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| 1 | Vanadium recovery from clay vanadium mineral using an acid leaching method显示文摘包括直接酸的沥滤的一种技术,钒降水与碱,钠氢氧化物重新沥滤,杂质由由烤步调整 pH 价值,有铵氯化物的降水钒,和钒 pentoxide 搬迁根据 Xichuan 的特征被建议泥土钒矿物质。影响象温度和硫磺的酸的集中那样的沥滤的钒的因素被调查并且优化。试验性的结果显示 V2O5 的摘录比率能分别地在 3% 的钠氯酸盐比率和 3% 的锰二氧化物比率到达 94% 和 92% 。一个完全化学的降水方法被采用清除并且在酸的沥滤溶液充实钒。X 光检查衍射(XRD ) 模式和钒 pentoxide 的纯净分析显示最后的钒 pentoxide 的纯净能到达 99% 并且遇见标准说明。全部的恢复能到达大约 75% 。这种技术作为与传统的咸烤方法相比有简洁,更少的投资,和更多的环境安全的特征。 | LI Haoran FENG Yali LIANG Jianglong LUO Xiaobing DU Zhuwei | 2008 | Rare Metals2008，27，2： | 23 |
| 2 | Emerging roles of transforming growth factor β signaling in wet age-related macular degeneration显示文摘Age-related macular degeneration (AMD) is one of the major causes of irreversible blindness among aging populations in developed countries and can be classified as dry or wet according to its progression.Wet AMD,which is characterized by angiogenesis on the choroidal membrane,is uncommonly seen but more severe.Controlling or completely inhibiting the factors that contribute to the progression of events that lead to angiogenesis may be an effective strategy for treating wet AMD.Emerging evidence has shown that transforming growth factor-β(TGF-β) signaling plays a significant role in the progression of wet AMD.In this review,we described the roles of and changes in TGF-β signaling in the development of AMD and discussed the mechanisms of the TGF-β superfamily in choroidal neovascularization (CNV) and wet AMD,including the modulation of angiogenesis-related factors,inflammation,vascular fibrosis,and immune responses,as well as cross-talk with other signaling pathways.These remarkable findings indicate that TGF-β signaling is a potential target for wet AMD treatment. | Kai Wang Haoran Li Ruipu Sun Chaxian Liu Yunfei Luo Shuhua Fu Ying Ying | 2019 | Acta Biochimica et Biophysica Sinica2019，51，1： | 5 |
| 3 | Infrared spectroscopic study on chemical and phase equilibrium in triethylammonium acetate显示文摘Protic ionic liquid (PIL) triethylammonium acetate was prepared by mixing equimolar amounts of acetic acid and triethylamine, and then studied using the combination of the Attenuated Total Reflection Fourier Transform Infrared spectroscopy, in-situ infrared spectroscopy, pH, and conductivity titration measurements. It was found that the equimolar synthesized triethylammonium acetate was separated into two layers, which suggesting that there were both chemical and phase equilibrium in this solution. Molecular species could be directly observed in the IR spectra over the range of 1200-1800 cm-1 and also checked by 1H NMR. Based on analysis, the upper layer was rich in amine with little acid and PIL, and the down layer was rich in PIL with residual acetic acid and amine. And single PIL-rich layer could be separated into two layers again when the mole ratio of newly added triethyamine to the theoretical produced triethylammonium acetate reached 0.12. | LV YiQi GUO Yan LUO XiaoYan LI HaoRan | 2012 | Science China Chemistry2012，55，8： | 2 |
| 4 | The SACT Template:A Human Brain Diffusion Tensor Template for School-age Children显示文摘School-age children are in a specific development stage corresponding to juvenility,when the white matter of the brain experiences ongoing maturation.Dffusion-weighted magnetic resonance imaging(DWI),especially diffusion tensor imaging(DTI),is extensively used to characterize the maturation by assessing white matter properties in vivo.In the analysis of DWI data,spatial normalization is crucial for conducting inter-subject analyses or linking the individual space with the reference space.Using tensor-based registration with an appropriate diffusion tensor template presents high accuracy regarding spatial normalization.However,there is a lack of a standardized diffusion tensor template dedicated to school-age children with ongoing brain development.Here,we established the school-age children diffusion tensor(SACT)template by optimizing tensor reorientation on high-quality DTI data from a large sample of cognitively normal participants aged 6-12 years.With an age-balanced design,the SACT template represented the entire age range well by showing high similarity to the age-specific templates.Compared with the tensor template of adults,the SACT template revealed significantly higher spatial normalization accuracy and inter-subject coherence upon evaluation of subjects in two different datasets of schoolage children.A practical application regarding the age associations with the normalized DTI-derived data was conducted to further compare the SACT template and the adult template.Although similar spatial patterns were found,the SACT template showed significant effects on the distributions of the statistical results,which may be related to the performance of spatial normalization.Looking forward,the SACT template could contribute to future studies of white matter development in both healthy and clinical populations.The SACT template is publicly available now(tp://igshare com/aricles/dataseu'SACT_.template/14071283). | Congying Chu Haoran Guan Sangma Xie Yanpei Wang Jie Luo Gai Zhao Zhiying Pan Mingming Hu Weiwei Men Shuping Tan Jia-Hong Gao Shaozheng Qin Yong He Lingzhong Fan Qi Dong Sha Tao | 2022 | Neuroscience Bulletin2022，38，6： | 1 |
| 5 | New Campus Design of Institute of Technology, Jiangxi Normal University显示文摘The construction of new campus of Institute of Technology,Jiangxi Normal University was based on 'returning to teaching',natural ecological conditions of the local area and enclosed house characterized by 'Gan-Po culture'(culture of Jiangxi and Lake Poyang) were integrated into the design,and innovative auxiliary pedestrian roads introduced,so as to build an ecological,natural and humanistic campus with regional characteristics,multiple-level and three-dimensional development. A novel mode was given to the campus construction from a brand-new perspective. | LENG Haoran LUO Qi CHEN Xiaogang | 2013 | Journal of Landscape Research2013，5，10： | 1 |
| 6 | Efficacy and complications of inoperable malignant distal biliary obstruction treatment by metallic stents:fully covered or uncovered?显示文摘Obstructive jaundice caused by malignant distal biliary obstruction is a common clinical symptom in patients with inoperable biliary–pancreatic cancer.Endoscopic retrograde cholangiopancreatography(ERCP)-guided stent implantation is an effective treatment for obstructive jaundice.Internal stent drainage is more physiologic and associated with a better quality of life than external stent drainage methods such as percutaneous transhepatic gallbladder drainage or percutaneous transhepatic cholangiodrainage.Selfexpanding metallic stents,which may be covered and uncovered,are commonly used.However,some uncertainties remain regarding the selection of metallic stents,including drainage patency time,clinical effect,stent migration,and post-operative complications such as pancreatitis,bleeding,and cholecystitis.This review aims to summarize the current progress and controversies surrounding the use of covered or uncovered metallic stents in inoperable common biliary obstruction via ERCP. | Jiangning Gu Xiaoyi Guo Yong Sun Bin Fan Haoran Li Ting Luo Haifeng Luo Jiao Liu Feng Gao Yuan Gao Guang Tan Xiaoming Liu Zhuo Yang | 2023 | Gastroenterology Report2023，11，1： | 0 |
| 7 | Sorption mechanisms of diphenylarsinic acid on natural magnetite and siderite:Evidence from sorption kinetics,sequential extraction and extended X-ray absorption fine-structure spectroscopy analysis显示文摘Diphenylarsinic acid(DPAA)is both the prime starting material and major metabolite of chemical weapons(CWs).Because of its toxicity and the widespread distribution of abandoned CWs in burial site,DPAA sorption by natural Fe minerals is of considerable interest.Here we report the first study on DPAA sorption by natural magnetite and siderite using macroscopic sorption kinetics,sequential extraction procedure(SEP)and microscopic extended X-ray absorption fine-structure spectroscopy(EXAFS).Our results show that the sorption pseudo-equilibrated in 60 minutes and that close to 50%and 20%–30%removal can be achieved for magnetite and siderite,respectively,at the initial DPAA concentrations of 4–100 mg/L.DPAA sorption followed pseudo-secondary and intra-particle diffusion kinetics models,and the whole process was mainly governed by intra-particle diffusion and chemical bonding.SEP and EXAFS results revealed that DPAA mainly formed inner-sphere complexes on magnetite(>80%),while on siderite it simultaneously resulted in outer-sphere and inner-sphere complexes.EXAFS analysis further confirmed the formation of inner-sphere bidentate binuclear corner-sharing complexes(^(2)C)for DPAA.Comparison of these results with previous studies suggests that phenyl groups are likely to impact the sorption capacity and structure of DPAA by increasing steric hindrance or affecting the way the central arsenic(As)atom maintains charge balance.These results improve our knowledge of DPAA interactions with Fe minerals,which will help to develop remediation technology and predict the fate of DPAA in soil-water environments. | Meng Zhu Yuhuan He Xiaobao Wei Haoran Qi Yunpeng Zhang Yijun Zhang Ruyi Yang Yongming Luo | 2022 | Frontiers of Environmental Science & Engineering2022，16，9： | 0 |
| 8 | A modified single edge V-notched beam method for evaluating surface fracture toughness of thermal barrier coatings显示文摘The surface fracture toughness is an important mechanical parameter for studying the failure behavior of air plasma sprayed(APS)thermal barrier coatings(TBCs).As APS TBCs are typical multilayer porous ceramic materials,the direct applications of the traditional single edge notched beam(SENB)method that ignores those typical structural characters may cause errors.To measure the surface fracture toughness more accurately,the effects of multilayer and porous characters on the fracture toughness of APS TBCs should be considered.In this paper,a modified single edge V-notched beam(MSEVNB)method with typical structural characters is developed.According to the finite element analysis(FEA),the geometry factor of the multilayer structure is recalculated.Owing to the narrower V-notches,a more accurate critical fracture stress is obtained.Based on the Griffith energy balance,the reduction of the crack surface caused by micro-defects is corrected.The MSEVNB method can measure the surface fracture toughness more accurately than the SENB method. | Haoran BAI Zhanyu WANG Sangyu LUO Zhaoliang QU Daining FANG | 2023 | Applied Mathematics and Mechanics(English Edition)2023，44，5： | 0 |
| 9 | Assessment on gas-polyethylene terephthalate solid interface partial discharge properties of C4F7N/CO_(2)gas mixture for eco-friendly gas insulating transformer显示文摘The eco-friendly insulating gas perfluoroisobutyronitrile(C_(4)F_(7)N)is potentially used in gas-insulated transformers(GIT)to replace sulphur hexafluoride(SF_(6)).However,evaluation of the long-term insulation reliability and gas–solid interface discharge decomposition characteristics of the gas–solid film insulation structure in GIT is indispensable.The authors simulated the gas–solid film insulation structure in GIT and explored the interface partial discharge(PD)characteristics of C4F7N/CO_(2)gas mixture with polyethylene terephthalate(PET).The effect of gas pressure,mixing ratio on gas–solid interface gas decomposition,PET degradation was investigated,and the interaction mechanism was analysed.It is found that the interface PD generated three degradation regions on a PET film.The gas–solid interface reaction in the electrode contact region and the discharge development trace was significantly higher than that of halation region.The content of gas decomposition products decreases with the increase of gas pressure and the PD intensity of SF6-PET is inferior to that of C_(4)F_(7)N/CO_(2)under the same condition.Relevant results provide reference for the development and application of C_(4)F_(7)N/CO_(2)based GIT. | Song Xiao Yifan Wang Chenhua Ren Haoran Xia Yue Zhao Jingzi Qin Xiaoxing Zhang Yi Luo Yi Li | 2024 | High Voltage2024，9，1： | 0 |
| 10 | The Effect of Sleep on Workplace Interpersonal Conflict: The Mediating Role of Ego Depletion显示文摘This study aimed to investigate the relationship between sleep and workplace interpersonal conflict and the role ofego depletion as the mediating mechanism. A survey was conducted daily for two weeks using an experience samplingmethod. A sample of 79 employees from the East Coast of China was collected. A multilevel regression analysiswas conducted to test the proposed hypotheses. Results indicated that higher sleep quantity was associatedwith lower daily ego depletion at noon and lower workplace interpersonal conflict. Moreover, ego depletionmediated the effects of sleep quantity on workplace interpersonal conflict. The findings identified the adverseeffects of insufficient sleep on daily interpersonal interactions and provided a valuable perspective on workplaceinterpersonal conflict management. Furthermore, the study broadened the scope of antecedents that impact howemployees experience daily workplace interpersonal conflict and assessed the mediating role of ego depletion inthis relationship. | Mei Chen Haoran Dong Yang Luo Hui Meng | 2022 | International Journal of Mental Health Promotion2022，24，6： | 0 |
| 11 | Evaluating Tislelizumab, Lenvatinib, and FOLFOX4-HAIC as a Conversion Therapy for Unresectable Hepatocellular Carcinoma显示文摘Background and aims:Conversion therapy downstages tumors and renders patients with unresectable hepatocel-lular carcinoma(HCC)eligible for radical resection.This study aimed to evaluate the efficacy and safety of tislelizumab plus lenvatinib and hepatic artery infusion chemotherapy with oxaliplatin,fluorouracil,and leuco-vorin(FOLFOX4-HAIC)as a first-line conversion therapy.Methods:Clinical data from HCC patients who were treated with the triple therapy between April 2021 and April 2022 were retrospectively analyzed.The primary outcome included objective response rate(ORR),disease control rate(DCR),conversion resection rate(CRR),and treatment-related adverse events(TRAEs).Results:A total of 18 patients completed conversion therapy assessment,which ended on March 27,2023.The patients had a median age of 55.5(37–72)years,and 94.4%were male.According to mRECIST,tumor shrinkage was observed in all patients,with an ORR of 94.4%(17/18),a DCR of 94.4%(17/18),and a median time to response of 1.4(0.7–3.0)months.Successful conversion was observed in 61.1%(11/18)of patients(mRECIST).The CRR and pathological complete response were 38.9%(7/18)and 57.1%(4/7),respectively.The median progression-free survival(PFS)was 17.8 months,while median overall survival was not reached.The 6-and 9-month PFS rates were 83.3%and 66.7%,respectively.The most common TRAE(16/18 patients,88.9%)was an increase in aspartate aminotransferase levels.Conclusion:Tislelizumab combined with lenvatinib and FOLFOX4-HAIC achieved a high conversion rate and acceptable toxicity in patients with unresectable HCC,suggesting that this combination may represent a new conversion strategy for this population. | Kai Tan Xiaojun He Haoran Yuan Shoujie Zhao Chenyu Gong Yaoyao Zhao Haiyan Nan Li Zang Zhonghua Luo Xilin Du | 2023 | iLIVER2023，2，3： | 0 |
| 12 | Accelerated discovery of novel high-performance zinc-ion battery cathode materials by combining high-throughput screening and experiments显示文摘Aqueous zinc ion batteries(AZIBs)have attracted much attention in recent years due to their high safety,low cost,and decent electrochemical performance.However,the traditional electrodes development process requires tedious synthesis and testing procedures,which reduces the efficiency of developing highperformance battery devices.Here,we proposed a high-throughput screening strategy based on firstprinciples calculations to aid the experimental development of high-performance spinel cathode materials for AZIBs.We obtained 14 spinel materials from 12,047 Mn/Zn-O based materials by examining their structures and whether they satisfy the basic properties of electrodes.Then their band structures and density of states,open circuit voltage and volume expansion rate,ionic diffusion coefficient and energy barrier were further evaluated by first-principles calculations,resulting in five potential candidates.One of the promising candidates identified,Mg_(2)MnO_(4),was experimentally synthesized,characterized and integrated into an AZIB based cell to verify its performance as a cathode.The Mg_(2)MnO_(4)cathode exhibits excellent cycling stability,which is consistent with the theoretically predicted low volume expansion.Moreover,at high current density,the Mg_(2)MnO_(4)cathode still exhibits high reversible capacity and excellent rate performance,indicating that it is an excellent cathode material for AZIBs.Our work provides a new approach to accelerate the development of high-performance cathodes for AZIBs and other ion batteries. | Haoran Luo Jiangbin Deng Qianzhi Gou Omololu Odunmbaku Kuan Sun Juanxiu Xiao Meng Li Yujie Zheng | 2023 | Chinese Chemical Letters2023，34，8： | 0 |
| 13 | Enhanced thermal performance from liquid metal in copper/graphite filled elastomer显示文摘With the increasing integration level of modern electronics,thermal management becomes an urgent issue for guaranteeing the work efficiency and lifespan of electronics.On the basis of intrinsic high thermal conductivity nature,highly ordered graphite and copper stripes are densely aligned in the silicone gel pads in vertical(VCuGr)and oblique(@15°CuGr)directions to couple the high thermal conductivity and mechanical softness.The wetting nature of liquid metal(LM)on the chemically treated Cu surface is utilized to form a LM layer on the two surfaces of thermal pads.The obtained LM-pad TIMs possessed ultrahigh through-plane thermal conductivity(VCuGr:71.4 W/(m K),@15°CuGr:62.5 W/(m K))under the normal packaging pressure.The thermal resistance decreased from 0.69 cm^(2) K/W to 0.25 cm^(2) K/W with the surface modification with LM.Theoretical simulation and practical thermal dissipation test results further demonstrate the excellent thermal management capability of these composites in high-power electronics. | Yisimayili Tuersun Xu Huang Mingdeng Huang Weiguang Lin Pingjun Luo Haoran Yang Sheng Chu | 2023 | Journal of Materials Science & Technology2023，，21： | 0 |
| 14 | One-pot Baeyer-Villiger oxidation of cyclohexanone with in situ generated hydrogen peroxide over Sn-Beta zeolites显示文摘ε-Caprolactone is traditionally produced through Baeyer-Villiger oxidation of cyclohexanone oxidized by peracids in industry,which inevitably results in large discard acid and environmental pollution.To this end,a green route toε-caprolactone was developed by coupling the direct generation of hydrogen peroxide from aerobic oxidation of benzhydrol catalyzed by NHPI and Baeyer-Villiger oxidation of cyclohexanone with the in situ hydrogen peroxide over Sn-Beta zeolites in one pot.Molecular oxygen was employed as the terminal oxidant,and the effects of several reaction factors were studied.Compared with one-step process,the one-pot two-step method noticeably improved the selectivity ofε-caprolactone.When the amount of in situ hydrogen peroxide was 0.72 equivalent,the selectivity ofε-caprolactone was obtained 94.8%with 39.2%conversion of cyclohexanone,and the efficiency of H_(2)O_(2) was up to 51.5%.As compared to the commercial 30 wt%aqueous H_(2)O_(2) added directly,in situ H_(2)O_(2) dramatically improved the selectivity ofε-caprolactone and had higher efficiency.Additionally,the catalyst could be easily separated from the reaction solution and reused several times without the remarkable loss of activity. | Jianwei Luo Haoran Yuan Hui Liu Jingbo Li Yu Wang Yong Wang Jia Yao Haoran Li | 2021 | Green Chemical Engineering2021，2，3： | 0 |
| 15 | Planckian dissipation and non-Ginzburg-Landau type upper critical field in Bi2201显示文摘Resistivity and Hall effect measurements have been carried out on a micro-fabricated bridge of Bi2201 single crystal at low temperatures down to 0.4 K under high magnetic fields.When superconductivity is crashed by a high magnetic field,the recovered 'normal state' resistivity still shows a linear temperature dependence in the low temperature region.Combining with the effective mass and the charge carrier density,we get a linear scattering rate 1/τ=αkBT/h with 0.77 <α <1.16,which gives a strong evidence of the Planckian dissipation.Furthermore,our results reveal a new type of temperature dependence of the upper critical field,H_(c2)(T)=H*■,which is totally different from the expectation of the Ginzburg-Landau theory,and suggests the existence of uncondensed Cooper pairs above H_(c2)(T) line. | Qihao Zang Zhengyan Zhu Zuyu Xu Shichao Qi Haoran Ji Yiwen Li Jian Wang Huiqian Luo Hua-Bing Wang Hai-Hu Wen | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，3： | 0 |
| 16 | Transport mechanism in Hf_(0.5)Zr_(0.5)O_(2)-based ferroelectric diodes显示文摘Doped HfO_(2),as an emerging ferroelectric material,could overcome the shortcomings of traditional ferroelectrics[1].Hf_(0.5)Zr_(0.5)O_(2)(HZO)is a good choice for Hf-doped materials because of its excellent ferroelectric properties and mature preparation process.In our previous studies,we proposed a new HZO switchable ferroelectric diode(FE diode)with several advantages,such as high operating speed. | Haoran YU Tiancheng GONG Peng YUAN Yuan WANG Zhaomeng GAO Xiaoxin XU Ying SUN Ran CHENG Jianfeng GAO Junfeng LI Bing CHEN Qing LUO | 2023 | Science China(Information Sciences)2023，66，12： | 0 |
| 17 | Accelerating net-zero carbon emissions by electrochemical reduction of carbon dioxide显示文摘Electroreduction of CO_(2)shows great potential for global CO_(2)utilization and uptake when collaborated with renewable electricity.Recent advances have been achieved in fundamental understanding and electrocatalyst development for CO_(2)electroreduction.We think this research area has progressed to the stage where significant efforts can focus on translating the obtained knowledge to the development of largescale electrolyzers,which have the potential to accelerate the transition of the current energy system into a sustainable and zero-carbon emission energy structure.In this perspective paper,we first critically evaluate the advancement of vapor-feed devices that use CO_(2)as reactants,from the point of view of industry applications.Then,by carefully comparing their performance to the state-of-the-art water electrolyzers which are well-established technology providing realistic performance targets,we looped back and discussed the remaining challenges including electrode catalysts,reaction conditions,mass transporting,membrane,device durability,operation mode,and so on.Finally,we provide perspectives on the challenges and suggest opportunities for generating fundamental knowledge and achieving technological progress toward the development of practical CO_(2)electrolyzers for the goal of building lowcarbon or/and net carbon-free economies. | Fan He Sirui Tong Zhouyang Luo Haoran Ding Ziye Cheng Chenxi Li Zhifu Qi | 2023 | Journal of Energy Chemistry2023，，4： | 0 |
| 18 | Cooperative multi-target hunting by unmanned surface vehicles based on multi-agent reinforcement learning显示文摘To solve the problem of multi-target hunting by an unmanned surface vehicle(USV)fleet,a hunting algorithm based on multi-agent reinforcement learning is proposed.Firstly,the hunting environment and kinematic model without boundary constraints are built,and the criteria for successful target capture are given.Then,the cooperative hunting problem of a USV fleet is modeled as a decentralized partially observable Markov decision process(Dec-POMDP),and a distributed partially observable multitarget hunting Proximal Policy Optimization(DPOMH-PPO)algorithm applicable to USVs is proposed.In addition,an observation model,a reward function and the action space applicable to multi-target hunting tasks are designed.To deal with the dynamic change of observational feature dimension input by partially observable systems,a feature embedding block is proposed.By combining the two feature compression methods of column-wise max pooling(CMP)and column-wise average-pooling(CAP),observational feature encoding is established.Finally,the centralized training and decentralized execution framework is adopted to complete the training of hunting strategy.Each USV in the fleet shares the same policy and perform actions independently.Simulation experiments have verified the effectiveness of the DPOMH-PPO algorithm in the test scenarios with different numbers of USVs.Moreover,the advantages of the proposed model are comprehensively analyzed from the aspects of algorithm performance,migration effect in task scenarios and self-organization capability after being damaged,the potential deployment and application of DPOMH-PPO in the real environment is verified. | Jiawei Xia Yasong Luo Zhikun Liu Yalun Zhang Haoran Shi Zhong Liu | 2023 | Defence Technology(防务技术)2023，29，11： | 0 |
| 19 | Boosting cycling stability by regulating surface oxygen vacancies of LNMO by rapid calcination显示文摘Spinel LiNi_(0.5-x)Mn_(1.5+x)O_(4)(LNMO)has attracted intensive interest for lithium-ion battery due to its high voltage and high energy density.However,severe capacity fade attributed to unstable surface structure has hampered its commercialization.Oxygen vacancies(OVs)tend to occur in the surface of the material and lead to surface structure reconstruction,which deteriorates the battery performance during electrochemical cycling.Here,we utilize high-temperature-shock(HTS)method to synthesize LNMO materials with fewer surface OVs.Rapid calcination drives lower surface OVs concentration,reducing the content of Mn^(3+)and surface reconstruction layers,which is beneficial to obtain a stable crystal structure.The LNMO material synthesized by HTS method delivers an initial capacity of 127 mAh·g^(-1) at 0.1 C and capacity retention of 81.6%after 300 cycles at 1 C,and exhibits excellent performance at low temperature. | Haoran Jiang Cuihua Zeng Wei Zhu Jiawei Luo Zhedong Liu Jingchao Zhang Rui Liu Yunhua Xu Yanan Chen Wenbin Hu | 2024 | Nano Research2024，17，4： | 0 |
| 20 | Establishment and validation of psoriasis evaluation models显示文摘Psoriasis is a common inflammatory skin disease that seriously affects the patient's quality of life.The diagnosis of psoriasis is mainly based on clinical and pathological features,and the assessment depends on the psoriasis area and severity index(PASI).However,there are few reliable and accurate evaluation methods to assess lesion severity and therapeutic effects.This work identified 17 model genes from GEO datasets and established 6 psoriasis evaluation models by LASSO regression,linear regression,and random forest separately.Models were trained and evaluated in different GEO datasets.All 6 models accurately classified psoriatic lesions and non-lesional skin in training and testing data,and showed good AUC.In biologics-treated samples,the model scores were positively correlated with the severity of lesions and negatively correlated with treatment length.Thus,models have the potential to assess the therapeutic effects.In addition,the expression of model genes was examined in keratinocytes,skin of IMQ-induced psoriatic mice,and lesions of psoriasis patients.The RNA and protein levels of model genes increased in cytokine-stimulated keratinocytes and psoriatic lesions as expected.This work provides new methods to assess the lesion severity and therapeutic effects of biologies in psoriasis. | Yibo Hu Ling Jiang Li Lei Liping Luo Haoran Guo Ying Zhou Jinhua Huang Jing Chen Qinghai Zeng | 2022 | Fundamental Research2022，2，1： | 0 |
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