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| 1 | Molecularly imprinted TiO2 thin film using stable ground- state complex as template as applied to selective electrochemical determination of mercury显示文摘 | Liu Zhihang Huan Shuangyan Jiang jianhui | 2006 | Talanta2006，68，4： | 1 |
| 2 | Preliminary study on the application of near infrared spectroscopy and pattern recognition methods to classify different types of apple samples显示文摘 | LUO Weiqi HUAN Shuangyan FU Haiyan | 2011 | Food Chemistry2011，128，2： | 1 |
| 3 | Preliminary study on the application of near infrared spectroscopy and pattern recognition methods to classify different types of apple samples显示文摘 | Weiqi Luo Shuangyan Huan Haiyan Fu | | 0，，02： | 1 |
| 4 | Preliminary study on the application of near infrared spectroscopy and pattern recognition methods to classify different types of apple samples显示文摘 | Weiqi Luo Shuangyan Huan Haiyan Fu | | 0，，02： | 1 |
| 5 | Preliminary study on the application of near infrared spectroscopy and pattern recognition methods to classify different types of apple samples显示文摘 | Luo Weiqi Huan Shuangyan FuHaiyanm | | 0，，02： | 1 |
| 6 | Preliminary study on the application of near infrared spectroscopy and pattern recognition methods to classify different types of apple samples显示文摘 | Weiqi Luo Shuangyan Huan Haiyan Fu | 2011 | Food Chemistry2011，，128： | 1 |
| 7 | A reversible chemosensor for nitrite based on the fluorescence quenching of a carbazole derivative显示文摘 | Jiao Chenxu Niu Chenggang Huan Shuangyan | 2004 | Talanta2004，64，： | 1 |
| 8 | Preliminary study on the application of near infrared spectroscopy and pattern recognition methods to classify different types of apple samples显示文摘 | Luo Weiqi Huan Shuangyan Fu Haiyan | 2011 | Food Chemistry2011，128，2： | 1 |
| 9 | Manganese-Fluorouracil Metallodrug Nanotheranostic for MRI-Correlated Drug Release and Enhanced Chemoradiotherapy显示文摘For cancer therapy,drug delivery systems are often limited by insufficient drug loading capacity,which usually results in systemic toxicity and heavy metabolic burden to excrete the carriers.Herein,we reported a“one-pot”method for constructing metal(Mn^(2+))–fluorouracil(FU)-coordinated nanotheranostics(Mn-FU)by self-assembly of FU(as bridging ligands)and Mn^(2+)(as metal nodes)through Mn–N/O coordination interactions.Importantly,owing to the effective coordination between Mn and FU,Mn-FU exhibits high drug loading efficacy(47.7 wt%),encapsulation efficacy(82.6%),and relatively large yield(1 g/pot).In acidic tumor microenvironments,efficient release of FU and Mn^(2+)is realized because of nitrogen protonation.The released FU and Mn^(2+)from Mn-FU are used for chemotherapy and turn on magnetic resonance imaging(MRI),respectively,achieving MRI-correlated drug release.After PEG modification,Mn-FU displays high tumor homing ability via enhanced permeability and retention effects and quick renal clearance owing to the disassembly in acidic biological conditions.As a result,Mn-FU substantially enhances the synergistic effects of chemoradiotherapy.Meanwhile,the systemic toxic side effects of free FU-based chemoradiotherapy were greatly reduced through this nanotheranostic.Our strategy offers a facile way to construct metallodrug nanotheranostics for efficient cancer theranostics. | Chan Yang Guosheng Song Haifeng Yuan Yue Yang Yuqi Wang Deju Ye Hongmin Meng Shuangyan Huan Xiao-Bing Zhang | 2021 | CCS Chemistry2021，3，4： | 0 |
| 10 | Copper-thioguanine metallodrug with self-reinforcing circular catalysis for activatable MRI imaging and amplifying specificity of cancer therapy显示文摘For chemotherapy, drug delivery systems often suffer from the inefficient drug loading capability, which usually cause systems toxicity and extra burden to excrete carrier itself. Moreover, the cancer therapeutic efficacy is also greatly limited by the specificity of tumor microenvironment for reactive oxygen species(ROS) based cancer therapeutic strategy(e.g., chemodynamic therapy). Herein, we have developed metal-drug coordination nanoplatform that can not only be responsive to tumor microenvironment but also modulate it, so as to achieve efficient treatment of cancer. Excitingly, by employing small molecule drug(6-thioguanine) as ligand copper ions, we achieve a high drug loading rate(60.1%) and 100% of utilization of metal-drug coordination nanoplatform(Cu-TG). Interestingly, Cu-TG possessed high-efficiently horseradish peroxidase-like, glutathione peroxidase-like and catalase-like activity. Under the tumor microenvironment, Cu-TG exhibited the self-reinforcing circular catalysis that is able to amplify the cellular oxidative stress, inducing notable cancer cellular apoptosis. Moreover, Cu-TG could be activated with glutathione(GSH) and facilitated for GSH triggered 6-TG release, higher selective therapeutic effect toward cancer cells, and GSH activated T1 weight-magnetic resonance imaging. Based on the above properties, Cu-TG exhibited magnetic resonance imaging(MRI) guiding, efficient and synergistic combination of chemodynamic and chemotherapy with self-reinforcing therapeutic outcomes in vivo. | Haifeng Yuan Yan Zhao Chan Yang Cheng Zhang Yue Yang Hongmin Meng Shuangyan Huan Guosheng Song Xiaobing Zhang | 2020 | Science China Chemistry2020，63，7： | 0 |
| 11 | Functional Xeno Nucleic Acids for Biomedical Application显示文摘Functional nucleic acids(FNAs)refer to a type of oligonucleotides with functions over the traditional genetic roles of nucleic acids,which have been widely applied in screening,sensing and imaging fields.However,the potential application of FNAs in biomedical field is still restricted by the unsatisfactory stability,biocompatibility,biodistribution and immunity of natural nucleic acids(DNA/RNA).Xeno nucleic acids(XNAs)are a kind of nucleic acid analogues with chemically modified sugar groups that possess improved biological properties,including improved biological stability,increased binding affinity,reduced immune responses,and enhanced cell penetration or tissue specificity.In the last two decades,scientists have made great progress in the research of functional xeno nucleic acids,which makes it an emerging attractive biomedical application material.In this review,we summarized the design of functional xeno nucleic acids and their applications in the biomedical field. | TU Tingting HUAN Shuangyan KE Guoliang ZHANG Xiaobing | 2022 | Chemical Research in Chinese Universities2022，38，4： | 0 |
| 12 | A controllable self-localized imaging strategy capable of synchronous in situ tracking of local changes in intracellular bioactive small-molecules显示文摘In situ tracking and localization of ubiquitous bioactive small molecules(BSMs)within their native habitats is particularly challenging because of their low-molecular weight and widespread distribution properties.We report the proof of concept of a synchronous in situ imaging strategy,whereby the representative BSM amino-biothiols(ABs)mediate activation of the selflocalizable probe HYPQS,thereby releasing insoluble emissive precipitates to afford holistic distribution information of ABs.Notably,three organelle-targetable ABs inhibitors were innovatively fabricated for directed clearance of ABs in particular organelles,providing a powerful aid for HYPQS to achieve programmed in situ tracking of ABs in different organelles“on demand”.Biological transmission electron microscopy images confirmed that this probe released insoluble emissive precipitates at the reaction sites,which is of primary importance for achieving synchronous in situ tracking of BSMs.Furthermore,the probe HYPQS was successfully applied to monitor the dynamic changes in the endogenous ABs pool during diverse cell events.This strategy opens a promising avenue for investigating the undiscovered functional mechanism of local BSMs in relevant biological processes. | Ke Li Shuai Xu Benhua Wang Shuangyan Huan Xiangzhi Song Lin Yuan Xiao-Bing Zhang | 2023 | Science China Chemistry2023，66，8： | 0 |
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