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| 1 | Cytotoxic T Lymphocytes Efficiently Recognize Human Colon Cancer Stem-Like Cells显示文摘 | Satoko Inoda Yoshihiko Hirohashi Toshihiko Torigoe Rena Morita Akari Takahashi Hiroko Asanuma Munehide Nakatsugawa Satoshi Nishizawa Yasuaki Tamura Tetsuhiro Tsuruma Takeshi Terui Toru Kondo Kunihiko Ishitani Tadashi Hasegawa Koichi Hirata Noriyuki Sato | 2011 | The American Journal of Pathology2011，，4： | 2 |
| 2 | Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance显示文摘 | Sizuo Kajiyama Goji Hasegawa Mai Asano Hiroko Hosoda Michiaki Fukui Naoto Nakamura Jo Kitawaki Saeko Imai Koji Nakano Mitsuhiro Ohta Tetsuo Adachi Hiroshi Obayashi Toshikazu Yoshikawa | 2008 | Nutrition Research2008，，3： | 1 |
| 3 | Clinical Characteristics and Genetic Background of Congenital Long-QT Syndrome Diagnosed in Fetal, Neonatal, and Infantile Life: A Nationwide Questionnaire Survey in Japan显示文摘 | Hitoshi Horigome Masami Nagashima Naokata Sumitomo Masao Yoshinaga Hiroya Ushinohama Mari Iwamoto Junko Shiono Koh Ichihashi Satoshi Hasegawa Tadahiro Yoshikawa Tamotsu Matsunaga Hiroko Goto Kenji Waki Masaki Arima Hisashi Takasugi Yasuhiko Tanaka Nobuo T | 2010 | Circulation: Arrhythmia and Electrophysiology2010，，1： | 1 |
| 4 | Nocardioides sp. strain WSN05-2, isolated from a wheat field, degrades deoxynivalenol, producing the novel intermediate 3-epi-deoxynivalenol显示文摘 | Yoko Ikunaga Ikuo Sato Stephanie Grond Nobutaka Numaziri Shigenobu Yoshida Hiroko Yamaya Syuntaro Hiradate Morifumi Hasegawa Hiroaki Toshima Motoo Koitabashi Michihiro Ito Petr Karlovsky Seiya Tsushima | 2011 | Applied Microbiology and Biotechnology2011，，2： | 1 |
| 5 | Optimal indications for second-line chemotherapy in advanced gastric cancer显示文摘 | Hiroko Hasegawa Kazumasa Fujitani Shoichi Nakazuru Motohiro Hirao Eiji Mita Toshimasa Tsujinaka | 2012 | Anti-Cancer Drugs2012，，4： | 1 |
| 6 | Rapid on‐site evaluation by endosonographer during endoscopic ultrasound‐guided fine needle aspiration for pancreatic solid masses显示文摘 | Tsuyoshi Hayashi Hirotoshi Ishiwatari Makoto Yoshida Michihiro Ono Tsutomu Sato Koji Miyanishi Yasushi Sato Masayoshi Kobune Rishu Takimoto Tomoko Mitsuhashi Hiroko Asanuma Jiro Ogino Tadashi Hasegawa Tomoko Sonoda Junji Kato | 2013 | J Gastroenterol Hepatol2013，，4： | 1 |
| 7 | Poorly differentiated endocrine carcinoma of the pancreas responded to gemcitabine:Case report显示文摘Poorly differentiated endocrine carcinoma (PDEC) of the pancreas is a rare and aggressive tumor. First-line treatment is commonly a combination of etoposide and cisplatin, but there is no consensus regarding further treatment recommendations. In this report, we describe a case of pancreatic PDEC treated with gemcitabine as third-line chemotherapy. A 62-year-old man with pancreatic PDEC was administered etoposide plus cisplatin as first-line treatment; he then received irinotecan for tumor relapse. However, because irinotecan induced ileus in this patient, we chose gemcitabine as thirdline chemotherapy. After two cycles of gemcitabine (1000 mg/m2 on days 1, 8 and 15 every 4 wk), a partialtumor response was noted by computed tomography (approximately 68% reduction in tumor size). Our patient survived for 15 mo after diagnosis. This is a rare case of unresectable pancreatic PDEC, which showed a partial response to gemcitabine after the failure of two other regimens. Gemcitabine could be an effective treatment option for pancreatic PDEC that is resistant to other treatments. | Shoichi Nakazuru Toshiyuki Yoshio Shigeki Suemura Mari Itoh Manabu Araki Chiaki Yoshioka Makiyo Ohta Yuka Sueyoshi Takashi Ohta Hiroko Hasegawa Kaori Morita Takashi Toyama Noriyoshi Kuzushita Yoshinori Kodama Masayuki Mano Eiji Mita | 2010 | World Journal of Gastroenterology2010，16，30： | 0 |
| 8 | Development of risky varices in alcoholic cirrhosis with a well-maintained nutritional status显示文摘AIM: To compare the nutritional status between alcoholic compensated cirrhotic patients and hepatitis C virus(HCV)-related cirrhotic patients with portal hypertension.METHODS: A total of 21 patients with compensated cirrhosis(14 with HCV-related cirrhosis and seven with alcoholic cirrhosis) who had risky esophageal varices were investigated. In addition to physical variables, including the body mass index, triceps skinfold thickness, and arm-muscle circumference, the nutritional status was also assessed using the levels of pre-albumin(pre-ALB), retinol-binding protein(RBP) and non-protein respiratory quotient(NPRQ) measured with an indirect calorimeter.RESULTS: A general assessment for the nutritional status with physical examinations did not show a significant difference between HCV-related cirrhosis and alcoholic cirrhosis. However, the levels of pre-ALB and RBP in alcoholic compensated cirrhotic patients were significantly higher than those in HCV-related compensated cirrhotic patients. In addition, the frequency of having a normal nutritional status(NPRQ ≥ 0.85 and ALB value > 3.5 g/d L) in alcoholic compensated cirrhotic patients was significantly higher than that in HCV-related compensated cirrhotic patients.CONCLUSION: According to our small scale study, alcoholic compensated cirrhotic patients can develop severe portal hypertension even with a relatively well-maintained liver function and nutritional status compared with HCV-related cirrhosis. | Hirayuki Enomoto Yoshiyuki Sakai Yoshinori Iwata Ryo Takata Nobuhiro Aizawa Naoto Ikeda Kunihiro Hasegawa Chikage Nakano Takashi Nishimura Kazunori Yoh Akio Ishii Tomoyuki Takashima Hiroki Nishikawa Hiroko Iijima Shuhei Nishiguchi | 2015 | World Journal of Hepatology2015，7，21： | 0 |
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