球蛋白 + cyclophosphamide 以后被完成。所有病人与正常肾的功能被解除,意味着班 1 PRA 是 14% ,吝啬的类 PRA 是 35% 。PRA 在与 RTX 相结合的 immunoadsorption 能安全地减少的 3 cases.Conclusion 蛋白质是完全否定的体液的拒绝在的出现高度敏化肾移植接受者。 | YIN Hang HU Xiao-peng LI Xiao-bei LIU Hang WANG Wei REN Liang WANG Yong ZHANG Xiao-dong | 2009 | Chinese Medical Journal2009，，22： | 9 |
| 8 | Magnesium-based biomaterials as emerging agents for bone repair and regeneration:from mechanism to application显示文摘Magnesium(Mg)is the fourth most abundant element in the human body and is important in terms of specific osteogenesis functions.Here,we provide a comprehensive review of the use of magnesium-based biomaterials(MBs)in bone reconstruction.We review the history of MBs and their excellent biocompatibility,biodegradability and osteopromotive properties,highlighting them as candidates for a new generation of biodegradable orthopedic implants.In particular,the results reported in the field-specific literature(280 articles)in recent decades are dissected with respect to the extensive variety of MBs for orthopedic applications,including Mg/Mg alloys,bioglasses,bioceramics,and polymer materials.We also summarize the osteogenic mechanism of MBs,including a detailed section on the physiological process,namely,the enhanced osteogenesis,promotion of osteoblast adhesion and motility,immunomodulation,and enhanced angiogenesis.Moreover,the merits and limitations of current bone grafts and substitutes are compared.The objective of this review is to reveal the strong potential of MBs for their use as agents in bone repair and regeneration and to highlight issues that impede their clinical translation.Finally,the development and challenges of MBs for transplanted orthopedic materials are discussed. | Hang Zhou Bing Liang Haitao Jiang Zhongliang Deng Kexiao Yu | 2021 | Journal of Magnesium and Alloys2021，9，3： | 9 |
| 9 | Shipborne Underwater Acoustic Communication System and Sea Trials with Submersible Shenhai Yongshi显示文摘The Shipborne acoustic communication system of the submersible Shenhai Yongshi works in vertical, horizontal and slant channels according to the relative positions. For ease of use, an array combined by a vertical-cone directional transducer and a horizontal-toroid one is installed on the mothership. Improved techniques are proposed to combat adverse channel conditions, such as frequency selectivity, non-stationary ship noise, and Doppler effects of the platform's nonlinear movement. For coherent modulation, a turbo-coded single-carrier scheme is used. In the receiver, the sparse decision-directed Normalized Least-Mean-Square soft equalizer automatically adjusts the tap pattern and weights according to the multipath structure, the two receivers' asymmetry, the signal's frequency selectivity and the noise's spectrum fluctuation. The use of turbo code in turbo equalization significantly suppresses the error floor and decreases the equalizer's iteration times, which is verified by both the extrinsic information transfer charts and bit-error-rate performance. For noncoherent modulation, a concatenated error correction scheme of nonbinary convolutional code and Hadamard code is adopted to utilize full frequency diversity. Robust and lowcomplexity synchronization techniques in the time and Doppler domains are proposed. Sea trials with the submersible to a maximum depth of over 4500 m show that the shipborne communication system performs robustly during the adverse conditions. From the ten-thousand communication records in the 28 dives in 2017, the failure rate of the coherent frames and that of the noncoherent packets are both below 10%, where both synchronization errors and decoding errors are taken into account. | WU Yan-bo ZHU Min LIANG Tao WANG Wei YANG Bo HANG Linyuan LI Xin-guo LIU Ye-yao | 2018 | China Ocean Engineering2018，32，6： | 8 |
| 10 | Endovascular therapy for Acute ischemic Stroke Trial (EAST): study protocol for a prospective, multicentre control trial in China显示文摘Background and purpose:5 recent trials have shown the benefit of endovascular treatment for acute ischaemic stroke(AIS)due to large vessel occlusion of the anterior circulation.This study aims to evaluate the safety and efficacy of Solitaire thrombectomy in patients with moderate-to-severe stroke in the Chinese population,which has a high prevalence of intracranial atherosclerosis.Methods and analysis:This multicentre prospective control study will involve 17 stroke centres in China,and plans to recruit 150 patients in the intervention group,and 150 patients in the medical group,in which patients meet enrolment criteria but refuse intervention.Patients with AIS due to large vessel occlusion indicated for treatment with Solitaire stent retriever within 12 hours of symptom onset,and who meet the inclusion and exclusion criteria,will be enrolled in this study.The primary efficacy endpoint is functional independence as defined by a modified Rankin Scale(mRS)score≤2 at 90 days or by functional improvement as defined by mRS,using shift analysis.The procedural efficacy endpoint is arterial recanalisation of the occluded target vessel measured by a modified Thrombolysis in Cerebral Infarction(mTICI)score equal or superior to 2b right following the use of the study device.The primary safety endpoint is symptomatic intracranial haemorrhage(sICH)within 24±3 hours postprocedure.Ethics and dissemination:The protocol was approved by the Ethics Committee at the coordinating centre and by the local Institutional Review Board of each participating centre.Trial registration number:NCT02350283. | Zhongrong Miao Xiaochuan Huo Feng Gao Xiaoling Liao Chunjuan Wang Ya Peng Yibin Cao Shengli Chen Meng Zhang Changchun Jiang Xiaoxiang Peng Cunfeng Song Liping Wei Qiyi Zhu Zaiyu Guo Li Liu Hang Lin Hua Yang Wei Wu Hui Liang Anding Xu Kangning Chen Xingquan Zhao Yuesong Pan Hao Li Liping Liu Yilong Wang Yongjun Wang EAST investigators | 2016 | Stroke & Vascular Neurology2016，1，2： | 8 |
| 11 | Factors affecting the long-term renal allograft survival显示文摘在过去的十年的背景, cadaveric 的一个年接枝幸存肾的 allografts 显著地被改进了,但是他们的长期的幸存没保留步。在一年以后幸存的肾的 allografts 的摩擦率仍然保持几乎未改变。为迟了的接枝损失的原因是多重的。这研究的目的是分析在我们回顾地分析了的肾 transplantation.Methods 以后影响接枝的长期的幸存的预兆的因素在我们在1991年1月和2000年1月之间的医院里被对待的 524 个肾移植病人,包括生活了的 254 个病人有正常接枝功能(长幸存组)的超过 10 年,和其肾的接枝不到 10 年(控制组)幸存的 270 个盒子。明确地,我们分析了可以潜在地由 univariate 和逻辑模型 multivariate 分析影响接枝幸存指出分析显示出的独立风险 factors.Results Univariate 的 10 个因素没有重要差别在接受者的年龄或性存在,分离时间, lymphotoxin 层次,或在二之间的冷局部缺血时间组织。然而,推迟的接枝功能的比率和尖锐拒绝,和在长幸存的病人的尿酸层次组织是比在控制组(P 0.01 ) 的那些显著地低的。而且,我们发现在在移植和为在长幸存组以内的病人的施主接受者的 histocompatibility 抗原匹配以后的一年的 cyclosporin A 的集中比在控制组(P 0.01 ) 的那些显著地高。而且, multivariate 分析证明这四个因素是影响推迟的接枝功能和尖锐拒绝,在在移植以后的一年的 cyclosporin A 的集中,和尿酸铺平的浆液的比率是的耐心的 survival.Conclusions 的独立风险因素影响肾的接枝的长期的幸存的很重要的因素。 | WANG Wei LI Xiao-bei YIN Hang YANG Xiao-yong LIU Hang REN Liang HU Xiao-peng WANG Yong ZHANG Xiao-dong | 2011 | Chinese Medical Journal2011，，8： | 7 |
| 12 | Design, Synthesis and Antifungal Activity of Benzofuran and Its Analogues显示文摘Summary of main observation and conclusion Benzofuran has antifungal activity as the inhibitor of N-myristoyltransferase.Twenty-nine novel benzofuran-semicarbazide hybrids were designed and synthesized by principle of drug combinationatory.On this basis,the benzofuran ring was simplified to a resorcinol structure,and sixteen novel 1,3-dialkoxybenzene-semicarbazide hybrids were designed and synthesized.All structures of the target compounds were characterized by HRMS and NMR.The in vitro antifungal activity of target compounds was evaluated using the microdilution broth method against eight strains of pathogenic fungi with fluconazole as positive control.According to the results of the target compounds,structure-activity relationship(SAR)is summarized.The inhibitory activity against the tested strains of simplified compounds(K01-K16)has different levels improvement compared with compounds Z01-Z29.K01-K16 showed significant antifungal activities against A.fumigatus,C.kruseii,and sensitive C.albicans 5314.Notably,compounds Z20,Z22,K10,K11 and K16 also displayed different activities against two fluconazole-resistance strains that were isolated from AIDS patients.The minimal inhibitory concentration(MIC)values against fluconazole-resistant strains were in the range of 2-8μg/mL and 4-32μg/mL,respectively.Furthermore,molecular docking was performed to investigate the binding affinities and interaction modes between the target compound and N-myristoyltransferase. | Hang Xu Zhuang Hou Zhen Liang Meng-Bi Guo Xin Su Chun Guo | 2019 | Chinese Journal of Chemistry2019，37，12： | 5 |
| 13 | A retrospective comparison of the efficacy and safety in kidney transplant recipients with basiliximab and anti-thymocyte globulin显示文摘 | WANG Wei YIN Hang LI Xiao-bei HU Xiao-peng YANG Xiao-yong LIU Hang REN Liang WANG Yong ZHANG Xiao-dong | 2012 | Chinese Medical Journal2012，，6： | 5 |
| 14 | 2010–2014年广州市结直肠癌发病率的时空分析显示文摘背景与目的结直肠癌(colorectal cancer,CRC)是一种常见的恶性肿瘤。本研究分析了2010–2014年广州地区结直肠癌发病率的时空分布。方法结直肠癌发病数据来自广州癌症登记系统。采用空间自相关分析和回顾性时空扫描评估CRC病例的时空聚集分布。结果 2010–2014年期间,在广州共登记了14,618例CRC病例,粗发病率为35.56/100,000,世界人口标化发病率(age?standardized rate of incidence by the world standard population,ASRIW)为23.58/100,000。粗发病率从2010年(32.88/100,000)到2014年(39.36/100,000)增长了19.70%,平均年变化率(average annual percentage change,AAPC)为4.33%。ASRIW的AAPC无统计学意义。空间自相关分析显示了广州市中心城区为一个CRC的发病热点,该区域包括了位于白云区西南部、海珠区西北部以及荔湾和越秀区的交界部的共25条街道。CRC发病聚集区的时空扫描分析确定了3个高发和5个低发病聚集区。高发聚集区位于中心城区,包括白云、海珠、荔湾和越秀区之间的交界地区。结论本研究展示出了广州地区CRC发病率的时空聚集模式。该数据可为CRC筛查中合理分配健康资源提供参考信息。 | Ke Li Guo-Zhen Lin Yan Li Hang Dong Huan Xu Shao-Fang Song Ying-Ru Liang Hua-Zhang Liu | 2018 | 癌症2018，37，5： | 4 |
| 15 | Sub-micrometer-scale chemical analysis by nanosecond-laser-induced tip-enhanced ablation and ionization time-of-flight mass spectrometry显示文摘The tip-enhanced near-field technique has drawn great attention recently becauseit is a promising technique for nanoscale chemical analysis when combined withother spectroscopic methods. Furthermore, this integration can improve the spatialresolution of mass spectrometry. In this stud~ a nanosecond-laser (nsqaser)-inducedtip-enhanced ablation and ionization source was coupled to an in-house-builtlaser ionization time-of-flight mass spectrometer. Sub-micrometer-sized craters(with diameters of 200-300 nm) were observed on titanium (Ti) film coated ontoa gold (Au) substrate. The corresponding mass spectra were acquired, whichverified that sub-micrometer-sized ablation (and subsequently ionization) couldbe achieved by the ns-laser-induced tip-enhanced electromagnetic field. Inaddition, formation of the crater was studied with an increased number of laserpulses. Furthermore, a mass spectrometry imaging (MSI) experiment wasperformed with potassium chloride (KC1) residue dropped onto nano-patternedgold pillars, achieving 80-nm lateral resolution. | Xiaoping Li Zhisen Liang Shudi Zhang Tongtong Wang Wei Hang | 2018 | Nano Research2018，11，11： | 4 |
| 16 | Controllable photodynamic performance via an acidic microenvironment based on two-dimensional metal-organic frameworks for photodynamic therapy显示文摘Photodynamic therapy(PDT)is a widely-used technology for cancer therapy,but conventional photosensitizers still face some drawbacks,such as hydrophobicity,inadequate pharmacokinetics,low cell/tissue specificity,and uncontrollable photodynamic performance during the therapeutic process.Herein,we present a controllable photodynamic performance based on two-dimensional metal-organic frameworks(2D Zn-TCPP MOF)that displayed a week PDT effect under a neutral environment upon exposure to a 660 nm laser due to the degeneracy of Q bands of TCPP.However,the 2D Zn-TCPP MOF showed a significantly enhanced PDT effect in an acidic environment under irradiation with a 660 nm laser due to the released TCPP from decomposed MOF structure.From the in vitro outcomes,the 2D Zn-TCPP MOF showed controllable photodynamic performance from neutral to acidic environments.Due to the acidic tumor microenvironment,the 2D Zn-TCPP MOF presented the strongest antitumor effect in vivo under irradiation with a 660 nm laser.This work offers a promising strategy to develop a next-generation photosensitizer. | Lifeng Hang Tao Zhang Hua Wen Lianbao Liang Wuming Li Xiaofen Ma Guihua Jiang | 2021 | Nano Research2021，14，3： | 4 |
| 17 | Cyanobacteria-based near-infrared light-excited self-supplying oxygen system for enhanced photodynamic therapy of hypoxic tumors显示文摘Tumor hypoxia has been considered to induce tumor cell resistance to radiotherapy and anticancer chemotherapy,as well as predisposing for increased tumor metastases.Therefore,strategies for the eradication of the hypoxic tumor are highly desirable.Photodynamic therapy(PDT)is a new technique that can be used to treat tumors using laser irradiation to photochemically activate a photosensitizer.Compared to traditional radiotherapy and chemotherapy,photodynamic therapy has many advantages,such as good selectivity,low toxicity,and less trauma and resistance.However,PDT is oxygen-dependent,and the lack of oxygen in hypoxic tumors renders photodynamic therapy ineffective.Cyanobacteria,the earliest photosynthetic oxygen-generating organisms,can utilize water as an electron donor to reduce CO_(2) into organic carbon compounds along with continuously releasing oxygen under sunlight.Inspired by this,herein,cyanobacteria were used as a living carrier of photosensitizer conjugated upconversion nanoparticles(UCNP)to construct a self-supplying oxygen PDT system.Improvement in the PDT efficiency for hypoxic tumors can be achieved as a result of in situ oxygen production by cyanobacteria under near-infrared(NIR)light using UCNP as a light harvesting antenna.A successful demonstration of this concept would be of great significance and could open the door to a new generation of carrier systems in the field of hypoxia-targeted drug transport platforms. | Yinghua Zhang Huifang Liu Xinyue Dai Hang Li Xiaohan Zhou Shizhu Chen Jinchao Zhang Xing-Jie Liang Zhenhua Li | 2021 | Nano Research2021，14，3： | 4 |
| 18 | Changes in biochemical parameters on the first day after kidney transplantation: risk factors for nosocomial infection?显示文摘在早移植以后的时期的背景医院的感染是为肾移植的一个坚韧的问题。很少报告在肾移植探索了在生物化学的参数和医院的感染之间的关系。这回顾的研究被执行在肾移植的早时期描述医院的感染的特征并且在生物化学的参数和他们的改变决定风险因素。在北京 Chao-Yang 医院里从 2001 年 1 月经历了他们的第一肾移植到 2009 年 3 月的方法病人被招募,医院的传染事件为这研究是镇定的。性,年龄,施主类型,推迟的接枝函数(DGF ) 和象浆液那样的生物化学的参数白天 0 上的尿酸,类脂化合物文件和白朊(在移植前) 并且白天 1 (在移植以后的 24 个小时) 并且他们的变化为医院的感染与逻辑回归模型一起被分析。405 个病人(315 个男人和 90 个女人) 全部的结果 A 涉及这研究。有 80 个病人,经历 113 个感染事件,微生物的 105 紧张是 indentified。在 univariate 分析,在 DGF 有重要差别,白天 0 上的白朊,白天 1 上的脂蛋白(a)( Lp (a)),在低密度脂蛋白胆固醇的变化( LDL-C ,白天1天 0 )并且在尿酸变化(白天1天 0 )在医院的感染病人和 noninfectious 病人之间( P < 0.05 )。在 multivariate 分析,在尿酸变化(白天 1 天 0 )( 离开 5.139, 95% Cl 1.176-22.465, P < 0.05 ) ,在 LDL-C 的变化(白天 1 天 0 ){ OR4.179, 95% Cl 1.375-12.703, P < 0.05 ) 并且 DGF (吗?14.409, 95% Cl 1.603-129.522, P < 0.05 ) 在肾移植为医院的感染作为独立风险因素被识别。在肾移植的早手术后的时期的结论很医院的感染是细菌的,特别与克否定的细菌。最普通的感染地点是呼吸的道,尿道和外科的地点。DGF, LDL-C 的减少和尿酸的增加能为医院的感染增加风险。 | YANG Yi REN Liang ZHANG Yong LIU Hang CAO Bin ZHANG Xiao-dong | 2010 | Chinese Medical Journal2010，，5： | 4 |
| 19 | Investigation of Portevin–Le Chatelier effect in rolled α-phase Mg-Li alloy during tensile and compressive deformation显示文摘Avoiding the Portevin-Le Chatelier(PLC)effect is very important concern for wrought Mg-Li alloys.In this study,the special PLC effect was found in rolled Mg-5Li-3Al-2Zn(LAZ532)alloy during tensile and compressive deformation.By observing microstructure evolution of the alloy during tensile and compressive deformation,it was found that prismaticand pyramidalslips were activated during tensile deformation,resulting in plenty of dislocation accumulation.In the deformation process after compressive yielding,the deformations in coarse grains and fine grains were dominated by{1012}extension twinning and grain boundary slip,respectively.Based on experimental result analysis,the sudden appearance of PLC effect in the later stage of axial tensile deformation(along rolled direction)was caused by interaction between solute atoms and dislocations.In the process of axial compressive deformation(along rolled direction),PLC effect presented the complex and changeable phenomenon of appeared-disappeared-appeared,which was mainly caused by the continuous nucleation of twin in the material,the activation of grain boundary slip and the shear deformation of twin,respectively. | Xiaoqiang Li Chunlong Cheng Qichi Le Lei Bao Peipeng Jin Ping Wang Liang Ren Hang Wang Xiong Zhou Chenglu Hu | 2020 | Journal of Materials Science & Technology2020，52，17： | 3 |
| 20 | Tectonics-palaeogeomorphology in rift basins: controlling effect on the sequence architecture显示文摘The relationship between deposition and tectonics of sedimentary basins has been a significant subject in recent years.Using typical rift basins such as the Nanpu Sag as an example,combined with the analysis of the tectonics-palaeogeomorphology of basins,we undertook a detailed study of the differences of the third-order sequences in different basins,the combination of depositional systems within the sequence framework and the distribution of depocenters and subsidence centers.Our results revealed a significant relationship between the tectonics-palaeogeomorphology of rift basins and the filling styles of sedimentary sequences.The basin structure plays a primary role in controlling the development of the third-order sequences and the boundary of these sequences is easily formed in basins with gentle slopes,shallow water and a small area.The characteristics of the tectonics-palaeogeomorphology of rift basins are dominated by half-grabens of extensional faults,which affect the temporal and spatial combination of sedimentary systems within the sequences as well as the distribution of depocenters and subsidence centers.Based on the development rules of the faults dominating the half-grabens of extensional faults,rift basins are classified into two types: the single fault segmented-linkage type and the multi-fault combination type.The main controlling factors of the temporal and spatial combination of sedimentary systems and the distribution of depocenters and subsidence centers in different basins are different.The characteristics of early segmentation and later linkage of the faults play a critical role in controlling the sedimentary system combination within the sequence framework and the temporal and spatial differences of depocenters and subsidence centers of the single fault segmented-linkage rift basins,while the differences in fault activities are the dominating factors of the multi-fault combination rift basins. | Ji Hancheng Jia Haibo Sun Simin Chen Liang Tang Yang Chen Wei Geng Yikai Zhou Hang | 2013 | Petroleum Science2013，10，4： | 3 |
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