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| 1 | PROTAC-induced BTK degradation as a novel therapy for mutated BTK C481S induced ibrutinib-resistant B-cell malignancies显示文摘 | Yonghui Sun Xingwang Zhao Ning Ding Hongying Gao Yue Wu Yiqing Yang Meng Zhao Jinseok Hwang Yuqin Song Wanli Liu Yu Rao | 2018 | Cell Research2018，28，7： | 29 |
| 2 | Natural Variations at TIG1 Encoding a TCP Tran scription Factor Contribute to Plant Architecture Domestication in Rice显示文摘The modification of plant architecture is a crucial target in rice domestication and modern genetic improvement.Although several genes regulating rice plant architecture have been characterized,the molecular mechanisms underlying rice plant architecture domestication remain largely unclear.Here we show that the inclined tiller growth in wild rice is controlled by a single dominant gene,TILLER INCLINED GROWTH 1 (T/Gf),which is located on chromosome 8 and encodes a TCP transcriptional activator.TIG1 is primarily expressed in the adaxial side of the tiller base,promotes cell elongation,and enlarges the tiller angle in wild rice.Variations in the TIG1 promoter of indica cultivars {tig1 allele) resulted in decreased expression of TIG1 in the adaxial side of tiller base and reduced cell length and tiller angle,leading to the transition from inclined tiller growth in wild rice to erect tiller growth during rice domestication.TIG1 positively regulates the expression of EXP A3,EXPB5,and SAUR39 to promote cell elongation and increase the tiller angle.Selective sweep analysis revealed that the tig1 allele was selected in indica cultivars by human beings.The cloning and characterization of TIG1 supports a new scenario of plant architecture evolution in rice. | Weifeng Zhang Lubin Tan Hongying Sun Xinhui Zhao Fengxia Liu Hongwei Cai Yongcai Fu Xianyou Sun Ping Gu Zuofeng Zhu Chuanqing Sun | 2019 | Molecular Plant2019，12，8： | 13 |
| 3 | Graft-accelerated virus-induced gene silencing facilitates functional genomics in rose flowers显示文摘Rose has emerged as a model ornamental plant for studies of flower development, senescence, and morphology, as well as the metabolism of floral fragrances and colors.Virus-induced gene silencing(VIGS) has long been used in functional genomics studies of rose by vacuum infiltration of cuttings or seedlings with an Agrobacterium suspension carrying TRV-derived vectors. However, VIGS in rose flowers remains a challenge because of its low efficiency and long time to establish silencing. Here we present a novel and rapid VIGS method that can be used to analyze gene function in rose,called ‘graft-accelerated VIGS', where axil ary sprouts are cut from the rose plant and vacuum infiltrated with Agrobacterium. The inoculated scions are then grafted back onto the plants to flower and silencing phenotypes can be observed within 5 weeks, post-infiltration. Using this new method, we successfully silenced expression of the RhDFR_1, RhA G, and RhNUDX_1 in rose flowers, and affected their color, petal number, as well as fragrance, respectively. This grafting method will facilitate high-throughput functional analysis of genes in rose flowers. Importantly, it may also be applied to other woody species that are not currently amenable to VIGS by conventional leaf or plantlet/seedling infiltration methods. | Huijun Yan Shaochuan Shi Nan Ma Xiaoqian Cao Hao Zhang Xianqin qiu Qigang Wang Hongying Jian Ningning Zhou Zhao Zhang Kaixue Tang | 2018 | Journal of Integrative Plant Biology2018，60，1： | 11 |
| 4 | Progress and Applications of Visual SLAM显示文摘Visual simultaneous localization and mapping (SLAM) provides mapping and self-localization results for a robot in an unknown environment based on visual sensors, that have the advantages of small volume, low power consumption, and richness of information acquisition. Visual SLAM is essential and plays a significant role in supporting automated and intelligent applications of robots. This paper presents the key techniques of visual SLAM, summarizes the current research status, and analyses the new trends of visual SLAM research and development. Finally, specific applications of visual SLAM in restricted environments, including deep space and indoor scenarios, are discussed. | Kaichang DI Wenhui WAN Hongying ZHAO Zhaoqin LIU Runzhi WANG Feizhou ZHANG | 2019 | Journal of Geodesy and Geoinformation Science2019，2，2： | 11 |
| 5 | Ultra-deep desulfurization by reactive adsorption desulfurization on copper-based catalysts显示文摘In this paper,a novel copper-based catalyst for FCC gasoline improving the ability of removal the sulfur and avoiding the loss of the octane number from olefin saturation by reactive adsorption desulfurization(RADS) was investigated.The series of Cu/Zn O-Al_2 O_3 catalysts were characterized by X-ray powder diffraction(XRD),N_2 adsorption analysis and temperature-programmed reduction(TPR) studies,X-ray photoelectron spectroscopy(XPS),scanning electron microscope(SEM) and transmission electron microscopy(TEM).The experiment results showed that the catalysts had an optimum desulfurization ability with copper loading 6 wt%,which the sulfur contents of product decreased less than 10 μg/g and olefin contents decreased from 16.19% to 14.14% for the long period operation.The appropriate Cu loading content could lead to the high active and low apparent activation energy(E_a).Therefore,the Cu-based catalyst may become a novel catalyst for second-generation for reactive adsorption desulfurization,which achieves the high desulfurization active and low olefins saturation to satisfy the upgrading the product. | Yaqing Liu Hongying Wang Jinchong Zhao Yunqi Liu Chenguang Liu | 2019 | Journal of Energy Chemistry2019，28，2： | 6 |
| 6 | A Novel System for Moving Object Detection Using Bionic Compound Eyes显示文摘 | Huabo Sun Haimeng Zhao Peter Mooney Hongying Zhao Daping Liu Lei Yan | 2011 | Journal of Bionic Engineering2011，8，3： | 6 |
| 7 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 8 | Improvement of the assimilable organic carbon (AOC) analytical method for reclaimed water显示文摘 | Xin ZHAO Hongying HU Shuming LIU Feng JIANG Xiaolei SHI Mingtang LI Xueqiao XU | 2013 | Frontiers of Environmental Science & Engineering2013，7，4： | 5 |
| 9 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 10 | Microlens Light Field Imaging Method Based on Bionic Vision and 3-3 Dimensional Information Transforming显示文摘his paper adopts the 3-3-2 information processing method for the capture of moving objects as its premise, and proposes a basic principle of three-dimensional (3D) imaging using biological compound eye. Traditional bionic vision is limited by the available hardware. Therefore, in this paper, the new-generation technology of microlens-array light-field camera is proposed as a potential method for the extraction of depth information from a single image. A significant characteristic of light-field imaging is that it records intensity and directional information from the lights entering the camera. Herein, a refocusing method using light-field image is proposed. By calculating the focusing cost at different depths from the object, the imaging plane of the object is determined, and a depth map is constructed based on the position of the object’s imaging plane. Compared with traditional light-field depth estimation, the depth map calculated by this method can significantly improve resolution and does not depend on the number of light-field microlenses. In addition, considering that software algorithms rely on hardware structure, this study develops an imaging hardware that is only 7 cm long based on the second-generation microlens camera’s structure, further validating its important refocusing characteristics. It thereby provides a technical foundation for 3D imaging with a single camera. | Shoujiang ZHAO Fan LIU Peng YANG Hongying ZHAO Anand ASUNDI Lei YAN Haimeng ZHAO | 2019 | Journal of Geodesy and Geoinformation Science2019，2，2： | 4 |
| 11 | Methods of Studying Petroleum Systems in Residual Basins-A Case Study of Mesozoic and Palaeozoic MarineBasins in Southern China显示文摘 | ZHAO Zongju, ZHU Yan, YANG Shufeng, WANG Genghai,XU Yunjun, FENG Jialiang and DENG Hongying Department of Geoscience, Zhejiang University, Hangzhou 310027, Zhejiang Hangzhou Institute of Petroleum Geology, Hangzhou 310023, Zhejiang Zhou Jian Fei Zhenbi | 2002 | Acta Geologica Sinica(English Edition)2002，76，2： | 4 |
| 12 | Recent advances and trends of heterogeneous electro-Fenton process for wastewater treatment-review显示文摘Electrochemical advanced oxidation processes (EAOPs) are effective and environmentally friendly for the treatment of refractory organic pollutants.Among EAOPs,heterogeneous electro-Fenton (EF) process with in-situ formation of hydrogen peroxide (H_(2)O_(2)) is an eco-friendly,cost-effective and easy-operable technology to generate hydroxyl radicals (;OH) with high redox potential.The generation of;OH is determined by the synergistic H_(2)O_(2)formation and activation.The surface catalytic mechanisms for H_(2)O_(2)activation in the heterogeneous EF process were discussed.Some required features such as heteroatom doping and oxygen groups for H_(2)O_(2)formation via selective two-electron oxygen reduction reaction (ORR) with carbonaceous electrode are summarized.The solid Fenton catalysts and integrated functional cathodes that widely used in heterogeneous EF for wastewater treatment are grouped into few classes.And the brief discussion on catalytic activity and stability of materials over different experimental conditions are given.In addition,the application of heterogeneous EF process on the remediation of emerging contaminants is provided.The challenges and future prospects of the heterogeneous EF processes about catalytic fall-off and multi-step/complex techniques for water purification are emphasized. | Zining Wang Mingyue Liu Fan Xiao Georgeta Postole Hongying Zhao Guohua Zhao | 2022 | Chinese Chemical Letters2022，33，2： | 4 |
| 13 | Morphology-selective synthesis of active and durable gold catalysts with high catalytic performance in the reduction of 4-nitrophenol显示文摘由 nanosized Au 粒子组成的一系列新奇催化剂与血小板(PL ) 在 micro-mesoporous ZSM-5/SBA-15 (ZSBA ) 材料限制了,杆(RD ) ,并且六角形棱柱(HP ) 形态学在 situ 被综合了。这些催化剂拥有 SBA-15 和 ZSM-5 结构并且在 ZSBA 以内由 Au nanoparticles (NP ) 的监禁展出他们的活跃地点的优秀稳定性。催化剂深入地被描绘了理解他们的结构性质关系。金 NP 尺寸和催化剂的毛孔结构,被发现对锻烧温度和合成条件敏感,被显示在 4-nitrophenol 的减小起重要作用。与短 mesochannels (210 nm ) 和一条大毛孔直径(6.7 nm ) ,而与长 mesochannels 和相对更小的毛孔尺寸, Au/ZSBA-HP 和 Au/ZSBA-RD 给穷人看催化活动, Au/ZSBA-PL 在 4-nitrophenol 的减小展出高催化的性能。在有不同金 NP 尺寸的催化剂的情况中,有 4.0 nm 的一条 Au NP 直径的 Au/ZSBA-PL-350 展出最高的反应率常数(0.14 min -1) 和周转频率(0.0341 s -1) 。另外, 4-nitrophenol 的减小上的反应参数的效果系统地被调查了。为在 Au/ZSBA 催化剂上的 4-nitrophenol 减小的可能的机制被建议。 | Daowei Gao Xin Zhang Xiaoping Dai Yuchen Qin Aijun Duan Yanbing Yu Hongying Zhuo Hairui Zhao Pengfang Zhang Yan Jiang Jianmei Li Zhen Zhao | 2016 | Nano Research2016，9，10： | 4 |
| 14 | Effects of design parameters on rooftop photovoltaic economics in the urban environment:A case study in Melbourne,Australia显示文摘Many researchers found high potential of adopting building photovoltaic(PV)systems in urban areas,especially on building rooftop,to improve the sustainability of urban environment.However,the optimal energy output performance and economic benefit of the PV system are affected by the usable roof area,PV array layout,and shading effect considering high city density.This study aims to understand the effects of these design parameters in the urban environment of rooftop PV's economic performance.This study carries out a case study in the urban area of Melbourne with 90 PV designs under three shading conditions to generate 270 scenarios.Through a lifecycle cost-benefit analysis,including net present value(NPV),NPV per kW,internal return rate(IRR),and payback year,the results can help in developing a comprehensive understanding of the economic performance of rooftop PV designs that cover most of the urban areas of Melbourne.The optimal PV design scenarios for the urban environment are identified,thereby providing investors and industry professionals with useful information on value-for-money PV design.Meanwhile,the maximum shading loss that makes the PV systems financially unfeasible is investigated,and design scenarios with greatest ability to sustain the shading effect are identified.This research can also support the policy makers'decision on the development and deployment of the roof PV systems in urban planning. | Hongying ZHAO Chaohong YANG W.M·Pabasara U.WIJERATNE Chengyang LIU Xiaolong XUE Nishara ABDEEN | 2019 | Frontiers of Engineering Management2019，6，3： | 2 |
| 15 | GOLM1 restricts colitis and colon tumorigenesis by ensuring Notch signaling equilibrium in intestinal homeostasis显示文摘Intestinal epithelium serves as the first barrier against the infections and injuries that mediate colonic inflammation.Colorectal cancer is often accompanied with chronic inflammation.Differed from its well-known oncogenic role in many malignancies,we present here that Golgi membrane protein 1(G0LM1,also referred to as GP73)suppresses colorectal tumorigenesis via maintenance of intestinal epithelial barrier.G0LM1 deficiency in mice conferred susceptibility to mucosal inflammation and colitis-induced epithelial damage,which consequently promoted colon cancer.Mechanistically,depletion of G0LM1 in intestinal epithelial cells(lECs)led to aberrant Notch activation that interfered with IEC differentiation,maturation,and lineage commitment in mice.Pharmacological inhibition of Notch pathway alleviated epithelial lesions and restrained pro-tumorigenic inflammation in G0LM1-deficient mice.Therefore,G0LM1 maintains IEC homeostasis and protects against colitis and colon tumorigenesis by modulating the equilibrium of Notch signaling pathway. | Yang Pu Ya Song Mengdi Zhang Caifeng Long Jie Li Yanan Wang Yinzhe Xu Fei Pan Na Zhao Xinyu Zhang Yanan Xu Jianxin Cui Hongying Wang Yan Li Yong Zhao Di Jin Hongbing Zhang | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 2 |
| 16 | Growth variations and stability analyses of seven poplar clones at three sites in northeast China显示文摘Growth characteristics have complex inheritance patterns and genotype(G) by environment(E) interaction make predicting tree response to environmental changes difficult.In this study,the growth of seven poplar clones at three different sites was taken as the research focus,and heights and basal diameters were investigated in the second growing season.An ANOVA showed that all main effects,site,clone number and their interactions were highly significant in the overall F-tests.The coefficients of variation and repeatability of different traits ranged from 15.5 to 43.9%and from 0.549 to 0.912,respectively.AMMI(Additive Main Effects and Multiplicative Interaction) analysis results showed that genotype,environment and G × E interaction were significantly highly correlated.The stability analysis indicated that different clones showed different growth traits on different sites,which suggests that elite clones should be selected separately for different sites.Based on the growth traits,under a 10% selection rate,three clones were selected for different sites and the genetic gains of growth traits ranged from 4.7 to 11.2%.The three selected clones could be used to establish plantations in the future in different sites. | Xiaona Pei Luping Jiang Ammar khalil Mohamed Ahmed Hongying Yu Rizheng Chong Xiangling You Xiyang Zhao | 2021 | Journal of Forestry Research2021，32，4： | 2 |
| 17 | Electro-Fenton oxidation of pesticides with a novel Fe 3 O 4 @Fe 2 O 3 /activated carbon aerogel cathode: High activity, wide pH range and catalytic mechanism显示文摘 | Hongying Zhao Yujing Wang Yanbin Wang Tongcheng Cao Guohua Zhao | 2012 | Applied Catalysis B: Environmental2012，，： | 2 |
| 18 | Effect of Soil C,N and P Stoichiometry on Soil Organic C Fractions After Afforestation显示文摘Afforestation is recognized as an important driving force for soil organic C(SOC) dynamics and soil element cycling.To evaluate the relationships between soil C:N:P stoichiometry and SOC fractions,soil C:N:P stoichiometry distributions at 0–200 cm soil depths were analyzed and the contents of SOC fractions were evaluated in 9 typical land-use systems on the Loess Plateau of China.The contents of light fraction organic C,particulate organic C(>53,53–2 000,and>2 000 μm),labile organic C,microbial biomass C,and dissolved organic C decreased with increasing soil depth and were higher in afforested soil than in slope cropland soil.Compared with the slope cropland,different vegetation types influenced soil C:N,C:P,and N:P ratios,especially when C:P and N:P ratios were significantly higher(P<0.05).Moreover,SOC fractions at the 0–10 and 10–40 cm depths were particularly affected by soil C:P ratio,whereas those at the 40–100 and 100–200 cm soil depths were significantly affected(P<0.05) by soil N:P ratio.These results indicate that changes in SOC fractions are largely driven by soil C:P and N:P ratios at different soil depths after afforestation. | ZHAO Fazhu ZHANG Lu SUN Jiao REN Chengjie HAN Xinhui YANG Gaihe PANG Guowei BAI Hongying WANG Jun | 2017 | Pedosphere2017，27，4： | 1 |
| 19 | Ozonation as an efficient pretreatment method to alleviate reverse osmosis membrane fouling caused by complexes of humic acid and calcium ion显示文摘Humic acid has been considered as one of the most significant sources in feed water causing organic fouling of reverse osmosis (RO) membranes, but the relationship between the fouling behavior of humic acid and the change of its molecular structure has not been well developed yet. In this study, the RO membrane fouling behavior of humic acid was studied systematically with ozonation as a pretreatment method to control RO membrane fouling. Furthermore, the effect of ozone on the structure ofhumic acid was also explored to reveal the mechanisms. Humic acid alone (10-90 mg/L, in deionized water) was found not to cause obvious RO membrane fouling in 45-h operation. However, the presence of Ca^2+ aggravated significantly the RO membrane fouling caused by humic acid, with significant flux reduction and denser fouling layer on RO membrane, as it was observed by scanning electron microscope (SEM) and atomic force microscope (AFM). However, after the pretreatment by ozone, the influence of Ca^2+ was almost eliminated. Further analysis revealed that the addition of Ca^2+ increased the particle size of humic acid solution significantly, while ozonation reduced the SUVA254, particle size and molecular weight of the complexes of humic acid and Ca^2+(HA-Ca^2+ complexes). According to these results and literature, the bridge effect of Ca^2+ aggregating humic acid molecules and the cleavage effect of ozone breaking HA-Ca^2+ complexes were summarized. The change of the structure of humic acid under the effect of Ca^2+ and ozone is closely related to the change of its membrane fouling behavior. | Xuehao Zhao Yinhu Wu Xue Zhang Xin Tong Tong Yu Yunhong Wang Nozomu Ikuno Kazuki Ishii Hongying Hu | 2019 | Frontiers of Environmental Science & Engineering2019，13，4： | 1 |
| 20 | An approach of fast image mosaic based on binary region segmentation显示文摘 | Xiaowei Han LeiYan Hongying Zhao | | 0，，： | 1 |
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