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| 1 | A unified algorithm for mobility load balancing in 3GPP LTE multi-cell networks显示文摘3GPP long term evolution (LTE) is a promising candidate for the next-generation wireless network, which is expected to achieve high spectrum efficiency by using advanced physical layer techniques and flat network structures. However, the LTE network still faces the problem of load imbalance as in GSM/WCDMA networks, and this may cause significant deterioration of system performance. To deal with this problem, mobility load balancing (MLB) has been proposed as an important use case in 3GPP self-organizing network (SON), in which the serving cell of a user can be selected to achieve load balancing rather than act as the cell with the maximum received power. Furthermore, the LTE network aims to serve users with different quality-of-service (QoS) requirements, and the network-wide objective function for load balancing is distinct for different kinds of users. Thus, in this paper, a unified algorithm is proposed for MLB in the LTE network. The load balancing problem is first formulated as an optimization problem with the optimizing variables being cell-user connections. Then the complexity and overhead of the optimal solution is analyzed and a practical and distributed algorithm is given. After that, the proposed algorithm is evaluated for users with different kinds of QoS requirements, i.e., guaranteed bit rate (GBR) users with the objective function of load balance index and non-GBR (nGBR) users with the objective function of total utility, respectively. Simulation results show that the proposed algorithm leads to significantly balanced load distribution for GBR users to decrease the new call blocking rate, and for nGBR users to improve the cell-edge throughput at the cost of only slight deterioration of total throughput. | WANG Hao LIU Nan LI ZhiHang WU Ping PAN ZhiWen YOU XiaoHu | 2013 | Science China(Information Sciences)2013，56，2： | 7 |
| 2 | QoS and channel state aware load balancing in 3GPP LTE multi-cell networks显示文摘In this paper,we investigate the load balancing problem with the consideration of different qualityof-service(QoS) and channel state in 3GPP long term evolution(LTE) multi-cell networks.Load imbalance among nearby cells often causes inefficient utilization of the system resources.Then in overloaded cells,users cannot get satisfied services for short resources,while in idle cells,there is plenty of unoccupied resources.However,switching users only for load balancing with no consideration of channel state often results in aggressive handover of users,which may occupy too many resources in their target cells and deteriorate the network efficiency.Thus,how to efficiently perform load balancing with the consideration of channel state becomes an important issue.Meanwhile,LTE network aims to serve users with different QoS requirements,which should be taken into account when performing load balancing.Thus we propose a multi-objective optimization problem,whose objectives are load balancing index and network average load for users with QoS requirements and a unified utility function for users without QoS requirements.The constraints are physical resource limits and users' QoS demands.Then we analyze its complexity and propose a practical algorithm,load balancing,with the consideration of different QoS requirements and channel state services(LBQC).Extensive simulations are conducted.The results show that the proposed algorithm can approximate the optimal algorithm efficiently,and leads to significantly better performances than load balancing with no consideration of channel state,e.g.a lower new call blocking rate with a fewer system resources occupation for users with QoS requirements,a higher cell edge throughput and total throughput for users without QoS requirements. | LI ZhiHang WANG Hao PAN ZhiWen LIU Nan YOU XiaoHu | 2013 | Science China(Information Sciences)2013，56，4： | 6 |
| 3 | Intelligent lesion blood–brain barrier targeting nano-missiles for Alzheimer's disease treatment by anti-neuroinflammation and neuroprotection显示文摘The treatment of Alzheimer's disease(AD)is one of the most difficult challenges in neurodegenerative diseases due to the insufficient blood‒brain barrier(BBB)permeability and unsatisfactory intra-brain distribution of drugs.Therefore,we established an ibuprofen and FK506 encapsulated drug co-delivery system(Ibu&FK@RNPs),which can target the receptor of advanced glycation endproducts(RAGE)and response to the high level of reactive oxygen species(ROS)in AD.RAGE is highly and specifically expressed on the lesion neurovascular unit of AD,this property helps to improve targeting specificity of the system and reduce unselective distribution in normal brain.Meanwhile,these two drugs can be specifically released in astrocytes of AD lesion in response to high levels of ROS.As a result,the cognition of AD mice was significantly improved and the quantity of Aβplaques was decreased.Neurotoxicity was also alleviated with structural regeneration and functional recovery of neurons.Besides,the neuroinflammation dominated by NF-κB pathway was significantly inhibited with decreased NF-κB and IL-1βin the brain.Overall,Ibu&FK@RNPs can efficiently and successively target diseased BBB and astrocytes in AD lesion.Thus it significantly enhances intracephalic accumulation of drugs and efficiently treats AD by anti-neuroinflammation and neuroprotection. | Xueqin He Xiaorong Wang Lianyi Yang Zhihang Yang Wenqi Yu Yazhen Wang Rui Liu Meiwan Chen Huile Gao | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 3 |
| 4 | A power adjustment based e ICIC algorithm for hyper-dense Het Nets considering the alteration of user association显示文摘This paper evaluates power adjustment based enhanced inter-cell interference coordination(e ICIC)problem in the hyper-dense Het Net under the practical serving cell selection rule where each user selects the base station with the strongest received signal power as its serving cell while the alteration of the serving cell happens during the power adjusting process. In this paper, the e ICIC problem is solved by cooperatively adjusting the transmission power of all small cells. A power adjustment method based on modified particle swarm optimization(MPSO) is proposed to tackle the NP-hard e ICIC problem caused by the alteration of the serving cell, and considering the drawbacks of MPSO, an improved MPSO is proposed for effective algorithm.Local search and multi-restart process are introduced in the improved MPSO based e ICIC algorithm to guarantee the local and then global optimality, and the convergence conditions and the global optimality are proved by mathematical deduction to guide the selection of the parameters. Simulations show that, while considering the fifty-picocell case as an example, the proposed improved MPSO based e ICIC algorithm can increase the system throughput by 66.0% compared with the full power transmission, and compared with the existing schemes which do not alter the serving cells, the proposed algorithm can improve the system throughput by 32.2%. By improving MPSO, the consequent algorithm costs less iteration time to achieve higher system throughput, and it is effective and feasible to solve the e ICIC problem in the hyper-dense Het Net. | JIANG HuiLin TONG En LI ZhiHang PHAN NhuQuan PAN ZhiWen LIU Nan | 2015 | Science China(Information Sciences)2015，58，8： | 3 |
| 5 | A survey of HIV infection and related high-risk factors among men who have sex with men in Suzhou,Jiangsu,China显示文摘A cross-sectional study using the snowball sampling method was conducted in May 2008 to investigate human immunodeficiency virus (HIV) infection status and related high risk factors among men who have sex with men (MSM) in Suzhou city of Jiangsu province. The researchers carried out a face-to-face questionnaire interview among MSM, and collected their blood samples to test for HIV and other sexually transmitted diseases (STDs). Among the 280 respondents, 91.1% had homosexual acts in the past 6 months and 87.5% had multiple homosexual partners; 46.4% had heterosexual sex in the past 6 months and 33.1% had multiple heterosexual partners. The rate of continued condom use was 44.3% in homosexual sex in the past 6 months, while the rate in heterosexual sex was 33.9%. Laboratory test results showed that the prevalences of HIV and syphilis were 7.1% (20/280) and 15.0% (42/280), respectively, but no HCV-positive person was found. In the multivariate logistic regression model, subjects with a monthly income of more than RMB $ 1,000 (OR=4.83,95% CI=1.44-16.22), subjects who often went to bars for sexual partners (OR=2.25, 95%CI=1.21-4.20), and subjects who had more than one sexual partner in the past 6 months (OR=0.49, 95%CI=0.25-0.97) and had sex with fixed sexual partners in the past 6 months (OR=0.42, 95%CI=0.25-0.75) were significantly associated with the rate of continued condom use in homosexual sex in the past 6 months. Unprotected sex and multiple sexual partners were more common among MSM in Suzhou city; furthermore, the prevalences of HIV infection and syphilis were relatively high. HIV preventive measures should be designed to address these risk factors and control the spread of HIV among MSM. | Hongling Bai Xiping Huan Weiming Tang Xin Chen Hongjing Yan Xiaoyan Liu Haitao Yang Zhihang Peng Xiuping Zhao Rongbin Yu Hao Yu Feng Chen | 2011 | The Journal of Biomedical Research2011，25，1： | 2 |
| 6 | Molecularly imprinted TiO2 thin film using stable ground- state complex as template as applied to selective electrochemical determination of mercury显示文摘 | Liu Zhihang Huan Shuangyan Jiang jianhui | 2006 | Talanta2006，68，4： | 1 |
| 7 | Dielectric properties and impedance analysis in Aurivillius-type (Na 0.25 K 0.25 Bi 0.5 ) 1? x (LiCe) x /2 [] x /2 Bi 4 Ti 4 O 15 ceramics显示文摘 | Zhihang Peng Qiang Chen Jiagang Wu Dan Liu Dinquan Xiao Jianguo Zhu | 2012 | Journal of Alloys and Compounds2012，，： | 1 |
| 8 | A novel broadband and high-gain microstrip reflectarray antenna with variable polarization显示文摘This article proposes a new kind of microstrip reflectarray antenna,of which the polarization could be reconfigured among all the polarization states instead of some fixed states in a dual-or multi-polarized antenna.The mechanism for polarized variability is so simple that only mechanical rotation is needed.Theoretical analysis shows that the reflected polarization covers all states and that the dual-or multi-layered unit structure sandwiched with air-gaps can broaden the bandwidth efficiently.Moreover,it is demonstrated that adopting more elements can enhance antenna gain.With these advantageous features,this kind of antenna has the potential significance for engineering applications in radar,communication,etc.In this article,a complete theoretical analysis as well as a specific design sample is given to verify this method. | Zhihang WU Wenxun ZHANG Zhenguo LIU Wei SHEN | 2008 | Frontiers of Electrical and Electronic Engineering in China2008，3，1： | 1 |
| 9 | Customer-driven Product Configuration Optimization for Assemble-to-order Manufacturing Enterprises 显示文摘 | Chunjing Zhou Zhihang Lin Chuntao Liu | 2007 | The International Journal of Advanced Manufacturing Technology2007，38，12： | 1 |
| 10 | Research on the nonuniformity correction of linear TDI CCD remote camera显示文摘 | Liu Yaxia Hao Zhihang | 2005 | Advanced Materials and Devices for Sensing and Imaging II Proceedings of SPIE2005，5633，： | 1 |
| 11 | Development of a rapid and sensitive LC–MS/MS assay for the determination of combretastatin A4 phosphate, combretastatin A4 and combretastatin A4 glucuronide in beagle dog plasma and its application to a pharmacokinetic study显示文摘 | Xiaojing Wang Zhihang Chen Jinjing Che Qingfang Meng Chengqi Shan Yunan Hou Xiaolei Liu Yifeng Chai Yuanguo Cheng | 2009 | Journal of Chromatography B2009，，30： | 1 |
| 12 | Evolution of microstructure and dielectric properties of (LiCe)-doped Na 0.5 Bi 2.5 Nb 2 O 9 Aurivillius type ceramics显示文摘 | Zhihang Peng Qiang Chen Dan Liu Yadan Wang Dinquan Xiao Jianguo Zhu | 2013 | Current Applied Physics2013，，： | 1 |
| 13 | The compact Casπ(Cas12l)‘bracelet’provides a unique structural platform for DNA manipulation显示文摘CRISPR-Cas modules serve as the adaptive nucleic acid immune systems for prokaryotes,and provide versatile tools for nucleic acid manipulation in various organisms.Here,we discovered a new miniature type V system,CRISPR-Casπ(Cas12l)(~860 aa),from the environmental metagenome.Complexed with a large guide RNA(~170 nt)comprising the tracrRNA and crRNA,Casπ(Cas12l)recognizes a unique 5′C-rich PAM for DNA cleavage under a broad range of biochemical conditions,and generates gene editing in mammalian cells.Cryo-EM study reveals a‘bracelet’architecture of Casπeffector encircling the DNA target at 3.4Åresolution,substantially different from the canonical‘two-lobe’architectures of Cas12 and Cas9 nucleases.The large guide RNA serves as a‘two-arm’scaffold for effector assembly.Our study expands the knowledge of DNA targeting mechanisms by CRISPR effectors,and offers an efficient but compact platform for DNA manipulation. | Ao Sun Cheng-Ping Li Zhihang Chen Shouyue Zhang Dan-Yuan Li Yun Yang Long-Qi Li Yuqian Zhao Kaichen Wang Zhaofu Li Jinxia Liu Sitong Liu Jia Wang Jun-Jie Gogo Liu | 2023 | Cell Research2023，33，3： | 1 |
| 14 | NAS4RRAM: neural network architecture search for inference on RRAM-based accelerators显示文摘The RRAM-based accelerators enable fast and energy-efficient inference for neural networks.However, there are some requirements to deploy neural networks on RRAM-based accelerators, which are not considered in existing neural networks.(1) Because the noise problem and analog-digital converters/digitalanalog converters(ADC/DAC) affect the prediction accuracy, they should be modeled in networks.(2) Because the weights are mapped to the RRAM cells, they should be quantized, and the number of weights is limited by the number of RRAM cells in the accelerator. These requirements motivate us to customize the hardware-friendly network for the RRAM-based accelerator. We take the idea of network architecture search(NAS) to design networks with high prediction accuracy that meet the requirements. We propose a framework called NAS4RRAM to search for the optimal network on the given RRAM-based accelerator. The experiments demonstrate that NAS4RRAM can apply to different RRAM-based accelerators with different scales. The performance of searched networks outperforms the manually designed ResNet. | Zhihang YUAN Jingze LIU Xingchen LI Longhao YAN Haoxiang CHEN Bingzhe WU Yuchao YANG Guangyu SUN | 2021 | Science China(Information Sciences)2021，64，6： | 0 |
| 15 | Mitigating Lattice Distortion of High‑Voltage LiCoO_(2)via Core‑Shell Structure Induced by Cationic Heterogeneous Co‑Doping for Lithium‑Ion Batteries显示文摘Inactive elemental doping is commonly used to improve the structural stability of high-voltage layered transition-metal oxide cathodes.However,the one-step co-doping strategy usually results in small grain size since the low diffusivity ions such as Ti^(4+)will be concentrated on grain boundaries,which hinders the grain growth.In order to synthesize large single-crystal layered oxide cathodes,considering the different diffusivities of different dopant ions,we propose a simple two-step multi-element co-doping strategy to fabricate core–shell structured LiCoO_(2)(CS-LCO).In the current work,the high-diffusivity Al^(3+)/Mg^(2+)ions occupy the core of single-crystal grain while the low diffusivity Ti^(4+)ions enrich the shell layer.The Ti^(4+)-enriched shell layer(~12 nm)with Co/Ti substitution and stronger Ti–O bond gives rise to less oxygen ligand holes.In-situ XRD demonstrates the constrained contraction of c-axis lattice parameter and mitigated structural distortion.Under a high upper cut-off voltage of 4.6 V,the single-crystal CS-LCO maintains a reversible capacity of 159.8 mAh g^(−1)with a good retention of~89%after 300 cycles,and reaches a high specific capacity of 163.8 mAh g^(−1)at 5C.The proposed strategy can be extended to other pairs of low-(Zr^(4+),Ta^(5+),and W6+,etc.)and high-diffusivity cations(Zn^(2+),Ni^(2+),and Fe^(3+),etc.)for rational design of advanced layered oxide core–shell structured cathodes for lithium-ion batteries. | Zezhou Lin Ke Fan Tiancheng Liu Zhihang Xu Gao Chen Honglei Zhang Hao Li Xuyun Guo Xi Zhang Ye Zhu Peiyu Hou Haitao Huang | 2024 | Nano-Micro Letters2024，16，3： | 0 |
| 16 | Bornyl acetate extracted from Sharen(Fructus Amomi)inhibits proliferation,invasion and induces apoptosis by suppressing phosphatidylinositol-3-kinase/protein kinase B signaling in colorectal cancer显示文摘OBJECTIVE:To investigate the antitumor effects of bornyl acetate(BA)isolated from Sharen(Fructus Amomi)in colorectal cancer(CRC)and the underlying mechanisms.METHODS:SW480 and HT29 cells were treated with increasing doses of BA in order to determine its antitumor effects in vitro.Cell viability,colony formation,cell cycle,and apoptosis as well as migration and invasion were assessed using various assays.In addition,the in vivo antitumor effects of BA were assessed using a xenograft mouse model.We then assessed the mechanism of action of BA by conducting pathway activator-mediated rescue experiments and assessed the protein levels by Western blot analysis.RESULTS:BA showed anti-CRC tumor activities in vitro by suppressing cell proliferation and colony formation,inducing apoptosis,blocking cell cycle,and inhibiting migration and invasion.These effects were mediated via suppression of the phosphatidylinositol-3-kinase/protein kinase B(PI3K/AKT)pathway.In the tumor xenograft experiment,BA was found to repress tumor growth in vivo with low toxicity.CONCLUSIONS:The results demonstrated that BA exerts antitumor effects by suppressing the PI3K/AKT pathway,with low toxicity.Thus,BA might be a potential novel therapeutic agent for CRC. | LI Xiaohua DUAN Zhihang YUE Jianjun ZHANG Yongyu LI Yihang LIU Shifang NIE Qu YANG Depo ZHANG Lixia | 2023 | Journal of Traditional Chinese Medicine2023，43，6： | 0 |
| 17 | Modeling and coverage analysis of heterogeneous sub-6GHz-millimeter wave networks显示文摘The joint adoption of sub-6GHz and millimeter wave(mmWave)technology can prevent the blind spots of coverage,enabling comprehensive coverage while realizing high-speed communication rate.According to the sensitivity of mmWave,base stations should be more densely deployed,which is not well described by existing Poisson hole process(PHP)and the Poisson point process(PPP)models.This paper establishes a sub-6GHz and mmWave hybrid heterogeneous cellular network based on the modified Poisson hole process(MPHP).In our proposed model,the sub-6GHz base stations follow the PPP,and the mmWave base stations(MBSs)follow MPHP distribution.The expressions of the coverage probability are derived by using the interference calculation method of integrating the nearest sector exclusion area.Our theoretical analysis has been verified through simulation results,suggesting that the increase in the cell radius decreases the coverage probability of signal-to-interference-plus-noise ratio(SINR),whereas the increase in the sector parameter has the opposite effect.The variation of sub-6GHz base stations(SBSs)density imposes more significant impact than the MBSs on the SINR coverage probability.In addition,the decrease in MBSs density will reduce the average bandwidth allocated to the user equipment(UE),thus reducing the rate coverage probability. | Cheng Pan Yi Guo Gang Liu Haiyang Ding Zhihang Fu | 2023 | Journal of Information and Intelligence2023，1，4： | 0 |
| 18 | TIGER:A Web Portal of Tumor Immunotherapy Gene Expression Resource显示文摘Immunotherapy is a promising cancer treatment method;however,only a few patients benefit from it.The development of new immunotherapy strategies and effective biomarkers of response and resistance is urgently needed.Recently,high-throughput bulk and single-cell gene expression profling technologies have generated valuable resources.However,these resources are not well organized and systematic analysis is difficult.Here,we present TIGER,a tumor immunotherapy gene expression resource,which contains bulk transcriptome data of 1508 tumor samples with clinical immunotherapy outcomes and 11,057 tumor/normal samples without clinical immunotherapy outcomes,as well as single-cell transcriptome data of 2,116,945 immune cells from 655 samples.TIGER provides many useful modules for analyzing collected and user-provided data.Using the resource in TIGER,we identified a tumor-enriched subset of CD4^(+)T cells.Patients with melanoma with a higher signature score of this subset have a significantly better response and survival under immunotherapy.We believe that TIGER will be helpful in understanding anti-tumor immunity mechanisms and discovering effective biomarkers. | Zhihang Chen Ziwei Luo Di Zhang Huiqin Li Xuefei Liu Kaiyu Zhu Hongwan Zhang Zongping Wang Penghui Zhou Jian Ren An Zhao Zhixiang Zuo | 2023 | Genomics, Proteomics & Bioinformatics2023，21，2： | 0 |
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