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| 1 | The Yanshan orogeny and late Mesozoic multi-plate convergence in East Asia—Commemorating 90th years of the “Yanshan Orogeny”显示文摘The Yanshan movement/orogeny has been proposed for 90 years, which is of special significance in the history of geological research in China. This study conducted a review by synthesizing major achievements regarding episodic deformation features, sedimentary and magmatic records of the Yanshan orogeny in China, and clarified the episodic tectono-magmatism and its geodynamic origins. The tectonic implications of the Yanshan orogeny are discussed in the context of global plate tectonics and supercontinent reconstruction. Lines of evidence from structural, sedimentary and magmatic data suggest that the Yanshan orogeny represents a regional-scale tectonic event that affected the entire China continent in late Mesozoic period. Numerous age and structural constraints consistently indicate that the Yanshan orogeny was initiated in the Jurassic(at ~170±5 Ma). and was characterized by alternating stages of crustal shortening at ~170–136 Ma, crustal extension at ~135–90 Ma, and weak shortening at ~80 Ma. The 170–136 Ma crustal shortening was reflected in the generation of two regional stratigraphic unconformities(the Tiaojishan and Zhangjiakou unconformities), which were initially named the A and B episodes of 'the Yanshan Orogeny' by Mr.Wong Wenhao in 1928. Geodynamically, the Yanshan orogeny in East Asia was associated with nearly coeval oceanic subduction and continental convergence in the Paleo-Pacific, Neo-Tethys, and Mongol-Okhotsk tectonic domains. As a consequence, three giant accretionary-collisional tectonic systems were formed along the continental margins of East Asia, i.e., the Mongol-Okhotsk, Bangonghu-Nujiang, and SE China subduction-and collision-related accretionary systems. The Yanshan orogeny induced widespread crustal-scale folding and thrusting, tectonic reactivation of long-lived zones of crustal weakness,and extensive magmatism and mineralization in intraplate regions. Based on the time principle of supercontinent assembly and break-up, we propose that the mid-Late Jurassic multi-plate convergence in East Asia might represent the initiation of the assembly of the Amasia supercontinent, and the Yanshan orogeny might be the first 'stirrings' that is a prerequisite for the birth of the Amasia supercontinent. | Shuwen DONG Yueqiao ZHANG Hailong LI Wei SHI Huaimin XUE Jianhua LI Shiqi HUANG Yongchao WANG | 2018 | Science China Earth Sciences2018，61，12： | 21 |
| 2 | Overcharge-to-thermal-runaway behavior and safety assessment of commercial lithium-ion cells with different cathode materials:A comparison study显示文摘In this paper,overcharge behaviors and thermal runaway(TR)features of large format lithium-ion(Liion)cells with different cathode materials(LiFePO4(LFP),Li[Ni_(1/3)Co_(1/3)Mn_(1/3)]O_(2)(NCM111),Li[Ni_(0.6)Co_(0.2)Mn_(0.2)]O_(2)(NCM622)and Li[Ni_(0.8)Co_(0.1)Mn_(0.1)]O_(2)(NCM811))were investigated.The results showed that,under the same overcharge condition,the TR of LFP Li-ion cell occurred earlier compared with the NCM Li-ion cells,indicating its poor overcharge tolerance and high TR risk.However,when TR occurred,LFP Li-ion cell exhibited lower maximum temperature and mild TR response.All NCM Liion cells caught fire or exploded during TR,while the LFP Li-ion cell only released a large amount of smoke without fire.According to the overcharge behaviors and TR features,a safety assessment score system was proposed to evaluate the safety of the cells.In short,NCM Li-ion cells have better performance in energy density and overcharge tolerance(or low TR risk),while LFP Li-ion cell showed less severe response to overcharging(or less TR hazards).For NCM Li-ion cells,as the ratio of nickel in cathode material increases,the thermal stability of the cathode materials becomes poorer,and the TR hazards increase.Such a comparison study on large format Li-ion cells with different cathode materials can provide deeper insights into the overcharge behaviors and TR features,and provide guidance for engineers to reasonably choose battery materials in automotive applications. | Zhenpo Wang Jing Yuan Xiaoqing Zhu Hsin Wang Lvwei Huang Yituo Wang Shiqi Xu | 2021 | Journal of Energy Chemistry2021，30，4： | 12 |
| 3 | Influence of physical properties of carrier on the performance of dry powder inhalers显示文摘Dry powder inhalers(DPIs) offer distinct advantages as a means of pulmonary drug delivery and have attracted much attention in the field of pharmaceutical science. DPIs commonly contain micronized drug particles which, because of their cohesiveness and strong propensity to aggregate, have poor aerosolization performance. Thus carriers with a larger particle size are added to address this problem. However, the performance of DPIs is profoundly influenced by the physical properties of the carrier, particularly their particle size, morphology/shape and surface roughness. Because these factors are interdependent, it is difficult to completely understand how they individually influence DPI performance.The purpose of this review is to summarize and illuminate how these factors affect drug–carrier interaction and influence the performance of DPIs. | Tingting Peng Shiqi Lin Boyi Niu Xinyi Wang Ying Huang Xuejuan Zhang Ge Li Xin Pan Chuanbin Wu | 2016 | Acta Pharmaceutica Sinica B2016，6，4： | 8 |
| 4 | A DISTRIBUTED QOS ROUTING BASED ON ANT ALGORITHM FOR LEO SATELLITE NETWORK显示文摘Low Earth Orbit (LEO) satellites provide short round-trip delays and are becoming in- creasingly important. One of the challenges in LEO satellite networks is the development of specialized and efficient routing algorithms. To satisfy the QoS requirements of multimedia applications, satellite routing protocols should consider handovers and minimize their effect on the active connections. A distributed QoS routing scheme based on heuristic ant algorithm is proposed for satisfying delay bound and avoiding link congestion. Simulation results show that the call blocking probabilities of this al- gorithm are less than that of Shortest Path First (SPF) with different delay bound. | Xu Hui Huang Fei Wu Shiqi | 2007 | Journal of Electronics(China)2007，24，6： | 7 |
| 5 | Retina-Inspired Organic Heterojunction-Based Optoelectronic Synapses for Artificial Visual Systems显示文摘For the realization of retina-inspired neuromorphic visual systems which simulate basic functions of human visual systems,optoelectronic synapses capable of combining perceiving,processing,and memorizing in a single device have attracted immense interests.Here,optoelectronic synaptic transistors based on tris(2-phenylpyridine)iridium(Ir(ppy)_(3))and poly(3,3-didodecylquarterthiophene)(PQT-12)heterojunction structure are presented.The organic heterojunction serves as a basis for distinctive synaptic characteristics under different wavelengths of light.Furthermore,synaptic transistor arrays are fabricated to demonstrate their optical perception efficiency and color recognition capability under multiple illuminating conditions.The wavelength-tunability of synaptic behaviors further enables the mimicry of mood-modulated visual learning and memorizing processes of humans.More significantly,the computational dynamics of neurons of synaptic outputs including associated learning and optical logic functions can be successfully demonstrated on the presented devices.This work may locate the stage for future studies on optoelectronic synaptic devices toward the implementation of artificial visual systems. | Junyao Zhang Yang Lu Shilei Dai Ruizhi Wang Dandan Hao Shiqi Zhang Lize Xiong Jia Huang | 2021 | Research2021，，1： | 3 |
| 6 | Low-cost hybrid integrated 4 × 25.78 Gb/s CWDM TOSA for 10 km transmission using DFB-LDs and an arrayed waveguide grating multiplexer显示文摘We have developed a cost-effective and highly compact 100-Gb/s coarse wavelength division multiplexing(CWDM) transmitter optical subassembly(TOSA) using lens-free hybrid integration. To achieve large alignment tolerances, distributed feedback laser diodes(DFB-LDs) are butt-coupled to a four-channel silica-based planar lightwave circuit(PLC) arrayed waveguide grating, with the silicon sub-mounts and PLC adhesively bonded.Then, a flexible printed circuit is employed to connect the internal DFB-LDs and the exterior of the TOSA package for radiofrequency signal transmission, eliminating the expensive ceramic feed-through. The packaged CWDM TOSA, which is 15.8 mm × 7.0 mm × 6.0 mm in size, shows a side-mode suppression ratio of>40 dB, a 3 dB bandwidth of >18 GHz, and error-free transmission with an average optical output power of >0 dBm and dynamic extinction ratio of >4.0 dB at 25.78125 Gb/s over a 10 km single-mode fiber for all four lanes. | J1UN LIU QINGZHONG HUANG SHIQI TAO CHENG ZENG JINSONG XIA | 2018 | Photonics Research2018，，11： | 3 |
| 7 | Athermal 4-channel (de-)multiplexer in silicon nitride fabricated at low temperature显示文摘We have designed and realized an athermal 4-channel wavelength(de-)multiplexer in silicon nitride(Si N).Minimized thermal sensitivity is achieved in a wide wavelength range by using wide and narrow waveguides with low and different thermal-optic coefficients in the two arms of Mach–Zehnder interferometers(MZIs). The Si N core layer and Si O2 cladding layers are deposited by a low-temperature plasma-enhanced chemical vapor deposition process. The fabricated MZI filter exhibits a thermal sensitivity within 2.0 pm∕°C in a wavelength range of 55 nm to near 1300 nm. Then, an athermal(de-)multiplexer based on cascaded MZIs has been demonstrated with a crosstalk ≤-22 d B and a thermal sensitivity <4.8 pm∕°C for all four channels, reduced by 77% compared to a conventional Si N(de-)multiplexer. Owing to the passive operation and compatibility with the CMOS backend process, our devices have potential applications in 3 D integration of photonics and electronics. | SHIQI TAO QINGZHONG HUANG LIANGQIU ZHU JUN LIU YINGLU ZHANG YING HUANG YI WANG JINSONG XIA | 2018 | Photonics Research2018，6，7： | 3 |
| 8 | Proteomics provides individualized options of precision medicine for patients with gastric cancer显示文摘While precision medicine driven by genome sequencing has revolutionized cancer care,such as lung cancer,its impact on gastric cancer(GC)has been minimal.GC patients are routinely treated with chemotherapy,but only a fraction of them receive the clinical benefit.There is an urgent need to develop biomarkers or algorithms to select chemo-sensitive patients or apply targeted therapy.Here,we carried out retrospective analyses of 1,020 formalin-fixed,paraffin-embedded GC surgical resection samples from 5 hospitals and developed a mass spectrometry-based workflow for proteomic subtyping of GC.We identified two proteomic subtypes:the chemo-sensitive group(CSG)and the chemo-insensitive group(CIG)in the discovery set.The 5-year overall survival of CSG was significantly improved in patients who had received adjuvant chemotherapy after surgery compared with those who received surgery only(64.2%vs.49.6%;Cox P-value=0.002),whereas no such improvement was observed in CIG(50.0%vs.58.6%;Cox P-value=0.495).We validated these results in an independent validation set.Further,differential proteome analysis uncovered 9 FDA-approved drugs that may be applicable for targeted therapy of GC.A prospective study is warranted to test these findings for future GC patient care. | Wenwen Huang Dongdong Zhan Yazhuo Li Nairen Zheng Xin Wei Bin Bai Kecheng Zhang Mingwei Liu Xuefei Zhao Xiaotian Ni Xia Xia Jinwen Shi Cheng Zhang Zhihao Lu Jiafu Ji Juan Wang Shiqi Wang Gang Ji Jipeng Li Yongzhan Nie Wenquan Liang Xiaosong Wu Jianxin Cui Yongsheng Meng Feilin Cao Tieliu Shi Weimin Zhu Yi Wang Lin Chen Qingchuan Zhao Hongwei Wang Lin Shen Jun Qin | 2021 | Science China(Life Sciences)2021，64，8： | 3 |
| 9 | 财政分权与小学义务教育:中国案例(英文)显示文摘主流的财政分权理论一般认为,通过“用手投票”和“用脚投票”两种机制可以提高教育、卫生、社会保障等方面的社会福利水平,本文将这一理论应用于1978年以来的财政分权改革与中国小学义务教育的案例,发现财政分权并没有增加小学义务教育的有效供给。本文认为,出现这一结果的内在机制是,西方通行的财政分权促进社会福利水平提高的两种机制在中国并不成立,尤其是人口流动障碍及其地区性差异导致地方政府行为向追求资本投资与经济增长率的方向转变,这导致各地区激烈的财政竞争并相应挤占了义务教育等外部性较强的准公共产品性质的财政支出。本文还发现财政分权对富裕地区与贫困地区经济增长的影响是不一样的,它推动了富裕地区的经济增长而抑制了后者。 | 乔宝云 范剑勇 冯兴元 Huang Shiqi(译) | 2006 | Social Sciences in China2006，27，2： | 2 |
| 10 | Indocyanine green assembled free oxygen-nanobubbles towards enhanced near-infrared induced photodynamic therapy显示文摘Photodynamic therapy(PDT)has shown a promising capability for cancer treatment with minimal side effects.Indocyanine green(ICG),the only clinically approved near-infrared(NIR)fluorophore,has been used as a photosensitizer for PDT in clinical application.However,the main obstacle of directly utilizing ICG in the clinic lies in its low singlet oxygen(1O_(2))quantum yield(QY)and instability in aqueous solution.To improve the PDT efficacy of ICG,free ICG molecules were assembled with free oxygen nanobubbles(NBs-O_(2))to fabricate ICG-NBs-O_(2) by hydrophilic-hydrophobe interactions on the gas-liquid interface.Interestingly,1O2 QY of ICG-NBs-O_(2) solution was significantly increased to 1.6%,which was estimated to be 8 times as high as that of free ICG solution.Meanwhile,ICG-NBs-O_(2) exhibited better aqueous solution stability compared with free ICG.Furthermore,through establishing tumor models in nude mice,the therapeutic efficacy of ICG-NBs-O_(2) was also assessed in the PDT treatment of oral cancer.The tumor volume in ICG-NBs-O_(2) treated group on day 14 decreased to 0.56 of the initial tumor size on day 1,while the tumor volume in free ICG treated group increased to 2.4 times.The results demonstrated that ICG-NBs-O_(2) showed excellent tumor ablation in vivo.Therefore,this facile method provided an effective strategy for enhanced PDT treatment of ICG and showed great potential in clinical application. | Li Yang Bin Huang Shiqi Hu Yuan An Jingyi Sheng Yan Li Yuxin Wang Ning Gu | 2022 | Nano Research2022，15，5： | 2 |
| 11 | Artemisinin analogue SM934 protects against lupus-associated antiphospholipid syndrome via activation of Nrf2 and its targets显示文摘Kidney is a major target organ in both antiphospholipid syndrome(APS)and systemic lupus erythematosus(SLE).The etiology of antiphospholipid syndrome nephropathy associated lupus nephritis(APSN-LN)is intricate and remains largely unrevealed.We proposed in present work,that generation of antiphospholipid antibodies(aPLs),especially those directed towards the oxidized neoepitopes,are largely linked with the redox status along with disease progression.Moreover,we observed that compromised antioxidative capacity coincided with turbulence of inflammatory cytokine profile in the kidney of male NZW×BXSB F1 mice suffered from APSN-LN.SM934 is an artemisinin derivative that has been proved to have potent immunosuppressive properties.In current study,we elaborated the therapeutic benefits of SM934 in male NZW×BXSB F1 mice,a murine model develops syndrome resembled human APS associated with SLE,for the first time.SM934 treatment comprehensively impeded autoantibodies production,inflammatory cytokine accumulation and excessive oxidative stress in kidney.Among others,we interpreted in present work that both anti-inflammatory and antioxidative effects of SM934 is closely correlated with the enhancement of Nrf2 signaling and expression of its targets.Collectively,our finding confirmed that therapeutic strategy simultaneously exerting antioxidant and anti-inflammatory efficacy provide a novel feasible remedy for treating APSN-LN. | Zemin Lin Yuting Liu Li Chen Shiqi Cao Yueteng Huang Xiaoqian Yang Fenghua Zhu Wei Tang Shijun He Jianping Zuo | 2021 | Science China(Life Sciences)2021，64，10： | 2 |
| 12 | Effect of Nb on hydrogen-induced delayed fracture in high strength hot stamping steels显示文摘 | ZHANG Shiqi HUANG Yunhua SUN Bintang | 2015 | Materials Science and Engineering A2015，626，25： | 1 |
| 13 | A novel method for speckle noise reduction and ship target detection in SAR images显示文摘 | Huang Shiqi Liu Daizhi Gao Guiqing | 2009 | Pattern Recognition2009，42，7： | 1 |
| 14 | Evolution of AVS video coding standards:twenty years of innovation and development显示文摘Ever since the founding of the Audio and Video Coding Standard(AVS)Workgroup of China in 2002,it has been dedicated to advancing and innovating the digital audio-video industry with highly efficient and economical encoding/decoding technologies.Three representative generations of video coding standards have been finalized and published,consistently improving the coding performance in the past two decades.The series of AVS standards establish solid foundations for ubiquitous video applications in the areas including acquisition,coding,production,delivery,integrated system,public service,general screen content,and mixed reality media.Along with the standardization process,an extensive amount of studies have been carried out on efficiency-aware designation,algorithm optimization,and hardware implementation of these innovative video coding techniques.This paper explains how those developed techniques provide a lasting impact on the video coding community,extensively,technologically,and systematically.In particular,we provide a comprehensive survey of the three generations of the standards,and timely and in-depth summarize the efforts of the AVS video coding standards in the twenty years.The rate-distortion performance comparisons,in particular in terms of the 8K ultra-high-definition(UHD)contents,reflect the elegant design of the state-of-the-art AVS3 standards.We have also elaborated on a variety of well-established and promising applications,including commercial level real-time 8K encoder,high-frame-rate decoder chip for cell phone,and live streaming solution for sports.In addition,the China Central Television(CCTV)of China Media Group(CMG),the state television of China,has officially launched the first 8K broadcasting channel(CCTV-8K)since 2021 using AVS3.Given the significant success realized by the AVS standards,it is envisioned that a new era of 8K UHD video is arriving. | Siwei MA Li ZHANG Shiqi WANG Chuanmin JIA Shanshe WANG Tiejun HUANG Feng WU Wen GAO | 2022 | Science China(Information Sciences)2022，65，9： | 1 |
| 15 | MICROSTRUCTURE AND MECHANICAL PROPERTIES OF TiAl+Nd ALLOYS显示文摘MICROSTRUCTUREANDMECHANICALPROPERTIESOFTiAl+NdALLOYS￥LeiChangming;HeYuehui;ChenShiqi;QuXuanhui;HuangBaiyun(Researchinstituteo... | Lei Changming He Yuehui Chen Shiqi Qu Xuanhui Huang Baiyun(Research institute of powder MetallurgyCentral South University of Technology, Changsha 410083) | 1996 | 中国有色金属学会会刊:英文版1996，6，3： | 1 |
| 16 | A Novel Cross-Project Software Defect Prediction Algorithm Based on Transfer Learning显示文摘Software Defect Prediction(SDP) technology is an effective tool for improving software system quality that has attracted much attention in recent years.However,the prediction of cross-project data remains a challenge for the traditional SDP method due to the different distributions of the training and testing datasets.Another major difficulty is the class imbalance issue that must be addressed in Cross-Project Defect Prediction(CPDP).In this work,we propose a transfer-leaning algorithm(TSboostDF) that considers both knowledge transfer and class imbalance for CPDP.The experimental results demonstrate that the performance achieved by TSboostDF is better than those of existing CPDP methods. | Shiqi Tang Song Huang Changyou Zheng Erhu Liu Cheng Zong Yixian Ding | 2022 | Tsinghua Science and Technology2022，27，1： | 1 |
| 17 | Cortical and Subcortical Grey Matter Abnormalities in White Matter Hyperintensities and Subsequent Cognitive Impairment显示文摘Grey matter(GM)alterations may contribute to cognitive decline in individuals with white matter hyperintensities(WMH)but no consensus has yet emerged.Here,we investigated cortical thickness and grey matter volume in 23 WMH patients with mild cognitive impairment(WMH-MCI),43 WMH patients without cognitive impairment,and 55 healthy controls.Both WMH groups showed GM atrophy in the bilateral thalamus,fronto-insular cortices,and several parietal-temporal regions,and the WMH-MCI group showed more extensive and severe GM atrophy.The GM atrophy in the thalamus and fronto-insular cortices was associated with cognitive decline in the WMH-MCI patients and may mediate the relationship between WMH and cognition in WMH patients.Furthermore,the main results were well replicated in an independent dataset from the Alzheimer's Disease Neuroimaging Initiative database and in other control analyses.These comprehensive results provide robust evidence of specific GM alterations underlying WMH and subsequent cognitive impairment. | Wenhao Zhu Hao Huang Shiqi Yang Xiang Luo Wenzhen Zhu Shabei Xu Qi Meng Chengchao Zuo Yong Liu Wei Wang Alzheimer’s Disease Neuroimaging Initiative | 2021 | Neuroscience Bulletin2021，37，6： | 1 |
| 18 | Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease显示文摘 | Zhiping Li Shiqi Yang Huizhi Lin Jiawen Huang Paul A. Watkins Ann B. Moser Claudio DeSimone Xiao-yu Song Anna Mae Diehl | 2003 | Hepatology2003，，2： | 1 |
| 19 | Oval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease显示文摘 | Shiqi Yang Ayman Koteish Huizhi Lin Jiawen Huang Tania Roskams Valina Dawson Anna Mae Diehl | 2004 | Hepatology2004，，2： | 1 |
| 20 | Unique and complementary suppression of cGAS-STING and RNA sensing- triggered innate immune responses by SARS-CoV-2 proteins显示文摘The emergence of SARS-CoV-2 has resulted in the COVID-19 pandemic,leading to millions of infections and hundreds of thousands of human deaths.The efficient replication and population spread of SARS-CoV-2 indicates an effective evasion of human innate immune responses,although the viral proteins responsible for this immune evasion are not clear.In this study,we identified SARS-CoV-2 structural proteins,accessory proteins,and the main viral protease as potent inhibitors of host innate immune responses of distinct pathways.In particular,the main viral protease was a potent inhibitor of both the RLR and cGAS-STING pathways.Viral accessory protein 0RF3a had the unique ability to inhibit STING,but not the RLR response.On the other hand,structural protein N was a unique RLR inhibitor.0RF3a bound STING in a unique fashion and blocked the nuclear accumulation of p65 to inhibit nuclear factor-KB signaling.3CL of SARS-CoV-2 inhibited K63-ubiquitin modification of STING to disrupt the assembly of the STING functional complex and downstream signaling.Diverse vertebrate STINGs,including those from humans,mice,and chickens,could be inhibited by 0RF3a and 3CL of SARS-CoV-2.The existence of more effective innate immune suppressors in pathogenic coronaviruses may allow them to replicate more efficiently in vivo.Since evasion of host innate immune responses is essential for the survival of all viruses,our study provides insights into the design of therapeutic agents against SARS-CoV-2. | Yajuan Rui Jiaming Su Si Shen Ying Hu Dingbo Huang Wenwen Zheng Meng Lou Yifei Shi Meng Wang Shiqi Chen Na Zhao Qi Dong Yong Cai Rongzhen Xu Shu Zheng Xiao-Fang Yu | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 1 |
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