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| 1 | Construction of a metabolomics profile of arsenic trioxide effect in gastric carcinoma cell line SGC7901显示文摘砷三氧化物(ATO ) 为对待尖锐 promyelocytic 白血病是高度有效的。它也为治疗稳固的肿瘤保持诺言,包括胃的癌。然而,到稳固的肿瘤的 ATO 的有效性的分子的机制仍然糟糕被理解。在这研究,我们 chosed 是的胃的癌一个例子并且试着通过 metabolomics 揭示 antitumor 机制。胃的癌房间线 SGC7901 为 6, 12,和 24 h 与 ATO 被对待。全球代谢物侧面被 metabolomics 分析用气体监视层析(GC )/mass spectrometry (MS ) 和液体层析 /MS/MS。281 的一个总数证明代谢物可靠地被检测。生物信息学分析证明那 glycerophospholipid 合成,一个碳合成,和谷胱甘肽合成戏剧性地被影响。被影响了的另外的细胞的功能 / 小径包括了煽动性的反应,菸碱腺嘌 dinucleotide (NAD +), 和 polyamine 生合成小径。在有以前的 transcriptomics 和 proteomics 数据的联合,从这研究的 metabolomics 数据能为 ATO 处理的特定的 antitumor 机制的理解用作珍贵资源。 | Ziqing Chen Hainan Zhang Lina Yang Hewei Jiang Shujuan Guo Yang Li Shengce Tao | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 5 |
| 2 | Effect of the pineal gland on 5-hydroxytryptamine and γ-aminobutyric acid secretion in the hippocampus of male rats during the summer and winter显示文摘Objective:The present study aimed to investigate the effect of seasonal variation on neurotransmitter release in the hippocampus of normal rats and rats with pineal excision.Methods:Two time points,the summer and winter solstice,which are the longest and shortest days of the year,respectively,were selected.Male Spraguee Dawley rats that underwent a sham operation without pineal excision were included as a control group.The concentrations of 5-hydroxytryptamine(5-HT)andγ-aminobutyric acid(GABA)were determined by radioimmunoassays and enzyme-linked immunosorbent assays,respectively.Results:In the winter,the 5-HT and GABA levels in normal rats exhibited a significant difference compared with those in the operation group(P<.01).A difference was also noted in GABA levels between the normal group and the sham operation group(P<.05).The concentrations of 5-HT and GABA in the hippocampal tissues of the normal group exhibited a seasonal rhythm consisting of elevation during the summer and reduction during the winter(P<.01),while the GABA levels in the sham operation group exhibited a significant difference,with elevation during the summer and reduction during the winter(P<.01).In the operation group,GABA showed the same trend(P<.01).Conclusion:The seasonal rhythm of neurotransmitter secretion by the hippocampus(5-HT and GABA)consisted of elevation during the summer and reduction during the winter.During the winter,the pineal gland exhibited a reverse regulatory effect on the secretion of 5-HT and GABA in the hippocampus,and it exhibited seasonal selectivity with regard to the regulation of 5-HT. | Ting Li Hailu Wang Hewei Zhang Leilei Liu Peipei Li Shuran Ma | 2020 | Journal of Traditional Chinese Medical Sciences2020，7，3： | 2 |
| 3 | Wet Chemical Synthesis of Amorphous Nanomaterials with Well-Defined Morphologies显示文摘CONSPECTUS:Amorphous nanomaterials,with unique structural features such as long-range atomic disorder and nanoscale particle or grain sizes,possess some advantageous properties for a number of materials applications.For example,amorphous vanadium oxide exhibits a record-high cycling stability for supercapacitors.Several synthetic strategies have been developed to produce amorphous nanomaterials,such as physical processing-based approaches including cutting,deposition,and spinning,as well as chemical syntheses by solution or solid state reactions.However,despite the rapid development of amorphous nanomaterials,their morphology is still irregular or primarily sphere-like.The limited morphology control is partially attributed to the lack of preferred growth direction for the amorphous materials.It will be interesting to know whether different morphologies of even amorphous nanomaterials can influence their properties as much as their crystalline counterparts.Wet chemical synthesis,which can usually be carried out under relatively facile reaction conditions,has achieved remarkable success for creating crystalline nanomaterials with well-defined shapes,such as one-dimensional(1D)nanowires,two-dimensional(2D)nanosheets,and three-dimensional(3D)complex structures.However,there are two main obstacles for shape control of amorphous nanomaterials using wet chemical strategies.First,it is difficult to form a stable amorphous state under wet chemical conditions.The amorphous state is metastable in solution according to classic nucleation theory,which is prone to phase transformation to form crystalline state.Second,common morphology control mechanisms for nanocrystals are ultimately relying on the intrinsic directionality of the lattices,which unfortunately is not relevant to the isotropic amorphous nanomaterials.In this Account,we describe how shape control of 1D,2D,and 3D amorphous nanomaterials can be achieved in wet chemical synthesis to create well-defined morphologies,which are based on two main strategies:Blocking agents that can stabilize the amorphous state in solution,and morphology-tunable parameters that can induce directional growth.Discussion on the phase transfer blocking mechanisms includes lattice disordering,controlled hydrolysis,rapid reaction,and ionic exchange,and for morphology control through confinement it includes precursor transformation,templated reactions,interfacial etching,and spatial confinement.In addition,we present examples showing how these well-defined morphology leads to desirable properties in applications of mechanics,energy storage,catalysis,and optics,highlighting their structural-properties relationship.Finally,some perspectives are discussed regarding future research opportunities in the area of amorphous nanomaterials. | Hewei Zhao Fengshi Li Shaoxiong Wang Lin Guo | 2021 | Accounts of Materials Research2021，2，9： | 1 |
| 4 | Review of Research on Early Cambrian Phosphatized Quadrapyrgites显示文摘The metazoan Quadrapyrgites consists, from proximal to distal ends, of an oral area, a cone, a collar, and an apex from the Early Cambrian Fortunian Stage in Xixiang Zhangjiagou section, southern Shaanxi Province, South China. Three morphological types of the apex, the most characteristic feature of the taxon, are identified from hundreds of Quadrapyrgites specimens. The Quadrapyrgites growth zone is situated at the oral end, where 12 terminal lobes are generated, uplifted, enlarged, and evaginated to form a crest; A one-by-one of crest number from 2 to 13 has been recognized. The unique growth pattern and ontogenetic sequence refute a cubozoan or cycloneuralian affinity for Olivooides and Quadrapyrgites, and instead defend a coronate scyphozoan hypothesis. An embryonic development and ontogenetic sequence with embryo and crest is constructed. | SHAO Tiequan WANG Qi LIU Yunhuan ZHANG Yanan LI Hewei HU Bo LI Chuang DONG Zhiguo ZHANG Hongtao | 2015 | Acta Geologica Sinica(English Edition)2015，89，4： | 1 |
| 5 | Typical adaptive neural control for hypersonic vehicle based on higher-order filters显示文摘A typical adaptive neural control methodology is used for the rigid body model of the hypersonic vehicle. The rigid body model is divided into the altitude subsystem and the velocity subsystem. The proportional integral differential(PID) controller is introduced to control the velocity track. The backstepping design is applied for constructing the controllers for the altitude subsystem.To avoid the explosion of differentiation from backstepping, the higher-order filter dynamic is used for replacing the virtual controller in the backstepping design steps. In the design procedure,the radial basis function(RBF) neural network is investigated to approximate the unknown nonlinear functions in the system dynamic of the hypersonic vehicle. The simulations show the effectiveness of the design method. | ZHAO Hewei LI Rui | 2020 | Journal of Systems Engineering and Electronics2020，31，5： | 1 |
| 6 | Application of X-ray CT to liquid security inspection: System analysisand beam hardening correction显示文摘 | GAO Hewei ZHANG Li CHEN Zhiqiang | 2007 | Nuclear Instruments and Methods in Physics Research A2007，5790，： | 1 |
| 7 | The binding epitope of sintilimab on PD-1 revealed by AbMap显示文摘PD-1 plays an important role as an immune checkpoint.Sintilimab is a newly approved PD-1 antibody for cancer immunotherapy with an unknown binding epitope on PD-1.In this study,to elucidate the molecular mechanism by which sintilimab blocks PD-1 activation,we applied Antibody binding epitope Mapping(AbMap)to identify the binding epitope of sintilimab.An epitope was successfully identified,i.e.SLAPKA,aa 127-132.By constructing a series of point mutations,the dominant residues S127,L128,A129,P130,and A132 of PD-1 were further validated by western blot analysis,biolayer interferometry,and flow cytometry.Structural analysis showed that the epitope is partially within the binding interface of PD-1 and PD-L1,and this epitope also partially overlaps with that of nivolumab and pembrolizumab.These results demonstrate that sintilimab can attenuate PD-1 activation by directly competing with the interaction between PD-1 and PD-L1 through binding with the key residues of the FG loop on PD-1.This study also demonstrates the high efficiency and accuracy of AbMap for determining the binding epitope of therapeutic antibodies. | Mingliang Ma Huan Qi Chuansheng Hu Zhaowei Xu Fanlin Wu Nan Wang Danyun Lai Yang Li Hainan Zhang Hewei Jiang Qingfeng Meng Shujuan Guo Yani Kang Xiaodong Zhao Hua Li Sheng-ce Tao | 2021 | Acta Biochimica et Biophysica Sinica2021，53，5： | 1 |
| 8 | Acoustic response characteristics and sensitivity of briquette and raw coal under temperature and pressure control显示文摘Acoustic testing is a widely used technique to measure the coal mechanical properties under high temperature and pressure in situ conditions.This study compared the acoustic wave characteristics of briquette and raw coal under various temperature and pressure conditions.The results show that the longitudinal wave velocity(Vp)decreases with an increasing vitrinite content.A large number of the vitrinite content enhances the process in which the temperature and pressure changed the Vp.The Vp of briquette decreases approximately linearly with the temperature compared to raw coal.The Vp of raw coal experiences initially a rapid,then gradual,and finally the moderate increasing trend with the increase in confining pressure.However,in briquette,the Vp increases approximately linearly with the confining pressure.The results indicate that the Vp is more sensitive to temperature under low confining pressure and peaks at 50℃−60℃ than high confining pressure.However,the Vp is less sensitive to temperature under higher confining pressure,and the positive effect of high confining pressure is dominant.Understanding the mechanical properties of coal under high pressure and temperature develops better insight into coalbed methane(CBM)exploration from deep reservoirs. | Hewei ZHANG Jian SHEN Kexin LI Xiaojie FANG Ziwei WANG Lei DU | 2023 | Frontiers of Earth Science2023，17，1： | 0 |
| 9 | Research on Real-Time High Reliable Network File Distribution Technology显示文摘The rapid development of Internet of Things(IoT)technology has made previously unavailable data available,and applications can take advantage of device data for people to visualize,explore,and build complex analyses.As the size of the network and the number of network users continue to increase,network requests tend to aggregate on a small number of network resources,which results in uneven load on network requests.Real-time,highly reliable network file distribution technology is of great importance in the Internet of Things.This paper studies real-time and highly reliable file distribution technology for large-scale networks.In response to this topic,this paper studies the current file distribution technology,proposes a file distribution model,and proposes a corresponding load balancing method based on the file distribution model.Experiments show that the system has achieved real-time and high reliability of network transmission. | Chenglong Li Peipeng Liu Hewei Yu Mengmeng Ge Xiangzhan Yu Yi Xin Yuhang Wang Dongyu Zhang | 2020 | Computers, Materials & Continua2020，，11： | 0 |
| 10 | Prognostic role of plasma levels ofγ-glutamyl transpeptidase in patients with advanced gastric cancer treated with anti-PD-1 immunotherapy显示文摘Objective Antibodies targeting programmed cell death protein 1(PD-1)have become the mainstay of treatment for chemotherapy-refractory gastric cancer,characterized by high levels of programmed cell death ligand-1(PDL-1)expression.However,the routine clinical implementation of PDL-1 testing is currently limited by the lack of robust detection methods.In this regard,the role of plasmaγ-glutamyl transpeptidase(GGT),an N-terminal nucleophilic hydrolase,as an independent predictor of the efficacy of anti-PD-1 therapy remains unknown.In this study,we aimed to assessed the prognostic role of changes in plasma GGT levels(6 weeks vs.baseline)in patients with advanced gastric cancer treated with anti-PD-1 immunotherapy.Methods We retrospectively analyzed data from 57 patients with gastric cancer treated with anti-PD-1 antibodies(camrelizumab,sintilimab,nivolumab,tislelizumab,and toripalimab)at the Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China,from July 2018 to February 2021.Results We found that after 6 weeks of treatment,there were significant differences between responders and non-responders with respect to plasma GGT levels(P<0.001).Multivariate logistic regression analysis revealed that the continuous value of the 6-week difference in GGT levels(OR=1.437,95%CI=1.116-1.849,P=0.005)and 6-week difference in GGT≥0 or<0(OR=53.675,95%CI=6.379-451.669,P<0.001)were independent predictors of disease control.Survival analysis indicated that a reduction in plasma GGT6 levels during treatment was significantly associated with a favorable progression-free survival(PFS)and overall survival(P<0.001).Consistently,univariate and multivariate Cox regression analyses revealed that a reduction in plasma GGT6 levels during treatment was an independent predictor of PFS(HR=1.033,95%CI=1.013-1.053,P=0.001).Conclusion Alterations in plasma GGT levels during treatment can be used as a predictor of disease progression and survival in patients with advanced gastric cancer undergoing treatment with anti-PD-1 antibodies. | Shaojie Xu Yiming Feng Xingyin Li Zaozao Huang Hewei Li Ganxin Wang | 2022 | Oncology and Translational Medicine2022，8，3： | 0 |
| 11 | Effect and Mechanism of Dicliptera chinensis Polysaccharide on miR-141/AMPK/SIRT1 Signaling Pathway in Rats with NAFLD显示文摘[Objectives]Non-alcoholic fatty liver disease(NAFLD)rat model was established by feeding high-fat and high-sugar fodder to rats,and the protective effect of Dicliptera chinensis polysaccharide(DCP)on NAFLD rats was studied to explore its potential mechanism.[Methods]45 SD rats were randomly divided into 4 groups:normal control group,model control group and DCP treatment groups(100 and 300 mg/kg).The rats in the normal control group were fed with ordinary fodder,and the rats in other groups were fed with high-fat and high-sugar diet for 14 weeks to establish NAFLD model.From the 9^(th)week,the rats in the DCP treatment groups were given different doses of DCP by intragastric administration(5 mL/kg)for 6 weeks.After the last intragastric administration,the rats fasted for 16 h,and the serum and liver of rats were collected for detection.Hematoxylin-eosin(HE)staining was conducted to observe the histopathological changes of rat liver,and alanine aminotransferase(ALT),aspartate aminotransferase(AST),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),malondialdehyde(MDA),triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),and high density lipoprotein cholesterol(HDL-C)were detected by biochemical method.Interleukin-6(IL-6),interleukin-1β(IL-1β),tumor necrosis factor(TNF-α)and micrornA-141(micro RNA-141)were detected by reverse transcription-polymerase chain reaction(RT-PCR).The expression of SIRT1 and adenosine 5'-monophosphate(AMP)-activated protein kinase(AMPK)in rat liver was detected by western blot.[Results]Compared with the model control group,the inflammatory damage and steatodegeneration of rats in the DCP groups were relieved to varying degrees,and the number of lipid vacuoles significantly reduced.The ALT,AST,TC,TG and LDL-C content in the serum and MDA content in the liver tissue decreased to varying degrees,while the HDL-C,SOD and GSH-Px content increased.The expression of SIRT1 and AMPK increased,while the expression of miR-141,TNF-α,IL-6 and IL-1βdeclined,and the DCP 300 mg/kg treatment group had better improvement effect.[Conclusions]DCP had a certain protective effect on NAFLD rats,which may be related to the regulation of miR-141/AMPK/SIRT1 signaling pathway. | Yifan YIN Haiping LIU Ya GAO Hewei LI Kefeng ZHANG | 2023 | Medicinal Plant2023，14，3： | 0 |
| 12 | Strong and Tough TPU Fibers with Orientedly Aligned CNTs Reinforced by Amorphous ZrO_(2)显示文摘High strength and high toughness are vital for fibers’engineering applications,but are hard to simultaneously achieve.Herein,we synthesize a carbon nanotube(CNT)-thermoplastic polyurethanes(TPU)fiber reinforced by an amorphous ZrO_(2)layer through the wet-spinning method.The amorphous ZrO_(2)layer is in-situ grown on the surface of CNT and the hybrid nanowires are orientedly aligned with TPU to form the ternary fiber.The fiber possesses an excellent combination of high strength(84.6 MPa)and toughness(126.7 MJ/m^(3)),which is outstanding when compared with previously reported CNT-TPU fibers.The pull-out of nanowires attributed to the oriented alignment structure and the enhanced interface and restriction of deformation obtained from the amorphous ZrO_(2)layer are considered as the primary strengthening and toughening mechanisms.We anticipate that our fiber synthesis strategy gives a new path to design strong and tough fibers. | LI Yangbei LIU Shaojia ZHAO Hewei GUO Lin | 2022 | Chemical Research in Chinese Universities2022，38，3： | 0 |
| 13 | Acupuncture and moxibustion for malignant tumor patients with psychological symptoms of insomnia,anxiety and depression:a systematic review and Meta-analysis显示文摘OBJECTIVE:To evaluate the efficacy and safety of acupuncture and moxibustion therapy(AMT) for cancerrelated psychological symptoms(CRPS) of insomnia,depression and anxiety.METHODS:Seven databases were searched for randomized controlled trials(RCT) comparing AMT to routine care or conventional drug for alleviating CRPS of insomnia,depression,and anxiety before April 2020.Two independent reviewers performed the data extraction and assessed the risk of bias.RESULTS:A total of 30 RCTs involving 2483 cancer patients were enrolled.The pooled analysis indicated that the treatment group was significantly better than the control group in improving the depression effective rate [RR = 1.29,95% CI(1.12,1.49),P = 0.0004],the quality of life(QOL) [MD = 1.11,95% CI(0.80,1.42),P < 0.000 01],and reducing Self-rating Anxiety Scale(SAS) [MD =﹣7.75,95% CI(﹣10.44,﹣5.05),P < 0.000 01].But there was no statistically significant difference between two groups in improving the insomnia effective rate [RR = 1.18,95% CI(0.93,1.51),P = 0.18].The subgroup analysis showed the effectiveness of different intervention on CRPS.Compared with routine care,AMT helps relieve CRPS better evaluated by Pittsburgh Sleep Quality Index(PSQI),Hamilton Depression Scale(HAMD),and Self-rating Depression Scale(SDS),and depression effective rate.Compared with conventional drug,AMT performs better evaluated by SDS,depression effective rate and QOL.Moreover,the conventional drug showed higher treatment efficacy on improving insomnia effective rate compared with AMT.Compared to conventional drug,AMT plus conventional drug resulted in a significant reduction on CRPS such as PSQI,HAMD,SDS,and SAS,and also had a meaningful improvement on insomnia effective rate,depression effective rate and QOL.Fewer published reports were found on the adverse events of AMT than the conventional drug.CONCLUSION:The results suggested that AMT might be effective in improving CPRI;however,a definite conclusion could not be drawn because the quality of trials are low.Further large-scale and high-quality RCTs to verify the efficacy and safety of AMT on CRPS are still warranted. | MA Fangfang ZHANG Hewei LI Bingxue CHENG Peiyu YU Mingwei WANG Xiaomin | 2023 | Journal of Traditional Chinese Medicine2023，43，3： | 0 |
| 14 | Cotton stalk restitution coefficient determination tests based on the binocular high-speed camera technology显示文摘The restitution coefficient(RC)of cotton stalks is an important elementary physical parameter that is required to establish the crushing mechanical model and research the film residue separation machinery.In this study,the calculation method of restitution coefficient considering the rotation motion of stalk-shaped agricultural materials was derived based on the principle of kinematics and the energy restitution coefficient method,and a test bench for measuring the RC was designed and built.The effects of collision material,moisture content,length,diameter,release height,and collision angle respectively on the RC were investigated by single-factor experiments and orthogonal experiments,and the regression models between influence factors and the RC were established.The results showed that Q235 showed the highest value of the RC,and it was followed by cotton stalks and soil lumps,sequentially.The RC of cotton stalks decreased with the increase of moisture content and diameter,while it increased at first and then decreased with the increase of length.As the release height was less than 500 mm,the RC increased with the increased release height.As the collision angle was less than 40°,the RC showed a linear increasing trend.The significance of the effects of factors on RC decreased with the following sequence:collision angle,length,release height,diameter,and moisture content.Length,collision angle,and release height were extremely significant.The contrast test results showed that the values based on Newton’s restitution coefficient method were smaller than that based on the energy restitution coefficient method.The verification test showed that the predicted rebound height of cotton stalks calculated based on the energy restitution coefficient method was closer to the actual rebound height,and the relative error was less than 5%. | Bingcheng Zhang Xuegeng Chen Rongqing Liang Jiali Li Xinzhong Wang Hewei Meng Za Kan | 2022 | International Journal of Agricultural and Biological Engineering2022，15，4： | 0 |
| 15 | Room-Temperature Single-Molecule Conductance Switch via Confined Coordination-Induced Spin-State Manipulation显示文摘The emergence of molecular spintronics offers a unique chance for the design of molecular devices with different spin-states,and the control of spin-state becomes essential for molecular spin switches.However,the intrinsic spin switching from low-to high-spin state is a temperature-dependent process with a small energy barrier where low temperature is required to maintain the low-spin state.Thus,the room-temperature operation of single-molecule devices has not yet been achieved.Herein,we present a reversible single-molecule conductance switch by manipulating the spin states of the molecule at room temperature using the scanning tunneling microscope break-junction(STM-BJ)technique.The manipulation of the spin states between S=0 and S=1 is achieved by complexing or decomplexing the pyridine derivative molecule with a square planar nickel(Ⅱ)porphyrin.The bias-dependent conductance evolution proves that the strong electric field between the nanoelectrodes plays a crucial role in the coordination reaction.The density functional theory(DFT)calculations further reveal that the conductance changes come from the geometric changes of the porphyrin ring and spin-state switching of the Ni(Ⅱ)ion.Our work provides a new avenue to investigate room-temperature spin-related sensors and molecular spintronics. | Jing Li Qingqing Wu Wei Xu Hai-Chuan Wang Hewei Zhang Yaorong Chen Yongxiang Tang Songjun Hou Colin JLambert Wenjing Hong | 2022 | CCS Chemistry2022，4，4： | 0 |
| 16 | Intermolecular coupling enhanced thermopower in single-molecule diketopyrrolopyrrole junctions显示文摘Sorting out organic molecules with high thermopower is essential for understanding molecular thermoelectrics.The intermolecular coupling offers a unique chance to enhance the thermopower by tuning the bandgap structure of molecular devices,but the investigation of intermolecular coupling in bulk materials remains challenging.Herein,we investigated the thermopower of diketopyrrolopyrrole(DPP)cored single-molecule junctions with different coupling strengths by varying the packing density of the self-assembled monolayers(SAM)using a customized scanning tunneling microscope break junction(STM-BJ)technique.We found that the thermopower of DPP molecules could be enhanced up to one order of magnitude with increasing packing density,suggesting that the thermopower increases with larger neighboring intermolecular interactions.The combined density functional theory(DFT)calculations revealed that the closely-packed configuration brings stronger intermolecular coupling and then reduces the highest occupied molecular orbital(HOMO)-lowest unoccupied molecular orbital(LUMO)gap,leading to an enhanced thermopower.Our findings offer a new strategy for developing organic thermoelectric devices with high thermopower. | Chao Fang Renad Almughathawi Qingqing Wu Wenqiang Cao Hang Chen Songjun Hou Yu Gu Hewei Zhang Yi Zhao Jueting Zheng Guopeng Li Jia Shi Junyang Liu Bing-Wei Mao Zitong Liu Colin J.Lambert Wenjing Hong | 2023 | National Science Open2023，2，1： | 0 |
| 17 | Applications of digital Medicine in oncology: Prospects and challenges显示文摘The current state of oncology medical services is not encouraging and is unable to fully meet the needs of patients with cancer.In recent years,rapidly developing artificial intelligence technology and gradual advancements in mobile phones,sensors,and wearable devices,which have made these more compact,affordable,and popular,have greatly expanded the development of digital medicine.Digital medicine refers to clinical evidence-based technology and products with a direct impact on disease management and research.Integrating digital medicine into clinical practice has the advantages of broader applicability,greater cost-effectiveness,better accessibility,and improved diagnostic and therapeutic performance.Digital medicine has emerged in different clinical application scenarios,including cancer prevention,screening,diagnosis,and treatment,as well as clinical trials.Additionally,big data generated from digital medicine can be used to improve levels of clinical diagnosis and treatment.However,digital medicine also faces many challenges,including security regulation and privacy protection,product usability,data management,and optimization of algorithms.In summary,the application and development of digital medicine in the field of cancer face numerous opportunities and challenges. | Hewei Ge Lixi Li Di Zhang Fei Ma | 2022 | Cancer Innovation2022，1，4： | 0 |
| 18 | Design and test of a multi-edge toothed cutting device for membraneimpurity mixed material显示文摘As the existing residual film crushing device in Xinjiang cannot directly crush membrane-impurity mixed material,by analyzing the compressive and cutting force characteristics of residual film material layer and cotton stalk,the cutting conditions of mixed materials were obtained,and the method of cutting was determined.A multi-edge toothed cutters was created,and a cutting device was built.It was preliminarily determined that the number of teeth in the cutters was 8,the clearance between the teeth and between the tooth and fixed blade was 3 mm,the speed of the high-speed cutter was 800 r/min,and the speed difference between the high-and low-speed cutters was-300 r/min.Test results show that the ratio of residual film to total residual film sampling mass was(2.22±0.30)%,(19.19±2.02)%,(58.94±3.19)% and(20.65±2.05)%,respectively,when the maximum outer profile size in the range of[0,20)mm,[20,100)mm,[100,500)mm and[500,~)mm.The mass of cotton stalks with lengths of[0,50)mm,[50,100)mm and[100,~)mm accounted for(32.57±1.5)%,(27.77±1.3)%and(39.66±1.75)%,respectively,and the cutting power consumption was(85.41±15.63)kJ.The test results can provide a basis for the subsequent membrane-impurity mixed material cutting technology,as well as some guidance for the separation of it. | Rongqing Liang Bingcheng Zhang Xuegeng Chen Hewei Meng Xinzhong Wang Congju Shen Yaping Li Za Kan | 2023 | International Journal of Agricultural and Biological Engineering2023，16，2： | 0 |
| 19 | SARS-CoV-2-specific antibody response characteristics in COVID-19 patients of different ages显示文摘Age has been found to be one of the main risk factors for the severity and outcome of COVID-19.However,differences in SARS-CoV-2 specific antibody responses among COVID-19 patients of different age groups remain largely unknown.In this study,we analyzed the IgG/IgM responses to 21 SARS-CoV-2 proteins and 197 peptides that fully cover the spike protein against 731 sera collected from 731 COVID-19 patients aged from 1 to 92 years.We show that there is no overall difference in SARS-CoV-2 antibody responses in COVID-19 patients in the 4 age groups.By antibody response landscape maps,we find that the IgG response profiles of SARS-CoV-2 proteins are positively correlated with age.The S protein linear epitope map shows that the immunogenicity of the S-protein peptides is related to peptide sequence,disease severity and age of the COVID-19 patients.Furthermore,the enrichment analysis indicates that low S1 IgG responses are enriched in patients aged<50 and high S1 IgG responses are enriched in mild COVID-19 patients aged>60.In addition,high responses of non-structural/accessory proteins are enriched in severe COVID-19 patients aged>70.These results suggest the distinct immune response of IgG/IgM to each SARS-CoV-2 protein in patients of different age,which may facilitate a deeper understanding of the immune responses in COVID-19 patients. | Linfang Lu Siqi Yu Min Liu Yang Li Qing Lei Mingxi Lin Danyun Lai Shujuan Guo Hewei Jiang Hongyan Hou Yunxiao Zheng Xuening Wang Mingliang Ma Bo Zhang Hong Chen Junbiao Xue Hainan Zhang Huan Qi Ziyong Sun Feng Wang Xionglin Fan Zhaowei Xu | 2022 | Acta Biochimica et Biophysica Sinica2022，54，4： | 0 |
| 20 | Shape evolution of antimony oxychloride from sheaf-like to quasi-wafer structures显示文摘Antimony oxychloride Sb8O11Cl2(H2O)6 products with various morphologies including sheaf-like,rhombic-plate,oval leaf-like and quasi-wafer have been successfully synthesized via a mild and facile solution route at room temperature.The morphologies and structures of the as-prepared samples were characterized by X-ray powder diffraction(XRD),scanning electron microscopy(SEM) and transmission electron microscopy(TEM).A possible formation mechanism of these structures is proposed according to the experimental results and analysis. | ZHOU Jing ZHAO HeWei LI LiDong GUO Lin | 2011 | Chinese Science Bulletin2011，56，35： | 0 |
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